• SOM SCD MR Results - L-Glutamine and SCD-related disease
    • L-Glutamine all individuals
      • Painful Crises
      • Cholecystectomy
      • Retinopathy
      • Priapism
      • Leg Ulcers
      • eGFR
      • Aseptic Necrosis
    • L-Glutamine individuals age 18 and older
      • Painful Crises
      • Cholecystectomy
      • Retinopathy
      • Priapism
      • Leg Ulcers
      • eGFR
      • Aseptic Necrosis
  • SOM SCD MR Results - other metabolites and SCD-related disease
    • Painful Crises
      • Pyroglutamine
    • eGFR
      • cis-Aconitic acid
      • Decanoylcarnitine
      • Dodecanoylcarnitine
      • L-Acetylcarnitine
      • Butyrylcarnitine
      • Tiglylcarnitine
      • Glutarylcarnitine
      • Isovalerylcarnitine
      • Hexanoylcarnitine
      • L-Octanoylcarnitine
      • Ureidopropionic acid
      • Aminoadipic acid
      • 2-Hydroxyglutarate
      • 3-Methyladipic acid
      • 4-Pyridoxic acid
      • Allantoin
      • 2-Hydroxybutyric acid
      • Beta-Alanine
      • Betaine
      • L-Carnitine
      • Choline
      • Citric acid
      • Citrulline
      • Creatinine
      • L-Cystathionine
      • Glycine
      • Hippuric acid
      • Indoxyl sulfate
      • Methylmalonylcarnitine
      • myo-Inositol
      • Kynurenic acid
      • L-Kynurenine
      • L-Lactic acid
      • Oxalic acid
      • Pantothenic acid
      • L-Phenylalanine
      • L-Proline
      • Pyruvic acid
      • Quinolinic acid
      • Salicyluric acid
      • L-Serine
      • Sorbitol
      • Sucrose
      • L-Tryptophan
      • Uric acid
    • Cholecystectomy
      • Deoxycholic acid glycine conjugate
      • Taurodeoxycholic acid

SOM SCD MR Results - L-Glutamine and SCD-related disease

Legend: The document presents the genetic associations for metabolites and SCD-related diseases and mendelian randomization analysis results. SNPs (effect alleles) are the lead variants in each gene region identified for their strong association (P < 5.0 × 10−5) with a given metabolite in GWASes of metabolite levels in Europe-ancestry individuals (Shin et al., Nature Genetics, 2014, n=7,824; Long et al., Nature Genetics, 2017, n=1,960). Association effect size with SCD-related diseases in the CSSCD are log odds ratios from logistic regression.

Abbreviations and symbols: *:Variants identified to be pleiotropic by Phenoscanner queries and were excluded from model 2 (Methods); EAF: Effect allele frequency; BETA: Regression effect size or log(odd ratio); P Value: Significance value; N:GWAS sample size; F = F-statistic; I2 = I square; Q=Cochrane Q; nSNP=number of SNPs; CI=confidence interval; Var_ex=variance explained; IVW(re)= Inverse variance weighted (multiplicative random effect).

L-Glutamine all individuals

Painful Crises

Instruments Associations with L-Glutamine & Painful Crises
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region L-glutamine (Shin et al/Long et al) Painful Crises (CSSCD)
rs524219(G)/1:100821493 CDC14A (0.93, -0.28, P = 4.7e-06, N = 1958) (0.99, 0.59, P = 0.24, N = 1101)
rs11166473(T)/1:101010015* GPR88 (0.92, -0.36, P = 9.3e-08, N = 1958) (0.47, -0.12, P = 0.31, N = 1101)
rs2811981(A)/1:23950147* MDS2 (0.89, -0.12, P = 3.8e-06, N = 1958) (0.88, -0.12, P = 0.49, N = 1101)
rs3127550(A)/1:49431909* AGBL4 (0.49, 0.19, P = 5.7e-06, N = 1958) (0.17, -0.021, P = 0.89, N = 1101)
rs7394051(T)/10:122008026* intergenic (0.7, 0.0055, P = 2.2e-06, N = 7372) (0.76, -0.052, P = 0.7, N = 1101)
rs10762121(T)/10:68708291 CTNNA3 (0.18, -0.0094, P = 3.1e-05, N = 1768) (0.4, -0.018, P = 0.88, N = 1101)
rs11596604(A)/10:87141944* intergenic (0.024, 0.032, P = 2.5e-06, N = 1768) (0.01, 0.16, P = 0.78, N = 1101)
rs7078003(T)/10:99359412* HOGA1 (0.17, 0.0087, P = 1.8e-06, N = 7372) (0.12, -0.12, P = 0.5, N = 1101)
rs7131407(T)/11:128431418 ETS1 (0.13, 0.0082, P = 3.2e-05, N = 7372) (0.16, 0.29, P = 0.074, N = 1101)
rs10431159(A)/11:70967219 SHANK2 (0.65, -0.0047, P = 4.8e-05, N = 7372) (0.15, -0.061, P = 0.71, N = 1101)
rs17666239(A)/12:47194757* SLC38A4 (0.078, 0.0092, P = 1.7e-05, N = 7372) (0.035, 0.24, P = 0.45, N = 1101)
rs735246(A)/12:52547743 intergenic (0.83, 0.0083, P = 4.8e-05, N = 7372) (0.81, -0.11, P = 0.42, N = 1101)
rs774044(T)/12:56837979* TIMELESS (0.055, -0.015, P = 5.6e-07, N = 7372) (0.045, 0.093, P = 0.74, N = 1101)
rs7313455(A)/12:56853231* MIP (0.44, 0.0062, P = 2.1e-08, N = 7372) (0.13, -0.026, P = 0.88, N = 1101)
rs2657879(A)/12:56865338* GLS2 (0.82, 0.015, P = 6.1e-18, N = 7372) (0.94, 0.25, P = 0.32, N = 1101)
rs12232026(A)/12:56960766* RBMS2 (0.12, -0.0097, P = 4.4e-06, N = 7372) (0.14, -0.32, P = 0.049, N = 1101)
rs941893(T)/14:100542061* EVL (0.74, -0.0049, P = 4.1e-05, N = 7372) (0.27, 0.013, P = 0.92, N = 1101)
rs144325715(A)/14:95948631 intergenic (0.021, -0.74, P = 5.3e-06, N = 1958) (0.044, 0.25, P = 0.4, N = 1101)
rs11636988(A)/15:26822814* GABRB3 (0.57, -0.16, P = 6.5e-06, N = 1958) (0.13, -0.0023, P = 0.99, N = 1101)
rs1910151(A)/15:38158699* intergenic (0.64, 0.0048, P = 2.2e-05, N = 7372) (0.64, 0.11, P = 0.36, N = 1101)
rs35150605(TAAC)/15:88047276 RP11-648K4.2 (0.25, -0.15, P = 6.3e-06, N = 1958) (0.3, 0.037, P = 0.77, N = 1101)
rs2560409(C)/16:24099496 PRKCB (0.51, 0.26, P = 1.4e-06, N = 1958) (0.18, -0.12, P = 0.43, N = 1101)
rs16977047(T)/16:27924612* GSG1L (0.7, -0.0056, P = 1.1e-06, N = 7372) (0.77, -0.11, P = 0.43, N = 1101)
rs12447776(T)/16:84053027 SLC38A8 (0.019, 0.029, P = 4.1e-05, N = 1768) (0.042, 0.057, P = 0.85, N = 1101)
rs9912445(A)/17:37202603 LRRC37A11P (0.79, 0.0052, P = 1.7e-05, N = 7372) (0.72, -0.17, P = 0.17, N = 1101)
rs8069305(A)/17:53638670 CTD-2033D24.2 (0.68, -0.0047, P = 4.9e-05, N = 7372) (0.19, 0.031, P = 0.84, N = 1101)
rs4798682(G)/18:8738265 SOGA2 (0.74, 0.15, P = 5e-06, N = 1958) (0.87, -0.17, P = 0.33, N = 1101)
rs73971292(C)/2:161821810 intergenic (0.023, -0.65, P = 5.1e-06, N = 1958) (0.025, 0.15, P = 0.69, N = 1101)
rs780093(T)/2:27742603* GCKR (0.4, -0.0058, P = 1.9e-07, N = 7372) (0.14, 0.15, P = 0.37, N = 1101)
rs2199619(T)/2:28854958* PLB1 (0.28, 0.0054, P = 5.2e-06, N = 7372) (0.22, -0.11, P = 0.45, N = 1101)
rs992580(C)/20:15246472* MACROD2 (0.44, 0.15, P = 6.2e-06, N = 1958) (0.47, -0.0083, P = 0.94, N = 1101)
rs6137021(A)/20:20375560* RALGAPA2 (0.67, -0.0083, P = 4.5e-05, N = 1768) (0.23, -0.32, P = 0.023, N = 1101)
rs2425059(C)/20:33912371* UQCC1 (0.38, 0.15, P = 5.6e-06, N = 1958) (0.56, -0.12, P = 0.31, N = 1101)
rs2948828(A)/3:124811942 SLC12A8 (0.56, 0.0053, P = 2.2e-05, N = 7372) (0.75, 0.056, P = 0.67, N = 1101)
rs73168973(T)/3:151691599 intergenic (0.21, -0.23, P = 4e-07, N = 1958) (0.079, -0.18, P = 0.42, N = 1101)
rs4699183(A)/4:106444435 AC004066.2 (0.9, -0.27, P = 6.2e-06, N = 1958) (0.92, 0.082, P = 0.71, N = 1101)
rs138354882(A)/4:171429817 intergenic (0.028, -0.36, P = 4.5e-06, N = 1958) (0.09, 0.24, P = 0.25, N = 1101)
rs7667615(C)/4:182921992* AC108142.1 (0.26, -0.17, P = 6.1e-06, N = 1958) (0.17, -0.031, P = 0.84, N = 1101)
rs542300(A)/6:12252237 intergenic (0.51, -0.13, P = 7.2e-06, N = 1958) (0.54, -0.064, P = 0.59, N = 1101)
rs9478369(A)/6:153269698* intergenic (0.25, 0.0049, P = 4.1e-05, N = 7372) (0.51, 0.052, P = 0.66, N = 1101)
rs71569656(C)/6:22903627 RP1-209A6.1 (0.28, -0.14, P = 8.9e-06, N = 1958) (0.095, 0.42, P = 0.04, N = 1101)
rs2748991(T)/6:52596516 intergenic (0.45, -0.007, P = 2.3e-06, N = 5604) (0.34, -0.091, P = 0.45, N = 1101)
rs1582256(C)/7:126634804 GRM8 (0.51, -0.18, P = 8.5e-06, N = 1958) (0.49, 0.092, P = 0.42, N = 1101)
rs767772939(CT)/7:128350744 FAM71F1 (0.096, 0.26, P = 4.1e-06, N = 1958) (0.82, -0.16, P = 0.29, N = 1101)
rs17837468(A)/7:138309274 SVOPL (0.88, 0.0088, P = 3.8e-05, N = 7372) (0.76, -0.14, P = 0.3, N = 1101)
rs17152416(T)/7:25765238 AC003090.1 (0.76, 0.0049, P = 3.9e-05, N = 7372) (0.71, -0.18, P = 0.17, N = 1101)
rs4722699(T)/7:27456500* intergenic (0.27, -0.0048, P = 3.8e-05, N = 7372) (0.2, -0.0076, P = 0.96, N = 1101)
rs1799211(T)/7:76240677 UPK3B (0.41, -0.0082, P = 4.2e-06, N = 1768) (0.24, 0.037, P = 0.79, N = 1101)
rs9314463(A)/8:2525166 RP11-134O21.1 (0.19, 0.27, P = 9.1e-07, N = 1958) (0.43, -0.073, P = 0.54, N = 1101)
rs112508772(A)/9:140016354 snoU13 (0.025, 0.48, P = 7e-07, N = 1958) (0.056, -0.11, P = 0.67, N = 1101)
rs7848854(C)/9:7766733* intergenic (0.11, 0.0083, P = 2.4e-05, N = 7372) (0.027, 0.68, P = 0.06, N = 1101)
Results from Univariable Mendelian Randomization of L-Glutamine & Painful Crises - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 51 -0.21 (-0.46- 0.03) P=0.086 12 30 0.000128 (0- 62.6) NA NA 0.016 P=0.56
MR-Egger 51 -0.27 (-0.61- 0.064) P=0.12 12 30 0.000128 (0- 62.6) 41 0.8 0.016 P=0.56
Weighted median 51 -0.26 (-0.63- 0.11) P=0.17 12 30 0.000128 (0- 62.6) NA NA 0.016 P=0.56
Results from Univariable MRPRESSO of L-Glutamine & Painful Crises - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.21 0.12 -1.72 0.09
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of L-Glutamine & Painful Crises - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 27 -0.38 (-0.65- -0.12) P=0.0048 16 22 0 (0- 58.4) NA NA -0.021 P=0.58
MR-Egger 27 -0.31 (-0.73- 0.11) P=0.16 16 22 0 (0- 58.4) 17 0.88 -0.021 P=0.58
Weighted median 27 -0.32 (-0.71- 0.084) P=0.12 16 22 0 (0- 58.4) NA NA -0.021 P=0.58
Results from Univariable MRPRESSO of L-Glutamine & Painful Crises - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.38 0.14 -2.82 0.01
beta.exposure Outlier-corrected NA NA NA NA

Cholecystectomy

Instruments Associations with L-Glutamine & Cholecystectomy
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region L-glutamine (Shin et al/Long et al) Cholecystectomy (CSSCD)
rs524219(G)/1:100821493 CDC14A (0.93, -0.28, P = 4.7e-06, N = 1958) (0.99, -0.66, P = 0.25, N = 1084)
rs11166473(T)/1:101010015* GPR88 (0.92, -0.36, P = 9.3e-08, N = 1958) (0.47, -0.08, P = 0.56, N = 1084)
rs2811981(A)/1:23950147* MDS2 (0.89, -0.12, P = 3.8e-06, N = 1958) (0.88, -0.07, P = 0.74, N = 1084)
rs3127550(A)/1:49431909* AGBL4 (0.49, 0.19, P = 5.7e-06, N = 1958) (0.17, 0.26, P = 0.15, N = 1084)
rs7394051(T)/10:122008026* intergenic (0.7, 0.0055, P = 2.2e-06, N = 7372) (0.76, -0.098, P = 0.53, N = 1084)
rs10762121(T)/10:68708291 CTNNA3 (0.18, -0.0094, P = 3.1e-05, N = 1768) (0.4, 0.042, P = 0.76, N = 1084)
rs11596604(A)/10:87141944* intergenic (0.024, 0.032, P = 2.5e-06, N = 1768) (0.01, 0.34, P = 0.63, N = 1084)
rs7078003(T)/10:99359412* HOGA1 (0.17, 0.0087, P = 1.8e-06, N = 7372) (0.12, -0.52, P = 0.01, N = 1084)
rs7131407(T)/11:128431418 ETS1 (0.13, 0.0082, P = 3.2e-05, N = 7372) (0.16, -0.4, P = 0.033, N = 1084)
rs10431159(A)/11:70967219 SHANK2 (0.65, -0.0047, P = 4.8e-05, N = 7372) (0.15, -0.0037, P = 0.98, N = 1084)
rs17666239(A)/12:47194757* SLC38A4 (0.078, 0.0092, P = 1.7e-05, N = 7372) (0.035, 0.2, P = 0.57, N = 1084)
rs735246(A)/12:52547743 intergenic (0.83, 0.0083, P = 4.8e-05, N = 7372) (0.81, 0.21, P = 0.2, N = 1084)
rs774044(T)/12:56837979* TIMELESS (0.055, -0.015, P = 5.6e-07, N = 7372) (0.044, -0.24, P = 0.48, N = 1084)
rs7313455(A)/12:56853231* MIP (0.44, 0.0062, P = 2.1e-08, N = 7372) (0.13, 0.1, P = 0.61, N = 1084)
rs2657879(A)/12:56865338* GLS2 (0.82, 0.015, P = 6.1e-18, N = 7372) (0.94, -0.22, P = 0.46, N = 1084)
rs12232026(A)/12:56960766* RBMS2 (0.12, -0.0097, P = 4.4e-06, N = 7372) (0.14, 0.043, P = 0.82, N = 1084)
rs941893(T)/14:100542061* EVL (0.74, -0.0049, P = 4.1e-05, N = 7372) (0.27, -0.21, P = 0.18, N = 1084)
rs144325715(A)/14:95948631 intergenic (0.021, -0.74, P = 5.3e-06, N = 1958) (0.044, -0.3, P = 0.37, N = 1084)
rs11636988(A)/15:26822814* GABRB3 (0.57, -0.16, P = 6.5e-06, N = 1958) (0.13, 0.14, P = 0.5, N = 1084)
rs1910151(A)/15:38158699* intergenic (0.64, 0.0048, P = 2.2e-05, N = 7372) (0.64, 0.086, P = 0.55, N = 1084)
rs35150605(TAAC)/15:88047276 RP11-648K4.2 (0.25, -0.15, P = 6.3e-06, N = 1958) (0.3, 0.25, P = 0.086, N = 1084)
rs2560409(C)/16:24099496 PRKCB (0.51, 0.26, P = 1.4e-06, N = 1958) (0.18, -0.19, P = 0.27, N = 1084)
rs16977047(T)/16:27924612* GSG1L (0.7, -0.0056, P = 1.1e-06, N = 7372) (0.76, 0.041, P = 0.79, N = 1084)
rs12447776(T)/16:84053027 SLC38A8 (0.019, 0.029, P = 4.1e-05, N = 1768) (0.042, -0.47, P = 0.16, N = 1084)
rs9912445(A)/17:37202603 LRRC37A11P (0.79, 0.0052, P = 1.7e-05, N = 7372) (0.73, -0.12, P = 0.4, N = 1084)
rs8069305(A)/17:53638670 CTD-2033D24.2 (0.68, -0.0047, P = 4.9e-05, N = 7372) (0.19, -0.058, P = 0.75, N = 1084)
rs4798682(G)/18:8738265 SOGA2 (0.74, 0.15, P = 5e-06, N = 1958) (0.87, -0.16, P = 0.42, N = 1084)
rs73971292(C)/2:161821810 intergenic (0.023, -0.65, P = 5.1e-06, N = 1958) (0.025, 0.11, P = 0.8, N = 1084)
rs780093(T)/2:27742603* GCKR (0.4, -0.0058, P = 1.9e-07, N = 7372) (0.14, 0.12, P = 0.53, N = 1084)
rs2199619(T)/2:28854958* PLB1 (0.28, 0.0054, P = 5.2e-06, N = 7372) (0.22, -0.12, P = 0.48, N = 1084)
rs992580(C)/20:15246472* MACROD2 (0.44, 0.15, P = 6.2e-06, N = 1958) (0.47, 0.12, P = 0.37, N = 1084)
rs6137021(A)/20:20375560* RALGAPA2 (0.67, -0.0083, P = 4.5e-05, N = 1768) (0.23, -0.16, P = 0.33, N = 1084)
rs2425059(C)/20:33912371* UQCC1 (0.38, 0.15, P = 5.6e-06, N = 1958) (0.56, -0.14, P = 0.29, N = 1084)
rs2948828(A)/3:124811942 SLC12A8 (0.56, 0.0053, P = 2.2e-05, N = 7372) (0.75, 0.23, P = 0.13, N = 1084)
rs73168973(T)/3:151691599 intergenic (0.21, -0.23, P = 4e-07, N = 1958) (0.078, 0.12, P = 0.65, N = 1084)
rs4699183(A)/4:106444435 AC004066.2 (0.9, -0.27, P = 6.2e-06, N = 1958) (0.92, -0.14, P = 0.59, N = 1084)
rs138354882(A)/4:171429817 intergenic (0.028, -0.36, P = 4.5e-06, N = 1958) (0.09, -0.32, P = 0.2, N = 1084)
rs7667615(C)/4:182921992* AC108142.1 (0.26, -0.17, P = 6.1e-06, N = 1958) (0.18, 0.027, P = 0.88, N = 1084)
rs542300(A)/6:12252237 intergenic (0.51, -0.13, P = 7.2e-06, N = 1958) (0.54, 0.054, P = 0.69, N = 1084)
rs9478369(A)/6:153269698* intergenic (0.25, 0.0049, P = 4.1e-05, N = 7372) (0.51, -0.36, P = 0.0077, N = 1084)
rs71569656(C)/6:22903627 RP1-209A6.1 (0.28, -0.14, P = 8.9e-06, N = 1958) (0.095, 0.46, P = 0.059, N = 1084)
rs2748991(T)/6:52596516 intergenic (0.45, -0.007, P = 2.3e-06, N = 5604) (0.33, 0.092, P = 0.51, N = 1084)
rs1582256(C)/7:126634804 GRM8 (0.51, -0.18, P = 8.5e-06, N = 1958) (0.49, 0.0036, P = 0.98, N = 1084)
rs767772939(CT)/7:128350744 FAM71F1 (0.096, 0.26, P = 4.1e-06, N = 1958) (0.82, -0.1, P = 0.54, N = 1084)
rs17837468(A)/7:138309274 SVOPL (0.88, 0.0088, P = 3.8e-05, N = 7372) (0.76, -0.13, P = 0.39, N = 1084)
rs17152416(T)/7:25765238 AC003090.1 (0.76, 0.0049, P = 3.9e-05, N = 7372) (0.71, 0.03, P = 0.84, N = 1084)
rs4722699(T)/7:27456500* intergenic (0.27, -0.0048, P = 3.8e-05, N = 7372) (0.2, 0.22, P = 0.19, N = 1084)
rs1799211(T)/7:76240677 UPK3B (0.41, -0.0082, P = 4.2e-06, N = 1768) (0.24, -0.23, P = 0.16, N = 1084)
rs9314463(A)/8:2525166 RP11-134O21.1 (0.19, 0.27, P = 9.1e-07, N = 1958) (0.43, -0.075, P = 0.58, N = 1084)
rs112508772(A)/9:140016354 snoU13 (0.025, 0.48, P = 7e-07, N = 1958) (0.056, -0.23, P = 0.44, N = 1084)
rs7848854(C)/9:7766733* intergenic (0.11, 0.0083, P = 2.4e-05, N = 7372) (0.026, -0.083, P = 0.85, N = 1084)
Results from Univariable Mendelian Randomization of L-Glutamine & Cholecystectomy - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 51 -0.06 (-0.39- 0.27) P=0.72 12 30 0 (0- 98) NA NA -0.051 P=0.13
MR-Egger 51 0.13 (-0.27- 0.54) P=0.52 12 30 0 (0- 98) 53 0.33 -0.051 P=0.13
Weighted median 51 -0.097 (-0.54- 0.35) P=0.67 12 30 0 (0- 98) NA NA -0.051 P=0.13
Results from Univariable MRPRESSO of L-Glutamine & Cholecystectomy - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.06 0.17 -0.36 0.72
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of L-Glutamine & Cholecystectomy - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 27 -0.17 (-0.56- 0.22) P=0.39 16 22 0 (0- 96.8) NA NA -0.041 P=0.38
MR-Egger 27 -0.027 (-0.53- 0.48) P=0.92 16 22 0 (0- 96.8) 27 0.36 -0.041 P=0.38
Weighted median 27 -0.25 (-0.78- 0.28) P=0.36 16 22 0 (0- 96.8) NA NA -0.041 P=0.38
Results from Univariable MRPRESSO of L-Glutamine & Cholecystectomy - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.17 0.2 -0.87 0.39
beta.exposure Outlier-corrected NA NA NA NA

Retinopathy

Instruments Associations with L-Glutamine & Retinopathy
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region L-glutamine (Shin et al/Long et al) Retinopathy (CSSCD)
rs524219(G)/1:100821493 CDC14A (0.93, -0.28, P = 4.7e-06, N = 1958) (0.98, 0.8, P = 0.1, N = 566)
rs11166473(T)/1:101010015* GPR88 (0.92, -0.36, P = 9.3e-08, N = 1958) (0.48, 0.096, P = 0.47, N = 566)
rs2811981(A)/1:23950147* MDS2 (0.89, -0.12, P = 3.8e-06, N = 1958) (0.88, 0.094, P = 0.63, N = 566)
rs3127550(A)/1:49431909* AGBL4 (0.49, 0.19, P = 5.7e-06, N = 1958) (0.18, -0.17, P = 0.3, N = 566)
rs7394051(T)/10:122008026* intergenic (0.7, 0.0055, P = 2.2e-06, N = 7372) (0.76, -0.09, P = 0.54, N = 566)
rs10762121(T)/10:68708291 CTNNA3 (0.18, -0.0094, P = 3.1e-05, N = 1768) (0.4, -0.13, P = 0.31, N = 566)
rs11596604(A)/10:87141944* intergenic (0.024, 0.032, P = 2.5e-06, N = 1768) (0.011, 0.31, P = 0.63, N = 566)
rs7078003(T)/10:99359412* HOGA1 (0.17, 0.0087, P = 1.8e-06, N = 7372) (0.11, 0.41, P = 0.046, N = 566)
rs7131407(T)/11:128431418 ETS1 (0.13, 0.0082, P = 3.2e-05, N = 7372) (0.17, 0.23, P = 0.19, N = 566)
rs10431159(A)/11:70967219 SHANK2 (0.65, -0.0047, P = 4.8e-05, N = 7372) (0.16, -0.24, P = 0.16, N = 566)
rs17666239(A)/12:47194757* SLC38A4 (0.078, 0.0092, P = 1.7e-05, N = 7372) (0.037, -0.36, P = 0.28, N = 566)
rs735246(A)/12:52547743 intergenic (0.83, 0.0083, P = 4.8e-05, N = 7372) (0.8, 0.081, P = 0.6, N = 566)
rs774044(T)/12:56837979* TIMELESS (0.055, -0.015, P = 5.6e-07, N = 7372) (0.039, 0.16, P = 0.63, N = 566)
rs7313455(A)/12:56853231* MIP (0.44, 0.0062, P = 2.1e-08, N = 7372) (0.13, 0.16, P = 0.41, N = 566)
rs2657879(A)/12:56865338* GLS2 (0.82, 0.015, P = 6.1e-18, N = 7372) (0.95, 0.2, P = 0.48, N = 566)
rs12232026(A)/12:56960766* RBMS2 (0.12, -0.0097, P = 4.4e-06, N = 7372) (0.14, 0.088, P = 0.63, N = 566)
rs941893(T)/14:100542061* EVL (0.74, -0.0049, P = 4.1e-05, N = 7372) (0.27, -0.4, P = 0.0062, N = 566)
rs144325715(A)/14:95948631 intergenic (0.021, -0.74, P = 5.3e-06, N = 1958) (0.042, -0.33, P = 0.31, N = 566)
rs11636988(A)/15:26822814* GABRB3 (0.57, -0.16, P = 6.5e-06, N = 1958) (0.13, 0.36, P = 0.065, N = 566)
rs1910151(A)/15:38158699* intergenic (0.64, 0.0048, P = 2.2e-05, N = 7372) (0.63, 0.06, P = 0.66, N = 566)
rs35150605(TAAC)/15:88047276 RP11-648K4.2 (0.25, -0.15, P = 6.3e-06, N = 1958) (0.31, -0.2, P = 0.15, N = 566)
rs2560409(C)/16:24099496 PRKCB (0.51, 0.26, P = 1.4e-06, N = 1958) (0.19, 0.026, P = 0.87, N = 566)
rs16977047(T)/16:27924612* GSG1L (0.7, -0.0056, P = 1.1e-06, N = 7372) (0.77, -0.2, P = 0.17, N = 566)
rs12447776(T)/16:84053027 SLC38A8 (0.019, 0.029, P = 4.1e-05, N = 1768) (0.04, -0.068, P = 0.84, N = 566)
rs9912445(A)/17:37202603 LRRC37A11P (0.79, 0.0052, P = 1.7e-05, N = 7372) (0.72, 0.028, P = 0.84, N = 566)
rs8069305(A)/17:53638670 CTD-2033D24.2 (0.68, -0.0047, P = 4.9e-05, N = 7372) (0.18, 0.019, P = 0.91, N = 566)
rs4798682(G)/18:8738265 SOGA2 (0.74, 0.15, P = 5e-06, N = 1958) (0.9, -0.11, P = 0.58, N = 566)
rs73971292(C)/2:161821810 intergenic (0.023, -0.65, P = 5.1e-06, N = 1958) (0.027, 0.51, P = 0.2, N = 566)
rs780093(T)/2:27742603* GCKR (0.4, -0.0058, P = 1.9e-07, N = 7372) (0.14, 0.12, P = 0.54, N = 566)
rs2199619(T)/2:28854958* PLB1 (0.28, 0.0054, P = 5.2e-06, N = 7372) (0.21, -0.033, P = 0.83, N = 566)
rs992580(C)/20:15246472* MACROD2 (0.44, 0.15, P = 6.2e-06, N = 1958) (0.48, -0.076, P = 0.55, N = 566)
rs6137021(A)/20:20375560* RALGAPA2 (0.67, -0.0083, P = 4.5e-05, N = 1768) (0.24, 0.078, P = 0.6, N = 566)
rs2425059(C)/20:33912371* UQCC1 (0.38, 0.15, P = 5.6e-06, N = 1958) (0.55, -0.049, P = 0.69, N = 566)
rs2948828(A)/3:124811942 SLC12A8 (0.56, 0.0053, P = 2.2e-05, N = 7372) (0.73, -0.36, P = 0.012, N = 566)
rs73168973(T)/3:151691599 intergenic (0.21, -0.23, P = 4e-07, N = 1958) (0.073, -0.12, P = 0.62, N = 566)
rs4699183(A)/4:106444435 AC004066.2 (0.9, -0.27, P = 6.2e-06, N = 1958) (0.92, -0.28, P = 0.24, N = 566)
rs138354882(A)/4:171429817 intergenic (0.028, -0.36, P = 4.5e-06, N = 1958) (0.087, -0.38, P = 0.09, N = 566)
rs7667615(C)/4:182921992* AC108142.1 (0.26, -0.17, P = 6.1e-06, N = 1958) (0.17, 0.29, P = 0.081, N = 566)
rs542300(A)/6:12252237 intergenic (0.51, -0.13, P = 7.2e-06, N = 1958) (0.53, 0.074, P = 0.57, N = 566)
rs9478369(A)/6:153269698* intergenic (0.25, 0.0049, P = 4.1e-05, N = 7372) (0.5, -0.076, P = 0.54, N = 566)
rs71569656(C)/6:22903627 RP1-209A6.1 (0.28, -0.14, P = 8.9e-06, N = 1958) (0.092, -0.36, P = 0.11, N = 566)
rs2748991(T)/6:52596516 intergenic (0.45, -0.007, P = 2.3e-06, N = 5604) (0.33, -0.09, P = 0.51, N = 566)
rs1582256(C)/7:126634804 GRM8 (0.51, -0.18, P = 8.5e-06, N = 1958) (0.49, 0.14, P = 0.29, N = 566)
rs767772939(CT)/7:128350744 FAM71F1 (0.096, 0.26, P = 4.1e-06, N = 1958) (0.81, -0.16, P = 0.34, N = 566)
rs17837468(A)/7:138309274 SVOPL (0.88, 0.0088, P = 3.8e-05, N = 7372) (0.74, -0.035, P = 0.81, N = 566)
rs17152416(T)/7:25765238 AC003090.1 (0.76, 0.0049, P = 3.9e-05, N = 7372) (0.72, 0.089, P = 0.53, N = 566)
rs4722699(T)/7:27456500* intergenic (0.27, -0.0048, P = 3.8e-05, N = 7372) (0.2, -0.096, P = 0.54, N = 566)
rs1799211(T)/7:76240677 UPK3B (0.41, -0.0082, P = 4.2e-06, N = 1768) (0.24, 0.21, P = 0.16, N = 566)
rs9314463(A)/8:2525166 RP11-134O21.1 (0.19, 0.27, P = 9.1e-07, N = 1958) (0.44, 0.15, P = 0.25, N = 566)
rs112508772(A)/9:140016354 snoU13 (0.025, 0.48, P = 7e-07, N = 1958) (0.057, -0.067, P = 0.8, N = 566)
rs7848854(C)/9:7766733* intergenic (0.11, 0.0083, P = 2.4e-05, N = 7372) (0.033, 0.43, P = 0.24, N = 566)
Results from Univariable Mendelian Randomization of L-Glutamine & Retinopathy - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 51 -0.073 (-0.4- 0.25) P=0.66 12 30 4.6 (0- 97.4) NA NA 0.022 P=0.5
MR-Egger 51 -0.16 (-0.57- 0.25) P=0.45 12 30 4.6 (0- 97.4) 61 0.12 0.022 P=0.5
Weighted median 51 -0.2 (-0.66- 0.26) P=0.4 12 30 4.6 (0- 97.4) NA NA 0.022 P=0.5
Results from Univariable MRPRESSO of L-Glutamine & Retinopathy - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.07 0.17 -0.44 0.66
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of L-Glutamine & Retinopathy - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 27 0.15 (-0.25- 0.54) P=0.46 16 22 5.05 (0- 97.5) NA NA 0.014 P=0.77
MR-Egger 27 0.1 (-0.42- 0.62) P=0.71 16 22 5.05 (0- 97.5) 32 0.16 0.014 P=0.77
Weighted median 27 0.21 (-0.31- 0.72) P=0.43 16 22 5.05 (0- 97.5) NA NA 0.014 P=0.77
Results from Univariable MRPRESSO of L-Glutamine & Retinopathy - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0.15 0.2 0.74 0.46
beta.exposure Outlier-corrected NA NA NA NA

Priapism

Instruments Associations with L-Glutamine & Priapism
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region L-glutamine (Shin et al/Long et al) Priapism (CSSCD)
rs524219(G)/1:100821493 CDC14A (0.93, -0.28, P = 4.7e-06, N = 1958) (0.99, -0.11, P = 0.88, N = 556)
rs11166473(T)/1:101010015* GPR88 (0.92, -0.36, P = 9.3e-08, N = 1958) (0.48, 0.13, P = 0.45, N = 556)
rs2811981(A)/1:23950147* MDS2 (0.89, -0.12, P = 3.8e-06, N = 1958) (0.89, 0.21, P = 0.44, N = 556)
rs3127550(A)/1:49431909* AGBL4 (0.49, 0.19, P = 5.7e-06, N = 1958) (0.17, -0.014, P = 0.95, N = 556)
rs7394051(T)/10:122008026* intergenic (0.7, 0.0055, P = 2.2e-06, N = 7372) (0.77, -0.069, P = 0.72, N = 556)
rs10762121(T)/10:68708291 CTNNA3 (0.18, -0.0094, P = 3.1e-05, N = 1768) (0.4, 0.098, P = 0.56, N = 556)
rs11596604(A)/10:87141944* intergenic (0.024, 0.032, P = 2.5e-06, N = 1768) (0.013, 0.073, P = 0.93, N = 556)
rs7078003(T)/10:99359412* HOGA1 (0.17, 0.0087, P = 1.8e-06, N = 7372) (0.11, 0.031, P = 0.9, N = 556)
rs7131407(T)/11:128431418 ETS1 (0.13, 0.0082, P = 3.2e-05, N = 7372) (0.15, -0.17, P = 0.46, N = 556)
rs10431159(A)/11:70967219 SHANK2 (0.65, -0.0047, P = 4.8e-05, N = 7372) (0.15, -0.19, P = 0.43, N = 556)
rs17666239(A)/12:47194757* SLC38A4 (0.078, 0.0092, P = 1.7e-05, N = 7372) (0.031, -0.19, P = 0.68, N = 556)
rs735246(A)/12:52547743 intergenic (0.83, 0.0083, P = 4.8e-05, N = 7372) (0.81, 0.065, P = 0.76, N = 556)
rs774044(T)/12:56837979* TIMELESS (0.055, -0.015, P = 5.6e-07, N = 7372) (0.044, 0.17, P = 0.69, N = 556)
rs7313455(A)/12:56853231* MIP (0.44, 0.0062, P = 2.1e-08, N = 7372) (0.13, -0.27, P = 0.3, N = 556)
rs2657879(A)/12:56865338* GLS2 (0.82, 0.015, P = 6.1e-18, N = 7372) (0.95, 0.71, P = 0.072, N = 556)
rs12232026(A)/12:56960766* RBMS2 (0.12, -0.0097, P = 4.4e-06, N = 7372) (0.15, -0.052, P = 0.83, N = 556)
rs941893(T)/14:100542061* EVL (0.74, -0.0049, P = 4.1e-05, N = 7372) (0.26, -0.0017, P = 0.99, N = 556)
rs144325715(A)/14:95948631 intergenic (0.021, -0.74, P = 5.3e-06, N = 1958) (0.042, -0.39, P = 0.35, N = 556)
rs11636988(A)/15:26822814* GABRB3 (0.57, -0.16, P = 6.5e-06, N = 1958) (0.12, -0.18, P = 0.48, N = 556)
rs1910151(A)/15:38158699* intergenic (0.64, 0.0048, P = 2.2e-05, N = 7372) (0.64, 0.029, P = 0.87, N = 556)
rs35150605(TAAC)/15:88047276 RP11-648K4.2 (0.25, -0.15, P = 6.3e-06, N = 1958) (0.3, 0.035, P = 0.85, N = 556)
rs2560409(C)/16:24099496 PRKCB (0.51, 0.26, P = 1.4e-06, N = 1958) (0.18, 0.24, P = 0.27, N = 556)
rs16977047(T)/16:27924612* GSG1L (0.7, -0.0056, P = 1.1e-06, N = 7372) (0.78, 0.034, P = 0.86, N = 556)
rs12447776(T)/16:84053027 SLC38A8 (0.019, 0.029, P = 4.1e-05, N = 1768) (0.048, -0.15, P = 0.7, N = 556)
rs9912445(A)/17:37202603 LRRC37A11P (0.79, 0.0052, P = 1.7e-05, N = 7372) (0.72, -0.12, P = 0.51, N = 556)
rs8069305(A)/17:53638670 CTD-2033D24.2 (0.68, -0.0047, P = 4.9e-05, N = 7372) (0.2, 0.21, P = 0.33, N = 556)
rs4798682(G)/18:8738265 SOGA2 (0.74, 0.15, P = 5e-06, N = 1958) (0.87, -0.19, P = 0.47, N = 556)
rs73971292(C)/2:161821810 intergenic (0.023, -0.65, P = 5.1e-06, N = 1958) (0.018, 0.3, P = 0.63, N = 556)
rs780093(T)/2:27742603* GCKR (0.4, -0.0058, P = 1.9e-07, N = 7372) (0.14, 0.3, P = 0.22, N = 556)
rs2199619(T)/2:28854958* PLB1 (0.28, 0.0054, P = 5.2e-06, N = 7372) (0.21, 0.23, P = 0.24, N = 556)
rs992580(C)/20:15246472* MACROD2 (0.44, 0.15, P = 6.2e-06, N = 1958) (0.47, 0.1, P = 0.53, N = 556)
rs6137021(A)/20:20375560* RALGAPA2 (0.67, -0.0083, P = 4.5e-05, N = 1768) (0.23, 0.21, P = 0.32, N = 556)
rs2425059(C)/20:33912371* UQCC1 (0.38, 0.15, P = 5.6e-06, N = 1958) (0.56, 0.031, P = 0.85, N = 556)
rs2948828(A)/3:124811942 SLC12A8 (0.56, 0.0053, P = 2.2e-05, N = 7372) (0.74, -0.18, P = 0.34, N = 556)
rs73168973(T)/3:151691599 intergenic (0.21, -0.23, P = 4e-07, N = 1958) (0.08, 0.13, P = 0.68, N = 556)
rs4699183(A)/4:106444435 AC004066.2 (0.9, -0.27, P = 6.2e-06, N = 1958) (0.92, 0.24, P = 0.45, N = 556)
rs138354882(A)/4:171429817 intergenic (0.028, -0.36, P = 4.5e-06, N = 1958) (0.095, -0.08, P = 0.79, N = 556)
rs7667615(C)/4:182921992* AC108142.1 (0.26, -0.17, P = 6.1e-06, N = 1958) (0.18, -0.014, P = 0.95, N = 556)
rs542300(A)/6:12252237 intergenic (0.51, -0.13, P = 7.2e-06, N = 1958) (0.54, -0.13, P = 0.47, N = 556)
rs9478369(A)/6:153269698* intergenic (0.25, 0.0049, P = 4.1e-05, N = 7372) (0.51, 0.12, P = 0.46, N = 556)
rs71569656(C)/6:22903627 RP1-209A6.1 (0.28, -0.14, P = 8.9e-06, N = 1958) (0.1, -0.18, P = 0.53, N = 556)
rs2748991(T)/6:52596516 intergenic (0.45, -0.007, P = 2.3e-06, N = 5604) (0.33, -0.13, P = 0.47, N = 556)
rs1582256(C)/7:126634804 GRM8 (0.51, -0.18, P = 8.5e-06, N = 1958) (0.48, -0.17, P = 0.33, N = 556)
rs767772939(CT)/7:128350744 FAM71F1 (0.096, 0.26, P = 4.1e-06, N = 1958) (0.81, -0.3, P = 0.16, N = 556)
rs17837468(A)/7:138309274 SVOPL (0.88, 0.0088, P = 3.8e-05, N = 7372) (0.75, -0.12, P = 0.53, N = 556)
rs17152416(T)/7:25765238 AC003090.1 (0.76, 0.0049, P = 3.9e-05, N = 7372) (0.71, -0.0019, P = 0.99, N = 556)
rs4722699(T)/7:27456500* intergenic (0.27, -0.0048, P = 3.8e-05, N = 7372) (0.2, 0.056, P = 0.79, N = 556)
rs1799211(T)/7:76240677 UPK3B (0.41, -0.0082, P = 4.2e-06, N = 1768) (0.25, -0.19, P = 0.35, N = 556)
rs9314463(A)/8:2525166 RP11-134O21.1 (0.19, 0.27, P = 9.1e-07, N = 1958) (0.43, 0.054, P = 0.75, N = 556)
rs112508772(A)/9:140016354 snoU13 (0.025, 0.48, P = 7e-07, N = 1958) (0.058, -0.11, P = 0.76, N = 556)
rs7848854(C)/9:7766733* intergenic (0.11, 0.0083, P = 2.4e-05, N = 7372) (0.029, 0.079, P = 0.87, N = 556)
Results from Univariable Mendelian Randomization of L-Glutamine & Priapism - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 51 0.034 (-0.24- 0.31) P=0.81 12 30 0 (0- 0) NA NA -0.014 P=0.73
MR-Egger 51 0.087 (-0.41- 0.58) P=0.73 12 30 0 (0- 0) 25 1 -0.014 P=0.73
Weighted median 51 0.13 (-0.42- 0.67) P=0.65 12 30 0 (0- 0) NA NA -0.014 P=0.73
Results from Univariable MRPRESSO of L-Glutamine & Priapism - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0.03 0.14 0.24 0.81
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of L-Glutamine & Priapism - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 27 0.091 (-0.25- 0.43) P=0.6 16 22 0 (0- 0) NA NA -0.029 P=0.6
MR-Egger 27 0.19 (-0.41- 0.8) P=0.54 16 22 0 (0- 0) 13 0.97 -0.029 P=0.6
Weighted median 27 0.21 (-0.45- 0.87) P=0.53 16 22 0 (0- 0) NA NA -0.029 P=0.6
Results from Univariable MRPRESSO of L-Glutamine & Priapism - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0.09 0.17 0.52 0.61
beta.exposure Outlier-corrected NA NA NA NA

Leg Ulcers

Instruments Associations with L-Glutamine & Leg Ulcers
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region L-glutamine (Shin et al/Long et al) Leg Ulcer (CSSCD)
rs524219(G)/1:100821493 CDC14A (0.93, -0.28, P = 4.7e-06, N = 1958) (0.99, -0.91, P = 0.11, N = 1155)
rs11166473(T)/1:101010015* GPR88 (0.92, -0.36, P = 9.3e-08, N = 1958) (0.47, 0.095, P = 0.47, N = 1155)
rs2811981(A)/1:23950147* MDS2 (0.89, -0.12, P = 3.8e-06, N = 1958) (0.88, -0.088, P = 0.66, N = 1155)
rs3127550(A)/1:49431909* AGBL4 (0.49, 0.19, P = 5.7e-06, N = 1958) (0.17, -0.36, P = 0.034, N = 1155)
rs7394051(T)/10:122008026* intergenic (0.7, 0.0055, P = 2.2e-06, N = 7372) (0.76, -0.22, P = 0.14, N = 1155)
rs10762121(T)/10:68708291 CTNNA3 (0.18, -0.0094, P = 3.1e-05, N = 1768) (0.4, 0.098, P = 0.47, N = 1155)
rs11596604(A)/10:87141944* intergenic (0.024, 0.032, P = 2.5e-06, N = 1768) (0.011, -0.62, P = 0.42, N = 1155)
rs7078003(T)/10:99359412* HOGA1 (0.17, 0.0087, P = 1.8e-06, N = 7372) (0.12, -0.02, P = 0.92, N = 1155)
rs7131407(T)/11:128431418 ETS1 (0.13, 0.0082, P = 3.2e-05, N = 7372) (0.16, -0.16, P = 0.39, N = 1155)
rs10431159(A)/11:70967219 SHANK2 (0.65, -0.0047, P = 4.8e-05, N = 7372) (0.15, 0.019, P = 0.92, N = 1155)
rs17666239(A)/12:47194757* SLC38A4 (0.078, 0.0092, P = 1.7e-05, N = 7372) (0.035, 0.33, P = 0.31, N = 1155)
rs735246(A)/12:52547743 intergenic (0.83, 0.0083, P = 4.8e-05, N = 7372) (0.81, -0.0017, P = 0.99, N = 1155)
rs774044(T)/12:56837979* TIMELESS (0.055, -0.015, P = 5.6e-07, N = 7372) (0.044, 0.58, P = 0.071, N = 1155)
rs7313455(A)/12:56853231* MIP (0.44, 0.0062, P = 2.1e-08, N = 7372) (0.13, 0.29, P = 0.13, N = 1155)
rs2657879(A)/12:56865338* GLS2 (0.82, 0.015, P = 6.1e-18, N = 7372) (0.94, -0.12, P = 0.69, N = 1155)
rs12232026(A)/12:56960766* RBMS2 (0.12, -0.0097, P = 4.4e-06, N = 7372) (0.14, -0.014, P = 0.94, N = 1155)
rs941893(T)/14:100542061* EVL (0.74, -0.0049, P = 4.1e-05, N = 7372) (0.28, -0.15, P = 0.31, N = 1155)
rs144325715(A)/14:95948631 intergenic (0.021, -0.74, P = 5.3e-06, N = 1958) (0.045, 0.03, P = 0.93, N = 1155)
rs11636988(A)/15:26822814* GABRB3 (0.57, -0.16, P = 6.5e-06, N = 1958) (0.13, 0.06, P = 0.77, N = 1155)
rs1910151(A)/15:38158699* intergenic (0.64, 0.0048, P = 2.2e-05, N = 7372) (0.64, -0.16, P = 0.24, N = 1155)
rs35150605(TAAC)/15:88047276 RP11-648K4.2 (0.25, -0.15, P = 6.3e-06, N = 1958) (0.3, -0.089, P = 0.53, N = 1155)
rs2560409(C)/16:24099496 PRKCB (0.51, 0.26, P = 1.4e-06, N = 1958) (0.18, 0.069, P = 0.68, N = 1155)
rs16977047(T)/16:27924612* GSG1L (0.7, -0.0056, P = 1.1e-06, N = 7372) (0.77, -0.26, P = 0.075, N = 1155)
rs12447776(T)/16:84053027 SLC38A8 (0.019, 0.029, P = 4.1e-05, N = 1768) (0.042, -0.39, P = 0.23, N = 1155)
rs9912445(A)/17:37202603 LRRC37A11P (0.79, 0.0052, P = 1.7e-05, N = 7372) (0.72, 0.0027, P = 0.98, N = 1155)
rs8069305(A)/17:53638670 CTD-2033D24.2 (0.68, -0.0047, P = 4.9e-05, N = 7372) (0.19, -0.024, P = 0.89, N = 1155)
rs4798682(G)/18:8738265 SOGA2 (0.74, 0.15, P = 5e-06, N = 1958) (0.87, 0.17, P = 0.39, N = 1155)
rs73971292(C)/2:161821810 intergenic (0.023, -0.65, P = 5.1e-06, N = 1958) (0.026, -0.53, P = 0.23, N = 1155)
rs780093(T)/2:27742603* GCKR (0.4, -0.0058, P = 1.9e-07, N = 7372) (0.14, 0.23, P = 0.23, N = 1155)
rs2199619(T)/2:28854958* PLB1 (0.28, 0.0054, P = 5.2e-06, N = 7372) (0.22, -0.091, P = 0.56, N = 1155)
rs992580(C)/20:15246472* MACROD2 (0.44, 0.15, P = 6.2e-06, N = 1958) (0.47, 0.18, P = 0.16, N = 1155)
rs6137021(A)/20:20375560* RALGAPA2 (0.67, -0.0083, P = 4.5e-05, N = 1768) (0.23, 0.0032, P = 0.98, N = 1155)
rs2425059(C)/20:33912371* UQCC1 (0.38, 0.15, P = 5.6e-06, N = 1958) (0.56, 0.07, P = 0.58, N = 1155)
rs2948828(A)/3:124811942 SLC12A8 (0.56, 0.0053, P = 2.2e-05, N = 7372) (0.75, 0.11, P = 0.46, N = 1155)
rs73168973(T)/3:151691599 intergenic (0.21, -0.23, P = 4e-07, N = 1958) (0.077, 0.16, P = 0.53, N = 1155)
rs4699183(A)/4:106444435 AC004066.2 (0.9, -0.27, P = 6.2e-06, N = 1958) (0.92, -0.032, P = 0.9, N = 1155)
rs138354882(A)/4:171429817 intergenic (0.028, -0.36, P = 4.5e-06, N = 1958) (0.089, -0.057, P = 0.81, N = 1155)
rs7667615(C)/4:182921992* AC108142.1 (0.26, -0.17, P = 6.1e-06, N = 1958) (0.17, -0.14, P = 0.4, N = 1155)
rs542300(A)/6:12252237 intergenic (0.51, -0.13, P = 7.2e-06, N = 1958) (0.54, 0.025, P = 0.85, N = 1155)
rs9478369(A)/6:153269698* intergenic (0.25, 0.0049, P = 4.1e-05, N = 7372) (0.51, 0.067, P = 0.61, N = 1155)
rs71569656(C)/6:22903627 RP1-209A6.1 (0.28, -0.14, P = 8.9e-06, N = 1958) (0.098, 0.14, P = 0.56, N = 1155)
rs2748991(T)/6:52596516 intergenic (0.45, -0.007, P = 2.3e-06, N = 5604) (0.34, 0.051, P = 0.7, N = 1155)
rs1582256(C)/7:126634804 GRM8 (0.51, -0.18, P = 8.5e-06, N = 1958) (0.49, -0.14, P = 0.28, N = 1155)
rs767772939(CT)/7:128350744 FAM71F1 (0.096, 0.26, P = 4.1e-06, N = 1958) (0.82, -0.075, P = 0.64, N = 1155)
rs17837468(A)/7:138309274 SVOPL (0.88, 0.0088, P = 3.8e-05, N = 7372) (0.76, -0.063, P = 0.66, N = 1155)
rs17152416(T)/7:25765238 AC003090.1 (0.76, 0.0049, P = 3.9e-05, N = 7372) (0.72, 0.24, P = 0.1, N = 1155)
rs4722699(T)/7:27456500* intergenic (0.27, -0.0048, P = 3.8e-05, N = 7372) (0.2, 0.059, P = 0.71, N = 1155)
rs1799211(T)/7:76240677 UPK3B (0.41, -0.0082, P = 4.2e-06, N = 1768) (0.24, -0.13, P = 0.4, N = 1155)
rs9314463(A)/8:2525166 RP11-134O21.1 (0.19, 0.27, P = 9.1e-07, N = 1958) (0.43, -0.15, P = 0.25, N = 1155)
rs112508772(A)/9:140016354 snoU13 (0.025, 0.48, P = 7e-07, N = 1958) (0.056, 0.54, P = 0.064, N = 1155)
rs7848854(C)/9:7766733* intergenic (0.11, 0.0083, P = 2.4e-05, N = 7372) (0.026, 0.26, P = 0.53, N = 1155)
Results from Univariable Mendelian Randomization of L-Glutamine & Leg Ulcers - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 51 0.091 (-0.19- 0.38) P=0.53 12 30 0.332 (0- 49.2) NA NA 0.0017 P=0.96
MR-Egger 51 0.084 (-0.29- 0.46) P=0.66 12 30 0.332 (0- 49.2) 45 0.64 0.0017 P=0.96
Weighted median 51 -0.034 (-0.47- 0.41) P=0.88 12 30 0.332 (0- 49.2) NA NA 0.0017 P=0.96
Results from Univariable MRPRESSO of L-Glutamine & Leg Ulcers - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0.09 0.15 0.62 0.54
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of L-Glutamine & Leg Ulcers - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 27 0.17 (-0.13- 0.48) P=0.26 16 22 0 (0- 28.3) NA NA -0.0013 P=0.98
MR-Egger 27 0.18 (-0.29- 0.65) P=0.46 16 22 0 (0- 28.3) 18 0.83 -0.0013 P=0.98
Weighted median 27 0.091 (-0.41- 0.59) P=0.72 16 22 0 (0- 28.3) NA NA -0.0013 P=0.98
Results from Univariable MRPRESSO of L-Glutamine & Leg Ulcers - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0.17 0.16 1.12 0.27
beta.exposure Outlier-corrected NA NA NA NA

eGFR

Instruments Associations with L-Glutamine & eGFR
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region L-glutamine (Shin et al/Long et al) eGFR (CSSCD)
rs524219(G)/1:100821493 CDC14A (0.93, -0.28, P = 4.7e-06, N = 1958) (0.99, -0.12, P = 0.56, N = 859)
rs11166473(T)/1:101010015* GPR88 (0.92, -0.36, P = 9.3e-08, N = 1958) (0.47, -0.0057, P = 0.91, N = 859)
rs2811981(A)/1:23950147* MDS2 (0.89, -0.12, P = 3.8e-06, N = 1958) (0.88, -0.022, P = 0.77, N = 859)
rs3127550(A)/1:49431909* AGBL4 (0.49, 0.19, P = 5.7e-06, N = 1958) (0.17, 0.093, P = 0.14, N = 859)
rs7394051(T)/10:122008026* intergenic (0.7, 0.0055, P = 2.2e-06, N = 7372) (0.76, 0.04, P = 0.47, N = 859)
rs10762121(T)/10:68708291 CTNNA3 (0.18, -0.0094, P = 3.1e-05, N = 1768) (0.4, -0.021, P = 0.67, N = 859)
rs11596604(A)/10:87141944* intergenic (0.024, 0.032, P = 2.5e-06, N = 1768) (0.011, -0.093, P = 0.69, N = 859)
rs7078003(T)/10:99359412* HOGA1 (0.17, 0.0087, P = 1.8e-06, N = 7372) (0.12, -0.13, P = 0.078, N = 859)
rs7131407(T)/11:128431418 ETS1 (0.13, 0.0082, P = 3.2e-05, N = 7372) (0.16, -0.075, P = 0.25, N = 859)
rs10431159(A)/11:70967219 SHANK2 (0.65, -0.0047, P = 4.8e-05, N = 7372) (0.15, -0.057, P = 0.37, N = 859)
rs17666239(A)/12:47194757* SLC38A4 (0.078, 0.0092, P = 1.7e-05, N = 7372) (0.037, -0.18, P = 0.15, N = 859)
rs735246(A)/12:52547743 intergenic (0.83, 0.0083, P = 4.8e-05, N = 7372) (0.81, 0.093, P = 0.12, N = 859)
rs774044(T)/12:56837979* TIMELESS (0.055, -0.015, P = 5.6e-07, N = 7372) (0.042, 0.063, P = 0.6, N = 859)
rs7313455(A)/12:56853231* MIP (0.44, 0.0062, P = 2.1e-08, N = 7372) (0.13, -0.075, P = 0.3, N = 859)
rs2657879(A)/12:56865338* GLS2 (0.82, 0.015, P = 6.1e-18, N = 7372) (0.95, 0.089, P = 0.4, N = 859)
rs12232026(A)/12:56960766* RBMS2 (0.12, -0.0097, P = 4.4e-06, N = 7372) (0.14, -0.0097, P = 0.89, N = 859)
rs941893(T)/14:100542061* EVL (0.74, -0.0049, P = 4.1e-05, N = 7372) (0.28, 0.021, P = 0.7, N = 859)
rs144325715(A)/14:95948631 intergenic (0.021, -0.74, P = 5.3e-06, N = 1958) (0.041, -0.011, P = 0.93, N = 859)
rs11636988(A)/15:26822814* GABRB3 (0.57, -0.16, P = 6.5e-06, N = 1958) (0.12, -0.014, P = 0.85, N = 859)
rs1910151(A)/15:38158699* intergenic (0.64, 0.0048, P = 2.2e-05, N = 7372) (0.64, -0.0076, P = 0.88, N = 859)
rs35150605(TAAC)/15:88047276 RP11-648K4.2 (0.25, -0.15, P = 6.3e-06, N = 1958) (0.3, -0.036, P = 0.5, N = 859)
rs2560409(C)/16:24099496 PRKCB (0.51, 0.26, P = 1.4e-06, N = 1958) (0.18, 0.15, P = 0.015, N = 859)
rs16977047(T)/16:27924612* GSG1L (0.7, -0.0056, P = 1.1e-06, N = 7372) (0.76, 0.041, P = 0.46, N = 859)
rs12447776(T)/16:84053027 SLC38A8 (0.019, 0.029, P = 4.1e-05, N = 1768) (0.039, -0.056, P = 0.66, N = 859)
rs9912445(A)/17:37202603 LRRC37A11P (0.79, 0.0052, P = 1.7e-05, N = 7372) (0.72, -0.12, P = 0.019, N = 859)
rs8069305(A)/17:53638670 CTD-2033D24.2 (0.68, -0.0047, P = 4.9e-05, N = 7372) (0.18, 0.034, P = 0.58, N = 859)
rs4798682(G)/18:8738265 SOGA2 (0.74, 0.15, P = 5e-06, N = 1958) (0.87, -0.064, P = 0.37, N = 859)
rs73971292(C)/2:161821810 intergenic (0.023, -0.65, P = 5.1e-06, N = 1958) (0.025, -0.1, P = 0.51, N = 859)
rs780093(T)/2:27742603* GCKR (0.4, -0.0058, P = 1.9e-07, N = 7372) (0.14, -0.071, P = 0.3, N = 859)
rs2199619(T)/2:28854958* PLB1 (0.28, 0.0054, P = 5.2e-06, N = 7372) (0.22, -0.027, P = 0.64, N = 859)
rs992580(C)/20:15246472* MACROD2 (0.44, 0.15, P = 6.2e-06, N = 1958) (0.47, 0.081, P = 0.085, N = 859)
rs6137021(A)/20:20375560* RALGAPA2 (0.67, -0.0083, P = 4.5e-05, N = 1768) (0.23, 0.0063, P = 0.91, N = 859)
rs2425059(C)/20:33912371* UQCC1 (0.38, 0.15, P = 5.6e-06, N = 1958) (0.56, -0.0017, P = 0.97, N = 859)
rs2948828(A)/3:124811942 SLC12A8 (0.56, 0.0053, P = 2.2e-05, N = 7372) (0.76, 0.09, P = 0.11, N = 859)
rs73168973(T)/3:151691599 intergenic (0.21, -0.23, P = 4e-07, N = 1958) (0.075, 0.14, P = 0.12, N = 859)
rs4699183(A)/4:106444435 AC004066.2 (0.9, -0.27, P = 6.2e-06, N = 1958) (0.92, 0.031, P = 0.74, N = 859)
rs138354882(A)/4:171429817 intergenic (0.028, -0.36, P = 4.5e-06, N = 1958) (0.088, 0.061, P = 0.48, N = 859)
rs7667615(C)/4:182921992* AC108142.1 (0.26, -0.17, P = 6.1e-06, N = 1958) (0.17, -0.065, P = 0.3, N = 859)
rs542300(A)/6:12252237 intergenic (0.51, -0.13, P = 7.2e-06, N = 1958) (0.54, 0.13, P = 0.012, N = 859)
rs9478369(A)/6:153269698* intergenic (0.25, 0.0049, P = 4.1e-05, N = 7372) (0.51, -0.035, P = 0.46, N = 859)
rs71569656(C)/6:22903627 RP1-209A6.1 (0.28, -0.14, P = 8.9e-06, N = 1958) (0.095, 0.067, P = 0.42, N = 859)
rs2748991(T)/6:52596516 intergenic (0.45, -0.007, P = 2.3e-06, N = 5604) (0.34, 0.021, P = 0.67, N = 859)
rs1582256(C)/7:126634804 GRM8 (0.51, -0.18, P = 8.5e-06, N = 1958) (0.5, -0.025, P = 0.6, N = 859)
rs767772939(CT)/7:128350744 FAM71F1 (0.096, 0.26, P = 4.1e-06, N = 1958) (0.81, -0.02, P = 0.74, N = 859)
rs17837468(A)/7:138309274 SVOPL (0.88, 0.0088, P = 3.8e-05, N = 7372) (0.75, -0.017, P = 0.76, N = 859)
rs17152416(T)/7:25765238 AC003090.1 (0.76, 0.0049, P = 3.9e-05, N = 7372) (0.72, 0.016, P = 0.77, N = 859)
rs4722699(T)/7:27456500* intergenic (0.27, -0.0048, P = 3.8e-05, N = 7372) (0.21, -0.014, P = 0.82, N = 859)
rs1799211(T)/7:76240677 UPK3B (0.41, -0.0082, P = 4.2e-06, N = 1768) (0.24, -0.0071, P = 0.9, N = 859)
rs9314463(A)/8:2525166 RP11-134O21.1 (0.19, 0.27, P = 9.1e-07, N = 1958) (0.43, -0.065, P = 0.18, N = 859)
rs112508772(A)/9:140016354 snoU13 (0.025, 0.48, P = 7e-07, N = 1958) (0.053, 0.065, P = 0.54, N = 859)
rs7848854(C)/9:7766733* intergenic (0.11, 0.0083, P = 2.4e-05, N = 7372) (0.027, 0.057, P = 0.7, N = 859)
Results from Univariable Mendelian Randomization of L-Glutamine & eGFR - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 51 0.027 (-0.085- 0.14) P=0.64 12 30 5.42 (0- 57.8) NA NA -0.0089 P=0.44
MR-Egger 51 0.061 (-0.08- 0.2) P=0.4 12 30 5.42 (0- 57.8) 50 0.43 -0.0089 P=0.44
Weighted median 51 0.015 (-0.15- 0.18) P=0.85 12 30 5.42 (0- 57.8) NA NA -0.0089 P=0.44
Results from Univariable MRPRESSO of L-Glutamine & eGFR - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0.03 0.06 0.47 0.64
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of L-Glutamine & eGFR - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 27 -0.026 (-0.18- 0.13) P=0.74 16 22 17 (0- 95.4) NA NA -0.011 P=0.56
MR-Egger 27 0.012 (-0.19- 0.21) P=0.91 16 22 17 (0- 95.4) 33 0.12 -0.011 P=0.56
Weighted median 27 -0.0049 (-0.2- 0.19) P=0.96 16 22 17 (0- 95.4) NA NA -0.011 P=0.56
Results from Univariable MRPRESSO of L-Glutamine & eGFR - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.03 0.08 -0.34 0.74
beta.exposure Outlier-corrected NA NA NA NA

Aseptic Necrosis

Instruments Associations with L-Glutamine & Aseptic Necrosis
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region L-glutamine (Shin et al/Long et al) Aseptic Necrosis (CSSCD)
rs524219(G)/1:100821493 CDC14A (0.93, -0.28, P = 4.7e-06, N = 1958) (0.99, 0.37, P = 0.5, N = 1155)
rs11166473(T)/1:101010015* GPR88 (0.92, -0.36, P = 9.3e-08, N = 1958) (0.47, -0.098, P = 0.45, N = 1155)
rs2811981(A)/1:23950147* MDS2 (0.89, -0.12, P = 3.8e-06, N = 1958) (0.88, 0.17, P = 0.39, N = 1155)
rs3127550(A)/1:49431909* AGBL4 (0.49, 0.19, P = 5.7e-06, N = 1958) (0.17, -0.19, P = 0.27, N = 1155)
rs7394051(T)/10:122008026* intergenic (0.7, 0.0055, P = 2.2e-06, N = 7372) (0.76, 0.096, P = 0.52, N = 1155)
rs10762121(T)/10:68708291 CTNNA3 (0.18, -0.0094, P = 3.1e-05, N = 1768) (0.4, 0.053, P = 0.69, N = 1155)
rs11596604(A)/10:87141944* intergenic (0.024, 0.032, P = 2.5e-06, N = 1768) (0.011, -0.51, P = 0.4, N = 1155)
rs7078003(T)/10:99359412* HOGA1 (0.17, 0.0087, P = 1.8e-06, N = 7372) (0.12, -0.011, P = 0.96, N = 1155)
rs7131407(T)/11:128431418 ETS1 (0.13, 0.0082, P = 3.2e-05, N = 7372) (0.16, -0.12, P = 0.5, N = 1155)
rs10431159(A)/11:70967219 SHANK2 (0.65, -0.0047, P = 4.8e-05, N = 7372) (0.15, -0.057, P = 0.75, N = 1155)
rs17666239(A)/12:47194757* SLC38A4 (0.078, 0.0092, P = 1.7e-05, N = 7372) (0.035, -0.29, P = 0.39, N = 1155)
rs735246(A)/12:52547743 intergenic (0.83, 0.0083, P = 4.8e-05, N = 7372) (0.81, -0.011, P = 0.94, N = 1155)
rs774044(T)/12:56837979* TIMELESS (0.055, -0.015, P = 5.6e-07, N = 7372) (0.044, 0.14, P = 0.65, N = 1155)
rs7313455(A)/12:56853231* MIP (0.44, 0.0062, P = 2.1e-08, N = 7372) (0.13, -0.28, P = 0.15, N = 1155)
rs2657879(A)/12:56865338* GLS2 (0.82, 0.015, P = 6.1e-18, N = 7372) (0.94, 0.12, P = 0.67, N = 1155)
rs12232026(A)/12:56960766* RBMS2 (0.12, -0.0097, P = 4.4e-06, N = 7372) (0.14, -0.3, P = 0.092, N = 1155)
rs941893(T)/14:100542061* EVL (0.74, -0.0049, P = 4.1e-05, N = 7372) (0.28, -0.41, P = 0.0053, N = 1155)
rs144325715(A)/14:95948631 intergenic (0.021, -0.74, P = 5.3e-06, N = 1958) (0.045, -0.2, P = 0.53, N = 1155)
rs11636988(A)/15:26822814* GABRB3 (0.57, -0.16, P = 6.5e-06, N = 1958) (0.13, 0.14, P = 0.49, N = 1155)
rs1910151(A)/15:38158699* intergenic (0.64, 0.0048, P = 2.2e-05, N = 7372) (0.64, -0.13, P = 0.32, N = 1155)
rs35150605(TAAC)/15:88047276 RP11-648K4.2 (0.25, -0.15, P = 6.3e-06, N = 1958) (0.3, -0.063, P = 0.65, N = 1155)
rs2560409(C)/16:24099496 PRKCB (0.51, 0.26, P = 1.4e-06, N = 1958) (0.18, -0.2, P = 0.23, N = 1155)
rs16977047(T)/16:27924612* GSG1L (0.7, -0.0056, P = 1.1e-06, N = 7372) (0.77, -0.022, P = 0.88, N = 1155)
rs12447776(T)/16:84053027 SLC38A8 (0.019, 0.029, P = 4.1e-05, N = 1768) (0.042, -0.33, P = 0.31, N = 1155)
rs9912445(A)/17:37202603 LRRC37A11P (0.79, 0.0052, P = 1.7e-05, N = 7372) (0.72, -0.36, P = 0.0085, N = 1155)
rs8069305(A)/17:53638670 CTD-2033D24.2 (0.68, -0.0047, P = 4.9e-05, N = 7372) (0.19, -0.077, P = 0.64, N = 1155)
rs4798682(G)/18:8738265 SOGA2 (0.74, 0.15, P = 5e-06, N = 1958) (0.87, 0.049, P = 0.8, N = 1155)
rs73971292(C)/2:161821810 intergenic (0.023, -0.65, P = 5.1e-06, N = 1958) (0.026, -0.65, P = 0.13, N = 1155)
rs780093(T)/2:27742603* GCKR (0.4, -0.0058, P = 1.9e-07, N = 7372) (0.14, 0.06, P = 0.74, N = 1155)
rs2199619(T)/2:28854958* PLB1 (0.28, 0.0054, P = 5.2e-06, N = 7372) (0.22, -0.067, P = 0.66, N = 1155)
rs992580(C)/20:15246472* MACROD2 (0.44, 0.15, P = 6.2e-06, N = 1958) (0.47, -0.14, P = 0.27, N = 1155)
rs6137021(A)/20:20375560* RALGAPA2 (0.67, -0.0083, P = 4.5e-05, N = 1768) (0.23, -0.21, P = 0.16, N = 1155)
rs2425059(C)/20:33912371* UQCC1 (0.38, 0.15, P = 5.6e-06, N = 1958) (0.56, -0.074, P = 0.56, N = 1155)
rs2948828(A)/3:124811942 SLC12A8 (0.56, 0.0053, P = 2.2e-05, N = 7372) (0.75, 0.15, P = 0.31, N = 1155)
rs73168973(T)/3:151691599 intergenic (0.21, -0.23, P = 4e-07, N = 1958) (0.077, -0.12, P = 0.62, N = 1155)
rs4699183(A)/4:106444435 AC004066.2 (0.9, -0.27, P = 6.2e-06, N = 1958) (0.92, -0.23, P = 0.34, N = 1155)
rs138354882(A)/4:171429817 intergenic (0.028, -0.36, P = 4.5e-06, N = 1958) (0.089, 0.19, P = 0.42, N = 1155)
rs7667615(C)/4:182921992* AC108142.1 (0.26, -0.17, P = 6.1e-06, N = 1958) (0.17, -0.25, P = 0.14, N = 1155)
rs542300(A)/6:12252237 intergenic (0.51, -0.13, P = 7.2e-06, N = 1958) (0.54, 0.0018, P = 0.99, N = 1155)
rs9478369(A)/6:153269698* intergenic (0.25, 0.0049, P = 4.1e-05, N = 7372) (0.51, -0.15, P = 0.23, N = 1155)
rs71569656(C)/6:22903627 RP1-209A6.1 (0.28, -0.14, P = 8.9e-06, N = 1958) (0.098, 0.17, P = 0.47, N = 1155)
rs2748991(T)/6:52596516 intergenic (0.45, -0.007, P = 2.3e-06, N = 5604) (0.34, -0.094, P = 0.48, N = 1155)
rs1582256(C)/7:126634804 GRM8 (0.51, -0.18, P = 8.5e-06, N = 1958) (0.49, 0.066, P = 0.6, N = 1155)
rs767772939(CT)/7:128350744 FAM71F1 (0.096, 0.26, P = 4.1e-06, N = 1958) (0.82, -0.38, P = 0.023, N = 1155)
rs17837468(A)/7:138309274 SVOPL (0.88, 0.0088, P = 3.8e-05, N = 7372) (0.76, 0.0033, P = 0.98, N = 1155)
rs17152416(T)/7:25765238 AC003090.1 (0.76, 0.0049, P = 3.9e-05, N = 7372) (0.72, -0.042, P = 0.77, N = 1155)
rs4722699(T)/7:27456500* intergenic (0.27, -0.0048, P = 3.8e-05, N = 7372) (0.2, 0.16, P = 0.32, N = 1155)
rs1799211(T)/7:76240677 UPK3B (0.41, -0.0082, P = 4.2e-06, N = 1768) (0.24, 0.11, P = 0.46, N = 1155)
rs9314463(A)/8:2525166 RP11-134O21.1 (0.19, 0.27, P = 9.1e-07, N = 1958) (0.43, -0.099, P = 0.45, N = 1155)
rs112508772(A)/9:140016354 snoU13 (0.025, 0.48, P = 7e-07, N = 1958) (0.056, -0.098, P = 0.73, N = 1155)
rs7848854(C)/9:7766733* intergenic (0.11, 0.0083, P = 2.4e-05, N = 7372) (0.026, 0.91, P = 0.026, N = 1155)
Results from Univariable Mendelian Randomization of L-Glutamine & Aseptic Necrosis - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 51 -0.12 (-0.44- 0.19) P=0.44 12 30 2.53 (0- 98.6) NA NA -0.024 P=0.45
MR-Egger 51 -0.031 (-0.43- 0.37) P=0.88 12 30 2.53 (0- 98.6) 55 0.25 -0.024 P=0.45
Weighted median 51 -0.095 (-0.52- 0.33) P=0.67 12 30 2.53 (0- 98.6) NA NA -0.024 P=0.45
Results from Univariable MRPRESSO of L-Glutamine & Aseptic Necrosis - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.12 0.16 -0.77 0.45
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of L-Glutamine & Aseptic Necrosis - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 27 -0.16 (-0.5- 0.19) P=0.37 16 22 3.47 (0- 65.3) NA NA -0.048 P=0.26
MR-Egger 27 0.012 (-0.45- 0.47) P=0.96 16 22 3.47 (0- 65.3) 22 0.61 -0.048 P=0.26
Weighted median 27 -0.24 (-0.78- 0.29) P=0.37 16 22 3.47 (0- 65.3) NA NA -0.048 P=0.26
Results from Univariable MRPRESSO of L-Glutamine & Aseptic Necrosis - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.16 0.18 -0.9 0.38
beta.exposure Outlier-corrected NA NA NA NA

L-Glutamine individuals age 18 and older

Painful Crises

Instruments Associations with L-Glutamine & Painful Crises
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region L-glutamine (Shin et al/Long et al) Painful Crises (CSSCD)
rs524219(G)/1:100821493 CDC14A (0.93, -0.28, P = 4.7e-06, N = 1958) (0.99, 0.073, P = 0.92, N = 387)
rs11166473(T)/1:101010015* GPR88 (0.92, -0.36, P = 9.3e-08, N = 1958) (0.47, -0.32, P = 0.061, N = 387)
rs2811981(A)/1:23950147* MDS2 (0.89, -0.12, P = 3.8e-06, N = 1958) (0.89, 0.032, P = 0.9, N = 387)
rs3127550(A)/1:49431909* AGBL4 (0.49, 0.19, P = 5.7e-06, N = 1958) (0.16, -0.025, P = 0.91, N = 387)
rs7394051(T)/10:122008026* intergenic (0.7, 0.0055, P = 2.2e-06, N = 7372) (0.75, 0.03, P = 0.88, N = 387)
rs10762121(T)/10:68708291 CTNNA3 (0.18, -0.0094, P = 3.1e-05, N = 1768) (0.38, -0.14, P = 0.42, N = 387)
rs11596604(A)/10:87141944* intergenic (0.024, 0.032, P = 2.5e-06, N = 1768) (0.01, -0.14, P = 0.87, N = 387)
rs7078003(T)/10:99359412* HOGA1 (0.17, 0.0087, P = 1.8e-06, N = 7372) (0.13, 0.31, P = 0.22, N = 387)
rs7131407(T)/11:128431418 ETS1 (0.13, 0.0082, P = 3.2e-05, N = 7372) (0.16, 0.37, P = 0.13, N = 387)
rs10431159(A)/11:70967219 SHANK2 (0.65, -0.0047, P = 4.8e-05, N = 7372) (0.16, -0.34, P = 0.15, N = 387)
rs17666239(A)/12:47194757* SLC38A4 (0.078, 0.0092, P = 1.7e-05, N = 7372) (0.047, 0.23, P = 0.55, N = 387)
rs735246(A)/12:52547743 intergenic (0.83, 0.0083, P = 4.8e-05, N = 7372) (0.81, -0.24, P = 0.26, N = 387)
rs774044(T)/12:56837979* TIMELESS (0.055, -0.015, P = 5.6e-07, N = 7372) (0.041, 0.67, P = 0.12, N = 387)
rs7313455(A)/12:56853231* MIP (0.44, 0.0062, P = 2.1e-08, N = 7372) (0.13, -0.18, P = 0.49, N = 387)
rs2657879(A)/12:56865338* GLS2 (0.82, 0.015, P = 6.1e-18, N = 7372) (0.95, 0.27, P = 0.49, N = 387)
rs12232026(A)/12:56960766* RBMS2 (0.12, -0.0097, P = 4.4e-06, N = 7372) (0.16, -0.34, P = 0.14, N = 387)
rs941893(T)/14:100542061* EVL (0.74, -0.0049, P = 4.1e-05, N = 7372) (0.26, -0.03, P = 0.88, N = 387)
rs144325715(A)/14:95948631 intergenic (0.021, -0.74, P = 5.3e-06, N = 1958) (0.039, 0.82, P = 0.066, N = 387)
rs11636988(A)/15:26822814* GABRB3 (0.57, -0.16, P = 6.5e-06, N = 1958) (0.11, -0.021, P = 0.94, N = 387)
rs1910151(A)/15:38158699* intergenic (0.64, 0.0048, P = 2.2e-05, N = 7372) (0.63, 0.066, P = 0.72, N = 387)
rs35150605(TAAC)/15:88047276 RP11-648K4.2 (0.25, -0.15, P = 6.3e-06, N = 1958) (0.32, 0.0033, P = 0.99, N = 387)
rs2560409(C)/16:24099496 PRKCB (0.51, 0.26, P = 1.4e-06, N = 1958) (0.17, -0.055, P = 0.8, N = 387)
rs16977047(T)/16:27924612* GSG1L (0.7, -0.0056, P = 1.1e-06, N = 7372) (0.76, -0.11, P = 0.57, N = 387)
rs12447776(T)/16:84053027 SLC38A8 (0.019, 0.029, P = 4.1e-05, N = 1768) (0.039, -0.064, P = 0.89, N = 387)
rs9912445(A)/17:37202603 LRRC37A11P (0.79, 0.0052, P = 1.7e-05, N = 7372) (0.73, -0.36, P = 0.053, N = 387)
rs8069305(A)/17:53638670 CTD-2033D24.2 (0.68, -0.0047, P = 4.9e-05, N = 7372) (0.18, 0.083, P = 0.71, N = 387)
rs4798682(G)/18:8738265 SOGA2 (0.74, 0.15, P = 5e-06, N = 1958) (0.89, -0.17, P = 0.51, N = 387)
rs73971292(C)/2:161821810 intergenic (0.023, -0.65, P = 5.1e-06, N = 1958) (0.018, 0.016, P = 0.98, N = 387)
rs780093(T)/2:27742603* GCKR (0.4, -0.0058, P = 1.9e-07, N = 7372) (0.14, -0.12, P = 0.61, N = 387)
rs2199619(T)/2:28854958* PLB1 (0.28, 0.0054, P = 5.2e-06, N = 7372) (0.21, 0.081, P = 0.7, N = 387)
rs992580(C)/20:15246472* MACROD2 (0.44, 0.15, P = 6.2e-06, N = 1958) (0.46, 0.0034, P = 0.98, N = 387)
rs6137021(A)/20:20375560* RALGAPA2 (0.67, -0.0083, P = 4.5e-05, N = 1768) (0.22, -0.34, P = 0.098, N = 387)
rs2425059(C)/20:33912371* UQCC1 (0.38, 0.15, P = 5.6e-06, N = 1958) (0.52, -0.12, P = 0.47, N = 387)
rs2948828(A)/3:124811942 SLC12A8 (0.56, 0.0053, P = 2.2e-05, N = 7372) (0.73, -0.16, P = 0.39, N = 387)
rs73168973(T)/3:151691599 intergenic (0.21, -0.23, P = 4e-07, N = 1958) (0.074, -0.21, P = 0.52, N = 387)
rs4699183(A)/4:106444435 AC004066.2 (0.9, -0.27, P = 6.2e-06, N = 1958) (0.92, 0.14, P = 0.65, N = 387)
rs138354882(A)/4:171429817 intergenic (0.028, -0.36, P = 4.5e-06, N = 1958) (0.087, 0.47, P = 0.12, N = 387)
rs7667615(C)/4:182921992* AC108142.1 (0.26, -0.17, P = 6.1e-06, N = 1958) (0.18, 0.16, P = 0.46, N = 387)
rs542300(A)/6:12252237 intergenic (0.51, -0.13, P = 7.2e-06, N = 1958) (0.52, -0.24, P = 0.16, N = 387)
rs9478369(A)/6:153269698* intergenic (0.25, 0.0049, P = 4.1e-05, N = 7372) (0.51, 0.17, P = 0.32, N = 387)
rs71569656(C)/6:22903627 RP1-209A6.1 (0.28, -0.14, P = 8.9e-06, N = 1958) (0.078, 0.5, P = 0.13, N = 387)
rs2748991(T)/6:52596516 intergenic (0.45, -0.007, P = 2.3e-06, N = 5604) (0.32, 0.19, P = 0.27, N = 387)
rs1582256(C)/7:126634804 GRM8 (0.51, -0.18, P = 8.5e-06, N = 1958) (0.5, 0.18, P = 0.28, N = 387)
rs767772939(CT)/7:128350744 FAM71F1 (0.096, 0.26, P = 4.1e-06, N = 1958) (0.8, -0.3, P = 0.15, N = 387)
rs17837468(A)/7:138309274 SVOPL (0.88, 0.0088, P = 3.8e-05, N = 7372) (0.75, -0.0072, P = 0.97, N = 387)
rs17152416(T)/7:25765238 AC003090.1 (0.76, 0.0049, P = 3.9e-05, N = 7372) (0.73, -0.3, P = 0.11, N = 387)
rs4722699(T)/7:27456500* intergenic (0.27, -0.0048, P = 3.8e-05, N = 7372) (0.2, -0.045, P = 0.83, N = 387)
rs1799211(T)/7:76240677 UPK3B (0.41, -0.0082, P = 4.2e-06, N = 1768) (0.24, 0.058, P = 0.77, N = 387)
rs9314463(A)/8:2525166 RP11-134O21.1 (0.19, 0.27, P = 9.1e-07, N = 1958) (0.45, -0.19, P = 0.26, N = 387)
rs112508772(A)/9:140016354 snoU13 (0.025, 0.48, P = 7e-07, N = 1958) (0.049, 0.23, P = 0.55, N = 387)
rs7848854(C)/9:7766733* intergenic (0.11, 0.0083, P = 2.4e-05, N = 7372) (0.026, -0.35, P = 0.52, N = 387)
Results from Univariable Mendelian Randomization of L-Glutamine & Painful Crises - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 51 -0.26 (-0.64- 0.12) P=0.18 12 30 7.65 (0- 50.6) NA NA 0.017 P=0.68
MR-Egger 51 -0.33 (-0.83- 0.17) P=0.2 12 30 7.65 (0- 50.6) 46 0.6 0.017 P=0.68
Weighted median 51 -0.25 (-0.86- 0.35) P=0.42 12 30 7.65 (0- 50.6) NA NA 0.017 P=0.68
Results from Univariable MRPRESSO of L-Glutamine & Painful Crises - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.26 0.19 -1.35 0.18
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of L-Glutamine & Painful Crises - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 27 -0.56 (-1- -0.082) P=0.022 16 22 0.000116 (0- 97.8) NA NA -0.05 P=0.38
MR-Egger 27 -0.38 (-1- 0.24) P=0.24 16 22 0.000116 (0- 97.8) 25 0.47 -0.05 P=0.38
Weighted median 27 -0.71 (-1.4- -0.049) P=0.035 16 22 0.000116 (0- 97.8) NA NA -0.05 P=0.38
Results from Univariable MRPRESSO of L-Glutamine & Painful Crises - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.56 0.24 -2.3 0.03
beta.exposure Outlier-corrected NA NA NA NA

Cholecystectomy

Instruments Associations with L-Glutamine & Cholecystectomy
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region L-glutamine (Shin et al/Long et al) Cholecystectomy (CSSCD)
rs524219(G)/1:100821493 CDC14A (0.93, -0.28, P = 4.7e-06, N = 1958) (0.99, -0.96, P = 0.17, N = 378)
rs11166473(T)/1:101010015* GPR88 (0.92, -0.36, P = 9.3e-08, N = 1958) (0.46, -0.24, P = 0.15, N = 378)
rs2811981(A)/1:23950147* MDS2 (0.89, -0.12, P = 3.8e-06, N = 1958) (0.88, -0.16, P = 0.54, N = 378)
rs3127550(A)/1:49431909* AGBL4 (0.49, 0.19, P = 5.7e-06, N = 1958) (0.16, 0.54, P = 0.017, N = 378)
rs7394051(T)/10:122008026* intergenic (0.7, 0.0055, P = 2.2e-06, N = 7372) (0.75, -0.17, P = 0.37, N = 378)
rs10762121(T)/10:68708291 CTNNA3 (0.18, -0.0094, P = 3.1e-05, N = 1768) (0.38, 0.0079, P = 0.96, N = 378)
rs7078003(T)/10:99359412* HOGA1 (0.17, 0.0087, P = 1.8e-06, N = 7372) (0.13, -0.45, P = 0.069, N = 378)
rs7131407(T)/11:128431418 ETS1 (0.13, 0.0082, P = 3.2e-05, N = 7372) (0.16, -0.22, P = 0.34, N = 378)
rs10431159(A)/11:70967219 SHANK2 (0.65, -0.0047, P = 4.8e-05, N = 7372) (0.16, -0.14, P = 0.55, N = 378)
rs17666239(A)/12:47194757* SLC38A4 (0.078, 0.0092, P = 1.7e-05, N = 7372) (0.046, -0.19, P = 0.62, N = 378)
rs735246(A)/12:52547743 intergenic (0.83, 0.0083, P = 4.8e-05, N = 7372) (0.81, 0.084, P = 0.68, N = 378)
rs774044(T)/12:56837979* TIMELESS (0.055, -0.015, P = 5.6e-07, N = 7372) (0.04, -0.076, P = 0.86, N = 378)
rs7313455(A)/12:56853231* MIP (0.44, 0.0062, P = 2.1e-08, N = 7372) (0.13, -0.041, P = 0.87, N = 378)
rs2657879(A)/12:56865338* GLS2 (0.82, 0.015, P = 6.1e-18, N = 7372) (0.95, -0.16, P = 0.67, N = 378)
rs12232026(A)/12:56960766* RBMS2 (0.12, -0.0097, P = 4.4e-06, N = 7372) (0.16, 0.18, P = 0.43, N = 378)
rs941893(T)/14:100542061* EVL (0.74, -0.0049, P = 4.1e-05, N = 7372) (0.26, -0.19, P = 0.34, N = 378)
rs144325715(A)/14:95948631 intergenic (0.021, -0.74, P = 5.3e-06, N = 1958) (0.04, 0.039, P = 0.93, N = 378)
rs11636988(A)/15:26822814* GABRB3 (0.57, -0.16, P = 6.5e-06, N = 1958) (0.12, 0.34, P = 0.21, N = 378)
rs1910151(A)/15:38158699* intergenic (0.64, 0.0048, P = 2.2e-05, N = 7372) (0.63, 0.11, P = 0.54, N = 378)
rs35150605(TAAC)/15:88047276 RP11-648K4.2 (0.25, -0.15, P = 6.3e-06, N = 1958) (0.31, 0.18, P = 0.31, N = 378)
rs2560409(C)/16:24099496 PRKCB (0.51, 0.26, P = 1.4e-06, N = 1958) (0.17, -0.33, P = 0.12, N = 378)
rs16977047(T)/16:27924612* GSG1L (0.7, -0.0056, P = 1.1e-06, N = 7372) (0.76, 0.14, P = 0.47, N = 378)
rs12447776(T)/16:84053027 SLC38A8 (0.019, 0.029, P = 4.1e-05, N = 1768) (0.04, -0.61, P = 0.15, N = 378)
rs9912445(A)/17:37202603 LRRC37A11P (0.79, 0.0052, P = 1.7e-05, N = 7372) (0.74, -0.0048, P = 0.98, N = 378)
rs8069305(A)/17:53638670 CTD-2033D24.2 (0.68, -0.0047, P = 4.9e-05, N = 7372) (0.18, 0.18, P = 0.4, N = 378)
rs4798682(G)/18:8738265 SOGA2 (0.74, 0.15, P = 5e-06, N = 1958) (0.88, -0.05, P = 0.85, N = 378)
rs73971292(C)/2:161821810 intergenic (0.023, -0.65, P = 5.1e-06, N = 1958) (0.017, -0.083, P = 0.9, N = 378)
rs780093(T)/2:27742603* GCKR (0.4, -0.0058, P = 1.9e-07, N = 7372) (0.15, 0.28, P = 0.25, N = 378)
rs2199619(T)/2:28854958* PLB1 (0.28, 0.0054, P = 5.2e-06, N = 7372) (0.21, -0.19, P = 0.36, N = 378)
rs992580(C)/20:15246472* MACROD2 (0.44, 0.15, P = 6.2e-06, N = 1958) (0.46, 0.16, P = 0.32, N = 378)
rs6137021(A)/20:20375560* RALGAPA2 (0.67, -0.0083, P = 4.5e-05, N = 1768) (0.22, -0.25, P = 0.2, N = 378)
rs2425059(C)/20:33912371* UQCC1 (0.38, 0.15, P = 5.6e-06, N = 1958) (0.52, -0.048, P = 0.77, N = 378)
rs2948828(A)/3:124811942 SLC12A8 (0.56, 0.0053, P = 2.2e-05, N = 7372) (0.73, 0.24, P = 0.19, N = 378)
rs73168973(T)/3:151691599 intergenic (0.21, -0.23, P = 4e-07, N = 1958) (0.074, -0.16, P = 0.61, N = 378)
rs4699183(A)/4:106444435 AC004066.2 (0.9, -0.27, P = 6.2e-06, N = 1958) (0.92, -0.57, P = 0.07, N = 378)
rs138354882(A)/4:171429817 intergenic (0.028, -0.36, P = 4.5e-06, N = 1958) (0.085, -0.51, P = 0.093, N = 378)
rs7667615(C)/4:182921992* AC108142.1 (0.26, -0.17, P = 6.1e-06, N = 1958) (0.18, -0.23, P = 0.29, N = 378)
rs542300(A)/6:12252237 intergenic (0.51, -0.13, P = 7.2e-06, N = 1958) (0.52, 0.14, P = 0.41, N = 378)
rs9478369(A)/6:153269698* intergenic (0.25, 0.0049, P = 4.1e-05, N = 7372) (0.52, -0.16, P = 0.33, N = 378)
rs71569656(C)/6:22903627 RP1-209A6.1 (0.28, -0.14, P = 8.9e-06, N = 1958) (0.078, 0.79, P = 0.016, N = 378)
rs2748991(T)/6:52596516 intergenic (0.45, -0.007, P = 2.3e-06, N = 5604) (0.31, 0.062, P = 0.72, N = 378)
rs1582256(C)/7:126634804 GRM8 (0.51, -0.18, P = 8.5e-06, N = 1958) (0.5, 0.14, P = 0.41, N = 378)
rs767772939(CT)/7:128350744 FAM71F1 (0.096, 0.26, P = 4.1e-06, N = 1958) (0.8, -0.065, P = 0.75, N = 378)
rs17837468(A)/7:138309274 SVOPL (0.88, 0.0088, P = 3.8e-05, N = 7372) (0.75, -0.18, P = 0.33, N = 378)
rs17152416(T)/7:25765238 AC003090.1 (0.76, 0.0049, P = 3.9e-05, N = 7372) (0.73, 0.03, P = 0.87, N = 378)
rs4722699(T)/7:27456500* intergenic (0.27, -0.0048, P = 3.8e-05, N = 7372) (0.2, 0.31, P = 0.13, N = 378)
rs1799211(T)/7:76240677 UPK3B (0.41, -0.0082, P = 4.2e-06, N = 1768) (0.24, -0.25, P = 0.23, N = 378)
rs9314463(A)/8:2525166 RP11-134O21.1 (0.19, 0.27, P = 9.1e-07, N = 1958) (0.45, -0.0087, P = 0.96, N = 378)
rs112508772(A)/9:140016354 snoU13 (0.025, 0.48, P = 7e-07, N = 1958) (0.049, -0.17, P = 0.67, N = 378)
rs7848854(C)/9:7766733* intergenic (0.11, 0.0083, P = 2.4e-05, N = 7372) (0.025, -0.54, P = 0.34, N = 378)
Results from Univariable Mendelian Randomization of L-Glutamine & Cholecystectomy - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 50 0.15 (-0.26- 0.56) P=0.47 12 30 5.78 (0- 71.1) NA NA -0.06 P=0.14
MR-Egger 50 0.39 (-0.12- 0.9) P=0.14 12 30 5.78 (0- 71.1) 51 0.34 -0.06 P=0.14
Weighted median 50 -0.039 (-0.64- 0.57) P=0.9 12 30 5.78 (0- 71.1) NA NA -0.06 P=0.14
Results from Univariable MRPRESSO of L-Glutamine & Cholecystectomy - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0.15 0.21 0.72 0.47
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of L-Glutamine & Cholecystectomy - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 27 -0.13 (-0.61- 0.36) P=0.61 16 22 0 (0- 77.1) NA NA -0.037 P=0.53
MR-Egger 27 0.0062 (-0.63- 0.64) P=0.98 16 22 0 (0- 77.1) 27 0.36 -0.037 P=0.53
Weighted median 27 -0.12 (-0.81- 0.57) P=0.73 16 22 0 (0- 77.1) NA NA -0.037 P=0.53
Results from Univariable MRPRESSO of L-Glutamine & Cholecystectomy - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.17 0.2 -0.87 0.39
beta.exposure Outlier-corrected NA NA NA NA

Retinopathy

Instruments Associations with L-Glutamine & Retinopathy
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region L-glutamine (Shin et al/Long et al) Retinopathy (CSSCD)
rs524219(G)/1:100821493 CDC14A (0.93, -0.28, P = 4.7e-06, N = 1958) (0.99, 1.1, P = 0.14, N = 268)
rs11166473(T)/1:101010015* GPR88 (0.92, -0.36, P = 9.3e-08, N = 1958) (0.48, 0.29, P = 0.13, N = 268)
rs2811981(A)/1:23950147* MDS2 (0.89, -0.12, P = 3.8e-06, N = 1958) (0.89, -0.25, P = 0.42, N = 268)
rs3127550(A)/1:49431909* AGBL4 (0.49, 0.19, P = 5.7e-06, N = 1958) (0.17, -0.53, P = 0.033, N = 268)
rs7394051(T)/10:122008026* intergenic (0.7, 0.0055, P = 2.2e-06, N = 7372) (0.75, -0.23, P = 0.29, N = 268)
rs10762121(T)/10:68708291 CTNNA3 (0.18, -0.0094, P = 3.1e-05, N = 1768) (0.39, -0.076, P = 0.7, N = 268)
rs11596604(A)/10:87141944* intergenic (0.024, 0.032, P = 2.5e-06, N = 1768) (0.013, 0.23, P = 0.8, N = 268)
rs7078003(T)/10:99359412* HOGA1 (0.17, 0.0087, P = 1.8e-06, N = 7372) (0.13, 0.64, P = 0.023, N = 268)
rs7131407(T)/11:128431418 ETS1 (0.13, 0.0082, P = 3.2e-05, N = 7372) (0.16, -0.011, P = 0.97, N = 268)
rs10431159(A)/11:70967219 SHANK2 (0.65, -0.0047, P = 4.8e-05, N = 7372) (0.17, 0.037, P = 0.88, N = 268)
rs17666239(A)/12:47194757* SLC38A4 (0.078, 0.0092, P = 1.7e-05, N = 7372) (0.05, -0.53, P = 0.21, N = 268)
rs735246(A)/12:52547743 intergenic (0.83, 0.0083, P = 4.8e-05, N = 7372) (0.81, 0.033, P = 0.88, N = 268)
rs774044(T)/12:56837979* TIMELESS (0.055, -0.015, P = 5.6e-07, N = 7372) (0.037, 0.63, P = 0.21, N = 268)
rs7313455(A)/12:56853231* MIP (0.44, 0.0062, P = 2.1e-08, N = 7372) (0.13, -0.065, P = 0.82, N = 268)
rs2657879(A)/12:56865338* GLS2 (0.82, 0.015, P = 6.1e-18, N = 7372) (0.95, 0.24, P = 0.57, N = 268)
rs12232026(A)/12:56960766* RBMS2 (0.12, -0.0097, P = 4.4e-06, N = 7372) (0.15, -0.19, P = 0.46, N = 268)
rs941893(T)/14:100542061* EVL (0.74, -0.0049, P = 4.1e-05, N = 7372) (0.26, -0.42, P = 0.06, N = 268)
rs144325715(A)/14:95948631 intergenic (0.021, -0.74, P = 5.3e-06, N = 1958) (0.041, -0.19, P = 0.7, N = 268)
rs11636988(A)/15:26822814* GABRB3 (0.57, -0.16, P = 6.5e-06, N = 1958) (0.12, 0.45, P = 0.14, N = 268)
rs1910151(A)/15:38158699* intergenic (0.64, 0.0048, P = 2.2e-05, N = 7372) (0.64, 0.011, P = 0.96, N = 268)
rs35150605(TAAC)/15:88047276 RP11-648K4.2 (0.25, -0.15, P = 6.3e-06, N = 1958) (0.34, -0.27, P = 0.16, N = 268)
rs2560409(C)/16:24099496 PRKCB (0.51, 0.26, P = 1.4e-06, N = 1958) (0.17, -0.21, P = 0.37, N = 268)
rs16977047(T)/16:27924612* GSG1L (0.7, -0.0056, P = 1.1e-06, N = 7372) (0.76, -0.19, P = 0.37, N = 268)
rs12447776(T)/16:84053027 SLC38A8 (0.019, 0.029, P = 4.1e-05, N = 1768) (0.034, -0.32, P = 0.54, N = 268)
rs9912445(A)/17:37202603 LRRC37A11P (0.79, 0.0052, P = 1.7e-05, N = 7372) (0.75, 0.063, P = 0.77, N = 268)
rs8069305(A)/17:53638670 CTD-2033D24.2 (0.68, -0.0047, P = 4.9e-05, N = 7372) (0.17, 0.27, P = 0.27, N = 268)
rs4798682(G)/18:8738265 SOGA2 (0.74, 0.15, P = 5e-06, N = 1958) (0.9, 0.024, P = 0.94, N = 268)
rs73971292(C)/2:161821810 intergenic (0.023, -0.65, P = 5.1e-06, N = 1958) (0.021, -0.027, P = 0.97, N = 268)
rs780093(T)/2:27742603* GCKR (0.4, -0.0058, P = 1.9e-07, N = 7372) (0.14, 0.4, P = 0.14, N = 268)
rs2199619(T)/2:28854958* PLB1 (0.28, 0.0054, P = 5.2e-06, N = 7372) (0.21, -0.15, P = 0.52, N = 268)
rs992580(C)/20:15246472* MACROD2 (0.44, 0.15, P = 6.2e-06, N = 1958) (0.49, -0.2, P = 0.28, N = 268)
rs6137021(A)/20:20375560* RALGAPA2 (0.67, -0.0083, P = 4.5e-05, N = 1768) (0.23, 0.06, P = 0.78, N = 268)
rs2425059(C)/20:33912371* UQCC1 (0.38, 0.15, P = 5.6e-06, N = 1958) (0.54, -0.12, P = 0.49, N = 268)
rs2948828(A)/3:124811942 SLC12A8 (0.56, 0.0053, P = 2.2e-05, N = 7372) (0.72, -0.35, P = 0.092, N = 268)
rs73168973(T)/3:151691599 intergenic (0.21, -0.23, P = 4e-07, N = 1958) (0.073, -0.23, P = 0.52, N = 268)
rs4699183(A)/4:106444435 AC004066.2 (0.9, -0.27, P = 6.2e-06, N = 1958) (0.92, 0.015, P = 0.97, N = 268)
rs138354882(A)/4:171429817 intergenic (0.028, -0.36, P = 4.5e-06, N = 1958) (0.093, 0.037, P = 0.91, N = 268)
rs7667615(C)/4:182921992* AC108142.1 (0.26, -0.17, P = 6.1e-06, N = 1958) (0.18, 0.26, P = 0.29, N = 268)
rs542300(A)/6:12252237 intergenic (0.51, -0.13, P = 7.2e-06, N = 1958) (0.52, 0.12, P = 0.52, N = 268)
rs9478369(A)/6:153269698* intergenic (0.25, 0.0049, P = 4.1e-05, N = 7372) (0.52, -0.02, P = 0.91, N = 268)
rs71569656(C)/6:22903627 RP1-209A6.1 (0.28, -0.14, P = 8.9e-06, N = 1958) (0.073, -0.46, P = 0.22, N = 268)
rs2748991(T)/6:52596516 intergenic (0.45, -0.007, P = 2.3e-06, N = 5604) (0.33, 0.0037, P = 0.98, N = 268)
rs1582256(C)/7:126634804 GRM8 (0.51, -0.18, P = 8.5e-06, N = 1958) (0.5, 0.13, P = 0.47, N = 268)
rs767772939(CT)/7:128350744 FAM71F1 (0.096, 0.26, P = 4.1e-06, N = 1958) (0.81, -0.26, P = 0.26, N = 268)
rs17837468(A)/7:138309274 SVOPL (0.88, 0.0088, P = 3.8e-05, N = 7372) (0.73, -0.27, P = 0.18, N = 268)
rs17152416(T)/7:25765238 AC003090.1 (0.76, 0.0049, P = 3.9e-05, N = 7372) (0.74, 0.16, P = 0.43, N = 268)
rs4722699(T)/7:27456500* intergenic (0.27, -0.0048, P = 3.8e-05, N = 7372) (0.2, -0.2, P = 0.39, N = 268)
rs1799211(T)/7:76240677 UPK3B (0.41, -0.0082, P = 4.2e-06, N = 1768) (0.24, 0.072, P = 0.75, N = 268)
rs9314463(A)/8:2525166 RP11-134O21.1 (0.19, 0.27, P = 9.1e-07, N = 1958) (0.45, 0.11, P = 0.55, N = 268)
rs112508772(A)/9:140016354 snoU13 (0.025, 0.48, P = 7e-07, N = 1958) (0.06, -0.07, P = 0.86, N = 268)
rs7848854(C)/9:7766733* intergenic (0.11, 0.0083, P = 2.4e-05, N = 7372) (0.026, 0.96, P = 0.1, N = 268)
Results from Univariable Mendelian Randomization of L-Glutamine & Retinopathy - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 51 -0.39 (-0.81- 0.027) P=0.067 12 30 0.000154 (0- 74.8) NA NA -0.015 P=0.73
MR-Egger 51 -0.33 (-0.88- 0.21) P=0.24 12 30 0.000154 (0- 74.8) 47 0.56 -0.015 P=0.73
Weighted median 51 -0.42 (-1- 0.19) P=0.18 12 30 0.000154 (0- 74.8) NA NA -0.015 P=0.73
Results from Univariable MRPRESSO of L-Glutamine & Retinopathy - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.39 0.21 -1.83 0.07
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of L-Glutamine & Retinopathy - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 27 -0.066 (-0.49- 0.36) P=0.76 16 22 0 (0- 29.4) NA NA -0.052 P=0.41
MR-Egger 27 0.12 (-0.56- 0.8) P=0.73 16 22 0 (0- 29.4) 16 0.91 -0.052 P=0.41
Weighted median 27 -0.055 (-0.75- 0.64) P=0.88 16 22 0 (0- 29.4) NA NA -0.052 P=0.41
Results from Univariable MRPRESSO of L-Glutamine & Retinopathy - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0.15 0.2 0.74 0.46
beta.exposure Outlier-corrected NA NA NA NA

Priapism

Instruments Associations with L-Glutamine & Priapism
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region L-glutamine (Shin et al/Long et al) Priapism (CSSCD)
rs524219(G)/1:100821493 CDC14A (0.93, -0.28, P = 4.7e-06, N = 1958) (0.99, -0.31, P = 0.76, N = 167)
rs11166473(T)/1:101010015* GPR88 (0.92, -0.36, P = 9.3e-08, N = 1958) (0.48, 0.2, P = 0.44, N = 167)
rs2811981(A)/1:23950147* MDS2 (0.89, -0.12, P = 3.8e-06, N = 1958) (0.89, 0.32, P = 0.44, N = 167)
rs3127550(A)/1:49431909* AGBL4 (0.49, 0.19, P = 5.7e-06, N = 1958) (0.13, -0.91, P = 0.014, N = 167)
rs7394051(T)/10:122008026* intergenic (0.7, 0.0055, P = 2.2e-06, N = 7372) (0.76, -0.2, P = 0.49, N = 167)
rs10762121(T)/10:68708291 CTNNA3 (0.18, -0.0094, P = 3.1e-05, N = 1768) (0.39, 0.42, P = 0.11, N = 167)
rs7078003(T)/10:99359412* HOGA1 (0.17, 0.0087, P = 1.8e-06, N = 7372) (0.13, 0.12, P = 0.77, N = 167)
rs7131407(T)/11:128431418 ETS1 (0.13, 0.0082, P = 3.2e-05, N = 7372) (0.16, -0.45, P = 0.22, N = 167)
rs10431159(A)/11:70967219 SHANK2 (0.65, -0.0047, P = 4.8e-05, N = 7372) (0.18, -0.11, P = 0.75, N = 167)
rs17666239(A)/12:47194757* SLC38A4 (0.078, 0.0092, P = 1.7e-05, N = 7372) (0.048, -0.053, P = 0.93, N = 167)
rs735246(A)/12:52547743 intergenic (0.83, 0.0083, P = 4.8e-05, N = 7372) (0.8, 0.095, P = 0.77, N = 167)
rs774044(T)/12:56837979* TIMELESS (0.055, -0.015, P = 5.6e-07, N = 7372) (0.045, 0.56, P = 0.4, N = 167)
rs7313455(A)/12:56853231* MIP (0.44, 0.0062, P = 2.1e-08, N = 7372) (0.14, -0.66, P = 0.076, N = 167)
rs2657879(A)/12:56865338* GLS2 (0.82, 0.015, P = 6.1e-18, N = 7372) (0.94, 0.95, P = 0.1, N = 167)
rs12232026(A)/12:56960766* RBMS2 (0.12, -0.0097, P = 4.4e-06, N = 7372) (0.15, -0.18, P = 0.62, N = 167)
rs941893(T)/14:100542061* EVL (0.74, -0.0049, P = 4.1e-05, N = 7372) (0.21, -0.74, P = 0.043, N = 167)
rs144325715(A)/14:95948631 intergenic (0.021, -0.74, P = 5.3e-06, N = 1958) (0.042, 0.11, P = 0.86, N = 167)
rs11636988(A)/15:26822814* GABRB3 (0.57, -0.16, P = 6.5e-06, N = 1958) (0.11, 0.053, P = 0.91, N = 167)
rs1910151(A)/15:38158699* intergenic (0.64, 0.0048, P = 2.2e-05, N = 7372) (0.62, 0.095, P = 0.72, N = 167)
rs35150605(TAAC)/15:88047276 RP11-648K4.2 (0.25, -0.15, P = 6.3e-06, N = 1958) (0.31, 0.35, P = 0.23, N = 167)
rs2560409(C)/16:24099496 PRKCB (0.51, 0.26, P = 1.4e-06, N = 1958) (0.14, 0.12, P = 0.75, N = 167)
rs16977047(T)/16:27924612* GSG1L (0.7, -0.0056, P = 1.1e-06, N = 7372) (0.77, 0.2, P = 0.48, N = 167)
rs12447776(T)/16:84053027 SLC38A8 (0.019, 0.029, P = 4.1e-05, N = 1768) (0.042, -0.5, P = 0.43, N = 167)
rs9912445(A)/17:37202603 LRRC37A11P (0.79, 0.0052, P = 1.7e-05, N = 7372) (0.73, -0.069, P = 0.8, N = 167)
rs8069305(A)/17:53638670 CTD-2033D24.2 (0.68, -0.0047, P = 4.9e-05, N = 7372) (0.2, 0.21, P = 0.53, N = 167)
rs4798682(G)/18:8738265 SOGA2 (0.74, 0.15, P = 5e-06, N = 1958) (0.91, -0.28, P = 0.53, N = 167)
rs780093(T)/2:27742603* GCKR (0.4, -0.0058, P = 1.9e-07, N = 7372) (0.14, 0.59, P = 0.11, N = 167)
rs2199619(T)/2:28854958* PLB1 (0.28, 0.0054, P = 5.2e-06, N = 7372) (0.2, 0.51, P = 0.092, N = 167)
rs992580(C)/20:15246472* MACROD2 (0.44, 0.15, P = 6.2e-06, N = 1958) (0.45, 0.19, P = 0.41, N = 167)
rs6137021(A)/20:20375560* RALGAPA2 (0.67, -0.0083, P = 4.5e-05, N = 1768) (0.23, 0.11, P = 0.74, N = 167)
rs2425059(C)/20:33912371* UQCC1 (0.38, 0.15, P = 5.6e-06, N = 1958) (0.53, 0.015, P = 0.95, N = 167)
rs2948828(A)/3:124811942 SLC12A8 (0.56, 0.0053, P = 2.2e-05, N = 7372) (0.7, -0.66, P = 0.013, N = 167)
rs73168973(T)/3:151691599 intergenic (0.21, -0.23, P = 4e-07, N = 1958) (0.078, 0.16, P = 0.75, N = 167)
rs4699183(A)/4:106444435 AC004066.2 (0.9, -0.27, P = 6.2e-06, N = 1958) (0.92, -0.19, P = 0.69, N = 167)
rs138354882(A)/4:171429817 intergenic (0.028, -0.36, P = 4.5e-06, N = 1958) (0.11, -0.7, P = 0.093, N = 167)
rs7667615(C)/4:182921992* AC108142.1 (0.26, -0.17, P = 6.1e-06, N = 1958) (0.19, -0.076, P = 0.83, N = 167)
rs542300(A)/6:12252237 intergenic (0.51, -0.13, P = 7.2e-06, N = 1958) (0.52, -0.088, P = 0.74, N = 167)
rs9478369(A)/6:153269698* intergenic (0.25, 0.0049, P = 4.1e-05, N = 7372) (0.52, 0.54, P = 0.038, N = 167)
rs71569656(C)/6:22903627 RP1-209A6.1 (0.28, -0.14, P = 8.9e-06, N = 1958) (0.075, -0.54, P = 0.31, N = 167)
rs2748991(T)/6:52596516 intergenic (0.45, -0.007, P = 2.3e-06, N = 5604) (0.29, 0.1, P = 0.7, N = 167)
rs1582256(C)/7:126634804 GRM8 (0.51, -0.18, P = 8.5e-06, N = 1958) (0.5, -0.035, P = 0.9, N = 167)
rs767772939(CT)/7:128350744 FAM71F1 (0.096, 0.26, P = 4.1e-06, N = 1958) (0.8, -0.65, P = 0.043, N = 167)
rs17837468(A)/7:138309274 SVOPL (0.88, 0.0088, P = 3.8e-05, N = 7372) (0.73, -0.15, P = 0.57, N = 167)
rs17152416(T)/7:25765238 AC003090.1 (0.76, 0.0049, P = 3.9e-05, N = 7372) (0.72, -0.1, P = 0.71, N = 167)
rs4722699(T)/7:27456500* intergenic (0.27, -0.0048, P = 3.8e-05, N = 7372) (0.21, 0.087, P = 0.79, N = 167)
rs1799211(T)/7:76240677 UPK3B (0.41, -0.0082, P = 4.2e-06, N = 1768) (0.23, 0.071, P = 0.83, N = 167)
rs9314463(A)/8:2525166 RP11-134O21.1 (0.19, 0.27, P = 9.1e-07, N = 1958) (0.46, 0.023, P = 0.93, N = 167)
rs112508772(A)/9:140016354 snoU13 (0.025, 0.48, P = 7e-07, N = 1958) (0.045, -0.54, P = 0.39, N = 167)
rs7848854(C)/9:7766733* intergenic (0.11, 0.0083, P = 2.4e-05, N = 7372) (0.027, 0.42, P = 0.58, N = 167)
Results from Univariable Mendelian Randomization of L-Glutamine & Priapism - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 49 -0.29 (-0.93- 0.35) P=0.38 12 28 1.25e-05 (0- 95.1) NA NA -0.062 P=0.33
MR-Egger 49 -0.047 (-0.85- 0.76) P=0.91 12 28 1.25e-05 (0- 95.1) 52 0.3 -0.062 P=0.33
Weighted median 49 -0.1 (-1- 0.82) P=0.83 12 28 1.25e-05 (0- 95.1) NA NA -0.062 P=0.33
Results from Univariable MRPRESSO of L-Glutamine & Priapism - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.29 0.33 -0.89 0.38
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of L-Glutamine & Priapism - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 26 -0.16 (-0.87- 0.56) P=0.67 15 20 0 (0- 84.1) NA NA -0.19 P=0.036
MR-Egger 26 0.51 (-0.44- 1.5) P=0.3 15 20 0 (0- 84.1) 18 0.8 -0.19 P=0.036
Weighted median 26 0.012 (-1- 1) P=0.98 15 20 0 (0- 84.1) NA NA -0.19 P=0.036
Results from Univariable MRPRESSO of L-Glutamine & Priapism - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0.13 0.18 0.71 0.49
beta.exposure Outlier-corrected NA NA NA NA

Leg Ulcers

Instruments Associations with L-Glutamine & Leg Ulcers
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region L-glutamine (Shin et al/Long et al) Leg Ulcer (CSSCD)
rs524219(G)/1:100821493 CDC14A (0.93, -0.28, P = 4.7e-06, N = 1958) (0.99, -0.66, P = 0.33, N = 394)
rs11166473(T)/1:101010015* GPR88 (0.92, -0.36, P = 9.3e-08, N = 1958) (0.46, 0.13, P = 0.41, N = 394)
rs2811981(A)/1:23950147* MDS2 (0.89, -0.12, P = 3.8e-06, N = 1958) (0.88, -0.18, P = 0.47, N = 394)
rs3127550(A)/1:49431909* AGBL4 (0.49, 0.19, P = 5.7e-06, N = 1958) (0.16, -0.47, P = 0.031, N = 394)
rs7394051(T)/10:122008026* intergenic (0.7, 0.0055, P = 2.2e-06, N = 7372) (0.74, -0.26, P = 0.17, N = 394)
rs10762121(T)/10:68708291 CTNNA3 (0.18, -0.0094, P = 3.1e-05, N = 1768) (0.38, 0.2, P = 0.22, N = 394)
rs11596604(A)/10:87141944* intergenic (0.024, 0.032, P = 2.5e-06, N = 1768) (0.01, -0.94, P = 0.31, N = 394)
rs7078003(T)/10:99359412* HOGA1 (0.17, 0.0087, P = 1.8e-06, N = 7372) (0.12, -0.25, P = 0.28, N = 394)
rs7131407(T)/11:128431418 ETS1 (0.13, 0.0082, P = 3.2e-05, N = 7372) (0.16, -0.19, P = 0.39, N = 394)
rs10431159(A)/11:70967219 SHANK2 (0.65, -0.0047, P = 4.8e-05, N = 7372) (0.16, 0.29, P = 0.21, N = 394)
rs17666239(A)/12:47194757* SLC38A4 (0.078, 0.0092, P = 1.7e-05, N = 7372) (0.046, 0.26, P = 0.49, N = 394)
rs735246(A)/12:52547743 intergenic (0.83, 0.0083, P = 4.8e-05, N = 7372) (0.81, -0.28, P = 0.15, N = 394)
rs774044(T)/12:56837979* TIMELESS (0.055, -0.015, P = 5.6e-07, N = 7372) (0.041, 0.058, P = 0.89, N = 394)
rs7313455(A)/12:56853231* MIP (0.44, 0.0062, P = 2.1e-08, N = 7372) (0.13, 0.39, P = 0.1, N = 394)
rs2657879(A)/12:56865338* GLS2 (0.82, 0.015, P = 6.1e-18, N = 7372) (0.95, -0.15, P = 0.69, N = 394)
rs12232026(A)/12:56960766* RBMS2 (0.12, -0.0097, P = 4.4e-06, N = 7372) (0.16, 0.14, P = 0.51, N = 394)
rs941893(T)/14:100542061* EVL (0.74, -0.0049, P = 4.1e-05, N = 7372) (0.26, 0.059, P = 0.75, N = 394)
rs144325715(A)/14:95948631 intergenic (0.021, -0.74, P = 5.3e-06, N = 1958) (0.039, 0.22, P = 0.59, N = 394)
rs11636988(A)/15:26822814* GABRB3 (0.57, -0.16, P = 6.5e-06, N = 1958) (0.12, 0.23, P = 0.38, N = 394)
rs1910151(A)/15:38158699* intergenic (0.64, 0.0048, P = 2.2e-05, N = 7372) (0.63, -0.11, P = 0.53, N = 394)
rs35150605(TAAC)/15:88047276 RP11-648K4.2 (0.25, -0.15, P = 6.3e-06, N = 1958) (0.31, 0.073, P = 0.67, N = 394)
rs2560409(C)/16:24099496 PRKCB (0.51, 0.26, P = 1.4e-06, N = 1958) (0.17, -0.078, P = 0.7, N = 394)
rs16977047(T)/16:27924612* GSG1L (0.7, -0.0056, P = 1.1e-06, N = 7372) (0.76, -0.11, P = 0.56, N = 394)
rs12447776(T)/16:84053027 SLC38A8 (0.019, 0.029, P = 4.1e-05, N = 1768) (0.038, -0.54, P = 0.2, N = 394)
rs9912445(A)/17:37202603 LRRC37A11P (0.79, 0.0052, P = 1.7e-05, N = 7372) (0.73, -0.12, P = 0.48, N = 394)
rs8069305(A)/17:53638670 CTD-2033D24.2 (0.68, -0.0047, P = 4.9e-05, N = 7372) (0.18, -0.048, P = 0.82, N = 394)
rs4798682(G)/18:8738265 SOGA2 (0.74, 0.15, P = 5e-06, N = 1958) (0.89, 0.076, P = 0.76, N = 394)
rs73971292(C)/2:161821810 intergenic (0.023, -0.65, P = 5.1e-06, N = 1958) (0.019, -1, P = 0.085, N = 394)
rs780093(T)/2:27742603* GCKR (0.4, -0.0058, P = 1.9e-07, N = 7372) (0.14, 0.25, P = 0.27, N = 394)
rs2199619(T)/2:28854958* PLB1 (0.28, 0.0054, P = 5.2e-06, N = 7372) (0.21, -0.2, P = 0.3, N = 394)
rs992580(C)/20:15246472* MACROD2 (0.44, 0.15, P = 6.2e-06, N = 1958) (0.46, 0.16, P = 0.3, N = 394)
rs6137021(A)/20:20375560* RALGAPA2 (0.67, -0.0083, P = 4.5e-05, N = 1768) (0.22, 0.054, P = 0.77, N = 394)
rs2425059(C)/20:33912371* UQCC1 (0.38, 0.15, P = 5.6e-06, N = 1958) (0.53, -0.073, P = 0.64, N = 394)
rs2948828(A)/3:124811942 SLC12A8 (0.56, 0.0053, P = 2.2e-05, N = 7372) (0.73, 0.0054, P = 0.98, N = 394)
rs73168973(T)/3:151691599 intergenic (0.21, -0.23, P = 4e-07, N = 1958) (0.074, 0.1, P = 0.74, N = 394)
rs4699183(A)/4:106444435 AC004066.2 (0.9, -0.27, P = 6.2e-06, N = 1958) (0.92, 0.082, P = 0.78, N = 394)
rs138354882(A)/4:171429817 intergenic (0.028, -0.36, P = 4.5e-06, N = 1958) (0.088, 0.029, P = 0.92, N = 394)
rs7667615(C)/4:182921992* AC108142.1 (0.26, -0.17, P = 6.1e-06, N = 1958) (0.18, -0.49, P = 0.019, N = 394)
rs542300(A)/6:12252237 intergenic (0.51, -0.13, P = 7.2e-06, N = 1958) (0.52, 0.057, P = 0.72, N = 394)
rs9478369(A)/6:153269698* intergenic (0.25, 0.0049, P = 4.1e-05, N = 7372) (0.52, 0.085, P = 0.6, N = 394)
rs71569656(C)/6:22903627 RP1-209A6.1 (0.28, -0.14, P = 8.9e-06, N = 1958) (0.077, 0.53, P = 0.091, N = 394)
rs2748991(T)/6:52596516 intergenic (0.45, -0.007, P = 2.3e-06, N = 5604) (0.32, -0.08, P = 0.63, N = 394)
rs1582256(C)/7:126634804 GRM8 (0.51, -0.18, P = 8.5e-06, N = 1958) (0.5, -0.25, P = 0.13, N = 394)
rs767772939(CT)/7:128350744 FAM71F1 (0.096, 0.26, P = 4.1e-06, N = 1958) (0.8, 0.012, P = 0.95, N = 394)
rs17837468(A)/7:138309274 SVOPL (0.88, 0.0088, P = 3.8e-05, N = 7372) (0.75, -0.11, P = 0.53, N = 394)
rs17152416(T)/7:25765238 AC003090.1 (0.76, 0.0049, P = 3.9e-05, N = 7372) (0.73, 0.34, P = 0.057, N = 394)
rs4722699(T)/7:27456500* intergenic (0.27, -0.0048, P = 3.8e-05, N = 7372) (0.2, 0.062, P = 0.75, N = 394)
rs1799211(T)/7:76240677 UPK3B (0.41, -0.0082, P = 4.2e-06, N = 1768) (0.24, -0.21, P = 0.29, N = 394)
rs9314463(A)/8:2525166 RP11-134O21.1 (0.19, 0.27, P = 9.1e-07, N = 1958) (0.45, -0.11, P = 0.49, N = 394)
rs112508772(A)/9:140016354 snoU13 (0.025, 0.48, P = 7e-07, N = 1958) (0.048, 0.47, P = 0.2, N = 394)
rs7848854(C)/9:7766733* intergenic (0.11, 0.0083, P = 2.4e-05, N = 7372) (0.025, 0.56, P = 0.29, N = 394)
Results from Univariable Mendelian Randomization of L-Glutamine & Leg Ulcers - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 51 -0.022 (-0.4- 0.36) P=0.91 12 30 0 (0- 70.1) NA NA -0.045 P=0.24
MR-Egger 51 0.15 (-0.32- 0.63) P=0.53 12 30 0 (0- 70.1) 50 0.42 -0.045 P=0.24
Weighted median 51 -0.3 (-0.81- 0.2) P=0.24 12 30 0 (0- 70.1) NA NA -0.045 P=0.24
Results from Univariable MRPRESSO of L-Glutamine & Leg Ulcers - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.02 0.19 -0.12 0.91
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of L-Glutamine & Leg Ulcers - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 27 0.054 (-0.4- 0.5) P=0.81 16 22 0.000147 (0- 94) NA NA -0.053 P=0.32
MR-Egger 27 0.24 (-0.34- 0.83) P=0.42 16 22 0.000147 (0- 94) 25 0.48 -0.053 P=0.32
Weighted median 27 -0.29 (-0.93- 0.35) P=0.37 16 22 0.000147 (0- 94) NA NA -0.053 P=0.32
Results from Univariable MRPRESSO of L-Glutamine & Leg Ulcers - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0.17 0.16 1.12 0.27
beta.exposure Outlier-corrected NA NA NA NA

eGFR

Instruments Associations with L-Glutamine & eGFR
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region L-glutamine (Shin et al/Long et al) eGFR (CSSCD)
rs524219(G)/1:100821493 CDC14A (0.93, -0.28, P = 4.7e-06, N = 1958) (0.98, 0.37, P = 0.23, N = 365)
rs11166473(T)/1:101010015* GPR88 (0.92, -0.36, P = 9.3e-08, N = 1958) (0.46, -0.044, P = 0.54, N = 365)
rs2811981(A)/1:23950147* MDS2 (0.89, -0.12, P = 3.8e-06, N = 1958) (0.88, -0.092, P = 0.43, N = 365)
rs3127550(A)/1:49431909* AGBL4 (0.49, 0.19, P = 5.7e-06, N = 1958) (0.16, 0.0081, P = 0.94, N = 365)
rs7394051(T)/10:122008026* intergenic (0.7, 0.0055, P = 2.2e-06, N = 7372) (0.74, 0.059, P = 0.5, N = 365)
rs10762121(T)/10:68708291 CTNNA3 (0.18, -0.0094, P = 3.1e-05, N = 1768) (0.39, -0.087, P = 0.26, N = 365)
rs11596604(A)/10:87141944* intergenic (0.024, 0.032, P = 2.5e-06, N = 1768) (0.011, -0.44, P = 0.22, N = 365)
rs7078003(T)/10:99359412* HOGA1 (0.17, 0.0087, P = 1.8e-06, N = 7372) (0.12, -0.025, P = 0.83, N = 365)
rs7131407(T)/11:128431418 ETS1 (0.13, 0.0082, P = 3.2e-05, N = 7372) (0.16, -0.039, P = 0.71, N = 365)
rs10431159(A)/11:70967219 SHANK2 (0.65, -0.0047, P = 4.8e-05, N = 7372) (0.17, 0.094, P = 0.32, N = 365)
rs17666239(A)/12:47194757* SLC38A4 (0.078, 0.0092, P = 1.7e-05, N = 7372) (0.049, 0.023, P = 0.89, N = 365)
rs735246(A)/12:52547743 intergenic (0.83, 0.0083, P = 4.8e-05, N = 7372) (0.81, 0.1, P = 0.27, N = 365)
rs774044(T)/12:56837979* TIMELESS (0.055, -0.015, P = 5.6e-07, N = 7372) (0.041, 0.088, P = 0.63, N = 365)
rs7313455(A)/12:56853231* MIP (0.44, 0.0062, P = 2.1e-08, N = 7372) (0.12, 0.08, P = 0.48, N = 365)
rs2657879(A)/12:56865338* GLS2 (0.82, 0.015, P = 6.1e-18, N = 7372) (0.95, -0.22, P = 0.18, N = 365)
rs12232026(A)/12:56960766* RBMS2 (0.12, -0.0097, P = 4.4e-06, N = 7372) (0.15, 0.0076, P = 0.94, N = 365)
rs941893(T)/14:100542061* EVL (0.74, -0.0049, P = 4.1e-05, N = 7372) (0.26, -0.12, P = 0.15, N = 365)
rs144325715(A)/14:95948631 intergenic (0.021, -0.74, P = 5.3e-06, N = 1958) (0.041, 0.15, P = 0.43, N = 365)
rs11636988(A)/15:26822814* GABRB3 (0.57, -0.16, P = 6.5e-06, N = 1958) (0.12, -0.065, P = 0.58, N = 365)
rs1910151(A)/15:38158699* intergenic (0.64, 0.0048, P = 2.2e-05, N = 7372) (0.63, -0.17, P = 0.032, N = 365)
rs35150605(TAAC)/15:88047276 RP11-648K4.2 (0.25, -0.15, P = 6.3e-06, N = 1958) (0.31, 0.061, P = 0.44, N = 365)
rs2560409(C)/16:24099496 PRKCB (0.51, 0.26, P = 1.4e-06, N = 1958) (0.16, 0.18, P = 0.06, N = 365)
rs16977047(T)/16:27924612* GSG1L (0.7, -0.0056, P = 1.1e-06, N = 7372) (0.76, -0.097, P = 0.24, N = 365)
rs12447776(T)/16:84053027 SLC38A8 (0.019, 0.029, P = 4.1e-05, N = 1768) (0.038, -0.15, P = 0.46, N = 365)
rs9912445(A)/17:37202603 LRRC37A11P (0.79, 0.0052, P = 1.7e-05, N = 7372) (0.74, -0.078, P = 0.34, N = 365)
rs8069305(A)/17:53638670 CTD-2033D24.2 (0.68, -0.0047, P = 4.9e-05, N = 7372) (0.18, 0.29, P = 0.0023, N = 365)
rs4798682(G)/18:8738265 SOGA2 (0.74, 0.15, P = 5e-06, N = 1958) (0.88, -0.011, P = 0.93, N = 365)
rs73971292(C)/2:161821810 intergenic (0.023, -0.65, P = 5.1e-06, N = 1958) (0.021, -0.45, P = 0.086, N = 365)
rs780093(T)/2:27742603* GCKR (0.4, -0.0058, P = 1.9e-07, N = 7372) (0.15, -0.022, P = 0.83, N = 365)
rs2199619(T)/2:28854958* PLB1 (0.28, 0.0054, P = 5.2e-06, N = 7372) (0.21, -0.04, P = 0.65, N = 365)
rs992580(C)/20:15246472* MACROD2 (0.44, 0.15, P = 6.2e-06, N = 1958) (0.46, 0.12, P = 0.1, N = 365)
rs6137021(A)/20:20375560* RALGAPA2 (0.67, -0.0083, P = 4.5e-05, N = 1768) (0.23, 0.0076, P = 0.93, N = 365)
rs2425059(C)/20:33912371* UQCC1 (0.38, 0.15, P = 5.6e-06, N = 1958) (0.54, -0.14, P = 0.061, N = 365)
rs2948828(A)/3:124811942 SLC12A8 (0.56, 0.0053, P = 2.2e-05, N = 7372) (0.73, 0.023, P = 0.78, N = 365)
rs73168973(T)/3:151691599 intergenic (0.21, -0.23, P = 4e-07, N = 1958) (0.071, 0.27, P = 0.064, N = 365)
rs4699183(A)/4:106444435 AC004066.2 (0.9, -0.27, P = 6.2e-06, N = 1958) (0.92, -0.15, P = 0.28, N = 365)
rs138354882(A)/4:171429817 intergenic (0.028, -0.36, P = 4.5e-06, N = 1958) (0.088, 0.086, P = 0.52, N = 365)
rs7667615(C)/4:182921992* AC108142.1 (0.26, -0.17, P = 6.1e-06, N = 1958) (0.18, -0.014, P = 0.89, N = 365)
rs542300(A)/6:12252237 intergenic (0.51, -0.13, P = 7.2e-06, N = 1958) (0.52, 0.048, P = 0.52, N = 365)
rs9478369(A)/6:153269698* intergenic (0.25, 0.0049, P = 4.1e-05, N = 7372) (0.52, -0.082, P = 0.25, N = 365)
rs71569656(C)/6:22903627 RP1-209A6.1 (0.28, -0.14, P = 8.9e-06, N = 1958) (0.078, -0.0094, P = 0.95, N = 365)
rs2748991(T)/6:52596516 intergenic (0.45, -0.007, P = 2.3e-06, N = 5604) (0.32, -0.02, P = 0.79, N = 365)
rs1582256(C)/7:126634804 GRM8 (0.51, -0.18, P = 8.5e-06, N = 1958) (0.5, -0.019, P = 0.8, N = 365)
rs767772939(CT)/7:128350744 FAM71F1 (0.096, 0.26, P = 4.1e-06, N = 1958) (0.8, -0.036, P = 0.69, N = 365)
rs17837468(A)/7:138309274 SVOPL (0.88, 0.0088, P = 3.8e-05, N = 7372) (0.74, -0.017, P = 0.84, N = 365)
rs17152416(T)/7:25765238 AC003090.1 (0.76, 0.0049, P = 3.9e-05, N = 7372) (0.73, 0.071, P = 0.39, N = 365)
rs4722699(T)/7:27456500* intergenic (0.27, -0.0048, P = 3.8e-05, N = 7372) (0.21, -0.038, P = 0.67, N = 365)
rs1799211(T)/7:76240677 UPK3B (0.41, -0.0082, P = 4.2e-06, N = 1768) (0.24, -0.035, P = 0.69, N = 365)
rs9314463(A)/8:2525166 RP11-134O21.1 (0.19, 0.27, P = 9.1e-07, N = 1958) (0.45, 0.058, P = 0.45, N = 365)
rs112508772(A)/9:140016354 snoU13 (0.025, 0.48, P = 7e-07, N = 1958) (0.051, 0.11, P = 0.53, N = 365)
rs7848854(C)/9:7766733* intergenic (0.11, 0.0083, P = 2.4e-05, N = 7372) (0.025, 0.047, P = 0.85, N = 365)
Results from Univariable Mendelian Randomization of L-Glutamine & eGFR - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 51 0.064 (-0.11- 0.24) P=0.48 12 30 3e-04 (0- 83.2) NA NA -0.011 P=0.52
MR-Egger 51 0.11 (-0.11- 0.33) P=0.34 12 30 3e-04 (0- 83.2) 52 0.35 -0.011 P=0.52
Weighted median 51 0.11 (-0.14- 0.37) P=0.39 12 30 3e-04 (0- 83.2) NA NA -0.011 P=0.52
Results from Univariable MRPRESSO of L-Glutamine & eGFR - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0.06 0.09 0.71 0.48
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of L-Glutamine & eGFR - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 27 0.046 (-0.18- 0.27) P=0.69 16 22 3.26 (0- 98.9) NA NA -0.016 P=0.55
MR-Egger 27 0.1 (-0.19- 0.4) P=0.5 16 22 3.26 (0- 98.9) 31 0.2 -0.016 P=0.55
Weighted median 27 0.074 (-0.22- 0.37) P=0.62 16 22 3.26 (0- 98.9) NA NA -0.016 P=0.55
Results from Univariable MRPRESSO of L-Glutamine & eGFR - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.03 0.08 -0.34 0.74
beta.exposure Outlier-corrected NA NA NA NA

Aseptic Necrosis

Instruments Associations with L-Glutamine & Aseptic Necrosis
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region L-glutamine (Shin et al/Long et al) Aseptic Necrosis (CSSCD)
rs524219(G)/1:100821493 CDC14A (0.93, -0.28, P = 4.7e-06, N = 1958) (0.99, 0.95, P = 0.19, N = 394)
rs11166473(T)/1:101010015* GPR88 (0.92, -0.36, P = 9.3e-08, N = 1958) (0.46, -0.1, P = 0.53, N = 394)
rs2811981(A)/1:23950147* MDS2 (0.89, -0.12, P = 3.8e-06, N = 1958) (0.88, 0.27, P = 0.3, N = 394)
rs3127550(A)/1:49431909* AGBL4 (0.49, 0.19, P = 5.7e-06, N = 1958) (0.16, -0.19, P = 0.41, N = 394)
rs7394051(T)/10:122008026* intergenic (0.7, 0.0055, P = 2.2e-06, N = 7372) (0.74, -0.083, P = 0.67, N = 394)
rs10762121(T)/10:68708291 CTNNA3 (0.18, -0.0094, P = 3.1e-05, N = 1768) (0.38, 0.15, P = 0.39, N = 394)
rs11596604(A)/10:87141944* intergenic (0.024, 0.032, P = 2.5e-06, N = 1768) (0.01, -0.31, P = 0.71, N = 394)
rs7078003(T)/10:99359412* HOGA1 (0.17, 0.0087, P = 1.8e-06, N = 7372) (0.12, 0.16, P = 0.52, N = 394)
rs7131407(T)/11:128431418 ETS1 (0.13, 0.0082, P = 3.2e-05, N = 7372) (0.16, -0.072, P = 0.76, N = 394)
rs10431159(A)/11:70967219 SHANK2 (0.65, -0.0047, P = 4.8e-05, N = 7372) (0.16, 0.27, P = 0.25, N = 394)
rs17666239(A)/12:47194757* SLC38A4 (0.078, 0.0092, P = 1.7e-05, N = 7372) (0.046, -0.1, P = 0.79, N = 394)
rs735246(A)/12:52547743 intergenic (0.83, 0.0083, P = 4.8e-05, N = 7372) (0.81, 0.2, P = 0.32, N = 394)
rs774044(T)/12:56837979* TIMELESS (0.055, -0.015, P = 5.6e-07, N = 7372) (0.041, 0.16, P = 0.71, N = 394)
rs7313455(A)/12:56853231* MIP (0.44, 0.0062, P = 2.1e-08, N = 7372) (0.13, -0.0075, P = 0.98, N = 394)
rs2657879(A)/12:56865338* GLS2 (0.82, 0.015, P = 6.1e-18, N = 7372) (0.95, -0.41, P = 0.28, N = 394)
rs12232026(A)/12:56960766* RBMS2 (0.12, -0.0097, P = 4.4e-06, N = 7372) (0.16, -0.16, P = 0.49, N = 394)
rs941893(T)/14:100542061* EVL (0.74, -0.0049, P = 4.1e-05, N = 7372) (0.26, -0.4, P = 0.038, N = 394)
rs144325715(A)/14:95948631 intergenic (0.021, -0.74, P = 5.3e-06, N = 1958) (0.039, 0.12, P = 0.78, N = 394)
rs11636988(A)/15:26822814* GABRB3 (0.57, -0.16, P = 6.5e-06, N = 1958) (0.12, -0.021, P = 0.94, N = 394)
rs1910151(A)/15:38158699* intergenic (0.64, 0.0048, P = 2.2e-05, N = 7372) (0.63, -0.045, P = 0.8, N = 394)
rs35150605(TAAC)/15:88047276 RP11-648K4.2 (0.25, -0.15, P = 6.3e-06, N = 1958) (0.31, -0.3, P = 0.1, N = 394)
rs2560409(C)/16:24099496 PRKCB (0.51, 0.26, P = 1.4e-06, N = 1958) (0.17, -0.31, P = 0.14, N = 394)
rs16977047(T)/16:27924612* GSG1L (0.7, -0.0056, P = 1.1e-06, N = 7372) (0.76, -0.14, P = 0.46, N = 394)
rs12447776(T)/16:84053027 SLC38A8 (0.019, 0.029, P = 4.1e-05, N = 1768) (0.038, -0.049, P = 0.91, N = 394)
rs9912445(A)/17:37202603 LRRC37A11P (0.79, 0.0052, P = 1.7e-05, N = 7372) (0.73, -0.33, P = 0.071, N = 394)
rs8069305(A)/17:53638670 CTD-2033D24.2 (0.68, -0.0047, P = 4.9e-05, N = 7372) (0.18, -0.08, P = 0.72, N = 394)
rs4798682(G)/18:8738265 SOGA2 (0.74, 0.15, P = 5e-06, N = 1958) (0.89, 0.18, P = 0.5, N = 394)
rs73971292(C)/2:161821810 intergenic (0.023, -0.65, P = 5.1e-06, N = 1958) (0.019, -0.89, P = 0.13, N = 394)
rs780093(T)/2:27742603* GCKR (0.4, -0.0058, P = 1.9e-07, N = 7372) (0.14, -0.24, P = 0.32, N = 394)
rs2199619(T)/2:28854958* PLB1 (0.28, 0.0054, P = 5.2e-06, N = 7372) (0.21, 0.12, P = 0.55, N = 394)
rs992580(C)/20:15246472* MACROD2 (0.44, 0.15, P = 6.2e-06, N = 1958) (0.46, -0.18, P = 0.28, N = 394)
rs6137021(A)/20:20375560* RALGAPA2 (0.67, -0.0083, P = 4.5e-05, N = 1768) (0.22, -0.28, P = 0.16, N = 394)
rs2425059(C)/20:33912371* UQCC1 (0.38, 0.15, P = 5.6e-06, N = 1958) (0.53, 0.0086, P = 0.96, N = 394)
rs2948828(A)/3:124811942 SLC12A8 (0.56, 0.0053, P = 2.2e-05, N = 7372) (0.73, 0.023, P = 0.9, N = 394)
rs73168973(T)/3:151691599 intergenic (0.21, -0.23, P = 4e-07, N = 1958) (0.074, -0.17, P = 0.6, N = 394)
rs4699183(A)/4:106444435 AC004066.2 (0.9, -0.27, P = 6.2e-06, N = 1958) (0.92, -0.36, P = 0.25, N = 394)
rs138354882(A)/4:171429817 intergenic (0.028, -0.36, P = 4.5e-06, N = 1958) (0.088, 0.05, P = 0.87, N = 394)
rs7667615(C)/4:182921992* AC108142.1 (0.26, -0.17, P = 6.1e-06, N = 1958) (0.18, -0.37, P = 0.093, N = 394)
rs542300(A)/6:12252237 intergenic (0.51, -0.13, P = 7.2e-06, N = 1958) (0.52, -0.022, P = 0.9, N = 394)
rs9478369(A)/6:153269698* intergenic (0.25, 0.0049, P = 4.1e-05, N = 7372) (0.52, -0.17, P = 0.32, N = 394)
rs71569656(C)/6:22903627 RP1-209A6.1 (0.28, -0.14, P = 8.9e-06, N = 1958) (0.077, 0.51, P = 0.13, N = 394)
rs2748991(T)/6:52596516 intergenic (0.45, -0.007, P = 2.3e-06, N = 5604) (0.32, -0.15, P = 0.38, N = 394)
rs1582256(C)/7:126634804 GRM8 (0.51, -0.18, P = 8.5e-06, N = 1958) (0.5, -0.046, P = 0.79, N = 394)
rs767772939(CT)/7:128350744 FAM71F1 (0.096, 0.26, P = 4.1e-06, N = 1958) (0.8, -0.31, P = 0.13, N = 394)
rs17837468(A)/7:138309274 SVOPL (0.88, 0.0088, P = 3.8e-05, N = 7372) (0.75, 0.06, P = 0.74, N = 394)
rs17152416(T)/7:25765238 AC003090.1 (0.76, 0.0049, P = 3.9e-05, N = 7372) (0.73, -0.016, P = 0.93, N = 394)
rs4722699(T)/7:27456500* intergenic (0.27, -0.0048, P = 3.8e-05, N = 7372) (0.2, 0.21, P = 0.31, N = 394)
rs1799211(T)/7:76240677 UPK3B (0.41, -0.0082, P = 4.2e-06, N = 1768) (0.24, 0.15, P = 0.45, N = 394)
rs9314463(A)/8:2525166 RP11-134O21.1 (0.19, 0.27, P = 9.1e-07, N = 1958) (0.45, -0.29, P = 0.087, N = 394)
rs112508772(A)/9:140016354 snoU13 (0.025, 0.48, P = 7e-07, N = 1958) (0.048, -0.17, P = 0.65, N = 394)
rs7848854(C)/9:7766733* intergenic (0.11, 0.0083, P = 2.4e-05, N = 7372) (0.025, 0.097, P = 0.86, N = 394)
Results from Univariable Mendelian Randomization of L-Glutamine & Aseptic Necrosis - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 51 -0.12 (-0.49- 0.26) P=0.53 12 30 3.44 (0- 41.6) NA NA 0.0033 P=0.93
MR-Egger 51 -0.13 (-0.62- 0.36) P=0.6 12 30 3.44 (0- 41.6) 45 0.62 0.0033 P=0.93
Weighted median 51 -0.14 (-0.73- 0.45) P=0.64 12 30 3.44 (0- 41.6) NA NA 0.0033 P=0.93
Results from Univariable MRPRESSO of L-Glutamine & Aseptic Necrosis - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.12 0.19 -0.62 0.54
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of L-Glutamine & Aseptic Necrosis - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 27 -0.21 (-0.69- 0.26) P=0.38 16 22 8.21 (0- 64.5) NA NA -0.029 P=0.61
MR-Egger 27 -0.11 (-0.73- 0.51) P=0.72 16 22 8.21 (0- 64.5) 26 0.42 -0.029 P=0.61
Weighted median 27 -0.19 (-0.91- 0.54) P=0.61 16 22 8.21 (0- 64.5) NA NA -0.029 P=0.61
Results from Univariable MRPRESSO of L-Glutamine & Aseptic Necrosis - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.16 0.18 -0.9 0.38
beta.exposure Outlier-corrected NA NA NA NA

SOM SCD MR Results - other metabolites and SCD-related disease

Painful Crises

Pyroglutamine

Instruments Associations with Pyroglutamine & Painful Crises
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region Pyroglutamine (Shin et al/Long et al) Painful Crises (CSSCD)
rs7512221(T)/1:220601623* AC096644.1 (0.95, -0.04, P = 5e-06, N = 7354) (0.58, 0.18, P = 0.13, N = 1101)
rs7556040(T)/1:220626220* RP11-410C4.1 (0.95, -0.041, P = 3.4e-06, N = 7354) (0.83, -0.37, P = 0.014, N = 1101)
rs9662967(T)/1:244957186 intergenic (0.7, -0.019, P = 7.4e-07, N = 7354) (0.38, -0.041, P = 0.74, N = 1101)
rs12098127(G)/1:48967002* RP11-329A14.2 (0.18, 0.2, P = 2.6e-06, N = 1956) (0.26, 0.035, P = 0.79, N = 1101)
rs56713017(C)/10:129008570 DOCK1 (0.11, 0.2, P = 5.4e-06, N = 1956) (0.18, 0.053, P = 0.72, N = 1101)
rs11007183(A)/10:28939852* RNU4ATAC6P (0.11, -0.025, P = 9.8e-06, N = 7354) (0.12, -0.056, P = 0.74, N = 1101)
rs2512652(C)/11:131259195 RNU6ATAC12P (0.7, -0.052, P = 5.8e-06, N = 1764) (0.88, -0.061, P = 0.72, N = 1101)
rs11223638(T)/11:133819222 IGSF9B (0.14, -0.25, P = 3.7e-07, N = 1956) (0.33, -0.052, P = 0.68, N = 1101)
rs11613331(A)/12:351467* SLC6A13 (0.55, 0.037, P = 2.2e-25, N = 7354) (0.28, 0.26, P = 0.044, N = 1101)
rs4140962(A)/12:475579* KDM5A (0.41, -0.033, P = 1.2e-19, N = 7354) (0.64, -0.25, P = 0.042, N = 1101)
rs11116175(A)/12:84431621 intergenic (0.16, 0.15, P = 7.1e-06, N = 1956) (0.035, -0.13, P = 0.68, N = 1101)
rs9547116(C)/13:85845121 intergenic (0.45, 0.16, P = 5.2e-06, N = 1956) (0.11, -0.13, P = 0.49, N = 1101)
rs9547119(G)/13:85846010 intergenic (0.45, 0.16, P = 4e-06, N = 1956) (0.11, -0.14, P = 0.48, N = 1101)
rs1600760(A)/14:85104707* intergenic (0.66, -0.022, P = 5.1e-09, N = 7354) (0.43, -0.1, P = 0.38, N = 1101)
rs12905776(T)/15:55170012 intergenic (0.53, 0.11, P = 4e-06, N = 1956) (0.27, 0.081, P = 0.53, N = 1101)
rs2551453(T)/18:53699500 CTD-2008L17.2 (0.26, -0.02, P = 7.3e-06, N = 7354) (0.063, -0.15, P = 0.53, N = 1101)
rs6511763(C)/19:12186857* ZNF844 (0.15, -0.15, P = 8.7e-06, N = 1956) (0.67, -0.13, P = 0.3, N = 1101)
rs1132054(T)/19:49102399* SULT2B1 (0.57, 0.02, P = 2.3e-06, N = 5590) (0.25, -0.00082, P = 1, N = 1101)
rs715(T)/2:211543055* CPS1 (0.71, 0.036, P = 2.5e-16, N = 7354) (0.82, -0.11, P = 0.45, N = 1101)
rs2371015(T)/2:211549609* intergenic (0.34, 0.021, P = 2.2e-08, N = 7354) (0.37, 0.1, P = 0.39, N = 1101)
rs11687290(A)/2:211647954* intergenic (0.73, -0.017, P = 7.4e-06, N = 7354) (0.83, -0.082, P = 0.6, N = 1101)
rs79740025(T)/2:27677763* IFT172 (0.19, 0.2, P = 2.9e-06, N = 1956) (0.024, -0.15, P = 0.7, N = 1101)
rs239019(G)/21:17699639* LINC00478 (0.97, 0.41, P = 9.1e-06, N = 1956) (0.39, -0.08, P = 0.5, N = 1101)
rs80164931(G)/21:17705595 LINC00478 (0.032, 0.43, P = 1.8e-06, N = 1956) (0.014, -0.4, P = 0.39, N = 1101)
rs139049(T)/22:44323597* PNPLA3 (0.41, 0.11, P = 3.9e-06, N = 1956) (0.36, -0.047, P = 0.7, N = 1101)
rs13057977(T)/22:49047339 FAM19A5 (0.15, 0.21, P = 9.9e-06, N = 1956) (0.32, 0.2, P = 0.1, N = 1101)
rs77502708(C)/3:181192900 SOX2-OT (0.026, 0.48, P = 2e-06, N = 1956) (0.099, 0.2, P = 0.32, N = 1101)
rs2159892(T)/3:45383676* intergenic (0.64, -0.02, P = 3.6e-08, N = 7354) (0.6, -0.043, P = 0.71, N = 1101)
rs17279437(A)/3:45814094* SLC6A20 (0.095, 0.059, P = 1.3e-20, N = 7354) (0.013, -0.0023, P = 1, N = 1101)
rs4071(C)/4:101319165* EMCN (0.76, -0.15, P = 8.9e-06, N = 1956) (0.84, 0.091, P = 0.57, N = 1101)
rs17776892(A)/4:137356574 intergenic (0.3, 0.035, P = 4e-06, N = 1764) (0.16, -0.076, P = 0.63, N = 1101)
rs73863916(T)/4:169462085 PALLD (0.021, 0.57, P = 4.5e-06, N = 1956) (0.17, -0.029, P = 0.85, N = 1101)
rs11729049(A)/4:180719585 intergenic (0.63, 0.017, P = 3.7e-06, N = 7354) (0.87, -0.26, P = 0.13, N = 1101)
rs17250948(C)/4:182771958* intergenic (0.4, 0.14, P = 4.5e-06, N = 1956) (0.28, -0.12, P = 0.34, N = 1101)
rs1203809(G)/4:2449545 RP11-503N18.3 (0.38, 0.09, P = 2.1e-06, N = 1956) (0.2, 0.15, P = 0.3, N = 1101)
rs73221060(T)/4:31439776 intergenic (0.051, -0.28, P = 1.8e-06, N = 1956) (0.34, -0.017, P = 0.89, N = 1101)
rs12233879(A)/4:54263624* FIP1L1 (0.14, -0.027, P = 4.5e-07, N = 7354) (0.046, -0.22, P = 0.44, N = 1101)
rs77471043(G)/4:75060135 MTHFD2L (0.01, 0.91, P = 2e-06, N = 1956) (0.16, 0.15, P = 0.33, N = 1101)
rs11727631(T)/4:77576975 SHROOM3 (0.29, 0.017, P = 5.2e-06, N = 7354) (0.47, -0.067, P = 0.57, N = 1101)
rs252984(T)/5:106752337 EFNA5 (0.19, -0.02, P = 7.6e-06, N = 7354) (0.23, 0.17, P = 0.2, N = 1101)
rs1449167(T)/5:119998008* PRR16 (0.64, 0.035, P = 5.4e-06, N = 1764) (0.72, -0.1, P = 0.42, N = 1101)
rs199639973(A)/5:97107215 intergenic (0.052, 0.28, P = 1.3e-06, N = 1956) (0.057, 0.41, P = 0.11, N = 1101)
rs9346808(C)/6:160532652* RP11-288H12.4 (0.23, -0.21, P = 7.5e-06, N = 1956) (0.3, -0.083, P = 0.52, N = 1101)
rs12670725(A)/7:119577292* intergenic (0.81, 0.021, P = 6.2e-06, N = 7354) (0.76, -0.049, P = 0.72, N = 1101)
rs5882739(GT)/7:20429461 ITGB8 (0.24, -0.06, P = 6.2e-06, N = 1956) (0.68, 0.16, P = 0.21, N = 1101)
rs56142483(T)/8:41334474 intergenic (0.088, -0.24, P = 8e-07, N = 1956) (0.17, -0.059, P = 0.7, N = 1101)
Results from Univariable Mendelian Randomization of Pyroglutamine & Painful Crises - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 46 1.1 (0.94- 1.4) P=0.21 11 24 0 (0- 74.8) NA NA 0.014 P=0.62
MR-Egger 46 1.1 (0.84- 1.4) P=0.54 11 24 0 (0- 74.8) 40 0.64 0.014 P=0.62
Weighted median 46 1.1 (0.85- 1.5) P=0.37 11 24 0 (0- 74.8) NA NA 0.014 P=0.62
Results from Univariable MRPRESSO of Pyroglutamine & Painful Crises - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0.12 0.1 1.26 0.21
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of Pyroglutamine & Painful Crises - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 23 1.2 (0.97- 1.4) P=0.093 14 16 0 (0- 65.2) NA NA -0.033 P=0.45
MR-Egger 23 1.3 (0.94- 1.7) P=0.13 14 16 0 (0- 65.2) 15 0.82 -0.033 P=0.45
Weighted median 23 1.2 (0.84- 1.6) P=0.35 14 16 0 (0- 65.2) NA NA -0.033 P=0.45
Results from Univariable MRPRESSO of Pyroglutamine & Painful Crises - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0.16 0.1 1.68 0.11
beta.exposure Outlier-corrected NA NA NA NA

eGFR

cis-Aconitic acid

Instruments Associations with Cis-aconitate & eGFR
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region cis-Aconitic acid (Shin et al/Long et al) eGFR (CSSCD)
rs35324600(T)/11:22530939 intergenic (0.49, 0.15, P = 3.1e-06, N = 1947) (0.28, 0.076, P = 0.16, N = 859)
rs6539223(G)/12:106007537 intergenic (0.61, -0.1, P = 3.4e-06, N = 1947) (0.89, -0.14, P = 0.065, N = 859)
rs138450783(CA)/14:63994788* PPP2R5E (0.061, -0.33, P = 3.1e-06, N = 1947) (0.061, 0.042, P = 0.67, N = 859)
rs11648258(T)/16:82677875 CDH13 (0.11, 0.16, P = 4.4e-06, N = 1947) (0.039, 0.27, P = 0.03, N = 859)
rs4798545(C)/18:7258907 intergenic (0.63, 0.15, P = 8.2e-07, N = 1947) (0.4, -0.00023, P = 1, N = 859)
rs2302891(T)/2:217064533 XRCC5 (0.24, 0.14, P = 2.3e-06, N = 1947) (0.3, -0.063, P = 0.24, N = 859)
rs77430920(A)/3:1496695 intergenic (0.097, -0.26, P = 6.5e-07, N = 1947) (0.024, -0.37, P = 0.017, N = 859)
rs67411255(A)/3:162259082 intergenic (0.29, 0.18, P = 2.3e-06, N = 1947) (0.45, -0.042, P = 0.37, N = 859)
rs7662761(G)/4:182654376* intergenic (0.85, 0.19, P = 3.8e-06, N = 1947) (0.81, -0.11, P = 0.066, N = 859)
rs7719640(A)/5:3752812* intergenic (0.58, 0.18, P = 4.8e-06, N = 1947) (0.31, -0.023, P = 0.65, N = 859)
rs233947(A)/6:132324555* RP11-69I8.3 (0.18, 0.13, P = 4.5e-06, N = 1947) (0.62, -0.026, P = 0.61, N = 859)
rs55753187(C)/6:132717587 MOXD1 (0.29, 0.16, P = 8.2e-06, N = 1947) (0.4, 0.027, P = 0.58, N = 859)
rs62572814(A)/9:83198655 intergenic (0.072, 0.33, P = 9.4e-06, N = 1947) (0.019, 0.02, P = 0.91, N = 859)
Results from Univariable Mendelian Randomization of Cis-aconitate & eGFR - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 13 -0.013 (-0.28- 0.26) P=0.92 20 13 29.6 (0- 89.6) NA NA 0.043 P=0.67
MR-Egger 13 -0.26 (-1.4- 0.88) P=0.66 20 13 29.6 (0- 89.6) 22 0.025 0.043 P=0.67
Weighted median 13 -0.13 (-0.41- 0.15) P=0.37 20 13 29.6 (0- 89.6) NA NA 0.043 P=0.67
Results from Univariable MRPRESSO of Cis-aconitate & eGFR - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.01 0.14 -0.09 0.93
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of Cis-aconitate & eGFR - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 9 0.15 (-0.22- 0.52) P=0.43 19 8.9 52.9 (0- 92.3) NA NA 0.018 P=0.92
MR-Egger 9 0.043 (-1.9- 2) P=0.97 19 8.9 52.9 (0- 92.3) 17 0.018 0.018 P=0.92
Weighted median 9 0.024 (-0.33- 0.38) P=0.89 19 8.9 52.9 (0- 92.3) NA NA 0.018 P=0.92
Results from Univariable MRPRESSO of Cis-aconitate & eGFR - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0.15 0.19 0.79 0.45
beta.exposure Outlier-corrected NA NA NA NA

Decanoylcarnitine

Instruments Associations with Decanoylcarnitine & eGFR
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region Decanoylcarnitine (Shin et al/Long et al) eGFR (CSSCD)
rs2336566(T)/1:12085097* MIIP (0.81, -0.021, P = 3.5e-05, N = 7824) (0.9, -0.049, P = 0.53, N = 859)
rs332765(T)/1:174655782* RABGAP1L (0.36, 0.13, P = 2.4e-06, N = 1950) (0.9, -0.075, P = 0.34, N = 859)
rs1434889(A)/1:213511231* intergenic (0.69, -0.017, P = 5e-05, N = 7824) (0.26, 0.089, P = 0.11, N = 859)
rs7552404(A)/1:76135946* intergenic (0.7, 0.056, P = 3.3e-43, N = 7824) (0.83, -0.12, P = 0.061, N = 859)
rs699683(A)/1:76172512* RP4-682C21.5 (0.068, 0.038, P = 1e-06, N = 7824) (0.024, 0.036, P = 0.82, N = 859)
rs12130832(T)/1:76234294* ACADM (0.71, -0.037, P = 2.8e-19, N = 7824) (0.79, 0.0095, P = 0.87, N = 859)
rs56352044(T)/1:76248706 RABGGTB (0.23, -0.3, P = 9.1e-15, N = 1950) (0.14, 0.15, P = 0.033, N = 859)
rs1144337(T)/1:76278877 MSH4 (0.1, 0.034, P = 1.5e-07, N = 7824) (0.19, -0.061, P = 0.31, N = 859)
rs1796810(T)/1:76403305 intergenic (0.29, 0.034, P = 8.6e-17, N = 7824) (0.32, -0.0091, P = 0.86, N = 859)
rs3762410(A)/1:97189288* PTBP2 (0.3, -0.018, P = 2.8e-05, N = 7824) (0.15, -0.042, P = 0.53, N = 859)
rs12255398(C)/10:122875878 intergenic (0.21, -0.19, P = 3.6e-06, N = 1950) (0.028, -0.04, P = 0.78, N = 859)
rs7894167(C)/10:47556919* intergenic (0.38, 0.17, P = 3.8e-06, N = 1950) (0.52, 0.1, P = 0.037, N = 859)
rs11212307(A)/11:107506922* ELMOD1 (0.95, -0.04, P = 3.7e-05, N = 7824) (0.94, -0.019, P = 0.85, N = 859)
rs7116229(T)/11:113998407* ZBTB16 (0.036, 0.048, P = 1.8e-05, N = 7824) (0.22, -0.036, P = 0.53, N = 859)
rs12787276(T)/11:20313272* intergenic (0.25, 0.02, P = 3.3e-05, N = 7824) (0.071, -0.16, P = 0.081, N = 859)
rs11828392(A)/11:21413243* NELL1 (0.055, -0.045, P = 4.2e-05, N = 7824) (0.012, -0.047, P = 0.83, N = 859)
rs10769307(T)/11:47923603* RP11-793I11.1 (0.86, 0.024, P = 1.5e-05, N = 7824) (0.74, 0.013, P = 0.8, N = 859)
rs7130402(A)/11:48115606* PTPRJ (0.93, 0.034, P = 2.4e-05, N = 7824) (0.91, -0.013, P = 0.88, N = 859)
rs12289557(A)/11:8344945* intergenic (0.43, -0.18, P = 5.3e-06, N = 1950) (0.028, 0.12, P = 0.42, N = 859)
rs11225932(T)/11:97160858 intergenic (0.072, -0.35, P = 8.4e-06, N = 1950) (0.013, 0.25, P = 0.24, N = 859)
rs7973509(A)/12:40354147* SLC2A13 (0.27, -0.018, P = 2.2e-05, N = 7824) (0.097, 0.042, P = 0.61, N = 859)
rs6538742(A)/12:97203085* C12orf55 (0.72, -0.017, P = 4.4e-05, N = 7824) (0.95, 0.044, P = 0.7, N = 859)
rs1557093(T)/13:108378235* FAM155A (0.89, -0.25, P = 2.6e-06, N = 1950) (0.79, 0.096, P = 0.095, N = 859)
rs1220578(A)/13:24730147* SPATA13 (0.078, -0.032, P = 6.9e-06, N = 7824) (0.098, 0.098, P = 0.22, N = 859)
rs9546715(T)/13:85064464* intergenic (0.83, -0.021, P = 3.1e-05, N = 7824) (0.88, -0.01, P = 0.89, N = 859)
rs8003176(T)/14:88760692* KCNK10 (0.77, 0.036, P = 2e-05, N = 7824) (0.9, 0.076, P = 0.34, N = 859)
rs11848217(G)/14:93048314* RIN3 (0.24, -0.18, P = 7.1e-06, N = 1950) (0.33, -0.029, P = 0.58, N = 859)
rs2062541(A)/16:16127235* ABCC1 (0.61, 0.022, P = 2.9e-08, N = 7824) (0.47, 0.048, P = 0.32, N = 859)
rs45512591(C)/16:16147264* ABCC1 (0.28, -0.23, P = 4.7e-08, N = 1950) (0.37, -0.056, P = 0.26, N = 859)
rs12932433(T)/16:7114043* RBFOX1 (0.71, 0.019, P = 6.3e-06, N = 7824) (0.59, 0.004, P = 0.94, N = 859)
rs11657401(A)/17:12762029* ARHGAP44 (0.77, -0.022, P = 4.4e-05, N = 7824) (0.91, -0.097, P = 0.24, N = 859)
rs4889820(A)/17:78089762* GAA (0.99, 0.091, P = 3.5e-05, N = 7824) (0.86, -0.06, P = 0.4, N = 859)
rs8076629(A)/17:8024808* HES7 (0.074, -0.033, P = 2.8e-05, N = 7824) (0.2, -0.02, P = 0.75, N = 859)
rs948386(C)/18:19998810* CTAGE1 (0.58, 0.017, P = 3.3e-05, N = 7824) (0.5, -0.051, P = 0.29, N = 859)
rs3914856(C)/18:2413983 intergenic (0.12, -0.025, P = 1.7e-05, N = 7824) (0.041, 0.21, P = 0.08, N = 859)
rs2156436(T)/18:57457267* intergenic (0.031, 0.14, P = 1.7e-06, N = 7824) (0.23, -0.027, P = 0.64, N = 859)
rs7257107(T)/19:35462829* intergenic (0.61, 0.018, P = 3.6e-05, N = 7824) (0.77, -0.2, P = 0.00062, N = 859)
rs2239510(A)/19:36611284* TBCB (0.33, 0.018, P = 1.9e-05, N = 7824) (0.23, 0.022, P = 0.7, N = 859)
rs2140779(T)/2:121302719* AC073257.2 (0.15, -0.025, P = 9.9e-06, N = 7824) (0.027, 0.11, P = 0.44, N = 859)
rs10191469(G)/2:149419648* EPC2 (0.78, 0.17, P = 8.6e-06, N = 1950) (0.36, -0.013, P = 0.79, N = 859)
rs10203979(C)/2:179022751* intergenic (0.23, 0.18, P = 3.4e-06, N = 1950) (0.36, -0.074, P = 0.14, N = 859)
rs4675009(A)/2:226660503* intergenic (0.82, 0.21, P = 3.6e-06, N = 1950) (0.82, -0.094, P = 0.14, N = 859)
rs2290101(C)/2:33952055* MYADML (0.34, 0.017, P = 4.4e-05, N = 7824) (0.44, -0.11, P = 0.025, N = 859)
rs10495981(T)/2:49883809* intergenic (0.94, -0.034, P = 4.4e-05, N = 7824) (0.99, -0.24, P = 0.25, N = 859)
rs1203869(T)/20:22533223* LINC00261 (0.015, 0.099, P = 2.8e-05, N = 7824) (0.15, -0.056, P = 0.39, N = 859)
rs2298450(T)/21:37623447* DOPEY2 (0.37, -0.017, P = 2.2e-05, N = 7824) (0.55, 0.0059, P = 0.9, N = 859)
rs5755595(T)/22:35518839* CTA-714B7.5 (0.27, 0.24, P = 3.3e-06, N = 1950) (0.055, 0.1, P = 0.35, N = 859)
rs331869(T)/3:255395 CHL1 (0.98, -0.13, P = 2.8e-06, N = 7824) (0.81, -0.061, P = 0.32, N = 859)
rs2700436(T)/3:41573511* ULK4 (0.76, -0.018, P = 4.4e-05, N = 7824) (0.9, -0.0033, P = 0.97, N = 859)
rs6537038(A)/4:142166712* RP11-586L23.1 (0.4, -0.019, P = 4.9e-06, N = 7824) (0.32, -0.012, P = 0.81, N = 859)
rs35055965(T)/4:159193901* RP11-597D13.7 (0.24, -0.23, P = 3.6e-09, N = 1950) (0.16, -0.023, P = 0.72, N = 859)
rs8396(T)/4:159630817* PPID (0.7, 0.053, P = 8.7e-38, N = 7824) (0.65, 0.014, P = 0.78, N = 859)
rs10857319(T)/4:159729794* FNIP2 (0.35, 0.02, P = 1.1e-06, N = 7824) (0.061, -0.071, P = 0.49, N = 859)
rs10003821(T)/4:159877388* C4orf45 (0.36, -0.029, P = 1.6e-12, N = 7824) (0.35, -0.0021, P = 0.97, N = 859)
rs595580(A)/4:24023919* intergenic (0.14, 0.022, P = 4.8e-05, N = 7824) (0.13, 0.11, P = 0.13, N = 859)
rs9790569(T)/4:46734416* COX7B2 (0.18, -0.2, P = 9.3e-06, N = 1950) (0.14, -0.096, P = 0.17, N = 859)
rs6848595(A)/4:66601246* intergenic (0.8, 0.021, P = 2.4e-05, N = 7824) (0.86, -0.015, P = 0.83, N = 859)
rs17157494(A)/5:104409021* CTD-2374C24.1 (0.074, 0.035, P = 2.2e-06, N = 7824) (0.03, -0.16, P = 0.25, N = 859)
rs10036208(T)/5:131571323* P4HA2 (0.34, 0.02, P = 1.5e-06, N = 7824) (0.22, 0.038, P = 0.51, N = 859)
rs1392171(A)/5:135631449* TRPC7 (0.89, 0.024, P = 3.5e-05, N = 7824) (0.87, -0.0074, P = 0.92, N = 859)
rs371846(T)/5:142188049* ARHGAP26 (0.083, -0.03, P = 4.2e-05, N = 7824) (0.25, -0.019, P = 0.73, N = 859)
rs447983(G)/5:155986075* SGCD (0.18, 0.22, P = 9.8e-06, N = 1950) (0.42, -0.0042, P = 0.93, N = 859)
rs2042990(A)/5:66232373* MAST4 (0.039, -0.04, P = 4.8e-05, N = 7824) (0.019, -0.25, P = 0.17, N = 859)
rs13195853(T)/6:165808391* PDE10A (0.65, 0.018, P = 1.9e-05, N = 7824) (0.85, 0.039, P = 0.57, N = 859)
rs4711830(T)/6:45810500* intergenic (0.13, 0.2, P = 6.1e-06, N = 1950) (0.098, -0.058, P = 0.48, N = 859)
rs9352088(C)/6:74987577* RP11-554D15.1 (0.75, -0.038, P = 3.1e-05, N = 7824) (0.56, 0.036, P = 0.46, N = 859)
rs7795715(A)/7:154639804* DPP6 (0.86, -0.025, P = 1.2e-05, N = 7824) (0.82, -0.03, P = 0.64, N = 859)
rs7789113(A)/7:52525621* intergenic (0.37, 0.017, P = 3.1e-05, N = 7824) (0.81, 0.081, P = 0.19, N = 859)
rs7800456(T)/7:81904348* CACNA2D1 (0.29, 0.018, P = 2.5e-05, N = 7824) (0.28, 0.063, P = 0.25, N = 859)
rs6958779(A)/7:92996871 intergenic (0.59, -0.017, P = 4.1e-05, N = 7824) (0.68, -0.016, P = 0.76, N = 859)
rs7819483(A)/8:144351394* GLI4 (0.72, -0.019, P = 7.5e-06, N = 7824) (0.46, -0.013, P = 0.79, N = 859)
rs7462737(T)/8:17615456* MTUS1 (0.17, -0.021, P = 1.9e-05, N = 7824) (0.26, -0.055, P = 0.31, N = 859)
rs3824142(A)/8:1947938* KBTBD11 (0.12, -0.025, P = 4.7e-05, N = 7824) (0.38, 0.006, P = 0.9, N = 859)
rs10504255(A)/8:59398461* CYP7A1 (0.65, 0.017, P = 4.1e-05, N = 7824) (0.93, -0.064, P = 0.49, N = 859)
rs7833895(A)/8:9989417* MSRA (0.93, 0.033, P = 1.5e-05, N = 7824) (0.83, -0.021, P = 0.75, N = 859)
rs9556(T)/9:102732237* STX17 (0.31, -0.019, P = 6.1e-06, N = 7824) (0.27, 0.013, P = 0.81, N = 859)
rs6475272(T)/9:18949249* FAM154A (0.23, -0.024, P = 9.1e-07, N = 7824) (0.067, 0.0017, P = 0.99, N = 859)
rs1556099(A)/9:7164502* KDM4C (0.75, 0.019, P = 1.8e-05, N = 7824) (0.85, 0.1, P = 0.14, N = 859)
Results from Univariable Mendelian Randomization of Decanoylcarnitine & eGFR - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 78 -0.08 (-0.22- 0.06) P=0.26 7.9 27 9.62 (0- 60.2) NA NA -0.0027 P=0.79
MR-Egger 78 -0.062 (-0.25- 0.13) P=0.52 7.9 27 9.62 (0- 60.2) 80 0.35 -0.0027 P=0.79
Weighted median 78 -0.059 (-0.28- 0.17) P=0.61 7.9 27 9.62 (0- 60.2) NA NA -0.0027 P=0.79
Results from Univariable MRPRESSO of Decanoylcarnitine & eGFR - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.08 0.07 -1.12 0.27
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of Decanoylcarnitine & eGFR - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 8 -0.34 (-0.74- 0.052) P=0.089 17 6.2 14 (0- 97.6) NA NA 0.0023 P=0.95
MR-Egger 8 -0.35 (-0.92- 0.22) P=0.27 17 6.2 14 (0- 97.6) 7.9 0.25 0.0023 P=0.95
Weighted median 8 -0.45 (-0.92- 0.028) P=0.065 17 6.2 14 (0- 97.6) NA NA 0.0023 P=0.95
Results from Univariable MRPRESSO of Decanoylcarnitinee & eGFR - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.34 0.2 -1.7 0.13
beta.exposure Outlier-corrected NA NA NA NA

Dodecanoylcarnitine

Instruments Associations with Dodecanoylcarnitine & eGFR
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region Dodecanoylcarnitine (Shin et al/Long et al) eGFR (CSSCD)
rs2154184(T)/1:111432037* CD53 (0.19, 0.22, P = 4.7e-06, N = 1955) (0.056, -0.032, P = 0.75, N = 859)
rs332765(T)/1:174655782* RABGAP1L (0.36, 0.13, P = 2.4e-06, N = 1955) (0.9, -0.075, P = 0.34, N = 859)
rs1408421(A)/1:17754767* RCC2 (0.36, 0.034, P = 4.8e-05, N = 7824) (0.24, -0.095, P = 0.091, N = 859)
rs736713(T)/1:19689279* CAPZB (0.047, -0.047, P = 2.4e-05, N = 7824) (0.34, 0.015, P = 0.77, N = 859)
rs12087648(T)/1:198488490* ATP6V1G3 (0.87, 0.029, P = 3.8e-05, N = 7824) (0.72, -0.05, P = 0.36, N = 859)
rs12081432(T)/1:224413515 NVL (0.33, -0.12, P = 1.8e-06, N = 1955) (0.32, 0.069, P = 0.19, N = 859)
rs66713312(T)/1:236526499* EDARADD (0.24, 0.13, P = 4.3e-06, N = 1955) (0.42, 0.036, P = 0.46, N = 859)
rs316841(T)/1:242322654* PLD5 (0.38, 0.033, P = 4.9e-05, N = 7824) (0.68, 0.0044, P = 0.93, N = 859)
rs7894167(C)/10:47556919* intergenic (0.38, 0.17, P = 3.8e-06, N = 1955) (0.52, 0.1, P = 0.037, N = 859)
rs12218054(T)/10:49801239* ARHGAP22 (0.22, -0.025, P = 1.4e-05, N = 7824) (0.19, 0.042, P = 0.49, N = 859)
rs7902782(T)/10:8777109* intergenic (0.16, -0.028, P = 3.9e-05, N = 7824) (0.22, -0.07, P = 0.22, N = 859)
rs4937603(T)/11:131022116* intergenic (0.43, 0.13, P = 1.6e-06, N = 1955) (0.3, 0.017, P = 0.75, N = 859)
rs10766637(A)/11:20245859* intergenic (0.53, -0.034, P = 3e-05, N = 7824) (0.21, 0.097, P = 0.11, N = 859)
rs9144(T)/11:87846757* RAB38 (0.59, -0.02, P = 4.7e-05, N = 7824) (0.84, -0.049, P = 0.46, N = 859)
rs10842869(A)/12:27335914* intergenic (0.44, -0.16, P = 2.8e-06, N = 1955) (0.61, -0.036, P = 0.48, N = 859)
rs75605489(C)/12:4342877 intergenic (0.061, -0.3, P = 9.7e-06, N = 1955) (0.16, 0.085, P = 0.19, N = 859)
rs11180195(A)/12:75144208* intergenic (0.011, 0.17, P = 8.6e-06, N = 7824) (0.04, -0.013, P = 0.92, N = 859)
rs2263942(A)/12:82420006* intergenic (0.97, 0.45, P = 1.1e-06, N = 1955) (0.66, 0.035, P = 0.49, N = 859)
rs4900991(C)/14:50618737* SOS2 (0.6, 0.021, P = 9.9e-06, N = 7824) (0.89, 0.04, P = 0.61, N = 859)
rs7162018(A)/15:39365195* RP11-624L4.1 (0.49, -0.022, P = 4.5e-06, N = 7824) (0.21, 0.011, P = 0.85, N = 859)
rs12902624(C)/15:82533236* EFTUD1 (0.88, 0.033, P = 4.3e-06, N = 7824) (0.98, -0.53, P = 0.0052, N = 859)
rs193537(C)/16:16135043* ABCC1 (0.3, -0.24, P = 1.8e-09, N = 1955) (0.66, -0.019, P = 0.71, N = 859)
rs16966673(T)/16:63897984* intergenic (0.026, 0.12, P = 7.9e-06, N = 7824) (0.11, 0.01, P = 0.9, N = 859)
rs10492879(T)/16:8432142* intergenic (0.94, -0.042, P = 1.8e-05, N = 7824) (0.89, -0.071, P = 0.36, N = 859)
rs12928583(A)/16:84961276* RP11-254F19.3 (0.54, 0.024, P = 9e-06, N = 7824) (0.25, 0.02, P = 0.71, N = 859)
rs2546027(T)/19:35454215* ZNF792 (0.54, 0.026, P = 4.1e-05, N = 7824) (0.65, 0.019, P = 0.71, N = 859)
rs1003470(C)/19:36602729* TBCB (0.45, 0.023, P = 1.2e-06, N = 7824) (0.3, 0.043, P = 0.41, N = 859)
rs346052(A)/19:44205082* intergenic (0.094, -0.16, P = 1.1e-06, N = 1955) (0.16, -0.03, P = 0.64, N = 859)
rs1982669(T)/2:120539339* PTPN4 (0.27, 0.02, P = 4.9e-05, N = 7824) (0.28, -0.028, P = 0.6, N = 859)
rs843200(C)/2:156424356 intergenic (0.54, -0.13, P = 8.9e-06, N = 1955) (0.46, 0.056, P = 0.23, N = 859)
rs764741(A)/2:158089779 intergenic (0.19, -0.27, P = 7.5e-06, N = 1955) (0.092, -0.054, P = 0.51, N = 859)
rs10198528(A)/2:159358192* PKP4 (0.58, 0.033, P = 3.1e-05, N = 7824) (0.75, 0.086, P = 0.12, N = 859)
rs1465827(T)/2:212090820* intergenic (0.91, 0.033, P = 3.6e-05, N = 7824) (0.95, -0.047, P = 0.67, N = 859)
rs2970899(T)/2:88421845* FABP1 (0.77, 0.024, P = 2.3e-05, N = 7824) (0.9, -0.073, P = 0.37, N = 859)
rs68088277(T)/20:16262002 KIF16B (0.019, 0.61, P = 7.5e-06, N = 1955) (0.1, 0.082, P = 0.31, N = 859)
rs73110340(G)/20:16262599 KIF16B (0.019, 0.61, P = 6.4e-06, N = 1955) (0.09, -0.0077, P = 0.93, N = 859)
rs4140469(A)/20:7152241 RP4-764O22.2 (0.76, -0.025, P = 9e-06, N = 7824) (0.97, 0.046, P = 0.73, N = 859)
rs2298565(C)/21:45643396* ICOSLG (0.55, 0.02, P = 2.4e-05, N = 7824) (0.68, 0.0037, P = 0.94, N = 859)
rs5755595(T)/22:35518839* CTA-714B7.5 (0.27, 0.24, P = 3.3e-06, N = 1955) (0.055, 0.1, P = 0.35, N = 859)
rs7631807(G)/3:104939338 intergenic (0.76, -0.21, P = 8.8e-06, N = 1955) (0.55, -0.098, P = 0.045, N = 859)
rs9880529(T)/3:176409064* RP11-644C3.1 (0.87, 0.033, P = 3.8e-06, N = 7824) (0.8, 0.035, P = 0.56, N = 859)
rs11927179(A)/3:68816377* FAM19A4 (0.064, -0.042, P = 1e-05, N = 7824) (0.15, -0.0077, P = 0.91, N = 859)
rs9852502(T)/3:88896473* intergenic (0.62, -0.26, P = 7.9e-06, N = 1955) (0.5, 0.02, P = 0.68, N = 859)
rs4352478(A)/4:104212131 RP11-328K4.1 (0.22, 0.024, P = 1.9e-05, N = 7824) (0.52, 0.0096, P = 0.84, N = 859)
rs2162399(T)/4:119822626 SYNPO2 (0.19, 0.044, P = 3.8e-05, N = 7824) (0.36, -0.034, P = 0.5, N = 859)
rs1353305(A)/4:124326814* SPRY1 (0.97, -0.1, P = 4.9e-05, N = 7824) (0.82, 0.045, P = 0.47, N = 859)
rs10002155(A)/4:15916508 intergenic (0.27, -0.18, P = 3.2e-06, N = 1955) (0.32, -0.0014, P = 0.98, N = 859)
rs4690909(C)/4:159629151* ETFDH (0.69, 0.03, P = 1.1e-09, N = 7824) (0.14, 0.012, P = 0.86, N = 859)
rs35189787(T)/4:159802267* FNIP2 (0.21, -0.29, P = 5.3e-10, N = 1955) (0.077, 0.091, P = 0.31, N = 859)
rs62306589(T)/4:56058510 intergenic (0.29, 0.16, P = 4.5e-06, N = 1955) (0.04, 0.093, P = 0.46, N = 859)
rs2535502(T)/4:58195220* intergenic (0.61, -0.021, P = 2.5e-05, N = 7824) (0.66, 0.13, P = 0.009, N = 859)
rs6834160(A)/4:68030397* intergenic (0.98, 0.065, P = 4.6e-05, N = 7824) (0.97, -0.22, P = 0.12, N = 859)
rs2119420(A)/4:80437117* LINC00989 (0.24, 0.024, P = 2e-05, N = 7824) (0.53, -0.068, P = 0.16, N = 859)
rs4836309(T)/5:126454090* intergenic (0.54, -0.022, P = 2.4e-06, N = 7824) (0.5, -0.074, P = 0.13, N = 859)
rs274559(A)/5:131720070* SLC22A5 (0.62, -0.023, P = 1.5e-06, N = 7824) (0.62, 0.0015, P = 0.98, N = 859)
rs447983(G)/5:155986075* SGCD (0.18, 0.22, P = 9.8e-06, N = 1955) (0.42, -0.0042, P = 0.93, N = 859)
rs7728965(T)/5:4231293* intergenic (0.23, 0.024, P = 3.9e-05, N = 7824) (0.28, 0.025, P = 0.64, N = 859)
rs4711830(T)/6:45810500* intergenic (0.13, 0.2, P = 6.1e-06, N = 1955) (0.098, -0.058, P = 0.48, N = 859)
rs1454715(A)/6:68827238* intergenic (0.22, 0.024, P = 2e-05, N = 7824) (0.45, 0.067, P = 0.18, N = 859)
rs943087(T)/6:76754976* IMPG1 (0.17, 0.031, P = 1.4e-06, N = 7824) (0.2, -0.063, P = 0.29, N = 859)
rs3815553(T)/7:104535572* LHFPL3 (0.47, -0.022, P = 4.1e-05, N = 7824) (0.74, 0.045, P = 0.41, N = 859)
rs73231995(T)/7:123940656 RP5-921G16.1 (0.12, -0.22, P = 9.7e-06, N = 1955) (0.012, 0.056, P = 0.8, N = 859)
rs1385234(A)/8:96681968* KB-1047C11.2 (0.32, 0.022, P = 7e-06, N = 7824) (0.39, 0.068, P = 0.18, N = 859)
rs10979297(A)/9:111024683* intergenic (0.67, -0.023, P = 6.9e-06, N = 7824) (0.92, -0.1, P = 0.28, N = 859)
rs10819159(C)/9:129208748 MVB12B (0.18, 0.2, P = 6.6e-06, N = 1955) (0.1, 0.085, P = 0.28, N = 859)
rs3860894(A)/9:84007235* intergenic (0.47, 0.021, P = 4e-05, N = 7824) (0.53, -0.032, P = 0.5, N = 859)
Results from Univariable Mendelian Randomization of Dodecanoylcarnitine & eGFR - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 66 0.045 (-0.05- 0.14) P=0.35 12 36 0.00418 (0- 74.5) NA NA -0.0066 P=0.5
MR-Egger 66 0.073 (-0.053- 0.2) P=0.26 12 36 0.00418 (0- 74.5) 65 0.43 -0.0066 P=0.5
Weighted median 66 0.067 (-0.072- 0.21) P=0.34 12 36 0.00418 (0- 74.5) NA NA -0.0066 P=0.5
Results from Univariable MRPRESSO of Dodecanoylcarnitine & eGFR - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0.05 0.05 0.93 0.36
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of Dodecanoylcarnitine & eGFR - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 14 0.045 (-0.093- 0.18) P=0.52 20 14 9.75 (0- 64.5) NA NA -0.021 P=0.45
MR-Egger 14 0.11 (-0.11- 0.33) P=0.34 20 14 9.75 (0- 64.5) 12 0.47 -0.021 P=0.45
Weighted median 14 0.022 (-0.18- 0.22) P=0.83 20 14 9.75 (0- 64.5) NA NA -0.021 P=0.45
Results from Univariable MRPRESSO of Dodecanoylcarnitine & eGFR - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0.04 0.07 0.64 0.53
beta.exposure Outlier-corrected NA NA NA NA

L-Acetylcarnitine

Instruments Associations with L-Acetylcarnitine & eGFR
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region L-Acetylcarnitine (Shin et al/Long et al) eGFR (CSSCD)
rs1281021(T)/1:11006668* C1orf127 (0.04, 0.048, P = 4.7e-05, N = 7824) (0.42, -0.091, P = 0.062, N = 859)
rs703116(A)/1:158644105* SPTA1 (0.43, -0.019, P = 5e-05, N = 7824) (0.12, -0.078, P = 0.29, N = 859)
rs16852535(A)/1:230881658* CAPN9 (0.32, 0.011, P = 2e-05, N = 7824) (0.54, -0.079, P = 0.11, N = 859)
rs2764907(C)/1:59356872* RP4-794H19.1 (0.086, 0.019, P = 1e-05, N = 7824) (0.015, -0.033, P = 0.87, N = 859)
rs1359850(A)/10:129785336* PTPRE (0.88, 0.015, P = 3e-05, N = 7824) (0.98, 0.11, P = 0.52, N = 859)
rs12268890(T)/10:45803909* OR13A1 (0.11, -0.015, P = 4.6e-05, N = 7824) (0.39, 0.025, P = 0.61, N = 859)
rs2242206(T)/10:61414011* SLC16A9 (0.26, 0.013, P = 1e-06, N = 7824) (0.09, 0.076, P = 0.36, N = 859)
rs1171614(T)/10:61469538* SLC16A9 (0.22, -0.028, P = 3.4e-23, N = 7824) (0.24, -0.02, P = 0.73, N = 859)
rs624016(A)/10:6486611 PRKCQ (0.34, -0.27, P = 8.2e-06, N = 1910) (0.44, -0.021, P = 0.66, N = 859)
rs6583751(C)/10:92838776* intergenic (0.6, -0.012, P = 3.6e-06, N = 7824) (0.49, 0.027, P = 0.58, N = 859)
rs2155639(T)/11:115492672* intergenic (0.34, -0.023, P = 1.3e-05, N = 7824) (0.29, -0.083, P = 0.11, N = 859)
rs493384(A)/11:122114071 RP11-820L6.1 (0.012, -0.091, P = 4.9e-05, N = 7824) (0.073, 0.033, P = 0.72, N = 859)
rs17831757(T)/11:61635200* FADS2 (0.9, -0.015, P = 1.9e-05, N = 7824) (0.95, -0.029, P = 0.78, N = 859)
rs10847395(A)/12:128007217* intergenic (0.48, -0.008, P = 2e-05, N = 7824) (0.85, 0.013, P = 0.84, N = 859)
rs11052231(A)/12:32931618 intergenic (0.046, -0.021, P = 4.4e-05, N = 7824) (0.18, -0.074, P = 0.21, N = 859)
rs2263487(T)/12:47250827* intergenic (0.52, -0.0077, P = 2.8e-05, N = 7824) (0.19, -0.01, P = 0.87, N = 859)
rs10735937(T)/12:67053882* GRIP1 (0.16, -0.015, P = 8e-06, N = 7824) (0.078, 0.2, P = 0.027, N = 859)
rs7332276(T)/13:107886865* FAM155A (0.47, -0.018, P = 3.1e-06, N = 7824) (0.23, 0.097, P = 0.089, N = 859)
rs975508(A)/13:26565586* ATP8A2 (0.55, -0.0081, P = 1.1e-05, N = 7824) (0.59, -0.019, P = 0.7, N = 859)
rs2239265(T)/14:72513858 RGS6 (0.36, -0.79, P = 5.6e-06, N = 1910) (0.48, -0.011, P = 0.82, N = 859)
rs10139470(T)/14:92150089* CATSPERB (0.25, -0.011, P = 3.9e-05, N = 7824) (0.23, 0.012, P = 0.82, N = 859)
rs2121212(T)/15:102073092* intergenic (0.84, -0.013, P = 1.5e-05, N = 7824) (0.63, 0.024, P = 0.64, N = 859)
rs2617228(T)/15:48991807 intergenic (0.76, 0.17, P = 1.2e-06, N = 1910) (0.71, -0.063, P = 0.22, N = 859)
rs8039391(A)/15:97234378* intergenic (0.16, -0.012, P = 1.4e-05, N = 7824) (0.15, -0.0074, P = 0.91, N = 859)
rs197055(A)/16:1131175 SSTR5 (0.17, 0.32, P = 5.2e-06, N = 1910) (0.024, 0.034, P = 0.83, N = 859)
rs9926669(A)/16:24318302 CACNG3 (0.2, 0.011, P = 2.6e-05, N = 7824) (0.45, 0.052, P = 0.28, N = 859)
rs8072316(T)/17:2785024 RAP1GAP2 (0.56, -0.013, P = 1.4e-05, N = 7824) (0.73, -0.0073, P = 0.89, N = 859)
rs60232438(A)/18:12003859 IMPA2 (0.15, 0.32, P = 9.2e-06, N = 1910) (0.17, -0.017, P = 0.79, N = 859)
rs1367865(C)/18:49961055 DCC (0.85, -0.25, P = 9.5e-06, N = 1910) (0.94, -0.073, P = 0.49, N = 859)
rs17077300(A)/18:65087840* intergenic (0.91, -0.014, P = 4.8e-05, N = 7824) (0.95, 0.17, P = 0.14, N = 859)
rs1401926(T)/19:21740932 RP11-678G14.2 (0.47, 0.0078, P = 2e-05, N = 7824) (0.5, 0.061, P = 0.2, N = 859)
rs34810593(G)/19:21825360 RP11-420K14.1 (0.68, -0.58, P = 5.8e-06, N = 1910) (0.33, 0.13, P = 0.011, N = 859)
rs2228070(T)/19:38956839* RYR1 (0.23, 0.012, P = 8.2e-06, N = 7824) (0.087, 0.16, P = 0.06, N = 859)
rs61003828(C)/19:4837150 PLIN3 (0.13, 0.23, P = 7.2e-06, N = 1910) (0.1, -0.074, P = 0.35, N = 859)
rs12971535(C)/19:51069278 LRRC4B (0.86, 0.25, P = 3.1e-06, N = 1910) (0.65, -0.042, P = 0.41, N = 859)
rs12462064(T)/19:53628653* ZNF415 (0.98, 0.064, P = 1.3e-05, N = 7824) (0.95, -0.16, P = 0.14, N = 859)
rs922920(A)/2:111695479* ACOXL (0.52, -0.0078, P = 2.5e-05, N = 7824) (0.32, -0.013, P = 0.8, N = 859)
rs2214270(T)/2:130336029 intergenic (0.45, 0.008, P = 1.3e-05, N = 7824) (0.36, -0.00081, P = 0.99, N = 859)
rs10194807(C)/2:171051041 MYO3B (0.39, 0.16, P = 1.5e-06, N = 1910) (0.62, 0.035, P = 0.48, N = 859)
rs34326128(T)/2:177202822* MTX2 (0.076, -0.37, P = 2.8e-07, N = 1910) (0.015, 0.19, P = 0.34, N = 859)
rs7579950(A)/2:200707606* FTCDNL1 (0.046, -0.065, P = 4.6e-06, N = 7824) (0.067, -0.036, P = 0.71, N = 859)
rs10164712(A)/2:218152840* AC009492.1 (0.21, -0.011, P = 3.7e-05, N = 7824) (0.23, 0.028, P = 0.63, N = 859)
rs11686145(T)/2:233121360* DIS3L2 (0.023, -0.032, P = 2.5e-05, N = 7824) (0.12, -0.062, P = 0.42, N = 859)
rs10210645(A)/2:237872402 intergenic (0.095, 0.17, P = 4.4e-06, N = 1910) (0.22, 0.035, P = 0.53, N = 859)
rs195592(T)/2:53488034* intergenic (0.82, -0.024, P = 4.8e-05, N = 7824) (0.88, -0.053, P = 0.48, N = 859)
rs12615875(A)/2:73081791* intergenic (0.17, -0.012, P = 6.2e-06, N = 7824) (0.53, 0.088, P = 0.061, N = 859)
rs6080491(T)/20:16900236* intergenic (0.17, -0.011, P = 1.8e-05, N = 7824) (0.03, 0.11, P = 0.43, N = 859)
rs2205690(G)/20:38688310 intergenic (0.95, -0.23, P = 2.4e-06, N = 1910) (0.74, -0.083, P = 0.13, N = 859)
rs6126825(A)/20:51999923* TSHZ2 (0.83, -0.011, P = 3.1e-05, N = 7824) (0.76, 0.01, P = 0.86, N = 859)
rs11698080(T)/20:60899182* LAMA5 (0.2, 0.011, P = 4e-05, N = 7824) (0.26, -0.12, P = 0.038, N = 859)
rs4578928(T)/20:7210072 RP4-764O22.2 (0.49, 0.31, P = 5e-06, N = 1910) (0.39, -0.099, P = 0.046, N = 859)
rs3773721(C)/3:122445778* PARP14 (0.099, 0.3, P = 6.6e-06, N = 1910) (0.049, 0.013, P = 0.91, N = 859)
rs1348656(T)/3:144933520* intergenic (0.8, -0.012, P = 6.5e-06, N = 7824) (0.61, 0.03, P = 0.56, N = 859)
rs9289719(T)/3:145983688* intergenic (0.81, 0.012, P = 7.4e-06, N = 7824) (0.41, 0.015, P = 0.76, N = 859)
rs9818568(G)/3:150300051 EIF2A (0.49, -0.13, P = 9.6e-06, N = 1910) (0.4, -0.032, P = 0.51, N = 859)
rs7665423(A)/4:10520600 CLNK (0.014, 0.083, P = 4e-05, N = 7824) (0.04, 0.013, P = 0.92, N = 859)
rs12506472(G)/4:124906097 intergenic (0.22, 0.31, P = 8.7e-06, N = 1910) (0.21, 8e-04, P = 0.99, N = 859)
rs3214037(A)/4:128688803* SLC25A31 (0.014, -0.037, P = 4e-05, N = 7824) (0.023, 0.16, P = 0.32, N = 859)
rs7688971(A)/4:145076356* intergenic (0.016, 0.073, P = 4.1e-05, N = 7824) (0.092, -0.016, P = 0.85, N = 859)
rs12510399(T)/4:157216074* AC108211.1 (0.13, -0.014, P = 3.8e-05, N = 7824) (0.065, 0.081, P = 0.4, N = 859)
rs78509047(G)/4:181215706* intergenic (0.019, 0.87, P = 7.4e-06, N = 1910) (0.14, 0.078, P = 0.27, N = 859)
rs6810706(A)/4:18750217* intergenic (0.55, 0.022, P = 5.4e-06, N = 7824) (0.38, -0.021, P = 0.67, N = 859)
rs2920179(C)/4:4216951* OTOP1 (0.21, 0.011, P = 3.8e-05, N = 7824) (0.077, -0.091, P = 0.31, N = 859)
rs35379510(A)/4:86384715* intergenic (0.029, -0.058, P = 2.2e-05, N = 7824) (0.21, 0.077, P = 0.19, N = 859)
rs17132827(T)/5:110489279* AC010468.3 (0.91, 0.015, P = 2.1e-05, N = 7824) (0.9, -0.058, P = 0.45, N = 859)
rs10037469(T)/5:130451873* intergenic (0.97, 0.03, P = 6e-07, N = 7824) (0.73, 0.05, P = 0.37, N = 859)
rs7356708(C)/5:130593723 CDC42SE2 (0.038, -0.024, P = 4.2e-05, N = 7824) (0.6, -0.031, P = 0.53, N = 859)
rs7716905(A)/5:131324377* ACSL6 (0.97, 0.032, P = 1.5e-07, N = 7824) (0.59, -0.046, P = 0.34, N = 859)
rs7705189(A)/5:131623358* P4HA2 (0.51, 0.01, P = 3.9e-05, N = 7824) (0.72, -0.13, P = 0.015, N = 859)
rs274567(T)/5:131714409* SLC22A5 (0.37, 0.018, P = 2.8e-12, N = 7824) (0.3, 0.049, P = 0.35, N = 859)
rs964922(A)/5:144943893* PRELID2 (0.046, -0.12, P = 2.2e-06, N = 1910) (0.078, 0.054, P = 0.56, N = 859)
rs17080396(A)/5:180005634* CNOT6 (0.94, -0.018, P = 4.4e-05, N = 7824) (0.9, -0.0076, P = 0.93, N = 859)
rs13184373(T)/5:30721169* intergenic (0.15, -0.012, P = 6.4e-06, N = 7824) (0.17, -0.013, P = 0.84, N = 859)
rs7734716(T)/5:53707175* LINC01033 (0.23, 0.023, P = 1.7e-05, N = 7824) (0.2, -0.13, P = 0.026, N = 859)
rs10066016(G)/5:86197530 intergenic (0.72, 0.32, P = 1.7e-06, N = 1910) (0.55, 0.088, P = 0.065, N = 859)
rs9385645(A)/6:133694314* EYA4 (0.84, 0.011, P = 3.3e-05, N = 7824) (0.78, -0.013, P = 0.83, N = 859)
rs6570549(A)/6:143466564* AIG1 (0.72, -0.011, P = 1.1e-05, N = 7824) (0.95, 0.078, P = 0.49, N = 859)
rs662138(C)/6:160564476* SLC22A1 (0.83, 0.014, P = 2.9e-07, N = 7824) (0.95, 0.099, P = 0.35, N = 859)
rs9348257(A)/6:170442668* intergenic (0.26, 0.012, P = 2.7e-06, N = 7824) (0.076, -0.049, P = 0.59, N = 859)
rs1655902(A)/6:29916855* HLA-A (0.82, -0.029, P = 1.3e-06, N = 7824) (0.77, -0.013, P = 0.82, N = 859)
rs1885674(T)/6:71999404* OGFRL1 (0.76, 0.011, P = 3.4e-05, N = 7824) (0.8, 0.13, P = 0.024, N = 859)
rs9447587(T)/6:76720204* IMPG1 (0.15, 0.015, P = 3.6e-05, N = 7824) (0.17, -0.01, P = 0.87, N = 859)
rs12154346(A)/7:33543638* BBS9 (0.9, 0.015, P = 2e-05, N = 7824) (0.83, -0.039, P = 0.55, N = 859)
rs17461606(T)/8:101876369* intergenic (0.16, -0.14, P = 3.6e-06, N = 1910) (0.021, -0.099, P = 0.56, N = 859)
rs17065805(T)/8:1150705* CTD-2281E23.2 (0.94, -0.022, P = 8.2e-06, N = 7824) (0.89, -0.027, P = 0.72, N = 859)
rs16904912(T)/8:134400251* CTC-369M3.1 (0.2, 0.025, P = 1.5e-05, N = 7824) (0.12, -0.0034, P = 0.96, N = 859)
rs4976950(A)/8:143297145* TSNARE1 (0.03, -0.068, P = 3.7e-06, N = 7824) (0.17, 0.013, P = 0.84, N = 859)
rs13257229(T)/8:21028044* intergenic (0.24, 0.021, P = 9.9e-06, N = 7824) (0.064, -0.07, P = 0.47, N = 859)
rs1545087(A)/8:23622382* RP11-175E9.1 (0.22, 0.011, P = 1.8e-05, N = 7824) (0.33, -0.01, P = 0.84, N = 859)
rs16895268(T)/8:98169720* intergenic (0.18, -0.011, P = 2.8e-05, N = 7824) (0.51, 0.0094, P = 0.84, N = 859)
rs10989419(T)/9:103934113* LPPR1 (0.19, 0.013, P = 3.8e-06, N = 7824) (0.1, -0.051, P = 0.54, N = 859)
rs7044502(A)/9:12481665 intergenic (0.23, -0.19, P = 8e-06, N = 1910) (0.27, 0.012, P = 0.82, N = 859)
rs11999015(C)/9:26942716 PLAA (0.076, 0.24, P = 4.6e-07, N = 1910) (0.17, 0.074, P = 0.26, N = 859)
rs1585956(T)/9:31371352* RP11-271O3.1 (0.49, 0.17, P = 7.2e-06, N = 1910) (0.66, 0.017, P = 0.73, N = 859)
rs2039787(T)/9:71875458* intergenic (0.18, 0.011, P = 4.5e-05, N = 7824) (0.032, -0.029, P = 0.83, N = 859)
rs4087415(C)/9:73785818* TRPM3 (0.98, 0.29, P = 8.7e-06, N = 1910) (0.91, 0.072, P = 0.4, N = 859)
Results from Univariable Mendelian Randomization of L-Acetylcarnitine & eGFR - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 96 -0.0073 (-0.074- 0.06) P=0.83 20 84 8.4 (0- 75.6) NA NA -0.0095 P=0.21
MR-Egger 96 0.019 (-0.059- 0.096) P=0.64 20 84 8.4 (0- 75.6) 95 0.44 -0.0095 P=0.21
Weighted median 96 0.026 (-0.093- 0.15) P=0.67 20 84 8.4 (0- 75.6) NA NA -0.0095 P=0.21
Results from Univariable MRPRESSO of L-Acetylcarnitine & eGFR - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.01 0.03 -0.21 0.83
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of L-Acetylcarnitine & eGFR - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 26 -0.023 (-0.1- 0.056) P=0.57 66 75 26 (0- 54) NA NA 0.032 P=0.065
MR-Egger 26 -0.1 (-0.22- 0.0076) P=0.08 66 75 26 (0- 54) 24 0.49 0.032 P=0.065
Weighted median 26 0.012 (-0.11- 0.14) P=0.85 66 75 26 (0- 54) NA NA 0.032 P=0.065
Results from Univariable MRPRESSO of L-Acetylcarnitine & eGFR - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.02 0.04 -0.56 0.58
beta.exposure Outlier-corrected NA NA NA NA

Butyrylcarnitine

Instruments Associations with Butyrylcarnitine & eGFR
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region Butyrylcarnitine (Shin et al/Long et al) eGFR (CSSCD)
rs71628219(T)/1:176928724 ASTN1 (0.042, 1.1, P = 6.3e-06, N = 1909) (0.013, 0.35, P = 0.086, N = 859)
rs1762470(T)/1:208423850* RP11-2P2.1 (0.55, 0.018, P = 4.7e-07, N = 7824) (0.81, 0.022, P = 0.72, N = 859)
rs7552486(C)/1:232645738 SIPA1L2 (0.94, 1, P = 5e-06, N = 1909) (0.98, -0.043, P = 0.82, N = 859)
rs3120706(T)/1:246714022* TFB2M (0.99, 1.3, P = 1.9e-07, N = 1909) (0.96, -0.008, P = 0.95, N = 859)
rs2201453(A)/1:80040353* intergenic (0.44, 0.015, P = 3.7e-05, N = 7824) (0.67, 0.058, P = 0.26, N = 859)
rs2804412(A)/10:101522647* intergenic (0.12, 0.62, P = 6.9e-07, N = 1909) (0.025, -0.081, P = 0.61, N = 859)
rs2242206(T)/10:61414011* SLC16A9 (0.26, 0.018, P = 3.5e-05, N = 7824) (0.09, 0.076, P = 0.36, N = 859)
rs1171615(T)/10:61469090* SLC16A9 (0.78, 0.035, P = 6.8e-14, N = 7824) (0.76, 0.02, P = 0.73, N = 859)
rs10997368(A)/10:68485405* CTNNA3 (0.42, -0.015, P = 2.9e-05, N = 7824) (0.32, 0.028, P = 0.58, N = 859)
rs2595414(A)/11:6918410 OR2D2 (0.83, -0.37, P = 4.6e-06, N = 1909) (0.55, -0.011, P = 0.82, N = 859)
rs2996029(C)/12:120165182* CIT (0.48, -0.017, P = 4.2e-05, N = 7824) (0.52, -0.1, P = 0.039, N = 859)
rs11611311(A)/12:120677587* PXN (0.86, 0.046, P = 1.6e-15, N = 7824) (0.86, 0.035, P = 0.61, N = 859)
rs2076022(T)/12:120875790* COX6A1 (0.39, -0.05, P = 4.2e-33, N = 7824) (0.46, -0.022, P = 0.64, N = 859)
rs1168067(T)/12:121082469* CABP1 (0.44, -0.081, P = 9.5e-87, N = 7824) (0.21, -0.013, P = 0.83, N = 859)
rs503667(A)/12:121088750* CABP1 (0.3, 0.054, P = 4.7e-36, N = 7824) (0.29, 0.0067, P = 0.9, N = 859)
rs10849776(A)/12:121110235* intergenic (0.37, -0.34, P = 1.3e-41, N = 1909) (0.68, 0.062, P = 0.23, N = 859)
rs10431384(A)/12:121127347* MLEC (0.68, -0.17, P = 1e-200, N = 7824) (0.65, -0.0093, P = 0.85, N = 859)
rs525425(A)/12:121195625* SPPL3 (0.52, -0.11, P = 1e-200, N = 7824) (0.9, -0.0025, P = 0.97, N = 859)
rs73214896(T)/12:121296608* SPPL3 (0.054, 0.21, P = 8.1e-07, N = 1909) (0.022, 0.37, P = 0.022, N = 859)
rs10849820(A)/12:121375558* intergenic (0.91, 0.068, P = 5.1e-24, N = 7824) (0.95, -0.025, P = 0.82, N = 859)
rs12368199(A)/12:121472167* OASL (0.15, 0.12, P = 1.7e-121, N = 7824) (0.11, 0.0095, P = 0.91, N = 859)
rs4556628(T)/12:121477912* OASL (0.3, 0.068, P = 7e-58, N = 7824) (0.35, 0.016, P = 0.76, N = 859)
rs10849843(A)/12:121544500* RP11-216P16.6 (0.043, -0.047, P = 6.6e-07, N = 7824) (0.055, -0.072, P = 0.5, N = 859)
rs7134248(T)/12:121897052* KDM2B (0.5, 0.031, P = 2.6e-05, N = 7824) (0.38, 0.017, P = 0.74, N = 859)
rs2656823(G)/12:127815260* RP11-955H22.3 (0.25, 1.2, P = 3.8e-06, N = 1909) (0.58, -0.026, P = 0.6, N = 859)
rs34875552(G)/12:127931158 intergenic (0.21, -0.51, P = 9.4e-07, N = 1909) (0.074, 0.032, P = 0.72, N = 859)
rs17582686(C)/12:41961745 PDZRN4 (0.12, 0.16, P = 2.8e-06, N = 1909) (0.022, -0.14, P = 0.37, N = 859)
rs1353147(A)/12:44815705* intergenic (0.91, 0.031, P = 4.2e-06, N = 7824) (0.54, -0.053, P = 0.28, N = 859)
rs76038866(G)/12:70398710 RP11-611E13.2 (0.15, -0.15, P = 3.2e-06, N = 1909) (0.019, 0.0063, P = 0.97, N = 859)
rs11843062(T)/13:105985355 intergenic (0.85, 0.021, P = 4.1e-05, N = 7824) (0.93, -0.18, P = 0.047, N = 859)
rs2323477(A)/13:37968251* intergenic (0.56, 0.92, P = 8.4e-06, N = 1909) (0.47, -0.097, P = 0.041, N = 859)
rs2762180(C)/13:43749805 intergenic (0.019, -0.42, P = 4e-06, N = 1909) (0.077, -0.014, P = 0.88, N = 859)
rs12866255(A)/13:46303377 intergenic (0.13, -0.32, P = 4.4e-06, N = 1909) (0.063, -0.092, P = 0.34, N = 859)
rs4982433(T)/14:21703122 HNRNPC (0.046, -0.43, P = 1e-05, N = 1909) (0.016, -0.25, P = 0.2, N = 859)
rs181315(A)/14:48336387 intergenic (0.93, 0.28, P = 6.4e-06, N = 1909) (0.99, -0.27, P = 0.24, N = 859)
rs11620955(A)/14:65491255* FNTB (0.48, -0.016, P = 9.9e-06, N = 7824) (0.29, -0.016, P = 0.76, N = 859)
rs77157541(C)/14:84364103 intergenic (0.085, -0.45, P = 1.7e-06, N = 1909) (0.011, 0.11, P = 0.63, N = 859)
rs58341578(A)/15:102065017 PCSK6 (0.035, 0.62, P = 2.6e-06, N = 1909) (0.052, 0.12, P = 0.28, N = 859)
rs2066705(T)/15:25937004 ATP10A (0.67, -0.38, P = 5.1e-06, N = 1909) (0.2, -0.0033, P = 0.96, N = 859)
rs1827480(T)/15:32018249 OTUD7A (0.69, 0.28, P = 1.1e-06, N = 1909) (0.61, 0.1, P = 0.044, N = 859)
rs8036376(A)/15:39868627 THBS1 (0.87, -0.022, P = 2.6e-05, N = 7824) (0.94, 0.16, P = 0.1, N = 859)
rs2956875(A)/15:76599041* ETFA (0.89, -0.034, P = 1.1e-08, N = 7824) (0.78, -0.024, P = 0.68, N = 859)
rs12903671(G)/15:86784034 AGBL1 (0.61, 0.22, P = 5.8e-06, N = 1909) (0.74, -0.062, P = 0.25, N = 859)
rs294546(A)/15:94847577 MCTP2 (0.55, -0.33, P = 4.6e-06, N = 1909) (0.77, 0.13, P = 0.031, N = 859)
rs7191762(A)/16:23752777* intergenic (0.2, 1.3, P = 6e-06, N = 1909) (0.17, 0.077, P = 0.23, N = 859)
rs2297514(C)/17:26093315 NOS2 (0.41, 0.77, P = 7.8e-06, N = 1909) (0.55, -0.026, P = 0.6, N = 859)
rs2106336(T)/17:49800464* CA10 (0.25, 0.69, P = 8.2e-06, N = 1909) (0.096, 0.02, P = 0.8, N = 859)
rs12970487(G)/18:25809979 intergenic (0.051, -0.41, P = 4.9e-07, N = 1909) (0.083, -0.036, P = 0.68, N = 859)
rs11660811(A)/18:59870563 KIAA1468 (0.12, -0.32, P = 1.5e-06, N = 1909) (0.026, -0.14, P = 0.35, N = 859)
rs12979749(G)/19:17463781* PLVAP (0.055, -0.35, P = 5.6e-06, N = 1909) (0.13, 0.092, P = 0.2, N = 859)
rs3974831(G)/19:54306299* NLRP12 (0.23, -0.4, P = 2.9e-06, N = 1909) (0.12, -0.094, P = 0.2, N = 859)
rs10166038(A)/2:127442846 GYPC (0.68, 0.018, P = 2.1e-05, N = 7824) (0.82, -0.0078, P = 0.9, N = 859)
rs4575678(C)/2:160184773 BAZ2B (0.73, -0.31, P = 3.2e-06, N = 1909) (0.43, 0.044, P = 0.35, N = 859)
rs355896(A)/2:165635908* COBLL1 (0.43, -0.014, P = 4.5e-05, N = 7824) (0.8, -0.0099, P = 0.87, N = 859)
rs35467545(A)/2:228119461 COL4A3 (0.093, -0.42, P = 7.7e-06, N = 1909) (0.038, 0.038, P = 0.77, N = 859)
rs4663190(T)/2:236174661 intergenic (0.26, 0.29, P = 7.3e-06, N = 1909) (0.7, -0.028, P = 0.61, N = 859)
rs150411636(T)/2:26280681 RAB10 (0.012, 0.67, P = 3.5e-06, N = 1909) (0.038, -0.022, P = 0.86, N = 859)
rs2122033(C)/2:6366461* intergenic (0.72, -0.19, P = 8.7e-06, N = 1909) (0.92, -0.094, P = 0.29, N = 859)
rs17697184(T)/2:70844368* ADD2 (0.017, 0.12, P = 4.2e-05, N = 7824) (0.03, -0.093, P = 0.5, N = 859)
rs17680254(C)/2:7405775* RP11-557L19.1 (0.17, -0.34, P = 7.8e-06, N = 1909) (0.033, 0.27, P = 0.043, N = 859)
rs6043520(C)/20:15738249 MACROD2 (0.38, 1, P = 7e-06, N = 1909) (0.66, 0.036, P = 0.49, N = 859)
rs79183297(C)/20:25726841 intergenic (0.05, 0.62, P = 9.9e-06, N = 1909) (0.044, 0.09, P = 0.44, N = 859)
rs564621(A)/21:31541034 CLDN17 (0.9, -0.34, P = 9.7e-07, N = 1909) (0.85, -0.063, P = 0.35, N = 859)
rs9613176(T)/22:26804801 intergenic (0.26, 1.3, P = 6.2e-06, N = 1909) (0.06, 0.03, P = 0.77, N = 859)
rs73479548(C)/22:48657745 intergenic (0.025, 0.27, P = 8.5e-07, N = 1909) (0.063, -0.094, P = 0.34, N = 859)
rs136770(G)/22:49800204* intergenic (0.53, -0.39, P = 1.4e-06, N = 1909) (0.46, -0.021, P = 0.66, N = 859)
rs6808851(T)/3:20505047 intergenic (0.88, 0.025, P = 2.3e-05, N = 7824) (0.74, 0.029, P = 0.6, N = 859)
rs11915197(T)/3:20781663 intergenic (0.59, -0.42, P = 6.6e-06, N = 1909) (0.52, -0.0098, P = 0.84, N = 859)
rs1515458(G)/3:21913964 ZNF385D (0.28, 0.44, P = 5.4e-06, N = 1909) (0.21, -0.028, P = 0.63, N = 859)
rs11923037(C)/3:22487778 intergenic (0.056, 0.73, P = 2.8e-06, N = 1909) (0.025, 0.062, P = 0.69, N = 859)
rs10510534(A)/3:23048172* intergenic (0.062, 0.95, P = 8.8e-06, N = 1909) (0.032, 0.034, P = 0.8, N = 859)
rs6445312(T)/3:63055960 LINC00698 (0.84, -0.5, P = 9.6e-06, N = 1909) (0.76, -0.0016, P = 0.98, N = 859)
rs12646870(C)/4:146764120 ZNF827 (0.52, 0.65, P = 9.2e-06, N = 1909) (0.59, -0.0069, P = 0.89, N = 859)
rs3103197(T)/4:42344469 RP11-63A11.1 (0.57, -0.017, P = 3.8e-05, N = 7824) (0.77, -0.0059, P = 0.92, N = 859)
rs72862822(C)/4:73516604* intergenic (0.069, 0.62, P = 3.5e-07, N = 1909) (0.22, -0.01, P = 0.86, N = 859)
rs71607390(G)/4:77775612 AC104687.1 (0.034, -0.37, P = 8.1e-06, N = 1909) (0.015, -0.21, P = 0.3, N = 859)
rs76135410(A)/5:111566364 EPB41L4A (0.097, -0.4, P = 9.5e-06, N = 1909) (0.077, 0.041, P = 0.66, N = 859)
rs10477531(T)/5:114714807* intergenic (0.47, 0.24, P = 5e-06, N = 1909) (0.34, -0.034, P = 0.51, N = 859)
rs12521097(A)/5:131575338* P4HA2 (0.47, -0.018, P = 3.6e-07, N = 7824) (0.43, 0.094, P = 0.054, N = 859)
rs7719428(C)/5:132180919* RNA5SP192 (0.33, -0.018, P = 1.6e-05, N = 7824) (0.47, -0.12, P = 0.017, N = 859)
rs1392378(T)/5:165821645* intergenic (0.77, 0.54, P = 8.2e-06, N = 1909) (0.38, 0.017, P = 0.73, N = 859)
rs9313646(G)/5:173155866 AC008674.1 (0.32, -0.4, P = 4e-06, N = 1909) (0.29, 0.034, P = 0.53, N = 859)
rs4458729(T)/6:104189269* intergenic (0.54, 0.78, P = 4.8e-06, N = 1909) (0.35, 0.032, P = 0.53, N = 859)
rs58492300(G)/6:110684097 METTL24 (0.33, -0.41, P = 3.6e-07, N = 1909) (0.34, -0.028, P = 0.58, N = 859)
rs1288153(A)/6:113293306 RNU6-1163P (0.98, -0.18, P = 7.9e-06, N = 1909) (0.85, 0.01, P = 0.88, N = 859)
rs10224061(C)/7:19852619* AC004543.2 (0.15, -0.15, P = 9.5e-06, N = 1909) (0.39, 0.018, P = 0.72, N = 859)
rs6462769(T)/7:37577324* intergenic (0.71, 0.019, P = 5.7e-06, N = 7824) (0.64, -0.0053, P = 0.92, N = 859)
rs9638994(C)/7:45895291* intergenic (0.31, 0.18, P = 1.4e-06, N = 1909) (0.56, -0.076, P = 0.13, N = 859)
rs2178045(A)/7:70231649 AUTS2 (0.099, -0.05, P = 3.7e-05, N = 7824) (0.1, -0.17, P = 0.031, N = 859)
rs695195(A)/8:8633528 RP11-211C9.1 (0.16, -0.21, P = 4.4e-06, N = 1909) (0.44, -0.032, P = 0.52, N = 859)
rs13289885(G)/9:108138947 SLC44A1 (0.029, 0.93, P = 9.5e-06, N = 1909) (0.32, 0.055, P = 0.29, N = 859)
rs62566532(G)/9:6743110 KDM4C (0.17, -0.19, P = 7.1e-07, N = 1909) (0.1, 0.022, P = 0.78, N = 859)
Results from Univariable Mendelian Randomization of Butyrylcarnitine & eGFR - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 92 0.003 (-0.025- 0.031) P=0.84 187 561 0.0128 (0- 48.5) NA NA 0.0042 P=0.65
MR-Egger 92 -0.0036 (-0.045- 0.037) P=0.86 187 561 0.0128 (0- 48.5) 85 0.63 0.0042 P=0.65
Weighted median 92 0.023 (-0.019- 0.066) P=0.28 187 561 0.0128 (0- 48.5) NA NA 0.0042 P=0.65
Results from Univariable MRPRESSO of Butyrylcarnitine & eGFR - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0 0.01 0.21 0.84
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of Butyrylcarnitine & eGFR - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 47 0.018 (-0.021- 0.057) P=0.37 190 298 0.00282 (0- 54.4) NA NA -0.016 P=0.4
MR-Egger 47 0.045 (-0.03- 0.12) P=0.25 190 298 0.00282 (0- 54.4) 39 0.72 -0.016 P=0.4
Weighted median 47 0.025 (-0.038- 0.089) P=0.43 190 298 0.00282 (0- 54.4) NA NA -0.016 P=0.4
Results from Univariable MRPRESSO of Butyrylcarnitine & eGFR - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0.02 0.02 0.89 0.38
beta.exposure Outlier-corrected NA NA NA NA

Tiglylcarnitine

Instruments Associations with Tiglylcarnitine & eGFR
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region Tiglylcarnitine (Shin et al/Long et al) eGFR (CSSCD)
rs115886573(A)/1:182541031 RNASEL (0.26, -0.15, P = 4.7e-06, N = 1956) (0.17, 0.036, P = 0.57, N = 859)
rs149513885(A)/10:36506292 intergenic (0.13, 0.17, P = 3.3e-06, N = 1956) (0.015, -0.18, P = 0.38, N = 859)
rs10904923(G)/10:6807941* intergenic (0.092, -0.23, P = 1.9e-06, N = 1956) (0.031, -0.075, P = 0.59, N = 859)
rs10998884(G)/10:71389673 C10orf35 (0.17, 0.27, P = 9.8e-06, N = 1956) (0.066, 0.15, P = 0.1, N = 859)
rs12814936(A)/12:30164763 intergenic (0.17, 0.17, P = 1.3e-06, N = 1956) (0.031, 0.13, P = 0.35, N = 859)
rs11856930(G)/15:34028778* RYR3 (0.46, -0.14, P = 9.2e-06, N = 1956) (0.38, 0.085, P = 0.089, N = 859)
rs8041137(G)/15:89570030 intergenic (0.63, 0.19, P = 1.9e-06, N = 1956) (0.93, 0.039, P = 0.67, N = 859)
rs924135(T)/16:16123459* ABCC1 (0.6, -0.15, P = 1.1e-06, N = 1956) (0.47, 0.06, P = 0.21, N = 859)
rs62097702(A)/18:77148177 intergenic (0.27, -0.2, P = 1.3e-06, N = 1956) (0.099, -0.099, P = 0.22, N = 859)
rs139567843(A)/19:45019167 CEACAM20 (0.013, -0.77, P = 9.1e-06, N = 1956) (0.012, 0.31, P = 0.17, N = 859)
rs56285383(T)/2:173602 intergenic (0.3, 0.11, P = 9.2e-06, N = 1956) (0.058, -0.11, P = 0.28, N = 859)
rs6717796(C)/2:18337669* KCNS3 (0.35, 0.18, P = 1.3e-06, N = 1956) (0.73, -0.091, P = 0.09, N = 859)
rs3092505(G)/20:44812412 CDH22 (0.27, 0.13, P = 1e-05, N = 1956) (0.23, -0.012, P = 0.84, N = 859)
rs73049045(G)/3:30034421 RBMS3 (0.086, 0.38, P = 4.6e-07, N = 1956) (0.016, -0.13, P = 0.52, N = 859)
rs62252141(C)/3:32514805 CMTM7 (0.093, 0.29, P = 2.7e-06, N = 1956) (0.015, 0.35, P = 0.068, N = 859)
rs1372425(C)/3:77317940 ROBO2 (0.11, -0.28, P = 3.5e-06, N = 1956) (0.14, 0.12, P = 0.093, N = 859)
rs372660405(AAAAC)/4:101436992 EMCN (0.083, 0.29, P = 2.6e-06, N = 1956) (0.024, 0.19, P = 0.24, N = 859)
rs28703837(C)/4:32085737 RP11-734I18.1 (0.11, -0.28, P = 4.1e-07, N = 1956) (0.22, 0.018, P = 0.75, N = 859)
rs112580372(A)/4:89315397* HERC6 (0.21, 0.21, P = 3.5e-06, N = 1956) (0.12, -0.07, P = 0.35, N = 859)
rs10043226(C)/5:107243859 FBXL17 (0.076, -0.33, P = 5.1e-06, N = 1956) (0.15, 0.035, P = 0.61, N = 859)
rs2338821(G)/5:141509433* NDFIP1 (0.52, -0.13, P = 3.6e-06, N = 1956) (0.78, -0.027, P = 0.65, N = 859)
rs115960372(T)/5:1518494 LPCAT1 (0.097, 0.29, P = 5.3e-06, N = 1956) (0.017, -0.34, P = 0.066, N = 859)
rs1874167(T)/5:62424015 intergenic (0.63, 0.21, P = 6.9e-06, N = 1956) (0.35, 0.029, P = 0.56, N = 859)
rs9370853(A)/6:15991331* RP11-401E14.2 (0.12, 0.23, P = 3.9e-06, N = 1956) (0.085, -0.074, P = 0.39, N = 859)
rs4367541(C)/8:13041969 DLC1 (0.56, 0.12, P = 4.8e-06, N = 1956) (0.51, -0.024, P = 0.61, N = 859)
rs1689897(A)/8:16847582 FGF20 (0.23, 0.18, P = 4.7e-06, N = 1956) (0.3, 0.035, P = 0.5, N = 859)
rs4875308(A)/8:4060604* CSMD1 (0.49, 0.17, P = 2.7e-06, N = 1956) (0.18, -0.063, P = 0.31, N = 859)
rs3824419(C)/9:1056728* DMRT2 (0.34, 0.16, P = 9.4e-07, N = 1956) (0.16, -0.028, P = 0.66, N = 859)
rs7021791(A)/9:10928554* intergenic (0.6, -0.12, P = 1e-06, N = 1956) (0.79, -0.022, P = 0.7, N = 859)
Results from Univariable Mendelian Randomization of Tiglylcarnitine & eGFR - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 29 -0.11 (-0.25- 0.022) P=0.1 25 36 0.00319 (0- 58.6) NA NA -0.0091 P=0.82
MR-Egger 29 -0.07 (-0.47- 0.33) P=0.73 25 36 0.00319 (0- 58.6) 30 0.31 -0.0091 P=0.82
Weighted median 29 -0.11 (-0.31- 0.088) P=0.28 25 36 0.00319 (0- 58.6) NA NA -0.0091 P=0.82
Results from Univariable MRPRESSO of Tiglylcarnitine & eGFR - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.11 0.07 -1.64 0.11
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of Tiglylcarnitine & eGFR - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 19 -0.033 (-0.21- 0.14) P=0.71 26 25 0.000966 (0- 76.4) NA NA 0.028 P=0.61
MR-Egger 19 -0.15 (-0.63- 0.33) P=0.55 26 25 0.000966 (0- 76.4) 22 0.2 0.028 P=0.61
Weighted median 19 -0.083 (-0.32- 0.15) P=0.49 26 25 0.000966 (0- 76.4) NA NA 0.028 P=0.61
Results from Univariable MRPRESSO of Tiglylcarnitine & eGFR - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.03 0.09 -0.37 0.72
beta.exposure Outlier-corrected NA NA NA NA

Glutarylcarnitine

Instruments Associations with Glutarylcarnitine & eGFR
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region Glutarylcarnitine (Shin et al/Long et al) eGFR (CSSCD)
rs7533102(T)/1:107828950 NTNG1 (0.38, 0.011, P = 1.6e-05, N = 7824) (0.19, 0.077, P = 0.2, N = 859)
rs2798691(T)/1:113579103* RP11-31F15.2 (0.32, 0.022, P = 2.4e-05, N = 7824) (0.29, 0.0043, P = 0.93, N = 859)
rs7531982(A)/1:154596122* ADAR (0.51, 0.011, P = 9.1e-06, N = 7824) (0.86, 0.11, P = 0.096, N = 859)
rs10918734(A)/1:167625495* RCSD1 (0.95, 0.024, P = 6e-06, N = 7824) (0.8, 0.0092, P = 0.88, N = 859)
rs17015767(C)/1:206951398 intergenic (0.24, -0.011, P = 3.9e-05, N = 7824) (0.13, -0.016, P = 0.83, N = 859)
rs13375749(T)/1:53695882* MAGOH (0.78, 0.03, P = 2.8e-28, N = 7824) (0.79, 0.048, P = 0.42, N = 859)
rs12035926(A)/1:53752134 LRP8 (0.61, -0.011, P = 1.7e-05, N = 7824) (0.91, -0.0038, P = 0.96, N = 859)
rs1193243(T)/1:7524776 CAMTA1 (0.4, 0.011, P = 4.3e-05, N = 7824) (0.58, -0.011, P = 0.82, N = 859)
rs12745456(T)/1:76108055* RP4-595K12.2 (0.73, 0.012, P = 7.3e-06, N = 7824) (0.94, 0.018, P = 0.87, N = 859)
rs11189859(A)/10:100657705* HPSE2 (0.89, 0.033, P = 1.5e-05, N = 7824) (0.95, -0.017, P = 0.88, N = 859)
rs7923727(A)/10:11165615 CELF2 (0.53, -0.012, P = 2.1e-06, N = 7824) (0.63, -0.071, P = 0.15, N = 859)
rs11017260(T)/10:129113943* DOCK1 (0.94, -0.022, P = 1.8e-05, N = 7824) (0.98, -0.13, P = 0.5, N = 859)
rs573812(T)/10:25631649 GPR158 (0.81, 0.012, P = 6.1e-06, N = 7824) (0.52, 0.032, P = 0.51, N = 859)
rs7071006(A)/10:98382165* PIK3AP1 (0.81, 0.014, P = 3.7e-05, N = 7824) (0.47, 0.016, P = 0.75, N = 859)
rs10895511(T)/11:103552188* RP11-563P16.1 (0.95, -0.053, P = 2.9e-06, N = 7824) (0.53, -0.019, P = 0.7, N = 859)
rs7118414(C)/11:117811548 intergenic (0.39, -0.011, P = 3.1e-05, N = 7824) (0.33, -0.048, P = 0.36, N = 859)
rs4964150(T)/12:106017797* intergenic (0.22, -0.011, P = 3e-05, N = 7824) (0.21, -0.038, P = 0.52, N = 859)
rs7970615(T)/12:130637090 FZD10-AS1 (0.23, 0.026, P = 1.9e-05, N = 7824) (0.25, -0.073, P = 0.19, N = 859)
rs716955(A)/12:75593472* KCNC2 (0.81, 0.013, P = 3.3e-05, N = 7824) (0.91, 0.096, P = 0.25, N = 859)
rs3809197(T)/12:96883418* C12orf55 (0.013, 0.11, P = 3.2e-07, N = 7824) (0.13, -0.076, P = 0.29, N = 859)
rs9573172(A)/13:73953498 intergenic (0.95, -0.023, P = 9.5e-06, N = 7824) (0.99, 0.054, P = 0.79, N = 859)
rs11625658(A)/14:100723577* YY1 (0.25, -0.013, P = 9e-07, N = 7824) (0.23, 0.0019, P = 0.97, N = 859)
rs1059264(T)/14:100769163 SLC25A29 (0.33, -0.015, P = 5.6e-08, N = 7824) (0.17, 0.042, P = 0.51, N = 859)
rs12050391(A)/14:32771346 intergenic (0.22, -0.011, P = 1.9e-05, N = 7824) (0.16, 0.013, P = 0.84, N = 859)
rs2291449(A)/15:76579234* ETFA (0.91, -0.028, P = 1.4e-10, N = 7824) (0.99, 0.1, P = 0.62, N = 859)
rs4636879(T)/15:76630303* ISL2 (0.19, 0.013, P = 5e-06, N = 7824) (0.73, 0.036, P = 0.51, N = 859)
rs246234(C)/16:16128742* ABCC1 (0.3, -0.02, P = 2.6e-14, N = 7824) (0.5, -0.052, P = 0.28, N = 859)
rs8054670(T)/16:16132134* ABCC1 (0.78, 0.015, P = 8e-09, N = 7824) (0.63, 0.047, P = 0.33, N = 859)
rs8056893(A)/16:68304392* SLC7A6 (0.73, -0.03, P = 2.2e-30, N = 7824) (0.95, 0.11, P = 0.33, N = 859)
rs11644360(T)/16:68327089* SLC7A6 (0.54, -0.018, P = 1.1e-12, N = 7824) (0.11, 0.012, P = 0.88, N = 859)
rs933457(A)/17:36897107 PCGF2 (0.95, -0.025, P = 4.1e-05, N = 7824) (0.71, 0.03, P = 0.57, N = 859)
rs766990(A)/18:6917171* ARHGAP28 (0.2, 0.014, P = 2.8e-05, N = 7824) (0.23, 0.033, P = 0.57, N = 859)
rs10411504(A)/19:12753644* MAN2B1 (0.93, -0.023, P = 2.8e-05, N = 7824) (0.93, 0.081, P = 0.4, N = 859)
rs4804736(A)/19:12936881 RTBDN (0.16, -0.018, P = 6.8e-06, N = 7824) (0.029, -0.12, P = 0.4, N = 859)
rs8012(A)/19:13010520 GCDH (0.44, 0.037, P = 6.4e-45, N = 7824) (0.19, 0.15, P = 0.014, N = 859)
rs11085835(T)/19:13332010 CACNA1A (0.2, 0.015, P = 1e-08, N = 7824) (0.13, 0.074, P = 0.29, N = 859)
rs7252894(T)/19:43719940 CEACAMP10 (0.032, -0.085, P = 2e-05, N = 7824) (0.8, -0.0037, P = 0.95, N = 859)
rs7255066(T)/19:45146103 PVR (0.74, -0.011, P = 4.3e-05, N = 7824) (0.19, 0.031, P = 0.61, N = 859)
rs3770471(T)/2:15770775 DDX1 (0.15, -0.015, P = 1.5e-05, N = 7824) (0.42, 0.034, P = 0.49, N = 859)
rs715(T)/2:211543055* CPS1 (0.72, 0.021, P = 3.5e-16, N = 7824) (0.81, -0.061, P = 0.33, N = 859)
rs4673545(A)/2:211565535* intergenic (0.73, 0.014, P = 4.5e-08, N = 7824) (0.79, 0.0017, P = 0.98, N = 859)
rs11687290(A)/2:211647954* intergenic (0.73, -0.012, P = 7e-06, N = 7824) (0.83, 0.02, P = 0.75, N = 859)
rs6745507(C)/2:213577416 AC079610.1 (0.62, -0.012, P = 3.7e-06, N = 7824) (0.45, -0.044, P = 0.36, N = 859)
rs12621141(A)/2:99927112 C2orf15 (0.42, -0.013, P = 9.2e-07, N = 7824) (0.24, 0.0089, P = 0.88, N = 859)
rs12625248(T)/20:55393483* intergenic (0.83, -0.03, P = 7.2e-06, N = 7824) (0.89, -0.18, P = 0.021, N = 859)
rs8134964(A)/21:23291223* intergenic (0.32, 0.013, P = 4.3e-05, N = 7824) (0.28, 0.028, P = 0.61, N = 859)
rs2838535(T)/21:45681579* DNMT3L (0.081, 0.037, P = 4.3e-05, N = 7824) (0.16, -0.044, P = 0.5, N = 859)
rs7364173(T)/22:50681029* TUBGCP6 (0.59, 0.011, P = 4.7e-05, N = 7824) (0.6, -0.057, P = 0.26, N = 859)
rs12635778(A)/3:103451972 intergenic (0.97, 0.033, P = 3.1e-05, N = 7824) (0.9, 0.077, P = 0.34, N = 859)
rs9844004(C)/3:170958358 TNIK (0.24, -0.016, P = 4.3e-05, N = 7824) (0.41, -0.03, P = 0.54, N = 859)
rs1524307(T)/3:22673600 intergenic (0.48, 0.025, P = 2e-06, N = 7824) (0.54, 0.056, P = 0.25, N = 859)
rs7633111(T)/3:30840808 GADL1 (0.58, -0.013, P = 1.9e-06, N = 7824) (0.2, -0.025, P = 0.68, N = 859)
rs9311834(A)/3:62030849* PTPRG (0.89, -0.015, P = 3.8e-05, N = 7824) (0.76, -0.013, P = 0.82, N = 859)
rs6853898(A)/4:142171146 RP11-586L23.1 (0.96, -0.025, P = 4.3e-05, N = 7824) (0.79, 0.034, P = 0.56, N = 859)
rs2070630(C)/4:159644494* PPID (0.29, -0.014, P = 1.4e-07, N = 7824) (0.29, -0.047, P = 0.38, N = 859)
rs17223240(A)/4:159924295* C4orf45 (0.091, -0.019, P = 2e-05, N = 7824) (0.012, 0.1, P = 0.66, N = 859)
rs13112606(A)/4:17468047* QDPR (0.78, -0.011, P = 3.5e-05, N = 7824) (0.82, 0.0036, P = 0.96, N = 859)
rs3911612(A)/4:180493646* intergenic (0.78, 0.011, P = 2.9e-05, N = 7824) (0.35, -0.054, P = 0.28, N = 859)
rs17608635(A)/4:45079676* intergenic (0.23, -0.013, P = 5e-07, N = 7824) (0.18, 0.017, P = 0.78, N = 859)
rs16837061(A)/4:5383127 STK32B (0.8, 0.012, P = 9.8e-06, N = 7824) (0.45, -0.09, P = 0.07, N = 859)
rs10003471(T)/4:92200866* CCSER1 (0.11, 0.02, P = 5.7e-07, N = 7824) (0.029, -0.091, P = 0.52, N = 859)
rs1981524(T)/5:131756506* C5orf56 (0.2, 0.016, P = 3.1e-09, N = 7824) (0.2, -0.13, P = 0.033, N = 859)
rs12521174(A)/5:156141605* SGCD (0.95, 0.027, P = 7.3e-06, N = 7824) (0.89, 0.011, P = 0.88, N = 859)
rs1486945(T)/5:1943884* RP11-259O2.1 (0.74, -0.012, P = 8.6e-06, N = 7824) (0.68, -0.02, P = 0.7, N = 859)
rs2441949(A)/5:2627075* intergenic (0.091, 0.021, P = 1.1e-05, N = 7824) (0.022, 0.032, P = 0.85, N = 859)
rs2561114(A)/5:38349215 EGFLAM (0.69, -0.011, P = 3.1e-05, N = 7824) (0.22, -0.051, P = 0.38, N = 859)
rs1697824(C)/5:73710929* CTC-419K13.1 (0.41, -0.022, P = 1.4e-05, N = 7824) (0.63, 0.0084, P = 0.87, N = 859)
rs1479045(T)/6:124963281* NKAIN2 (0.21, 0.011, P = 4.6e-05, N = 7824) (0.36, -0.055, P = 0.26, N = 859)
rs683369(C)/6:160551204* SLC22A1 (0.77, -0.014, P = 1.1e-07, N = 7824) (0.97, -0.17, P = 0.21, N = 859)
rs3798167(T)/6:160567928* SLC22A1 (0.2, -0.013, P = 7.3e-07, N = 7824) (0.16, -0.04, P = 0.55, N = 859)
rs3125055(A)/6:160736787* intergenic (0.12, 0.017, P = 2.1e-05, N = 7824) (0.22, 0.045, P = 0.42, N = 859)
rs6941991(T)/6:18396689* RNF144B (0.42, 0.021, P = 4.1e-05, N = 7824) (0.36, -0.038, P = 0.46, N = 859)
rs12202023(T)/6:19351564* RPL5P20 (0.79, -0.014, P = 3.9e-07, N = 7824) (0.92, 0.16, P = 0.077, N = 859)
rs807532(T)/6:24549668* KIAA0319 (0.069, 0.02, P = 7.5e-06, N = 7824) (0.15, 0.025, P = 0.71, N = 859)
rs12192135(A)/6:82001561* intergenic (0.26, -0.012, P = 4.7e-06, N = 7824) (0.053, 0.088, P = 0.41, N = 859)
rs9353315(A)/6:86149938* intergenic (0.88, -0.015, P = 2.2e-05, N = 7824) (0.73, -0.053, P = 0.34, N = 859)
rs10241456(A)/7:129712524 KLHDC10 (0.54, 0.012, P = 7.6e-06, N = 7824) (0.82, 0.13, P = 0.037, N = 859)
rs2161873(T)/7:131974388* PLXNA4 (0.71, 0.011, P = 3e-05, N = 7824) (0.65, -0.088, P = 0.087, N = 859)
rs6967077(A)/7:51628033 intergenic (0.21, 0.011, P = 4e-05, N = 7824) (0.32, -0.11, P = 0.034, N = 859)
rs11780215(A)/8:118057538* SLC30A8 (0.85, 0.016, P = 3.7e-06, N = 7824) (0.97, 0.12, P = 0.44, N = 859)
rs4307325(A)/8:124421397 ATAD2 (0.7, 0.011, P = 1.5e-05, N = 7824) (0.66, -0.11, P = 0.029, N = 859)
rs11784254(A)/8:40357901 intergenic (0.23, 0.011, P = 2.5e-05, N = 7824) (0.29, 0.078, P = 0.15, N = 859)
rs12680983(T)/8:42104338 RP11-231D20.2 (0.016, 0.11, P = 2.1e-05, N = 7824) (0.046, 0.0082, P = 0.94, N = 859)
rs10097669(T)/8:4437465 CSMD1 (0.68, 0.011, P = 4.3e-05, N = 7824) (0.95, 0.16, P = 0.16, N = 859)
rs10108023(A)/8:49717484 intergenic (0.26, 0.012, P = 9.8e-06, N = 7824) (0.77, 0.00052, P = 0.99, N = 859)
rs17641971(T)/8:49884817* intergenic (0.66, -0.025, P = 3.4e-22, N = 7824) (0.77, -0.078, P = 0.17, N = 859)
rs11779189(C)/8:50030592* intergenic (0.61, 0.018, P = 6.8e-13, N = 7824) (0.42, -0.0095, P = 0.84, N = 859)
rs12543837(A)/8:6413948 MCPH1 (0.88, 0.032, P = 1.7e-05, N = 7824) (0.94, -0.033, P = 0.74, N = 859)
rs2033069(T)/8:81079607 TPD52 (0.32, 0.011, P = 4.7e-05, N = 7824) (0.66, 0.033, P = 0.51, N = 859)
rs2987735(A)/9:103955515 LPPR1 (0.21, 0.011, P = 2.1e-05, N = 7824) (0.41, -0.044, P = 0.38, N = 859)
rs1169752(A)/9:29329933* intergenic (0.77, -0.011, P = 4.5e-05, N = 7824) (0.86, -0.06, P = 0.4, N = 859)
rs6559415(A)/9:81443855* intergenic (0.26, 0.011, P = 3e-05, N = 7824) (0.74, -0.011, P = 0.84, N = 859)
Results from Univariable Mendelian Randomization of Glutarylcarnitine & eGFR - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 92 0.18 (-0.34- 0.7) P=0.5 0.86 1 0 (0- 32.5) NA NA 0.0065 P=0.54
MR-Egger 92 -0.038 (-0.91- 0.83) P=0.93 0.86 1 0 (0- 32.5) 86 0.61 0.0065 P=0.54
Weighted median 92 0.044 (-0.85- 0.94) P=0.92 0.86 1 0 (0- 32.5) NA NA 0.0065 P=0.54
Results from Univariable MRPRESSO of Glutarylcarnitine & eGFR - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0.18 0.27 0.67 0.5
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of Glutarylcarnitine & eGFR - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 37 0.37 (-0.51- 1.3) P=0.41 0.88 0.42 2.54 (0- 66.8) NA NA 0.0047 P=0.77
MR-Egger 37 0.22 (-1.1- 1.6) P=0.75 0.88 0.42 2.54 (0- 66.8) 42 0.18 0.0047 P=0.77
Weighted median 37 0.044 (-1.3- 1.3) P=0.95 0.88 0.42 2.54 (0- 66.8) NA NA 0.0047 P=0.77
Results from Univariable MRPRESSO of Glutarylcarnitine & eGFR - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0.37 0.45 0.83 0.41
beta.exposure Outlier-corrected NA NA NA NA

Isovalerylcarnitine

Instruments Associations with Isovalerylcarnitine & eGFR
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region Isovalerylcarnitine (Shin et al/Long et al) eGFR (CSSCD)
rs990034(A)/1:147251898* RP11-433J22.3 (0.56, -0.012, P = 1.3e-05, N = 7824) (0.44, 0.084, P = 0.088, N = 859)
rs10919117(A)/1:162267823* NOS1AP (0.51, -0.013, P = 4e-05, N = 7824) (0.37, -0.07, P = 0.16, N = 859)
rs2501856(C)/1:212856985* BATF3 (0.54, 0.012, P = 5.8e-06, N = 7824) (0.75, 0.072, P = 0.19, N = 859)
rs10638035(TTG)/1:219889972 SLC30A10 (0.43, -0.13, P = 2.7e-06, N = 1959) (0.68, -0.016, P = 0.75, N = 859)
rs35800687(G)/1:22731893 intergenic (0.31, 0.22, P = 5e-06, N = 1959) (0.17, -0.061, P = 0.35, N = 859)
rs771390(T)/1:34750936* intergenic (0.24, -0.016, P = 1.2e-05, N = 7824) (0.19, -0.015, P = 0.8, N = 859)
rs10889028(A)/1:57625649* DAB1 (0.42, -0.013, P = 7.1e-07, N = 7824) (0.3, 0.089, P = 0.091, N = 859)
rs10157665(A)/1:97734344* DPYD (0.74, -0.017, P = 4.2e-05, N = 7824) (0.96, 0.14, P = 0.28, N = 859)
rs4918121(A)/10:106392464 intergenic (0.31, -0.23, P = 6.1e-06, N = 1959) (0.13, 0.11, P = 0.13, N = 859)
rs884263(T)/10:36964639 intergenic (0.53, 0.011, P = 4.4e-05, N = 7824) (0.5, 0.0013, P = 0.98, N = 859)
rs7903712(C)/10:60516806* BICC1 (0.21, 0.014, P = 4.9e-05, N = 7824) (0.36, 0.00082, P = 0.99, N = 859)
rs12778367(A)/10:88116246 GRID1 (0.18, 0.2, P = 6.8e-06, N = 1959) (0.026, -0.13, P = 0.38, N = 859)
rs2852371(A)/11:106408212* intergenic (0.58, 0.013, P = 4e-06, N = 7824) (0.55, 0.051, P = 0.29, N = 859)
rs12294679(C)/11:11078054 intergenic (0.23, -0.015, P = 3.8e-05, N = 7824) (0.058, 0.0012, P = 0.99, N = 859)
rs4483623(T)/11:113352557 intergenic (0.97, -0.038, P = 2.3e-05, N = 7824) (0.97, -0.026, P = 0.86, N = 859)
rs7106005(T)/11:11598372 GALNT18 (0.82, 0.02, P = 7.7e-07, N = 7824) (0.39, -0.061, P = 0.22, N = 859)
rs2198256(T)/11:80187596* intergenic (0.53, 0.011, P = 4.9e-05, N = 7824) (0.19, 0.011, P = 0.86, N = 859)
rs80291290(T)/11:88372241 GRM5 (0.18, 0.23, P = 2.6e-06, N = 1959) (0.034, 0.042, P = 0.75, N = 859)
rs12281336(T)/11:98040562* intergenic (0.032, -0.085, P = 5e-05, N = 7824) (0.09, -0.016, P = 0.85, N = 859)
rs2682783(A)/12:119114569* intergenic (0.49, 0.012, P = 1.1e-05, N = 7824) (0.51, -0.017, P = 0.71, N = 859)
rs4882733(C)/12:128796587 TMEM132C (0.81, -0.019, P = 3.6e-05, N = 7824) (0.6, -0.097, P = 0.045, N = 859)
rs56076700(A)/12:129163020 TMEM132C (0.077, 0.35, P = 5e-06, N = 1959) (0.069, 0.061, P = 0.52, N = 859)
rs4763908(T)/12:13100332 GPRC5D (0.29, -0.015, P = 2.4e-05, N = 7824) (0.78, -0.072, P = 0.21, N = 859)
rs11051552(A)/12:31890602* intergenic (0.52, -0.012, P = 8.5e-06, N = 7824) (0.36, -0.11, P = 0.032, N = 859)
rs11177321(A)/12:69031913* RAP1B (0.12, 0.019, P = 1.6e-05, N = 7824) (0.016, 0.011, P = 0.95, N = 859)
rs535554250(GA)/13:33192654 PDS5B (0.29, 0.15, P = 7.8e-06, N = 1959) (0.26, 0.064, P = 0.26, N = 859)
rs73178899(G)/13:37901134 intergenic (0.14, 0.25, P = 4.1e-06, N = 1959) (0.019, -0.12, P = 0.48, N = 859)
rs8003699(G)/14:21322586 intergenic (0.85, -0.16, P = 4.9e-06, N = 1959) (0.8, -0.039, P = 0.52, N = 859)
rs2354322(T)/14:62708880 intergenic (0.67, 0.014, P = 3.2e-05, N = 7824) (0.93, -0.32, P = 8e-04, N = 859)
rs8007846(A)/14:66262963* intergenic (0.55, 0.012, P = 8.4e-06, N = 7824) (0.22, -0.012, P = 0.83, N = 859)
rs16970633(T)/15:40642877 PHGR1 (0.16, -0.019, P = 7.4e-06, N = 7824) (0.33, 0.073, P = 0.15, N = 859)
rs9635324(A)/15:40703211* IVD (0.61, 0.034, P = 1.9e-35, N = 7824) (0.79, 0.022, P = 0.71, N = 859)
rs17672041(T)/15:40722426* IVD (0.12, 0.03, P = 1.3e-11, N = 7824) (0.019, 0.093, P = 0.6, N = 859)
rs2291449(A)/15:76579234* ETFA (0.91, -0.029, P = 2.4e-08, N = 7824) (0.99, 0.1, P = 0.62, N = 859)
rs7170052(T)/15:93457650* CHD2 (0.76, 0.015, P = 3.1e-05, N = 7824) (0.92, -0.18, P = 0.041, N = 859)
rs13338173(A)/16:54227083 intergenic (0.79, -0.014, P = 5e-05, N = 7824) (0.81, -0.00038, P = 0.99, N = 859)
rs7212115(T)/17:10891477* intergenic (0.73, -0.016, P = 1.2e-05, N = 7824) (0.57, 0.048, P = 0.28, N = 859)
rs8098563(A)/18:19930691* RP11-535A5.1 (0.46, 0.013, P = 3e-05, N = 7824) (0.37, 0.019, P = 0.71, N = 859)
rs16947039(T)/18:27211242* intergenic (0.074, 0.023, P = 1.9e-05, N = 7824) (0.16, -0.012, P = 0.86, N = 859)
rs16977314(C)/18:40710349 intergenic (0.89, 0.018, P = 4.7e-05, N = 7824) (0.98, -0.13, P = 0.41, N = 859)
rs1878679(T)/18:40726416 intergenic (0.11, -0.018, P = 4.4e-05, N = 7824) (0.056, 0.088, P = 0.41, N = 859)
rs8099211(A)/18:43103958 RP11-749H17.1 (0.21, -0.015, P = 1.9e-05, N = 7824) (0.39, -0.0087, P = 0.86, N = 859)
rs36035559(A)/19:7121597 INSR (0.17, 0.17, P = 8.9e-06, N = 1959) (0.015, 0.031, P = 0.88, N = 859)
rs2138480(A)/2:118142725* intergenic (0.12, -0.019, P = 1.8e-05, N = 7824) (0.02, -0.13, P = 0.46, N = 859)
rs76530645(A)/2:175558061 AC018890.6 (0.11, -0.16, P = 4.6e-06, N = 1959) (0.016, -0.043, P = 0.82, N = 859)
rs11680464(A)/2:1882824* MYT1L (0.066, 0.025, P = 2.9e-05, N = 7824) (0.043, -0.14, P = 0.24, N = 859)
rs4505564(T)/2:240871018* NDUFA10 (0.79, 0.016, P = 4.9e-06, N = 7824) (0.94, -0.041, P = 0.69, N = 859)
rs17546912(C)/2:66225155 AC074391.1 (0.11, -0.31, P = 3.5e-06, N = 1959) (0.015, -0.011, P = 0.96, N = 859)
rs2232575(C)/20:36974512 LBP (0.16, -0.017, P = 3.3e-05, N = 7824) (0.12, 0.006, P = 0.93, N = 859)
rs1201971(T)/20:59290436 intergenic (0.47, 0.012, P = 1.4e-05, N = 7824) (0.5, 0.02, P = 0.68, N = 859)
rs4616554(A)/21:32420859* intergenic (0.076, -0.026, P = 1.2e-05, N = 7824) (0.2, 0.033, P = 0.59, N = 859)
rs9289761(T)/3:147443447 intergenic (0.55, 0.023, P = 3.9e-05, N = 7824) (0.32, 0.06, P = 0.24, N = 859)
rs12636822(C)/3:36329450 intergenic (0.16, 0.21, P = 7.8e-06, N = 1959) (0.032, 0.16, P = 0.24, N = 859)
rs383911(A)/3:41122345* intergenic (0.56, -0.013, P = 3e-06, N = 7824) (0.33, -0.032, P = 0.54, N = 859)
rs13075137(T)/3:4765093* ITPR1 (0.44, -0.024, P = 7.5e-06, N = 7824) (0.23, 0.013, P = 0.82, N = 859)
rs12494255(A)/3:99003734 intergenic (0.77, 0.031, P = 2.7e-06, N = 7824) (0.8, -0.019, P = 0.74, N = 859)
rs6833958(T)/4:125848110 intergenic (0.88, -0.27, P = 9.7e-07, N = 1959) (0.84, -0.077, P = 0.24, N = 859)
rs7668227(A)/4:187061084 FAM149A (0.9, 0.024, P = 7.9e-06, N = 7824) (0.98, 0.16, P = 0.33, N = 859)
rs9327595(A)/5:130492613* HINT1 (0.031, -0.042, P = 6.9e-07, N = 7824) (0.23, -0.056, P = 0.34, N = 859)
rs7356708(C)/5:130593723 CDC42SE2 (0.039, -0.042, P = 4.4e-08, N = 7824) (0.6, -0.031, P = 0.53, N = 859)
rs6596022(T)/5:130767121* RAPGEF6 (0.96, 0.045, P = 6.8e-09, N = 7824) (0.57, 0.036, P = 0.46, N = 859)
rs3805681(T)/5:131537860* P4HA2 (0.54, 0.03, P = 1e-28, N = 7824) (0.75, 0.01, P = 0.86, N = 859)
rs334902(C)/5:131586559* P4HA2 (0.44, 0.029, P = 8e-27, N = 7824) (0.38, -0.031, P = 0.52, N = 859)
rs11950562(A)/5:131652529* SLC22A4 (0.52, 0.036, P = 2.3e-41, N = 7824) (0.74, -0.034, P = 0.54, N = 859)
rs11385258(TA)/5:131748241 C5orf56 (0.35, 0.13, P = 4.9e-06, N = 1959) (0.24, 0.12, P = 0.038, N = 859)
rs803222(A)/5:132208468* LEAP2 (0.54, 0.011, P = 2.6e-05, N = 7824) (0.31, 0.048, P = 0.35, N = 859)
rs10491300(T)/5:136354227* SPOCK1 (0.083, 0.022, P = 4.5e-05, N = 7824) (0.23, -0.06, P = 0.29, N = 859)
rs2963485(T)/5:148452043* CTC-529P8.1 (0.19, -0.018, P = 1.1e-06, N = 7824) (0.37, 0.013, P = 0.8, N = 859)
rs283429(C)/5:153904147* intergenic (0.088, 0.022, P = 4.2e-05, N = 7824) (0.31, -0.038, P = 0.45, N = 859)
rs13355460(T)/5:157385133 intergenic (0.65, 0.024, P = 4.9e-05, N = 7824) (0.53, -0.0023, P = 0.96, N = 859)
rs10062095(A)/5:81900261* intergenic (0.77, 0.026, P = 4.3e-05, N = 7824) (0.61, -0.021, P = 0.67, N = 859)
rs73435033(T)/6:11172620 RP3-510L9.1 (0.14, -0.24, P = 3.2e-06, N = 1959) (0.17, -0.11, P = 0.076, N = 859)
rs4463295(A)/6:123016251 PKIB (0.57, 0.013, P = 1.6e-06, N = 7824) (0.36, 0.0094, P = 0.85, N = 859)
rs9464891(T)/6:16389631* ATXN1 (0.12, -0.25, P = 5e-06, N = 1959) (0.23, 0.096, P = 0.087, N = 859)
rs2213581(T)/6:32388546* intergenic (0.2, -0.026, P = 4e-05, N = 7824) (0.22, 0.12, P = 0.033, N = 859)
rs10947808(T)/6:39323615* KIF6 (0.81, -0.017, P = 1.2e-06, N = 7824) (0.31, 0.00071, P = 0.99, N = 859)
rs972224(C)/6:41210049 TREML4 (0.092, 0.022, P = 3.3e-05, N = 7824) (0.3, -0.088, P = 0.1, N = 859)
rs9504983(A)/6:6989041 RP11-556O15.1 (0.24, 0.15, P = 4.1e-06, N = 1959) (0.052, -0.17, P = 0.13, N = 859)
rs444190(T)/7:101862777 CUX1 (0.94, -0.35, P = 8.5e-06, N = 1959) (0.83, 0.054, P = 0.4, N = 859)
rs917402(T)/7:150969535 SMARCD3 (0.1, 0.23, P = 4.1e-06, N = 1959) (0.013, -0.0089, P = 0.97, N = 859)
rs10259781(A)/7:152867025 intergenic (0.046, 0.032, P = 3.5e-05, N = 7824) (0.18, 0.019, P = 0.77, N = 859)
rs4716609(T)/7:155269627* CNPY1 (0.21, 0.015, P = 1.2e-05, N = 7824) (0.091, 0.1, P = 0.23, N = 859)
rs13242809(A)/7:22746564 intergenic (0.27, -0.11, P = 6.7e-06, N = 1959) (0.51, -0.05, P = 0.31, N = 859)
rs59591051(A)/7:29877857 WIPF3 (0.15, 0.23, P = 8.2e-06, N = 1959) (0.21, -0.066, P = 0.27, N = 859)
rs11774655(T)/8:11271426 C8orf12 (0.075, 0.024, P = 4.3e-05, N = 7824) (0.19, -0.016, P = 0.79, N = 859)
rs10096893(A)/8:2254703* intergenic (0.68, 0.034, P = 1e-05, N = 7824) (0.56, 0.11, P = 0.034, N = 859)
rs17054370(T)/8:25669353* intergenic (0.92, 0.022, P = 2.5e-05, N = 7824) (0.79, 0.0052, P = 0.93, N = 859)
rs891404(A)/8:40276391* intergenic (0.48, 0.012, P = 7.5e-06, N = 7824) (0.6, -0.019, P = 0.7, N = 859)
rs13292819(A)/9:38227878 intergenic (0.11, 0.022, P = 2.7e-05, N = 7824) (0.059, 0.15, P = 0.14, N = 859)
rs10867534(T)/9:83054485 intergenic (0.22, 0.18, P = 7.4e-06, N = 1959) (0.44, -0.053, P = 0.28, N = 859)
rs2031970(T)/9:92204172 intergenic (0.23, -0.24, P = 9.8e-06, N = 1959) (0.084, -0.094, P = 0.27, N = 859)
rs9775485(T)/9:95611913 ZNF484 (0.59, -0.014, P = 2e-07, N = 7824) (0.32, 0.037, P = 0.47, N = 859)
Results from Univariable Mendelian Randomization of Isovalerylcarnitine & eGFR - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 92 -0.0013 (-0.14- 0.14) P=0.99 7.3 31 7.69 (0- 72.6) NA NA -8.7e-05 P=0.99
MR-Egger 92 -0.00077 (-0.18- 0.17) P=0.99 7.3 31 7.69 (0- 72.6) 99 0.24 -8.7e-05 P=0.99
Weighted median 92 -0.11 (-0.35- 0.12) P=0.34 7.3 31 7.69 (0- 72.6) NA NA -8.7e-05 P=0.99
Results from Univariable MRPRESSO of Isovalerylcarnitine & eGFR - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0 0.07 -0.02 0.99
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of Isovalerylcarnitine & eGFR - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 48 0.039 (-0.12- 0.2) P=0.62 12 29 9.84 (0- 83.7) NA NA 0.001 P=0.94
MR-Egger 48 0.034 (-0.18- 0.25) P=0.76 12 29 9.84 (0- 83.7) 55 0.17 0.001 P=0.94
Weighted median 48 0.064 (-0.16- 0.29) P=0.58 12 29 9.84 (0- 83.7) NA NA 0.001 P=0.94
Results from Univariable MRPRESSO of Isovalerylcarnitine & eGFR - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0.04 0.08 0.49 0.63
beta.exposure Outlier-corrected NA NA NA NA

Hexanoylcarnitine

Instruments Associations with Hexanoylcarnitine & eGFR
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region Hexanoylcarnitine (Shin et al/Long et al) eGFR (CSSCD)
rs11184443(T)/1:105666096* intergenic (0.25, -0.015, P = 4e-05, N = 7824) (0.32, 0.045, P = 0.38, N = 859)
rs16852535(A)/1:230881658* CAPN9 (0.32, 0.016, P = 3.8e-06, N = 7824) (0.54, -0.079, P = 0.11, N = 859)
rs4649225(A)/1:233544651* intergenic (0.35, -0.014, P = 4.1e-05, N = 7824) (0.23, 0.033, P = 0.56, N = 859)
rs12060939(C)/1:74033051 intergenic (0.27, -0.014, P = 4.2e-05, N = 7824) (0.21, 0.0058, P = 0.92, N = 859)
rs10518500(T)/1:75808588* SLC44A5 (0.79, 0.016, P = 3.3e-06, N = 7824) (0.96, 0.018, P = 0.88, N = 859)
rs699683(A)/1:76172512* RP4-682C21.5 (0.066, 0.034, P = 5.4e-09, N = 7824) (0.024, 0.036, P = 0.82, N = 859)
rs11161521(T)/1:76216330* ACADM (0.7, 0.07, P = 6.4e-100, N = 7824) (0.86, -0.13, P = 0.055, N = 859)
rs56352044(T)/1:76248706 RABGGTB (0.23, -0.3, P = 9.1e-15, N = 1881) (0.14, 0.15, P = 0.033, N = 859)
rs5745331(A)/1:76273313* MSH4 (0.72, -0.048, P = 1.6e-45, N = 7824) (0.89, 0.085, P = 0.27, N = 859)
rs1144337(T)/1:76278877 MSH4 (0.1, 0.03, P = 2.6e-09, N = 7824) (0.19, -0.061, P = 0.31, N = 859)
rs1796810(T)/1:76403305 intergenic (0.29, 0.046, P = 5e-42, N = 7824) (0.32, -0.0091, P = 0.86, N = 859)
rs572200(T)/1:76724652* ST6GALNAC3 (0.21, -0.017, P = 4.9e-05, N = 7824) (0.18, -0.024, P = 0.7, N = 859)
rs11162212(A)/1:77256966* intergenic (0.43, 0.014, P = 1.4e-05, N = 7824) (0.53, -0.046, P = 0.34, N = 859)
rs228455(T)/1:79624739* intergenic (0.14, 0.036, P = 4.1e-05, N = 7824) (0.31, 0.066, P = 0.21, N = 859)
rs3738572(A)/1:85391140* MCOLN2 (0.46, 0.012, P = 1.4e-05, N = 7824) (0.26, -0.028, P = 0.61, N = 859)
rs4463806(C)/10:115597993* DCLRE1A (0.77, -0.18, P = 6e-06, N = 1881) (0.81, 0.1, P = 0.1, N = 859)
rs2242206(T)/10:61414011* SLC16A9 (0.26, 0.015, P = 2.3e-05, N = 7824) (0.09, 0.076, P = 0.36, N = 859)
rs1171615(T)/10:61469090* SLC16A9 (0.78, 0.025, P = 4e-11, N = 7824) (0.76, 0.02, P = 0.73, N = 859)
rs1998881(T)/10:8863208* intergenic (0.21, -0.017, P = 1.3e-06, N = 7824) (0.2, -0.0023, P = 0.97, N = 859)
rs17503531(T)/10:91732224* intergenic (0.096, 0.021, P = 3.3e-05, N = 7824) (0.17, 0.018, P = 0.78, N = 859)
rs12762813(A)/10:93461648* intergenic (0.12, -0.018, P = 3.7e-05, N = 7824) (0.012, -0.21, P = 0.34, N = 859)
rs76988133(G)/11:103471636 intergenic (0.061, -0.4, P = 1.2e-07, N = 1881) (0.042, 0.084, P = 0.49, N = 859)
rs1613187(G)/11:122430156 intergenic (0.8, 0.18, P = 8.7e-06, N = 1881) (0.95, 0.0085, P = 0.94, N = 859)
rs11224138(T)/11:134842214* intergenic (0.13, -0.041, P = 5.3e-06, N = 7824) (0.11, 0.17, P = 0.034, N = 859)
rs5806187(AAAT)/13:101608997 NALCN-AS1 (0.98, 0.38, P = 9.7e-06, N = 1881) (0.85, -0.034, P = 0.62, N = 859)
rs7991563(A)/13:43688013* DNAJC15 (0.8, -0.016, P = 2.7e-06, N = 7824) (0.8, -0.024, P = 0.7, N = 859)
rs9671614(C)/14:33037956* AKAP6 (0.44, 0.2, P = 6.7e-06, N = 1881) (0.68, -0.0037, P = 0.94, N = 859)
rs8022497(C)/14:87533611* intergenic (0.068, 0.025, P = 4.9e-05, N = 7824) (0.086, -0.031, P = 0.72, N = 859)
rs4779616(C)/15:33591069* RP11-489D6.2 (0.053, 0.03, P = 3.4e-05, N = 7824) (0.036, 0.072, P = 0.56, N = 859)
rs12915128(A)/15:68734922* intergenic (0.49, 0.027, P = 4.3e-05, N = 7824) (0.81, 0.12, P = 0.048, N = 859)
rs1368843(A)/15:94908904* MCTP2 (0.42, -0.014, P = 1.3e-05, N = 7824) (0.34, 0.0079, P = 0.87, N = 859)
rs3743527(T)/16:16235681* ABCC1 (0.22, 0.014, P = 4.7e-05, N = 7824) (0.14, -0.032, P = 0.65, N = 859)
rs36021(A)/16:55711950 SLC6A2 (0.53, -0.17, P = 2.1e-06, N = 1881) (0.64, -0.062, P = 0.21, N = 859)
rs8059932(A)/16:66155276* intergenic (0.08, -0.2, P = 9.8e-06, N = 1881) (0.23, 0.039, P = 0.5, N = 859)
rs75887526(GCA)/16:78196411* WWOX (0.23, -0.24, P = 1.7e-06, N = 1881) (0.23, -0.047, P = 0.42, N = 859)
rs12598663(T)/16:7846716* intergenic (0.93, 0.026, P = 3e-05, N = 7824) (0.98, 0.052, P = 0.79, N = 859)
rs3764247(A)/16:810039* MSLN (0.76, -0.017, P = 2.1e-05, N = 7824) (0.75, 0.00053, P = 0.99, N = 859)
rs8075029(G)/17:13395850* HS3ST3A1 (0.87, -0.22, P = 7.7e-07, N = 1881) (0.99, -0.5, P = 0.014, N = 859)
rs658591(T)/17:26610769 KRT18P55 (0.8, -0.019, P = 2e-06, N = 7824) (0.63, -0.067, P = 0.18, N = 859)
rs76620359(C)/19:55725087 PTPRH (0.054, 0.41, P = 2.7e-06, N = 1881) (0.044, -0.15, P = 0.17, N = 859)
rs10170989(T)/2:107177168* intergenic (0.81, 0.017, P = 3.3e-05, N = 7824) (0.86, -0.008, P = 0.91, N = 859)
rs10171649(C)/2:125399340* CNTNAP5 (0.056, 0.028, P = 2.5e-05, N = 7824) (0.15, 0.056, P = 0.41, N = 859)
rs10928415(A)/2:149553139 intergenic (0.76, 0.22, P = 3e-06, N = 1881) (0.35, -0.022, P = 0.66, N = 859)
rs3769423(A)/2:168872075* STK39 (0.019, 0.051, P = 9.8e-06, N = 7824) (0.36, -0.0088, P = 0.86, N = 859)
rs12987318(A)/2:19772919* intergenic (0.041, 0.034, P = 1.3e-05, N = 7824) (0.084, -0.075, P = 0.4, N = 859)
rs6705260(T)/2:205039136 intergenic (0.87, -0.25, P = 1.4e-06, N = 1881) (0.97, -0.13, P = 0.34, N = 859)
rs7579973(A)/2:34933627 AC073218.2 (0.61, -0.025, P = 3.2e-05, N = 7824) (0.61, 0.0033, P = 0.95, N = 859)
rs10164760(G)/2:62212279 COMMD1 (0.018, -0.61, P = 1.2e-06, N = 1881) (0.36, 0.02, P = 0.69, N = 859)
rs4671179(G)/2:67586247 intergenic (0.45, -0.15, P = 4.7e-06, N = 1881) (0.37, 0.00051, P = 0.99, N = 859)
rs113107938(G)/2:7630499 intergenic (0.018, 0.64, P = 1.3e-06, N = 1881) (0.026, 0.17, P = 0.28, N = 859)
rs1666769(T)/2:79224687* intergenic (0.67, 0.015, P = 1.4e-05, N = 7824) (0.57, 0.0097, P = 0.85, N = 859)
rs4669343(A)/2:8970482* KIDINS220 (0.98, 0.085, P = 1.7e-05, N = 7824) (0.93, -0.095, P = 0.3, N = 859)
rs143973511(T)/3:122452571* PARP14 (0.1, -0.26, P = 3.7e-06, N = 1881) (0.049, 0.013, P = 0.91, N = 859)
rs1348656(T)/3:144933520* intergenic (0.8, -0.015, P = 1.9e-05, N = 7824) (0.61, 0.03, P = 0.56, N = 859)
rs17189202(A)/3:181986146* intergenic (0.13, 0.031, P = 1.6e-05, N = 7824) (0.024, 0.014, P = 0.93, N = 859)
rs1682962(A)/3:3834752* SUMF1 (0.58, 0.028, P = 2.2e-05, N = 7824) (0.11, -0.18, P = 0.019, N = 859)
rs4074087(A)/3:4681908* ITPR1 (0.07, 0.048, P = 2.1e-05, N = 7824) (0.18, 0.05, P = 0.42, N = 859)
rs2070630(C)/4:159644494* PPID (0.29, -0.021, P = 6.8e-10, N = 7824) (0.29, -0.047, P = 0.38, N = 859)
rs6536381(T)/4:159882193* C4orf45 (0.3, 0.014, P = 2.2e-05, N = 7824) (0.17, 0.029, P = 0.64, N = 859)
rs6553778(T)/4:168351130* intergenic (0.23, -0.017, P = 1.2e-06, N = 7824) (0.28, 0.017, P = 0.75, N = 859)
rs4863170(C)/4:190333580* intergenic (0.37, -0.15, P = 5.6e-06, N = 1881) (0.31, 0.028, P = 0.59, N = 859)
rs11728264(T)/4:29777582* intergenic (0.24, -0.015, P = 2.8e-05, N = 7824) (0.74, -0.066, P = 0.23, N = 859)
rs1477626(A)/5:101329818 intergenic (0.55, -0.026, P = 2.3e-05, N = 7824) (0.33, -0.066, P = 0.21, N = 859)
rs3776418(A)/5:10708871* DAP (0.067, 0.024, P = 4.3e-05, N = 7824) (0.047, 0.0086, P = 0.94, N = 859)
rs7716905(A)/5:131324377* ACSL6 (0.96, 0.035, P = 2.2e-05, N = 7824) (0.59, -0.046, P = 0.34, N = 859)
rs7705189(A)/5:131623358* P4HA2 (0.51, 0.019, P = 1.6e-08, N = 7824) (0.72, -0.13, P = 0.015, N = 859)
rs272869(A)/5:131677997* SLC22A4 (0.37, 0.022, P = 1.4e-11, N = 7824) (0.27, 0.11, P = 0.046, N = 859)
rs439787(T)/5:132882522* FSTL4 (0.63, 0.025, P = 4.7e-05, N = 7824) (0.51, 0.0037, P = 0.94, N = 859)
rs3798138(A)/5:136983954* KLHL3 (0.023, -0.042, P = 4.1e-05, N = 7824) (0.27, 0.11, P = 0.04, N = 859)
rs371846(T)/5:142188049* ARHGAP26 (0.082, -0.025, P = 2.1e-05, N = 7824) (0.25, -0.019, P = 0.73, N = 859)
rs11135316(A)/5:163939367* CTC-340A15.2 (0.73, 0.028, P = 4e-05, N = 7824) (0.6, -0.047, P = 0.33, N = 859)
rs1540603(A)/5:17220275* BASP1 (0.012, -0.11, P = 1.2e-05, N = 7824) (0.017, -0.39, P = 0.037, N = 859)
rs2002548(T)/5:173150415 CTB-43E15.3 (0.26, -0.14, P = 5.6e-06, N = 1881) (0.28, 0.053, P = 0.33, N = 859)
rs13355979(A)/5:32984015* CTD-2066L21.3 (0.57, -0.014, P = 3.7e-05, N = 7824) (0.15, -0.047, P = 0.48, N = 859)
rs12521153(A)/5:52788201* intergenic (0.32, 0.16, P = 7.6e-06, N = 1881) (0.27, 0.13, P = 0.015, N = 859)
rs6861760(T)/5:557551 intergenic (0.025, 0.31, P = 4.4e-06, N = 1881) (0.28, 0.084, P = 0.12, N = 859)
rs7734050(T)/5:57173905* intergenic (0.73, 0.014, P = 4.2e-05, N = 7824) (0.65, -0.003, P = 0.95, N = 859)
rs1104684(G)/5:70968915 intergenic (0.47, -0.14, P = 9.1e-06, N = 1881) (0.83, -0.11, P = 0.084, N = 859)
rs4131193(A)/5:7583327* ADCY2 (0.31, 0.014, P = 2.2e-05, N = 7824) (0.56, -0.04, P = 0.42, N = 859)
rs10079045(A)/5:90266322 GPR98 (0.26, 0.17, P = 2.1e-06, N = 1881) (0.66, -0.081, P = 0.12, N = 859)
rs170734(A)/5:98147041* intergenic (0.73, -0.015, P = 6.8e-06, N = 7824) (0.69, -0.016, P = 0.76, N = 859)
rs10053087(C)/5:9920412* intergenic (0.033, 0.034, P = 4.2e-05, N = 7824) (0.27, -0.066, P = 0.23, N = 859)
rs7745587(A)/6:108010940* intergenic (0.74, -0.016, P = 6.7e-06, N = 7824) (0.87, -0.08, P = 0.25, N = 859)
rs11753995(A)/6:160575366* SLC22A1 (0.16, -0.023, P = 7.2e-08, N = 7824) (0.033, 0.013, P = 0.92, N = 859)
rs76002427(G)/6:164386971 intergenic (0.078, -0.28, P = 7.5e-07, N = 1881) (0.029, -0.26, P = 0.082, N = 859)
rs3846828(A)/6:24282117* DCDC2 (0.1, 0.021, P = 3.2e-05, N = 7824) (0.069, -0.038, P = 0.7, N = 859)
rs2071538(A)/6:32818678* TAP1 (0.23, 0.015, P = 1.7e-05, N = 7824) (0.026, -0.093, P = 0.53, N = 859)
rs9380734(C)/6:38293199 BTBD9 (0.02, -0.69, P = 7e-06, N = 1881) (0.27, 0.055, P = 0.31, N = 859)
rs9352088(C)/6:74987577* RP11-554D15.1 (0.75, -0.033, P = 3.1e-05, N = 7824) (0.56, 0.036, P = 0.46, N = 859)
rs884760(T)/6:8363853* intergenic (0.28, 0.014, P = 3e-05, N = 7824) (0.72, 0.00033, P = 1, N = 859)
rs4584058(A)/7:44132340* intergenic (0.35, -0.015, P = 1.1e-05, N = 7824) (0.56, -0.051, P = 0.29, N = 859)
rs10280701(T)/7:83627847* SEMA3A (0.21, 0.015, P = 1.3e-05, N = 7824) (0.076, 0.092, P = 0.3, N = 859)
rs10095671(T)/8:133378663* KCNQ3 (0.91, -0.024, P = 4e-06, N = 7824) (0.86, -0.00023, P = 1, N = 859)
rs145011241(GGAGT)/8:144238923 LY6H (0.41, -0.21, P = 7.2e-06, N = 1881) (0.47, 0.049, P = 0.31, N = 859)
rs11990475(A)/8:25954842* intergenic (0.9, -0.022, P = 1.9e-05, N = 7824) (0.85, 0.059, P = 0.37, N = 859)
rs10096903(T)/8:85661097* RALYL (0.25, 0.015, P = 2e-05, N = 7824) (0.4, -0.044, P = 0.38, N = 859)
rs11990096(A)/8:9195378* RP11-115J16.1 (0.22, -0.029, P = 2.8e-05, N = 7824) (0.42, 0.03, P = 0.55, N = 859)
rs2915420(T)/9:103955550* LPPR1 (0.16, -0.02, P = 2.1e-06, N = 7824) (0.17, 0.076, P = 0.25, N = 859)
rs3132311(A)/9:137430554* RP11-473E2.4 (0.21, 0.014, P = 4.4e-05, N = 7824) (0.037, -0.042, P = 0.74, N = 859)
rs79368155(T)/9:18097804* intergenic (0.047, 0.39, P = 6.2e-06, N = 1881) (0.01, -0.00031, P = 1, N = 859)
rs12340115(A)/9:8281308* intergenic (0.99, 0.11, P = 3.6e-05, N = 7824) (0.91, -0.088, P = 0.28, N = 859)
rs11141474(A)/9:89272127* RP11-395D3.1 (0.28, -0.014, P = 4.6e-05, N = 7824) (0.17, -0.073, P = 0.25, N = 859)
Results from Univariable Mendelian Randomization of Hexanoylcarnitine & eGFR - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 102 -0.046 (-0.13- 0.038) P=0.28 8 38 0 (0- 70.4) NA NA -0.0052 P=0.51
MR-Egger 102 -0.027 (-0.13- 0.072) P=0.59 8 38 0 (0- 70.4) 112 0.2 -0.0052 P=0.51
Weighted median 102 -0.06 (-0.17- 0.054) P=0.3 8 38 0 (0- 70.4) NA NA -0.0052 P=0.51
Results from Univariable MRPRESSO of Hexanoylcarnitine & eGFR - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.05 0.04 -1.07 0.28
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of Hexanoylcarnitine & eGFR - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 24 -0.046 (-0.14- 0.049) P=0.34 21 26 0 (0- 80.7) NA NA 0.012 P=0.55
MR-Egger 24 -0.078 (-0.22- 0.064) P=0.29 21 26 0 (0- 80.7) 28 0.18 0.012 P=0.55
Weighted median 24 -0.066 (-0.18- 0.052) P=0.27 21 26 0 (0- 80.7) NA NA 0.012 P=0.55
Results from Univariable MRPRESSO of Hexanoylcarnitine & eGFR - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.05 0.05 -0.95 0.35
beta.exposure Outlier-corrected NA NA NA NA

L-Octanoylcarnitine

Instruments Associations with L-Octanoylcarnitine & eGFR
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region L-Octanoylcarnitine (Shin et al/Long et al) eGFR (CSSCD)
rs11184443(T)/1:105666096* intergenic (0.25, -0.019, P = 1.4e-05, N = 7824) (0.32, 0.045, P = 0.38, N = 859)
rs857703(A)/1:158687224* OR6K3 (0.38, 0.014, P = 4.1e-05, N = 7824) (0.13, 0.12, P = 0.11, N = 859)
rs332765(T)/1:174655782* RABGAP1L (0.36, 0.13, P = 2.4e-06, N = 1948) (0.9, -0.075, P = 0.34, N = 859)
rs7552404(A)/1:76135946* intergenic (0.7, 0.075, P = 1.3e-77, N = 7824) (0.83, -0.12, P = 0.061, N = 859)
rs699683(A)/1:76172512* RP4-682C21.5 (0.067, 0.047, P = 5.4e-11, N = 7824) (0.024, 0.036, P = 0.82, N = 859)
rs12130832(T)/1:76234294* ACADM (0.71, -0.049, P = 5.4e-33, N = 7824) (0.79, 0.0095, P = 0.87, N = 859)
rs56352044(T)/1:76248706 RABGGTB (0.23, -0.3, P = 9.1e-15, N = 1948) (0.14, 0.15, P = 0.033, N = 859)
rs1144337(T)/1:76278877 MSH4 (0.1, 0.044, P = 3.3e-14, N = 7824) (0.19, -0.061, P = 0.31, N = 859)
rs1796810(T)/1:76403305 intergenic (0.29, 0.045, P = 6.1e-28, N = 7824) (0.32, -0.0091, P = 0.86, N = 859)
rs185292654(T)/1:76465955 intergenic (0.035, 0.55, P = 1.4e-06, N = 1948) (0.026, 0.0014, P = 0.99, N = 859)
rs4463806(C)/10:115597993* DCLRE1A (0.77, -0.18, P = 6e-06, N = 1948) (0.81, 0.1, P = 0.1, N = 859)
rs7894167(C)/10:47556919* intergenic (0.38, 0.17, P = 3.8e-06, N = 1948) (0.52, 0.1, P = 0.037, N = 859)
rs1998881(T)/10:8863208* intergenic (0.21, -0.017, P = 5e-05, N = 7824) (0.2, -0.0023, P = 0.97, N = 859)
rs17503531(T)/10:91732224* intergenic (0.096, 0.024, P = 4.2e-05, N = 7824) (0.17, 0.018, P = 0.78, N = 859)
rs582119(T)/11:107443420 intergenic (0.38, -0.015, P = 3.1e-05, N = 7824) (0.48, 0.024, P = 0.62, N = 859)
rs4757051(A)/11:20333248* intergenic (0.72, -0.018, P = 1.9e-05, N = 7824) (0.43, 0.11, P = 0.027, N = 859)
rs6485709(T)/11:46934309* LRP4 (0.011, 0.13, P = 5.3e-06, N = 7824) (0.041, 0.14, P = 0.25, N = 859)
rs7130402(A)/11:48115606* PTPRJ (0.93, 0.032, P = 9.9e-06, N = 7824) (0.91, -0.013, P = 0.88, N = 859)
rs1480639(T)/12:29014476 intergenic (0.57, -0.015, P = 3e-05, N = 7824) (0.73, -0.031, P = 0.57, N = 859)
rs7973509(A)/12:40354147* SLC2A13 (0.27, -0.018, P = 1.7e-05, N = 7824) (0.097, 0.042, P = 0.61, N = 859)
rs7334793(T)/13:106512641 intergenic (0.5, -0.015, P = 8e-06, N = 7824) (0.39, 0.031, P = 0.53, N = 859)
rs1446791(A)/13:85194772* intergenic (0.17, -0.037, P = 2e-05, N = 7824) (0.33, -0.061, P = 0.26, N = 859)
rs8012258(T)/14:104991128 TMEM179 (0.53, -0.014, P = 4.2e-05, N = 7824) (0.33, -0.0044, P = 0.93, N = 859)
rs8003176(T)/14:88760692* KCNK10 (0.77, 0.033, P = 4.5e-05, N = 7824) (0.9, 0.076, P = 0.34, N = 859)
rs11848217(G)/14:93048314* RIN3 (0.24, -0.18, P = 7.1e-06, N = 1948) (0.33, -0.029, P = 0.58, N = 859)
rs1801591(A)/15:76578762* ETFA (0.09, 0.029, P = 3.4e-05, N = 7824) (0.013, -0.1, P = 0.62, N = 859)
rs3816282(A)/15:79350840* RASGRF1 (0.91, 0.041, P = 1.9e-05, N = 7824) (0.94, 0.23, P = 0.025, N = 859)
rs2379991(T)/15:83445338* FSD2 (0.28, 0.017, P = 4.6e-05, N = 7824) (0.45, 0.0029, P = 0.95, N = 859)
rs924135(A)/16:16123459* ABCC1 (0.38, -0.021, P = 1.1e-09, N = 7824) (0.53, -0.06, P = 0.21, N = 859)
rs45512591(C)/16:16147264* ABCC1 (0.28, -0.23, P = 4.7e-08, N = 1948) (0.37, -0.056, P = 0.26, N = 859)
rs3743527(T)/16:16235681* ABCC1 (0.22, 0.019, P = 4.7e-06, N = 7824) (0.14, -0.032, P = 0.65, N = 859)
rs2239323(A)/16:16278695 ABCC6 (0.5, 0.015, P = 2.6e-05, N = 7824) (0.65, 0.04, P = 0.44, N = 859)
rs79825592(T)/16:73692861 intergenic (0.16, 0.28, P = 3.1e-06, N = 1948) (0.026, -0.14, P = 0.36, N = 859)
rs2133336(A)/17:8313854* NDEL1 (0.4, 0.015, P = 9.6e-06, N = 7824) (0.17, -0.029, P = 0.65, N = 859)
rs2156436(T)/18:57457267* intergenic (0.031, 0.12, P = 2.5e-05, N = 7824) (0.23, -0.027, P = 0.64, N = 859)
rs888860(A)/19:35465187* intergenic (0.35, -0.018, P = 9.4e-07, N = 7824) (0.1, 0.19, P = 0.021, N = 859)
rs7246133(T)/19:53162102* ZNF83 (0.66, 0.021, P = 9.5e-06, N = 7824) (0.48, -0.0079, P = 0.87, N = 859)
rs7255657(A)/19:55902257* RPL28 (0.93, 0.03, P = 3.7e-05, N = 7824) (0.76, -0.073, P = 0.18, N = 859)
rs10170989(T)/2:107177168* intergenic (0.81, 0.02, P = 4.8e-05, N = 7824) (0.86, -0.008, P = 0.91, N = 859)
rs1542341(T)/2:125383522* CNTNAP5 (0.94, -0.034, P = 2.5e-05, N = 7824) (0.8, -0.04, P = 0.51, N = 859)
rs10203979(C)/2:179022751* intergenic (0.23, 0.18, P = 3.4e-06, N = 1948) (0.36, -0.074, P = 0.14, N = 859)
rs11885860(T)/2:180398739* ZNF385B (0.93, -0.036, P = 3.9e-05, N = 7824) (0.95, 0.076, P = 0.49, N = 859)
rs6531077(A)/2:18237570* KCNS3 (0.46, 0.015, P = 1.2e-05, N = 7824) (0.8, -0.016, P = 0.79, N = 859)
rs4672596(T)/2:211648806* intergenic (0.4, 0.015, P = 9.6e-06, N = 7824) (0.44, -0.026, P = 0.58, N = 859)
rs4675009(A)/2:226660503* intergenic (0.82, 0.21, P = 3.6e-06, N = 1948) (0.82, -0.094, P = 0.14, N = 859)
rs17258702(A)/2:230764226* TRIP12 (0.23, -0.017, P = 4.7e-05, N = 7824) (0.036, 0.19, P = 0.15, N = 859)
rs2720162(T)/2:231629360* CAB39 (0.61, -0.015, P = 7.3e-06, N = 7824) (0.88, -0.12, P = 0.086, N = 859)
rs4241312(T)/2:3252636* TSSC1 (0.48, 0.015, P = 1.6e-05, N = 7824) (0.38, 0.0095, P = 0.85, N = 859)
rs2290101(C)/2:33952055* MYADML (0.34, 0.017, P = 2.7e-05, N = 7824) (0.44, -0.11, P = 0.025, N = 859)
rs112844005(T)/2:44684630* CAMKMT (0.05, 0.31, P = 9.7e-06, N = 1948) (0.043, -0.018, P = 0.87, N = 859)
rs6077844(A)/20:10579996* SLX4IP (0.42, 0.014, P = 2.5e-05, N = 7824) (0.35, -0.08, P = 0.12, N = 859)
rs1203869(T)/20:22533223* LINC00261 (0.015, 0.092, P = 4.9e-05, N = 7824) (0.15, -0.056, P = 0.39, N = 859)
rs542126572(GT)/20:32973901 ITCH (0.036, -0.23, P = 2e-06, N = 1948) (0.015, -0.026, P = 0.9, N = 859)
rs9979265(T)/21:29692982 intergenic (0.45, 0.014, P = 4.2e-05, N = 7824) (0.56, -0.014, P = 0.78, N = 859)
rs2776278(A)/21:37342699* RUNX1 (0.23, -0.017, P = 4.9e-05, N = 7824) (0.26, -0.00052, P = 0.99, N = 859)
rs2835328(A)/21:37622915* DOPEY2 (0.69, 0.018, P = 1.2e-05, N = 7824) (0.83, -0.019, P = 0.77, N = 859)
rs4239866(T)/22:17788722* intergenic (0.39, -0.029, P = 2.9e-05, N = 7824) (0.11, -0.047, P = 0.54, N = 859)
rs5755595(T)/22:35518839* CTA-714B7.5 (0.27, 0.24, P = 3.3e-06, N = 1948) (0.055, 0.1, P = 0.35, N = 859)
rs16855296(T)/3:144082862* intergenic (0.052, 0.038, P = 3.2e-05, N = 7824) (0.016, -0.047, P = 0.8, N = 859)
rs17756228(T)/3:172371929* NCEH1 (0.49, -0.014, P = 3.8e-05, N = 7824) (0.39, 0.07, P = 0.17, N = 859)
rs6443446(G)/3:177049627* intergenic (0.66, 0.15, P = 3.1e-06, N = 1948) (0.95, 0.042, P = 0.69, N = 859)
rs331869(T)/3:255395 CHL1 (0.98, -0.13, P = 7.8e-07, N = 7824) (0.81, -0.061, P = 0.32, N = 859)
rs4402896(T)/3:29848896* RBMS3 (0.56, 0.015, P = 1.8e-05, N = 7824) (0.61, -0.096, P = 0.051, N = 859)
rs1682962(A)/3:3834752* SUMF1 (0.58, 0.03, P = 3.7e-05, N = 7824) (0.11, -0.18, P = 0.019, N = 859)
rs12503954(A)/4:113916575* RP11-650J17.1 (0.29, -0.019, P = 2.1e-05, N = 7824) (0.6, -0.083, P = 0.095, N = 859)
rs7663005(T)/4:142092124* RNF150 (0.5, -0.014, P = 4.2e-05, N = 7824) (0.093, 0.044, P = 0.61, N = 859)
rs4835221(T)/4:146248122* intergenic (0.7, -0.03, P = 2.6e-05, N = 7824) (0.78, -0.00026, P = 1, N = 859)
rs956974(A)/4:156443527 RP13-487K5.1 (0.55, -0.014, P = 5e-05, N = 7824) (0.8, 0.0081, P = 0.89, N = 859)
rs35055965(T)/4:159193901* RP11-597D13.7 (0.24, -0.23, P = 3.6e-09, N = 1948) (0.16, -0.023, P = 0.72, N = 859)
rs8396(T)/4:159630817* PPID (0.7, 0.048, P = 1.4e-31, N = 7824) (0.65, 0.014, P = 0.78, N = 859)
rs10003821(T)/4:159877388* C4orf45 (0.36, -0.025, P = 6.6e-10, N = 7824) (0.35, -0.0021, P = 0.97, N = 859)
rs1347066(T)/4:159949116* C4orf45 (0.54, 0.015, P = 2.1e-05, N = 7824) (0.54, 0.031, P = 0.52, N = 859)
rs6857595(T)/4:187011126 TLR3 (0.28, 0.15, P = 9.6e-06, N = 1948) (0.31, 0.022, P = 0.66, N = 859)
rs9790569(T)/4:46734416* COX7B2 (0.18, -0.2, P = 9.3e-06, N = 1948) (0.14, -0.096, P = 0.17, N = 859)
rs17157494(A)/5:104409021* CTD-2374C24.1 (0.074, 0.029, P = 2.2e-05, N = 7824) (0.03, -0.16, P = 0.25, N = 859)
rs274567(T)/5:131714409* SLC22A5 (0.37, 0.016, P = 3.9e-06, N = 7824) (0.3, 0.049, P = 0.35, N = 859)
rs419418(T)/5:142175364* ARHGAP26 (0.92, 0.029, P = 4.7e-05, N = 7824) (0.76, 0.028, P = 0.62, N = 859)
rs1995777(T)/5:32987956* CTD-2066L21.3 (0.56, -0.014, P = 4.7e-05, N = 7824) (0.22, -0.04, P = 0.49, N = 859)
rs10940072(A)/5:65916784 MAST4 (0.39, -0.015, P = 1.2e-05, N = 7824) (0.31, 0.1, P = 0.052, N = 859)
rs1053657(T)/6:138734422* HEBP2 (0.13, 0.023, P = 4.8e-05, N = 7824) (0.54, 0.01, P = 0.83, N = 859)
rs13198822(T)/6:165806518* PDE10A (0.35, -0.014, P = 3.5e-05, N = 7824) (0.15, -0.039, P = 0.57, N = 859)
rs2989521(G)/6:167804569 intergenic (0.59, -0.16, P = 7.6e-06, N = 1948) (0.82, 0.12, P = 0.061, N = 859)
rs6907864(T)/6:24293324* DCDC2 (0.11, 0.026, P = 5.8e-06, N = 7824) (0.14, 0.02, P = 0.78, N = 859)
rs212934(T)/6:25537934* LRRC16A (0.39, -0.014, P = 3.8e-05, N = 7824) (0.34, 0.095, P = 0.065, N = 859)
rs9352088(C)/6:74987577* RP11-554D15.1 (0.75, -0.036, P = 3.3e-05, N = 7824) (0.56, 0.036, P = 0.46, N = 859)
rs884760(T)/6:8363853* intergenic (0.28, 0.019, P = 7.2e-06, N = 7824) (0.72, 0.00033, P = 1, N = 859)
rs6968131(T)/7:138468569* ATP6V0A4 (0.99, -0.19, P = 4.9e-05, N = 7824) (0.87, -0.0073, P = 0.92, N = 859)
rs7795715(A)/7:154639804* DPP6 (0.86, -0.024, P = 1.3e-05, N = 7824) (0.82, -0.03, P = 0.64, N = 859)
rs10235922(C)/7:155247106* EN2 (0.91, -0.03, P = 1.7e-05, N = 7824) (0.93, -0.03, P = 0.75, N = 859)
rs10224131(A)/7:35200804* DPY19L2P1 (0.42, -0.017, P = 3e-05, N = 7824) (0.48, 0.082, P = 0.088, N = 859)
rs12718664(A)/7:52527761 intergenic (0.59, -0.015, P = 2.4e-05, N = 7824) (0.31, -0.055, P = 0.29, N = 859)
rs2072454(T)/7:55214348* EGFR (0.54, -0.014, P = 4.9e-05, N = 7824) (0.5, 0.052, P = 0.28, N = 859)
rs7787623(T)/7:75404761* CCL26 (0.25, -0.043, P = 3.1e-05, N = 7824) (0.43, 0.017, P = 0.72, N = 859)
rs38558(T)/7:81884548* CACNA2D1 (0.74, -0.018, P = 2e-05, N = 7824) (0.93, -0.22, P = 0.015, N = 859)
rs7004977(T)/8:98483422* intergenic (0.82, 0.025, P = 4.9e-05, N = 7824) (0.81, 0.058, P = 0.34, N = 859)
rs140294778(TC)/9:101327543* GABBR2 (0.2, -0.18, P = 9.2e-06, N = 1948) (0.022, -0.11, P = 0.53, N = 859)
rs76592182(C)/9:118487530 intergenic (0.028, 0.58, P = 1.2e-06, N = 1948) (0.06, 0.085, P = 0.4, N = 859)
rs6475272(T)/9:18949249* FAM154A (0.23, -0.018, P = 2.2e-05, N = 7824) (0.067, 0.0017, P = 0.99, N = 859)
rs11143623(A)/9:76183000* intergenic (0.62, 0.014, P = 3.5e-05, N = 7824) (0.25, 0.072, P = 0.22, N = 859)
rs10868458(A)/9:89277187* RP11-395D3.1 (0.35, -0.017, P = 1.9e-06, N = 7824) (0.15, -0.068, P = 0.3, N = 859)
Results from Univariable Mendelian Randomization of L-Octanoylcarnitine & eGFR - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 100 -0.029 (-0.17- 0.11) P=0.68 7.3 31 9.22 (0- 79.2) NA NA -0.01 P=0.22
MR-Egger 100 0.034 (-0.14- 0.21) P=0.69 7.3 31 9.22 (0- 79.2) 115 0.11 -0.01 P=0.22
Weighted median 100 0.11 (-0.098- 0.33) P=0.29 7.3 31 9.22 (0- 79.2) NA NA -0.01 P=0.22
Results from Univariable MRPRESSO of L-Octanoylcarnitine & eGFR - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.03 0.07 -0.41 0.68
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of L-Octanoylcarnitine & eGFR - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 19 -0.092 (-0.3- 0.11) P=0.38 13 12 17.3 (0- 72.3) NA NA -0.0099 P=0.55
MR-Egger 19 -0.051 (-0.3- 0.19) P=0.69 13 12 17.3 (0- 72.3) 17 0.44 -0.0099 P=0.55
Weighted median 19 0.12 (-0.18- 0.42) P=0.44 13 12 17.3 (0- 72.3) NA NA -0.0099 P=0.55
Results from Univariable MRPRESSO of L-Octanoylcarnitine & eGFR - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.09 0.1 -0.88 0.39
beta.exposure Outlier-corrected NA NA NA NA

Ureidopropionic acid

Instruments Associations with Ureidopropionic acid & eGFR
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region Ureidopropionic acid (Shin et al/Long et al) eGFR (CSSCD)
rs75277555(T)/1:92235001 TGFBR3 (0.072, 0.16, P = 4e-06, N = 1956) (0.047, -0.008, P = 0.94, N = 859)
rs8013355(C)/14:52871418 intergenic (0.32, 0.16, P = 1.7e-06, N = 1956) (0.48, -0.013, P = 0.78, N = 859)
rs555045773(GA)/15:54319379 UNC13C (0.15, -1.1, P = 6.2e-06, N = 1956) (0.26, -0.069, P = 0.2, N = 859)
rs59930743(C)/17:3393604 ASPA (0.22, 0.18, P = 2.8e-06, N = 1956) (0.29, 0.013, P = 0.81, N = 859)
rs56104151(T)/18:61129481 intergenic (0.17, 0.15, P = 8.1e-06, N = 1956) (0.35, 0.031, P = 0.53, N = 859)
rs78734409(A)/2:12335302 AC096559.1 (0.038, 0.51, P = 3e-06, N = 1956) (0.025, 0.14, P = 0.37, N = 859)
rs71394795(GTTTA)/2:12355843 AC096559.1 (0.034, 0.19, P = 4.9e-07, N = 1956) (0.66, 0.016, P = 0.76, N = 859)
rs13427576(T)/2:56523619 CCDC85A (0.12, 0.16, P = 9e-06, N = 1956) (0.22, 0.0034, P = 0.95, N = 859)
rs11704820(G)/22:24912248 UPB1 (0.43, 0.16, P = 4.3e-07, N = 1956) (0.32, 0.0044, P = 0.93, N = 859)
rs77020847(G)/3:150016629 intergenic (0.013, 0.24, P = 2.1e-06, N = 1956) (0.014, 0.074, P = 0.71, N = 859)
rs6788347(C)/3:37754694* ITGA9 (0.5, 0.19, P = 4e-06, N = 1956) (0.52, 0.081, P = 0.1, N = 859)
rs4698029(G)/4:10312798* intergenic (0.19, -0.39, P = 3.5e-17, N = 1956) (0.21, -0.033, P = 0.56, N = 859)
rs13135526(A)/4:128932595* C4orf29 (0.51, -0.08, P = 9.1e-06, N = 1956) (0.61, 0.057, P = 0.25, N = 859)
rs2725772(T)/4:140438033* SETD7 (0.84, 0.21, P = 8.9e-08, N = 1956) (0.54, 0.08, P = 0.093, N = 859)
rs11735831(A)/4:9951591* SLC2A9 (0.22, -0.43, P = 1.4e-23, N = 1956) (0.45, -0.029, P = 0.54, N = 859)
rs33379(C)/5:171099634* intergenic (0.44, 0.16, P = 4e-06, N = 1956) (0.77, -0.033, P = 0.58, N = 859)
rs76129636(G)/6:130978833 intergenic (0.12, -0.41, P = 9.6e-06, N = 1956) (0.26, -0.0077, P = 0.89, N = 859)
rs113133874(T)/6:33379903 PHF1 (0.11, -0.42, P = 7e-06, N = 1956) (0.021, -0.051, P = 0.76, N = 859)
rs56286439(C)/7:14307105 DGKB (0.2, -0.13, P = 4.8e-06, N = 1956) (0.82, -0.0045, P = 0.94, N = 859)
rs2352451(G)/8:112781984 intergenic (0.74, 0.18, P = 5.3e-06, N = 1956) (0.78, -0.073, P = 0.21, N = 859)
rs7006208(A)/8:124157948 TBC1D31 (0.17, -0.96, P = 8e-06, N = 1956) (0.26, -0.087, P = 0.11, N = 859)
rs74795659(A)/8:73633099 KCNB2 (0.068, 0.15, P = 9e-06, N = 1956) (0.023, 0.24, P = 0.12, N = 859)
Results from Univariable Mendelian Randomization of Ureidopropionic acid & eGFR - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 22 0.078 (0.032- 0.12) P=0.00087 97 87 0 (0- 30.6) NA NA -0.0057 P=0.77
MR-Egger 22 0.089 (-0.0047- 0.18) P=0.077 97 87 0 (0- 30.6) 11 0.93 -0.0057 P=0.77
Weighted median 22 0.068 (-0.02- 0.16) P=0.13 97 87 0 (0- 30.6) NA NA -0.0057 P=0.77
Results from Univariable MRPRESSO of Ureidopropionic acid & eGFR - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0.08 0.02 3.33 0
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of Ureidopropionic acid & eGFR - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 16 0.07 (0.029- 0.11) P=0.00097 113 71 0 (0- 0) NA NA -0.011 P=0.64
MR-Egger 16 0.088 (-0.011- 0.19) P=0.1 113 71 0 (0- 0) 5.4 0.98 -0.011 P=0.64
Weighted median 16 0.068 (-0.028- 0.17) P=0.16 113 71 0 (0- 0) NA NA -0.011 P=0.64
Results from Univariable MRPRESSO of Ureidopropionic acid & eGFR - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0.07 0.02 3.3 0
beta.exposure Outlier-corrected NA NA NA NA

Aminoadipic acid

Instruments Associations with Aminoadipic acid & eGFR
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region Aminoadipic acid (Shin et al/Long et al) eGFR (CSSCD)
rs75602737(C)/1:112433228 KCND3 (0.09, -0.24, P = 3.5e-07, N = 1829) (0.049, 0.17, P = 0.12, N = 859)
rs16860185(A)/1:162294070* NOS1AP (0.099, 0.26, P = 6.7e-06, N = 1829) (0.012, 0.28, P = 0.22, N = 859)
rs6689907(T)/1:201701481 NAV1 (0.41, 0.2, P = 7.6e-06, N = 1829) (0.37, 0.054, P = 0.28, N = 859)
rs78186327(A)/1:26304015 PAFAH2 (0.27, -0.24, P = 7.8e-06, N = 1829) (0.034, 0.16, P = 0.21, N = 859)
rs61783628(T)/1:29209107 EPB41 (0.34, -0.18, P = 1.9e-06, N = 1829) (0.1, -0.097, P = 0.22, N = 859)
rs12414405(T)/10:12160108 DHTKD1 (0.11, -0.26, P = 2.5e-07, N = 1829) (0.021, -0.051, P = 0.76, N = 859)
rs12925619(C)/16:13529326 U91319.1 (0.9, -0.3, P = 7.3e-06, N = 1829) (0.98, -0.32, P = 0.033, N = 859)
rs1484093(T)/18:35705672 intergenic (0.71, 0.14, P = 8.4e-06, N = 1829) (0.95, -0.22, P = 0.055, N = 859)
rs9964369(T)/18:3773106 DLGAP1 (0.33, 0.14, P = 1.4e-07, N = 1829) (0.46, -0.0031, P = 0.95, N = 859)
rs1606889(G)/18:44214176* LOXHD1 (0.33, -0.18, P = 8.3e-06, N = 1829) (0.25, -0.079, P = 0.15, N = 859)
rs2161489(C)/19:17864452* FCHO1 (0.91, 0.3, P = 8.8e-06, N = 1829) (0.72, 0.064, P = 0.24, N = 859)
rs58855003(G)/2:150736508 intergenic (0.1, 0.25, P = 5.9e-06, N = 1829) (0.029, -0.19, P = 0.17, N = 859)
rs115962459(A)/2:216452525 AC012668.2 (0.017, -0.62, P = 7e-06, N = 1829) (0.024, -0.11, P = 0.48, N = 859)
rs3821665(A)/3:151133816* MED12L (0.51, -0.14, P = 2.4e-07, N = 1829) (0.3, -0.0077, P = 0.88, N = 859)
rs901212(A)/4:152913308 intergenic (0.29, -0.16, P = 4.5e-06, N = 1829) (0.38, 0.065, P = 0.18, N = 859)
rs2319481(T)/4:168502795 intergenic (0.61, 0.13, P = 3.1e-06, N = 1829) (0.3, 0.048, P = 0.36, N = 859)
rs793814(A)/4:185354974 IRF2 (0.63, -0.18, P = 5.5e-06, N = 1829) (0.78, -0.067, P = 0.26, N = 859)
rs6837120(T)/4:42649123 ATP8A1 (0.48, -0.12, P = 2.1e-06, N = 1829) (0.42, 0.099, P = 0.039, N = 859)
rs163450(T)/5:111868863 intergenic (0.077, -0.24, P = 5.1e-06, N = 1829) (0.2, -0.006, P = 0.92, N = 859)
rs4716060(A)/6:16310456 ATXN1 (0.27, -0.17, P = 2.4e-06, N = 1829) (0.72, -0.039, P = 0.46, N = 859)
rs876607(A)/6:16382649 ATXN1 (0.24, 0.17, P = 5e-06, N = 1829) (0.43, 0.081, P = 0.1, N = 859)
rs9464891(T)/6:16389631* ATXN1 (0.12, -0.25, P = 5e-06, N = 1829) (0.23, 0.096, P = 0.087, N = 859)
rs2490034(A)/6:3870889 intergenic (0.84, -0.26, P = 1.1e-06, N = 1829) (0.95, -0.047, P = 0.67, N = 859)
rs9361533(G)/6:80137259 intergenic (0.3, 0.2, P = 3.8e-06, N = 1829) (0.36, -0.052, P = 0.29, N = 859)
rs3800636(C)/7:137402718* DGKI (0.34, -0.19, P = 8.9e-06, N = 1829) (0.75, 0.0054, P = 0.93, N = 859)
rs3936106(A)/7:36731349 AOAH (0.18, 0.23, P = 6.4e-07, N = 1829) (0.32, 0.062, P = 0.23, N = 859)
rs7831286(G)/8:1122672 CTD-2281E23.2 (0.14, -0.15, P = 9.9e-06, N = 1829) (0.12, 0.02, P = 0.78, N = 859)
rs2125392(C)/9:76536127 intergenic (0.72, -0.19, P = 5e-06, N = 1829) (0.3, -0.02, P = 0.71, N = 859)
rs13295599(A)/9:87584025 NTRK2 (0.072, -0.41, P = 6.7e-06, N = 1829) (0.019, 0.19, P = 0.29, N = 859)
Results from Univariable Mendelian Randomization of Aminoadipic acid & eGFR - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 29 0.05 (-0.09- 0.19) P=0.48 24 38 19.1 (0- 72.3) NA NA -0.032 P=0.52
MR-Egger 29 0.21 (-0.28- 0.69) P=0.41 24 38 19.1 (0- 72.3) 39 0.059 -0.032 P=0.52
Weighted median 29 0.18 (0.0086- 0.35) P=0.04 24 38 19.1 (0- 72.3) NA NA -0.032 P=0.52
Results from Univariable MRPRESSO of Aminoadipic acid & eGFR - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0.05 0.07 0.7 0.49
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of Aminoadipic acid & eGFR - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 23 0.045 (-0.12- 0.21) P=0.6 24 30 18.3 (0- 76.1) NA NA -0.043 P=0.45
MR-Egger 23 0.26 (-0.32- 0.84) P=0.39 24 30 18.3 (0- 76.1) 31 0.066 -0.043 P=0.45
Weighted median 23 0.18 (-0.031- 0.39) P=0.095 24 30 18.3 (0- 76.1) NA NA -0.043 P=0.45
Results from Univariable MRPRESSO of Aminoadipic acid & eGFR - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0.05 0.09 0.53 0.6
beta.exposure Outlier-corrected NA NA NA NA

2-Hydroxyglutarate

Instruments Associations with 2-Hydroxyglutarate & eGFR
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region 2-Hydroxyglutarate (Shin et al/Long et al) eGFR (CSSCD)
rs6664149(T)/1:160600521 SLAMF1 (0.98, 0.081, P = 2.9e-05, N = 7824) (0.91, 0.053, P = 0.54, N = 859)
rs6540821(A)/1:214495298 SMYD2 (0.91, -0.24, P = 9.6e-06, N = 1945) (0.96, -0.0039, P = 0.98, N = 859)
rs11122423(A)/1:232257914 intergenic (0.26, -0.14, P = 8.9e-06, N = 1945) (0.59, 0.05, P = 0.3, N = 859)
rs1670157(T)/10:67667698 CTNNA3 (0.35, -0.022, P = 3e-05, N = 7824) (0.084, 0.12, P = 0.18, N = 859)
rs6484669(T)/11:11120287 intergenic (0.74, -0.02, P = 7.8e-06, N = 7824) (0.85, 0.057, P = 0.39, N = 859)
rs1647967(A)/11:130943681 intergenic (0.17, 0.018, P = 1.6e-05, N = 7824) (0.045, 0.1, P = 0.36, N = 859)
rs2949855(T)/11:93722540* HPRTP4 (0.19, -0.029, P = 1.1e-05, N = 7824) (0.12, 0.048, P = 0.52, N = 859)
rs7972211(A)/12:14269986* intergenic (0.76, -0.026, P = 2.6e-05, N = 7824) (0.74, -0.037, P = 0.49, N = 859)
rs4459375(T)/12:48356881 TMEM106C (0.53, 0.15, P = 6.9e-06, N = 1945) (0.54, -0.036, P = 0.47, N = 859)
rs36031950(TA)/12:49754105 DNAJC22 (0.064, 0.14, P = 1.6e-06, N = 1945) (0.64, 0.09, P = 0.067, N = 859)
rs16963602(T)/13:104501480* intergenic (0.99, -0.064, P = 3.5e-05, N = 7824) (0.89, -0.052, P = 0.5, N = 859)
rs7320880(A)/13:24350292 MIPEP (0.17, 0.018, P = 2.1e-05, N = 7824) (0.34, 0.063, P = 0.2, N = 859)
rs9544785(A)/13:78971070* RNF219-AS1 (0.36, -0.015, P = 6.6e-06, N = 7824) (0.31, 0.022, P = 0.67, N = 859)
rs1053019(A)/14:102808273 ZNF839 (0.061, 0.027, P = 3.7e-05, N = 7824) (0.17, -0.094, P = 0.16, N = 859)
rs4900072(T)/14:91636532 C14orf159 (0.35, 0.18, P = 2.9e-06, N = 1945) (0.14, -0.023, P = 0.75, N = 859)
rs12587020(T)/14:91678546 C14orf159 (0.57, -0.013, P = 4.2e-05, N = 7824) (0.18, 0.013, P = 0.84, N = 859)
rs12886872(T)/14:91678812* C14orf159 (0.44, 0.013, P = 4.8e-05, N = 7824) (0.82, -0.013, P = 0.84, N = 859)
rs1043239(A)/15:63618110* CA12 (0.42, 0.017, P = 1.4e-05, N = 7824) (0.61, 0.053, P = 0.28, N = 859)
rs937098(T)/15:68894559* CORO2B (0.14, -0.023, P = 1.4e-05, N = 7824) (0.53, -0.032, P = 0.5, N = 859)
rs2689255(C)/16:54222800* intergenic (0.56, 0.17, P = 6.9e-07, N = 1945) (0.55, -0.022, P = 0.65, N = 859)
rs57029062(GC)/16:72712738 RP5-991G20.1 (0.98, 0.15, P = 9e-06, N = 1945) (0.82, 0.023, P = 0.71, N = 859)
rs12716966(C)/16:83253620* CDH13 (0.71, -0.015, P = 1.4e-05, N = 7824) (0.53, -0.012, P = 0.8, N = 859)
rs16977497(A)/17:71021645* SLC39A11 (0.045, 0.054, P = 9.9e-06, N = 7824) (0.014, -0.055, P = 0.78, N = 859)
rs632953(A)/18:22000799 intergenic (0.9, -0.022, P = 1.2e-05, N = 7824) (0.77, -0.0061, P = 0.92, N = 859)
rs17654263(T)/18:28178839 intergenic (0.017, 0.055, P = 4.6e-05, N = 7824) (0.024, 0.12, P = 0.42, N = 859)
rs7566877(T)/2:139994754 intergenic (0.97, -0.04, P = 1.9e-05, N = 7824) (0.87, 0.026, P = 0.72, N = 859)
rs10196007(T)/2:145329033 AC010090.1 (0.82, -0.032, P = 7.6e-07, N = 7824) (0.64, -0.017, P = 0.74, N = 859)
rs78147778(C)/2:242682029 D2HGDH (0.24, 0.27, P = 3.7e-09, N = 1945) (0.22, -0.027, P = 0.64, N = 859)
rs6707874(G)/2:242709363 D2HGDH (0.36, 0.27, P = 2.1e-12, N = 1945) (0.71, 0.0033, P = 0.95, N = 859)
rs2314702(C)/2:4402929 intergenic (0.42, 0.022, P = 4.1e-05, N = 7824) (0.38, 0.056, P = 0.25, N = 859)
rs2555453(A)/2:64528233* intergenic (0.29, 0.014, P = 4.8e-05, N = 7824) (0.28, 0.079, P = 0.14, N = 859)
rs12106014(C)/20:10015761 ANKEF1 (0.55, 0.18, P = 6.4e-07, N = 1945) (0.79, 0.036, P = 0.54, N = 859)
rs17690784(A)/20:16929912 intergenic (0.89, -0.023, P = 2.2e-05, N = 7824) (0.98, -0.13, P = 0.5, N = 859)
rs6064820(T)/20:58206004 PHACTR3 (0.72, 0.015, P = 4e-06, N = 7824) (0.62, 0.064, P = 0.22, N = 859)
rs2426843(A)/20:58380845* PHACTR3 (0.93, -0.027, P = 3.3e-05, N = 7824) (0.28, 0.038, P = 0.48, N = 859)
rs670752(A)/3:107312980* BBX (0.3, 0.015, P = 1.9e-05, N = 7824) (0.28, -0.065, P = 0.21, N = 859)
rs1568101(T)/3:148590090 CPA3 (0.91, -0.025, P = 8.6e-06, N = 7824) (0.93, -0.042, P = 0.64, N = 859)
rs11915217(A)/3:174027279* intergenic (0.31, -0.18, P = 5.9e-06, N = 1945) (0.13, 0.074, P = 0.3, N = 859)
rs16832543(C)/3:181272496 SOX2-OT (0.9, -0.021, P = 3.1e-05, N = 7824) (0.8, 0.032, P = 0.6, N = 859)
rs12497680(A)/3:194573366 intergenic (0.075, -0.35, P = 4.6e-07, N = 1945) (0.081, 0.13, P = 0.15, N = 859)
rs73890624(A)/3:194752697 intergenic (0.02, -0.58, P = 1.1e-06, N = 1945) (0.15, -0.16, P = 0.022, N = 859)
rs17640193(A)/3:62569620* CADPS (0.07, 0.025, P = 2.1e-05, N = 7824) (0.03, 0.28, P = 0.049, N = 859)
rs2575453(A)/4:42685758 intergenic (0.75, 0.014, P = 4.8e-05, N = 7824) (0.53, 0.024, P = 0.64, N = 859)
rs6834396(C)/4:5403998* STK32B (0.17, 0.035, P = 1.9e-05, N = 7824) (0.71, -0.057, P = 0.28, N = 859)
rs344130(T)/4:77647590* SHROOM3 (0.37, -0.014, P = 1.6e-05, N = 7824) (0.56, 0.013, P = 0.79, N = 859)
rs6876258(A)/5:151191673 G3BP1 (0.18, 0.017, P = 4.7e-05, N = 7824) (0.34, 0.061, P = 0.24, N = 859)
rs10475642(A)/5:157325495* intergenic (0.46, -0.014, P = 1.2e-05, N = 7824) (0.6, 0.018, P = 0.71, N = 859)
rs7702827(C)/5:158879869 AC008703.1 (0.3, -0.015, P = 6.3e-06, N = 7824) (0.17, -0.02, P = 0.75, N = 859)
rs17060337(A)/5:161872504* intergenic (0.011, -0.1, P = 9e-06, N = 7824) (0.09, 0.041, P = 0.62, N = 859)
rs2122552(C)/5:165957260 intergenic (0.028, -0.065, P = 4.3e-05, N = 7824) (0.47, 0.0084, P = 0.86, N = 859)
rs6451885(C)/5:20715134* RP11-774D14.1 (0.85, -0.27, P = 5.4e-06, N = 1945) (0.9, 0.04, P = 0.62, N = 859)
rs7725624(A)/5:63010725* intergenic (0.086, -0.044, P = 3e-06, N = 7824) (0.23, 0.051, P = 0.36, N = 859)
rs114947484(C)/6:121292872 intergenic (0.058, 0.33, P = 3.9e-06, N = 1945) (0.023, -0.13, P = 0.44, N = 859)
rs11964335(A)/6:149658101 TAB2 (0.49, -0.014, P = 1.2e-05, N = 7824) (0.69, -0.023, P = 0.67, N = 859)
rs3757187(C)/6:28107654 ZKSCAN8 (0.22, 0.16, P = 1.9e-06, N = 1945) (0.32, -0.023, P = 0.66, N = 859)
rs9395212(C)/6:46726441* ANKRD66 (0.74, 0.23, P = 8.1e-07, N = 1945) (0.92, -0.082, P = 0.33, N = 859)
rs10806320(A)/6:86000465 RP11-30P6.1 (0.22, 0.17, P = 5.7e-06, N = 1945) (0.11, -0.024, P = 0.75, N = 859)
rs12174071(A)/6:98204538 intergenic (0.88, 0.022, P = 1.6e-05, N = 7824) (0.9, -0.035, P = 0.66, N = 859)
rs8176023(A)/7:142642596 KEL (0.93, -0.041, P = 2.5e-06, N = 7824) (0.99, -0.15, P = 0.52, N = 859)
rs17154808(T)/7:80788160 intergenic (0.016, -0.089, P = 4.4e-05, N = 7824) (0.13, -0.038, P = 0.59, N = 859)
rs933341(A)/7:83743619 SEMA3A (0.24, 0.017, P = 1.6e-06, N = 7824) (0.4, -0.01, P = 0.83, N = 859)
rs6558423(A)/8:1145909* CTD-2281E23.2 (0.2, -0.018, P = 1.8e-05, N = 7824) (0.42, -0.014, P = 0.78, N = 859)
rs11998124(T)/8:128085480 PCAT2 (0.053, 0.03, P = 4.9e-05, N = 7824) (0.45, -0.0036, P = 0.94, N = 859)
rs890519(A)/8:18905049* PSD3 (0.42, 0.015, P = 9.1e-06, N = 7824) (0.38, -0.028, P = 0.57, N = 859)
rs11991231(C)/8:19907912* intergenic (0.11, -0.39, P = 1e-08, N = 1945) (0.074, 0.11, P = 0.25, N = 859)
rs199605811(C)/8:54204040 intergenic (0.027, 0.3, P = 3.4e-06, N = 1945) (0.036, 0.15, P = 0.26, N = 859)
rs4837718(A)/9:122918241 intergenic (0.75, -0.014, P = 4.8e-05, N = 7824) (0.3, 0.089, P = 0.094, N = 859)
rs12341112(A)/9:22790893 RP11-399D6.2 (0.11, 0.021, P = 3.3e-05, N = 7824) (0.4, 0.065, P = 0.18, N = 859)
rs10966201(T)/9:24079188 intergenic (0.66, 0.015, P = 7.1e-06, N = 7824) (0.66, 0.031, P = 0.54, N = 859)
rs10816013(T)/9:8942036* PTPRD (0.14, -0.19, P = 8.6e-06, N = 1945) (0.035, -0.023, P = 0.86, N = 859)
rs1412466(T)/9:94282510 intergenic (0.23, 0.19, P = 2.8e-07, N = 1945) (0.29, 0.03, P = 0.58, N = 859)
rs4744059(C)/9:94337776 ROR2 (0.27, 0.18, P = 1.6e-07, N = 1945) (0.74, 0.009, P = 0.87, N = 859)
Results from Univariable Mendelian Randomization of 2-Hydroxyglutarate & eGFR - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 72 0.011 (-0.087- 0.11) P=0.82 9.5 33 4.61 (0- 4.54) NA NA 0.0028 P=0.76
MR-Egger 72 -0.0027 (-0.15- 0.14) P=0.97 9.5 33 4.61 (0- 4.54) 53 0.93 0.0028 P=0.76
Weighted median 72 -0.06 (-0.24- 0.12) P=0.52 9.5 33 4.61 (0- 4.54) NA NA 0.0028 P=0.76
Results from Univariable MRPRESSO of 2-Hydroxyglutarate & eGFR - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0.01 0.05 0.23 0.82
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of 2-Hydroxyglutarate & eGFR - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 46 0.072 (-0.038- 0.18) P=0.2 9.8 22 4.72 (0- 16.7) NA NA 0.0054 P=0.65
MR-Egger 46 0.047 (-0.12- 0.21) P=0.58 9.8 22 4.72 (0- 16.7) 34 0.86 0.0054 P=0.65
Weighted median 46 0.015 (-0.19- 0.22) P=0.89 9.8 22 4.72 (0- 16.7) NA NA 0.0054 P=0.65
Results from Univariable MRPRESSO of 2-Hydroxyglutarate & eGFR - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0.07 0.06 1.29 0.2
beta.exposure Outlier-corrected NA NA NA NA

3-Methyladipic acid

Instruments Associations with 3-Methyladipic acid & eGFR
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region 3-Methyladipic acid (Shin et al/Long et al) eGFR (CSSCD)
rs10908821(G)/1:161008535* TSTD1 (0.12, -0.19, P = 1.7e-07, N = 1947) (0.08, 0.19, P = 0.035, N = 859)
rs76552190(C)/14:28430652 intergenic (0.016, 0.65, P = 5.8e-06, N = 1947) (0.019, 0.35, P = 0.05, N = 859)
rs7143798(G)/14:33637107* NPAS3 (0.27, 0.2, P = 7.8e-06, N = 1947) (0.47, 0.015, P = 0.76, N = 859)
rs2460846(C)/15:36035176 DPH6-AS1 (0.41, -0.13, P = 5.7e-06, N = 1947) (0.63, -0.024, P = 0.62, N = 859)
rs11638741(C)/15:68734727* intergenic (0.98, -0.62, P = 7.7e-06, N = 1947) (0.83, -0.092, P = 0.14, N = 859)
rs1694246(G)/18:51401250* intergenic (0.89, -0.17, P = 7.6e-06, N = 1947) (0.73, -0.13, P = 0.022, N = 859)
rs637188(C)/18:58207240* intergenic (0.63, -0.11, P = 7.6e-06, N = 1947) (0.45, -0.00074, P = 0.99, N = 859)
rs536042327(CT)/2:188187872 AC007319.1 (0.01, 0.48, P = 8.7e-06, N = 1947) (0.4, -0.058, P = 0.24, N = 859)
rs6545578(C)/2:56784495* intergenic (0.84, 0.28, P = 1.2e-08, N = 1947) (0.97, -0.0061, P = 0.96, N = 859)
rs10805124(C)/4:44310296 KCTD8 (0.67, -0.2, P = 9.7e-06, N = 1947) (0.75, -0.028, P = 0.61, N = 859)
rs9292558(T)/5:34663830* RAI14 (0.075, -0.27, P = 3.9e-06, N = 1947) (0.052, 0.0091, P = 0.93, N = 859)
rs142983506(CAT)/6:126003666 RP1-293L8.2 (0.4, -0.13, P = 2.5e-06, N = 1947) (0.24, -0.0098, P = 0.86, N = 859)
rs1185568(A)/6:25834428* SLC17A1 (0.55, 0.4, P = 2.7e-30, N = 1947) (0.89, -0.039, P = 0.62, N = 859)
rs56144311(C)/7:21660173* DNAH11 (0.077, 0.26, P = 9.1e-06, N = 1947) (0.27, 0.048, P = 0.38, N = 859)
rs113283332(A)/7:36047671 intergenic (0.014, 0.73, P = 1e-06, N = 1947) (0.25, -0.012, P = 0.83, N = 859)
rs112212379(A)/7:36052900 intergenic (0.013, 0.69, P = 8.6e-06, N = 1947) (0.067, 0.11, P = 0.24, N = 859)
Results from Univariable Mendelian Randomization of 3-Methyladipic acid & eGFR - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 16 0.046 (-0.048- 0.14) P=0.34 31 25 14.6 (0- 82.7) NA NA 0.015 P=0.66
MR-Egger 16 0.013 (-0.16- 0.19) P=0.89 31 25 14.6 (0- 82.7) 19 0.18 0.015 P=0.66
Weighted median 16 -0.0021 (-0.13- 0.13) P=0.97 31 25 14.6 (0- 82.7) NA NA 0.015 P=0.66
Results from Univariable MRPRESSO of 3-Methyladipic acid & eGFR - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0.05 0.05 0.96 0.35
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of 3-Methyladipic acid & eGFR - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 7 0.015 (-0.099- 0.13) P=0.8 22 7.9 23.8 (0- 86.3) NA NA 0.014 P=0.78
MR-Egger 7 -0.013 (-0.23- 0.21) P=0.91 22 7.9 23.8 (0- 86.3) 6.9 0.23 0.014 P=0.78
Weighted median 7 -0.011 (-0.16- 0.13) P=0.88 22 7.9 23.8 (0- 86.3) NA NA 0.014 P=0.78
Results from Univariable MRPRESSO of 3-Methyladipic acid & eGFR - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0.02 0.06 0.26 0.8
beta.exposure Outlier-corrected NA NA NA NA

4-Pyridoxic acid

Instruments Associations with 4-Pyridoxic acid & eGFR
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region X4.pyridoxate (Shin et al/Long et al) eGFR (CSSCD)
rs66994930(G)/1:14288571 intergenic (0.098, 0.2, P = 3.7e-06, N = 1938) (0.097, -0.08, P = 0.32, N = 859)
rs7531679(T)/1:160634341 intergenic (0.9, 0.049, P = 9e-06, N = 7824) (0.96, -0.18, P = 0.17, N = 859)
rs670874(A)/1:182678213 RP11-317P15.3 (0.42, -0.17, P = 1.3e-07, N = 1938) (0.58, -0.042, P = 0.4, N = 859)
rs11119975(T)/1:212747722 ATF3 (0.15, -0.022, P = 1.4e-05, N = 7824) (0.02, -0.089, P = 0.6, N = 859)
rs11118327(T)/1:219692313* intergenic (0.36, -0.017, P = 2.4e-05, N = 7824) (0.067, 0.11, P = 0.22, N = 859)
rs11118329(A)/1:219701961 intergenic (0.64, 0.016, P = 4.6e-05, N = 7824) (0.93, -0.15, P = 0.12, N = 859)
rs1877156(G)/1:226313671 RP11-396C23.3 (0.59, 0.17, P = 8.3e-06, N = 1938) (0.36, 0.061, P = 0.23, N = 859)
rs77069129(T)/1:246823978 CNST (0.015, 0.51, P = 6.5e-06, N = 1938) (0.21, -0.022, P = 0.72, N = 859)
rs1392744(C)/1:37327225 GRIK3 (0.94, 0.31, P = 6e-06, N = 1938) (0.59, -0.025, P = 0.61, N = 859)
rs12025777(T)/1:41748897* RP11-399E6.1 (0.072, -0.33, P = 6.5e-06, N = 1938) (0.077, -0.091, P = 0.3, N = 859)
rs2125421(T)/1:96458324 RP11-147C23.1 (0.17, 0.02, P = 4.8e-05, N = 7824) (0.37, 0.06, P = 0.23, N = 859)
rs6696033(T)/1:97595784 DPYD (0.96, -0.055, P = 4.3e-06, N = 7824) (0.81, -0.041, P = 0.5, N = 859)
rs12573136(C)/10:28303355 RP11-218D6.4 (0.11, 0.32, P = 9.8e-06, N = 1938) (0.21, -0.064, P = 0.28, N = 859)
rs2123348(T)/10:4779211 intergenic (0.78, 0.018, P = 1.3e-05, N = 7824) (0.51, -0.047, P = 0.31, N = 859)
rs11214633(A)/11:113382519 intergenic (0.022, 0.053, P = 3e-05, N = 7824) (0.015, -0.038, P = 0.85, N = 859)
rs4755281(T)/11:44758398 RP11-45A12.2 (0.92, -0.03, P = 1.6e-05, N = 7824) (0.72, -0.036, P = 0.5, N = 859)
rs111633747(A)/11:80237332 RNU6-544P (0.092, -0.27, P = 8.6e-06, N = 1938) (0.07, -0.03, P = 0.75, N = 859)
rs55995000(T)/12:33046205 PKP2 (0.15, 0.3, P = 5e-07, N = 1938) (0.022, 0.23, P = 0.17, N = 859)
rs400120(A)/12:52831340* KRT75 (0.65, 0.019, P = 1.3e-06, N = 7824) (0.94, 0.074, P = 0.46, N = 859)
rs12814098(G)/12:5521537* intergenic (0.46, -0.17, P = 4.5e-07, N = 1938) (0.17, -0.0078, P = 0.9, N = 859)
rs35619331(A)/12:5526184 intergenic (0.21, 0.2, P = 6.8e-06, N = 1938) (0.043, 0.067, P = 0.58, N = 859)
rs2183242(C)/13:21271776* IL17D (0.042, 0.04, P = 3.5e-05, N = 7824) (0.11, 0.024, P = 0.76, N = 859)
rs1571295(T)/13:93116692 GPC5 (0.54, 0.014, P = 4.6e-05, N = 7824) (0.74, -0.027, P = 0.62, N = 859)
rs9556658(A)/13:97678251* intergenic (0.87, 0.023, P = 4e-05, N = 7824) (0.44, 0.034, P = 0.47, N = 859)
rs17750938(G)/14:94356089 intergenic (0.091, -0.25, P = 5.6e-06, N = 1938) (0.026, 0.063, P = 0.68, N = 859)
rs1370431(T)/15:61472687* RP11-39M21.1 (0.63, -0.017, P = 1.4e-05, N = 7824) (0.46, -0.056, P = 0.24, N = 859)
rs2572207(T)/15:66070693* DENND4A (0.25, -0.017, P = 4.3e-05, N = 7824) (0.38, 0.13, P = 0.0088, N = 859)
rs10500486(A)/16:64027542* intergenic (0.057, 0.034, P = 3.5e-05, N = 7824) (0.1, 0.064, P = 0.42, N = 859)
rs12931734(T)/16:8296086* intergenic (0.21, 0.022, P = 3.8e-06, N = 7824) (0.088, -0.00049, P = 1, N = 859)
rs8097(G)/16:8953081 CARHSP1 (0.65, 0.18, P = 1.3e-06, N = 1938) (0.35, -0.033, P = 0.53, N = 859)
rs13381663(T)/18:22860759 ZNF521 (0.79, -0.019, P = 3.7e-05, N = 7824) (0.72, -0.11, P = 0.042, N = 859)
rs28367036(C)/18:23029962 intergenic (0.093, 0.19, P = 3.3e-06, N = 1938) (0.059, -0.063, P = 0.52, N = 859)
rs12965568(A)/18:31034308 intergenic (0.34, 0.017, P = 1.4e-05, N = 7824) (0.36, -0.029, P = 0.56, N = 859)
rs1431844(T)/18:40071148 LINC00907 (0.026, 0.056, P = 2.3e-06, N = 7824) (0.11, 0.023, P = 0.76, N = 859)
rs12953402(T)/18:45852017* ZBTB7C (0.19, 0.021, P = 2.2e-05, N = 7824) (0.16, 0.061, P = 0.35, N = 859)
rs73936950(C)/19:45241350 intergenic (0.013, 0.72, P = 3.1e-06, N = 1938) (0.11, -0.0054, P = 0.95, N = 859)
rs6752425(T)/2:159323562* PKP4 (0.031, 0.097, P = 3.8e-06, N = 7824) (0.16, 0.092, P = 0.15, N = 859)
rs4674858(T)/2:224916420 intergenic (0.01, 0.15, P = 6.6e-06, N = 7824) (0.038, -0.17, P = 0.18, N = 859)
rs11125947(T)/2:63334101* RP11-511I11.1 (0.32, 0.018, P = 9.8e-06, N = 7824) (0.4, 0.011, P = 0.82, N = 859)
rs6013068(C)/20:49662264 intergenic (0.87, -0.19, P = 8.9e-06, N = 1938) (0.98, -0.12, P = 0.45, N = 859)
rs6127732(T)/20:54933104 FAM210B (0.052, 0.035, P = 2.8e-05, N = 7824) (0.019, -0.14, P = 0.44, N = 859)
rs11908680(A)/20:6681348 intergenic (0.96, -0.04, P = 2.8e-05, N = 7824) (0.91, 0.071, P = 0.41, N = 859)
rs4817986(T)/21:40465512* intergenic (0.26, 0.018, P = 2e-05, N = 7824) (0.13, 0.039, P = 0.58, N = 859)
rs5758632(T)/22:42578054 TCF20 (0.023, 0.053, P = 3e-05, N = 7824) (0.072, -0.055, P = 0.55, N = 859)
rs7510746(A)/22:49796563 intergenic (0.026, 0.6, P = 7.2e-06, N = 1938) (0.39, 0.049, P = 0.32, N = 859)
rs1350932(C)/3:110527632 intergenic (0.97, 0.5, P = 6.8e-07, N = 1938) (0.72, -0.093, P = 0.086, N = 859)
rs10001753(T)/4:27786481* intergenic (0.021, 0.75, P = 6.3e-06, N = 1938) (0.027, -0.15, P = 0.32, N = 859)
rs113718328(T)/5:178273952 intergenic (0.017, 0.58, P = 4.9e-06, N = 1938) (0.066, 0.056, P = 0.57, N = 859)
rs1878728(T)/6:118117328* intergenic (0.68, -0.017, P = 3.8e-05, N = 7824) (0.63, 0.098, P = 0.041, N = 859)
rs11758777(T)/6:153798688* intergenic (0.77, 0.018, P = 7.7e-06, N = 7824) (0.7, -0.056, P = 0.3, N = 859)
rs2197296(A)/6:160568997* SLC22A1 (0.25, 0.021, P = 4.7e-06, N = 7824) (0.12, -0.016, P = 0.83, N = 859)
rs7742715(A)/6:165298415* intergenic (0.36, 0.029, P = 6.6e-06, N = 7824) (0.38, -0.03, P = 0.54, N = 859)
rs9393768(A)/6:26885619* GUSBP2 (0.36, -0.017, P = 3.4e-05, N = 7824) (0.59, 0.00081, P = 0.99, N = 859)
rs4959343(T)/6:5669950* FARS2 (0.97, 0.37, P = 3.1e-06, N = 1938) (0.65, -0.027, P = 0.59, N = 859)
rs2643196(G)/6:74262700* RP11-505P4.7 (0.064, 0.3, P = 3.1e-06, N = 1938) (0.17, 0.045, P = 0.49, N = 859)
rs6464172(A)/7:151506039 PRKAG2 (0.45, 0.027, P = 2.9e-05, N = 7824) (0.63, -0.043, P = 0.38, N = 859)
rs4588750(A)/7:3403049 SDK1 (0.15, -0.23, P = 6.2e-06, N = 1938) (0.17, -0.0079, P = 0.9, N = 859)
rs11761829(A)/7:36556697* AOAH (0.96, -0.062, P = 4.9e-05, N = 7824) (0.64, 0.02, P = 0.69, N = 859)
rs4723965(A)/7:40540407 SUGCT (0.86, 0.23, P = 6.1e-06, N = 1938) (0.99, 0.047, P = 0.82, N = 859)
rs10950112(A)/7:67642170* RP5-945F2.3 (0.71, 0.017, P = 4.7e-05, N = 7824) (0.85, 0.0014, P = 0.98, N = 859)
rs6466258(A)/7:78143956 MAGI2 (0.57, 0.19, P = 9.8e-06, N = 1938) (0.83, -0.017, P = 0.79, N = 859)
rs7842609(A)/8:105697775* RP11-127H5.1 (0.48, -0.016, P = 3.4e-05, N = 7824) (0.67, 0.066, P = 0.19, N = 859)
rs11984592(C)/8:16367919* MSR1 (0.029, 0.49, P = 1.9e-06, N = 1938) (0.57, -0.035, P = 0.48, N = 859)
rs62490090(G)/8:16376078 MSR1 (0.029, 0.46, P = 6.3e-06, N = 1938) (0.011, 0.0045, P = 0.98, N = 859)
rs11204173(T)/8:21333478 intergenic (0.82, -0.025, P = 2.4e-05, N = 7824) (0.93, -0.022, P = 0.82, N = 859)
rs9314336(A)/8:26879523 intergenic (0.19, 0.033, P = 2.5e-05, N = 7824) (0.47, -0.014, P = 0.77, N = 859)
rs10099954(C)/8:27715891 intergenic (0.34, 0.18, P = 8.2e-06, N = 1938) (0.63, 0.025, P = 0.61, N = 859)
rs6988929(A)/8:38418517* RP11-675F6.4 (0.034, 0.089, P = 2.9e-05, N = 7824) (0.034, -0.089, P = 0.5, N = 859)
rs10820118(A)/9:105036692* intergenic (0.25, -0.018, P = 1.6e-05, N = 7824) (0.33, 0.006, P = 0.91, N = 859)
rs4740188(T)/9:134698342 RP11-323H21.3 (0.4, 0.016, P = 4.7e-05, N = 7824) (0.45, 0.017, P = 0.74, N = 859)
rs2383141(A)/9:20641181* intergenic (0.44, 0.016, P = 3.3e-05, N = 7824) (0.68, 0.01, P = 0.84, N = 859)
rs1927938(T)/9:73921879 TRPM3 (0.15, -0.024, P = 1.4e-06, N = 7824) (0.42, 0.014, P = 0.78, N = 859)
Results from Univariable Mendelian Randomization of 4-Pyridoxic acid & eGFR - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 72 -0.019 (-0.08- 0.042) P=0.54 11 38 0 (0- 25.9) NA NA -0.0057 P=0.55
MR-Egger 72 -0.0033 (-0.089- 0.082) P=0.94 11 38 0 (0- 25.9) 56 0.89 -0.0057 P=0.55
Weighted median 72 -0.034 (-0.14- 0.067) P=0.5 11 38 0 (0- 25.9) NA NA -0.0057 P=0.55
Results from Univariable MRPRESSO of 4-Pyridoxic acid & eGFR - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.02 0.03 -0.62 0.54
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of 4-Pyridoxic acid & eGFR - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 43 -0.013 (-0.081- 0.055) P=0.72 14 29 0.13 (0- 22.4) NA NA -0.0021 P=0.88
MR-Egger 43 -0.007 (-0.11- 0.1) P=0.9 14 29 0.13 (0- 22.4) 31 0.88 -0.0021 P=0.88
Weighted median 43 -0.007 (-0.13- 0.11) P=0.91 14 29 0.13 (0- 22.4) NA NA -0.0021 P=0.88
Results from Univariable MRPRESSO of 4-Pyridoxic acid & eGFR - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.01 0.03 -0.36 0.72
beta.exposure Outlier-corrected NA NA NA NA

Allantoin

Instruments Associations with Allantoin & eGFR
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region Allantoin (Shin et al/Long et al) eGFR (CSSCD)
rs12136839(A)/1:147232488 GJA5 (0.95, -0.037, P = 4.4e-05, N = 7824) (0.99, 0.11, P = 0.65, N = 859)
rs12132798(C)/1:216020536 USH2A (0.97, 0.061, P = 2.1e-06, N = 7824) (0.96, 0.057, P = 0.65, N = 859)
rs4579742(A)/1:239460167 intergenic (0.13, 0.029, P = 5.2e-06, N = 7824) (0.51, 0.065, P = 0.18, N = 859)
rs10799024(A)/1:30510681* RP11-111I12.1 (0.32, 0.019, P = 4.2e-05, N = 7824) (0.5, 0.011, P = 0.82, N = 859)
rs6659223(A)/1:39076845 intergenic (0.68, -0.019, P = 3.9e-05, N = 7824) (0.74, 0.12, P = 0.027, N = 859)
rs11211464(T)/1:47598032* CYP4A22-AS1 (0.69, 0.046, P = 4.7e-05, N = 7824) (0.68, 0.026, P = 0.61, N = 859)
rs2420679(A)/10:122035596* intergenic (0.26, 0.019, P = 4.1e-05, N = 7824) (0.19, -0.0079, P = 0.9, N = 859)
rs7917625(T)/10:19294417* intergenic (0.63, -0.018, P = 4.5e-05, N = 7824) (0.67, -0.004, P = 0.94, N = 859)
rs2388712(A)/10:8382503* intergenic (0.16, 0.024, P = 2.1e-05, N = 7824) (0.025, 0.0037, P = 0.98, N = 859)
rs7122363(T)/11:116449283 intergenic (0.17, -0.025, P = 4.5e-05, N = 7824) (0.12, -0.017, P = 0.82, N = 859)
rs496084(A)/11:128976002* ARHGAP32 (0.14, -0.063, P = 3.4e-05, N = 7824) (0.09, 0.057, P = 0.51, N = 859)
rs895797(A)/11:131264611* NTM (0.22, -0.02, P = 4e-05, N = 7824) (0.23, -0.019, P = 0.74, N = 859)
rs10492266(T)/12:115605697* intergenic (0.43, -0.017, P = 8.8e-06, N = 7824) (0.74, -0.024, P = 0.67, N = 859)
rs10771223(A)/12:25651899* IFLTD1 (0.78, 0.024, P = 2.9e-07, N = 7824) (0.7, 0.076, P = 0.15, N = 859)
rs11171691(A)/12:39699101 KIF21A (0.062, -0.088, P = 3.6e-05, N = 7824) (0.012, -0.047, P = 0.84, N = 859)
rs699634(T)/12:64546423* SRGAP1 (0.98, 0.23, P = 1.2e-05, N = 7824) (0.81, 0.044, P = 0.47, N = 859)
rs167277(A)/12:78483079* NAV3 (0.78, -0.021, P = 7.9e-06, N = 7824) (0.83, -0.049, P = 0.45, N = 859)
rs9301035(A)/13:106155027* DAOA-AS1 (0.43, 0.058, P = 1.8e-05, N = 7824) (0.88, -0.066, P = 0.37, N = 859)
rs7985555(T)/13:24660336* SPATA13 (0.55, -0.019, P = 4.3e-05, N = 7824) (0.43, 0.029, P = 0.54, N = 859)
rs11147404(T)/13:30539456 intergenic (0.89, 0.028, P = 8.7e-06, N = 7824) (0.81, 0.03, P = 0.64, N = 859)
rs2480555(T)/13:71887309* intergenic (0.85, 0.023, P = 4.2e-05, N = 7824) (0.75, 0.026, P = 0.65, N = 859)
rs17294670(T)/13:82296976* intergenic (0.96, -0.045, P = 3.2e-05, N = 7824) (0.89, -0.043, P = 0.57, N = 859)
rs2329277(T)/13:84131308 intergenic (0.17, 0.023, P = 2.2e-05, N = 7824) (0.29, -0.11, P = 0.038, N = 859)
rs9555859(T)/13:89862800* LINC01047 (0.97, -0.046, P = 3.7e-05, N = 7824) (0.92, -0.0043, P = 0.96, N = 859)
rs8020559(T)/14:52490690 NID2 (0.84, -0.024, P = 2.2e-05, N = 7824) (0.84, 0.012, P = 0.85, N = 859)
rs9323272(A)/14:55288924 intergenic (0.33, 0.045, P = 3.8e-05, N = 7824) (0.58, -0.029, P = 0.55, N = 859)
rs2293319(T)/15:31235357* MTMR10 (0.79, -0.022, P = 3.6e-06, N = 7824) (0.6, -0.0038, P = 0.94, N = 859)
rs2719726(A)/16:10779741* TEKT5 (0.52, 0.02, P = 1e-05, N = 7824) (0.3, 0.01, P = 0.85, N = 859)
rs9788926(A)/16:1807780* MAPK8IP3 (0.76, 0.019, P = 4.9e-05, N = 7824) (0.47, 0.00074, P = 0.99, N = 859)
rs11646986(T)/16:80855611 intergenic (0.82, -0.023, P = 2.1e-05, N = 7824) (0.77, 0.08, P = 0.16, N = 859)
rs2549842(T)/16:81023659* CMC2 (0.79, -0.021, P = 8.7e-06, N = 7824) (0.41, -0.023, P = 0.64, N = 859)
rs8064075(A)/16:87175636 C16orf95 (0.64, 0.047, P = 3.2e-05, N = 7824) (0.22, -0.002, P = 0.97, N = 859)
rs11658900(A)/17:27095485* FAM222B (0.56, -0.016, P = 1e-05, N = 7824) (0.096, -0.062, P = 0.46, N = 859)
rs8076290(A)/17:828023 NXN (0.048, 0.061, P = 3.9e-05, N = 7824) (0.33, 0.0063, P = 0.9, N = 859)
rs402573(T)/18:65248521* RP11-638L3.1 (0.15, -0.024, P = 1.8e-05, N = 7824) (0.21, 0.068, P = 0.23, N = 859)
rs8108144(T)/19:23373200 AC092329.1 (0.79, -0.023, P = 6.4e-07, N = 7824) (0.83, 0.04, P = 0.52, N = 859)
rs2972521(A)/19:48476964* BSPH1 (0.56, 0.02, P = 1.2e-05, N = 7824) (0.22, -0.012, P = 0.83, N = 859)
rs11564620(T)/19:48571072 PLA2G4C (0.9, -0.029, P = 3.4e-05, N = 7824) (0.77, 0.07, P = 0.21, N = 859)
rs4347830(A)/2:228058016* COL4A3 (0.34, 0.021, P = 2.7e-05, N = 7824) (0.58, 0.0042, P = 0.93, N = 859)
rs1431793(A)/2:236173098 intergenic (0.75, -0.022, P = 2.9e-06, N = 7824) (0.71, 0.12, P = 0.027, N = 859)
rs17398510(A)/2:35129873* AC012593.1 (0.88, -0.034, P = 2.2e-05, N = 7824) (0.98, -0.0049, P = 0.97, N = 859)
rs8184921(T)/21:22372723* NCAM2 (0.51, 0.017, P = 9.8e-06, N = 7824) (0.36, 0.096, P = 0.056, N = 859)
rs5767976(A)/22:48158986 RP11-191L9.4 (0.53, -0.045, P = 1.6e-05, N = 7824) (0.83, -0.045, P = 0.49, N = 859)
rs1499094(T)/3:1244434 CNTN6 (0.77, 0.021, P = 7.7e-06, N = 7824) (0.61, 0.046, P = 0.34, N = 859)
rs4894514(A)/3:171558472* TMEM212 (0.53, 0.018, P = 3.6e-05, N = 7824) (0.68, -0.021, P = 0.69, N = 859)
rs6804104(A)/3:1756711* intergenic (0.85, -0.026, P = 1.5e-05, N = 7824) (0.75, 0.04, P = 0.46, N = 859)
rs1799412(C)/3:40210125 MYRIP (0.84, -0.026, P = 2.3e-06, N = 7824) (0.82, 0.066, P = 0.29, N = 859)
rs1320934(A)/3:61884650 PTPRG (0.96, 0.12, P = 1.5e-06, N = 7824) (0.69, -0.039, P = 0.44, N = 859)
rs9834988(T)/3:79630364* ROBO1 (0.53, 0.018, P = 8e-07, N = 7824) (0.48, 0.011, P = 0.82, N = 859)
rs4698025(A)/4:10305157* intergenic (0.3, 0.019, P = 2.2e-05, N = 7824) (0.27, -0.013, P = 0.81, N = 859)
rs312360(T)/4:19259131* RP11-3J1.1 (0.82, 0.022, P = 4.7e-05, N = 7824) (0.88, -0.043, P = 0.54, N = 859)
rs544236(T)/4:20235828* intergenic (0.82, 0.023, P = 2.2e-05, N = 7824) (0.82, 0.027, P = 0.67, N = 859)
rs17553672(T)/4:24839564* CCDC149 (0.82, 0.023, P = 2.1e-05, N = 7824) (0.97, 0.2, P = 0.2, N = 859)
rs13117183(C)/4:43156439* RP11-395F4.1 (0.14, -0.028, P = 1.3e-05, N = 7824) (0.022, -0.25, P = 0.13, N = 859)
rs4705317(A)/5:148500566* RN7SKP145 (0.61, 0.019, P = 2.6e-05, N = 7824) (0.36, 0.064, P = 0.19, N = 859)
rs7723208(T)/5:174038768* intergenic (0.18, 0.023, P = 4.3e-05, N = 7824) (0.2, -0.0099, P = 0.87, N = 859)
rs16867673(A)/5:38730230 intergenic (0.96, 0.044, P = 3.4e-05, N = 7824) (0.86, 0.079, P = 0.26, N = 859)
rs27223(T)/5:59752640* SETP21 (0.64, -0.019, P = 3.5e-05, N = 7824) (0.89, -0.12, P = 0.12, N = 859)
rs2068093(C)/6:114097900* U3 (0.43, 0.044, P = 1.4e-05, N = 7824) (0.52, -0.055, P = 0.26, N = 859)
rs12203935(A)/6:121276377* intergenic (0.17, -0.023, P = 3.5e-05, N = 7824) (0.027, 0.08, P = 0.59, N = 859)
rs4869723(T)/6:151579432* AKAP12 (0.44, -0.016, P = 4e-05, N = 7824) (0.56, 0.068, P = 0.16, N = 859)
rs2064599(T)/6:47259683* TNFRSF21 (0.54, 0.016, P = 2e-05, N = 7824) (0.1, 0.018, P = 0.82, N = 859)
rs972709(A)/6:66255788 EYS (0.65, 0.048, P = 6.7e-06, N = 7824) (0.89, -0.07, P = 0.37, N = 859)
rs2875567(A)/6:90100643* RRAGD (0.89, 0.027, P = 2.2e-05, N = 7824) (0.83, 0.053, P = 0.43, N = 859)
rs12189555(A)/6:91104402 intergenic (0.77, 0.021, P = 5.1e-06, N = 7824) (0.94, 0.07, P = 0.48, N = 859)
rs9377577(A)/6:96666785 FUT9 (0.21, -0.052, P = 2.2e-05, N = 7824) (0.07, -0.14, P = 0.14, N = 859)
rs10953522(A)/7:106588426 intergenic (0.53, 0.018, P = 4.3e-05, N = 7824) (0.64, 0.067, P = 0.18, N = 859)
rs12718598(T)/7:50428445* IKZF1 (0.52, 0.018, P = 1.5e-06, N = 7824) (0.48, 0.01, P = 0.83, N = 859)
rs10505632(T)/8:135892340* RP11-1057B8.2 (0.17, -0.023, P = 3e-05, N = 7824) (0.083, 0.072, P = 0.39, N = 859)
rs965525(T)/8:22579627 PEBP4 (0.71, -0.019, P = 4.1e-05, N = 7824) (0.5, 0.09, P = 0.055, N = 859)
rs17069778(A)/8:4121520* CSMD1 (0.94, 0.034, P = 3.5e-05, N = 7824) (0.82, 0.0015, P = 0.98, N = 859)
rs1447307(T)/8:94286040 RP11-388K12.2 (0.23, -0.021, P = 5.7e-06, N = 7824) (0.21, 0.00097, P = 0.99, N = 859)
rs2781102(A)/9:122558384* intergenic (0.52, 0.016, P = 4.3e-05, N = 7824) (0.66, -0.015, P = 0.77, N = 859)
rs12352353(A)/9:4743341* AK3 (0.88, -0.027, P = 2.2e-05, N = 7824) (0.87, 0.0049, P = 0.94, N = 859)
Results from Univariable Mendelian Randomization of Allantoin & eGFR - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 74 -0.011 (-0.31- 0.29) P=0.94 2.4 2.3 0 (0- 26.7) NA NA -0.0048 P=0.64
MR-Egger 74 0.072 (-0.4- 0.55) P=0.77 2.4 2.3 0 (0- 26.7) 60 0.83 -0.0048 P=0.64
Weighted median 74 0.18 (-0.35- 0.71) P=0.5 2.4 2.3 0 (0- 26.7) NA NA -0.0048 P=0.64
Results from Univariable MRPRESSO of Allantoin & eGFR - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.01 0.15 -0.07 0.94
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of Allantoin & eGFR - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 27 -0.28 (-0.89- 0.32) P=0.36 3 1 4.65e-05 (0- 74.7) NA NA -0.029 P=0.22
MR-Egger 27 0.28 (-0.79- 1.4) P=0.61 3 1 4.65e-05 (0- 74.7) 31 0.18 -0.029 P=0.22
Weighted median 27 -0.22 (-1.1- 0.64) P=0.62 3 1 4.65e-05 (0- 74.7) NA NA -0.029 P=0.22
Results from Univariable MRPRESSO of Allantoin & eGFR - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.28 0.31 -0.91 0.37
beta.exposure Outlier-corrected NA NA NA NA

2-Hydroxybutyric acid

Instruments Associations with 2-Hydroxybutyric acid & eGFR
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region 2-Hydroxybutyric acid (Shin et al/Long et al) eGFR (CSSCD)
rs1517432(T)/1:103100912* intergenic (0.57, 0.011, P = 4.7e-05, N = 7824) (0.14, -0.065, P = 0.35, N = 859)
rs12240227(A)/1:168586539 intergenic (0.02, 0.085, P = 4.1e-05, N = 7824) (0.15, 0.013, P = 0.85, N = 859)
rs627629(T)/1:238255344* intergenic (0.99, -0.11, P = 1e-05, N = 7824) (0.78, -0.057, P = 0.31, N = 859)
rs3956419(A)/1:83836149 intergenic (0.25, 0.017, P = 2.3e-05, N = 7824) (0.056, 0.026, P = 0.81, N = 859)
rs7895521(A)/10:55856021* PCDH15 (0.24, -0.014, P = 3.6e-05, N = 7824) (0.075, -0.018, P = 0.85, N = 859)
rs224069(T)/10:64508126* intergenic (0.6, 0.011, P = 2.4e-05, N = 7824) (0.93, 0.029, P = 0.77, N = 859)
rs10822058(A)/10:64523582* intergenic (0.55, -0.011, P = 3.4e-05, N = 7824) (0.9, 0.0063, P = 0.94, N = 859)
rs1509960(A)/10:64620689 EGR2 (0.083, 0.026, P = 9.6e-06, N = 7824) (0.095, -0.16, P = 0.059, N = 859)
rs7100223(T)/10:72788676* intergenic (0.55, 0.011, P = 3.4e-05, N = 7824) (0.45, -0.0041, P = 0.93, N = 859)
rs11255096(T)/10:7418393 SFMBT2 (0.61, 0.012, P = 1e-05, N = 7824) (0.41, 0.018, P = 0.72, N = 859)
rs1832826(T)/10:92122362* intergenic (0.92, -0.021, P = 3.8e-05, N = 7824) (0.97, -0.17, P = 0.27, N = 859)
rs12808830(A)/11:134735855 intergenic (0.93, -0.025, P = 4.6e-05, N = 7824) (0.97, -0.004, P = 0.98, N = 859)
rs4388837(T)/11:26722592 SLC5A12 (0.98, 0.11, P = 4.2e-06, N = 7824) (0.84, 0.13, P = 0.045, N = 859)
rs10161318(T)/12:107551308* intergenic (0.96, 0.032, P = 5.1e-06, N = 7824) (0.74, 0.022, P = 0.69, N = 859)
rs3851600(C)/12:13040944* GPRC5A (0.78, -0.015, P = 1.3e-05, N = 7824) (0.65, -0.016, P = 0.74, N = 859)
rs17122565(T)/12:48412410* RP1-228P16.5 (0.25, -0.016, P = 2.8e-06, N = 7824) (0.4, 0.056, P = 0.25, N = 859)
rs7985908(T)/13:100186218* TM9SF2 (0.12, 0.019, P = 1e-05, N = 7824) (0.18, -0.033, P = 0.6, N = 859)
rs4771522(A)/13:106774078* intergenic (0.58, 0.011, P = 2.6e-05, N = 7824) (0.66, -0.001, P = 0.98, N = 859)
rs2146690(A)/13:108403984 FAM155A (0.85, -0.025, P = 1.2e-05, N = 7824) (0.8, 0.049, P = 0.42, N = 859)
rs4943375(T)/13:31985820* intergenic (0.57, 0.012, P = 1.6e-05, N = 7824) (0.92, -0.071, P = 0.41, N = 859)
rs9532194(A)/13:38836709* intergenic (0.19, 0.017, P = 2.3e-05, N = 7824) (0.02, -0.16, P = 0.37, N = 859)
rs4883910(A)/13:72997704* intergenic (0.56, -0.011, P = 3.4e-05, N = 7824) (0.62, 0.017, P = 0.73, N = 859)
rs7141156(A)/14:33825093* NPAS3 (0.3, -0.015, P = 1.8e-05, N = 7824) (0.31, -0.063, P = 0.22, N = 859)
rs17101344(A)/14:33970832* NPAS3 (0.78, -0.019, P = 5.6e-08, N = 7824) (0.91, 0.1, P = 0.23, N = 859)
rs1959592(A)/14:43969823 intergenic (0.6, 0.012, P = 1.4e-05, N = 7824) (0.6, 0.014, P = 0.78, N = 859)
rs7401717(A)/14:54393139* intergenic (0.042, 0.037, P = 1.2e-05, N = 7824) (0.3, 0.08, P = 0.13, N = 859)
rs9652375(C)/14:76781841* ESRRB (0.57, 0.011, P = 3.1e-05, N = 7824) (0.53, -0.055, P = 0.25, N = 859)
rs2680344(A)/15:73653485 HCN4 (0.78, -0.015, P = 2.1e-05, N = 7824) (0.39, 0.027, P = 0.59, N = 859)
rs7205092(T)/16:80945538* intergenic (0.79, -0.015, P = 3.4e-05, N = 7824) (0.77, 0.059, P = 0.3, N = 859)
rs872745(A)/16:82578355* intergenic (0.41, -0.013, P = 4.9e-07, N = 7824) (0.46, -0.05, P = 0.31, N = 859)
rs9303041(T)/17:11786569 DNAH9 (0.17, -0.017, P = 4.2e-05, N = 7824) (0.17, -0.0091, P = 0.88, N = 859)
rs1684660(A)/17:42108351* LSM12 (0.54, -0.012, P = 1.3e-05, N = 7824) (0.14, 0.074, P = 0.28, N = 859)
rs473719(C)/18:22086993* intergenic (0.49, -0.012, P = 1.1e-05, N = 7824) (0.15, -0.089, P = 0.19, N = 859)
rs7228646(C)/18:23027460 intergenic (0.042, -0.031, P = 1.3e-05, N = 7824) (0.13, -0.052, P = 0.47, N = 859)
rs1791285(T)/18:57366183 CCBE1 (0.85, 0.019, P = 2.6e-05, N = 7824) (0.86, 0.069, P = 0.34, N = 859)
rs8085727(T)/18:72768073* ZNF407 (0.82, -0.015, P = 1.4e-05, N = 7824) (0.72, -0.031, P = 0.56, N = 859)
rs304729(A)/19:44084403* XRCC1 (0.2, 0.015, P = 9.2e-06, N = 7824) (0.15, -0.03, P = 0.65, N = 859)
rs729253(T)/2:117932237 intergenic (0.58, 0.026, P = 7.5e-06, N = 7824) (0.19, 0.019, P = 0.75, N = 859)
rs13430006(T)/2:219113089* ARPC2 (0.5, -0.012, P = 1.4e-05, N = 7824) (0.11, 0.1, P = 0.19, N = 859)
rs12470565(T)/2:240640112 intergenic (0.57, 0.017, P = 1.1e-06, N = 7824) (0.64, 0.03, P = 0.56, N = 859)
rs1260326(T)/2:27730940* GCKR (0.4, 0.014, P = 7.9e-08, N = 7824) (0.14, -0.019, P = 0.79, N = 859)
rs3817588(T)/2:27731212* GCKR (0.81, 0.016, P = 4.6e-06, N = 7824) (0.97, 0.1, P = 0.46, N = 859)
rs4477896(T)/2:33952413* MYADML (0.22, 0.015, P = 2.8e-05, N = 7824) (0.38, -0.008, P = 0.88, N = 859)
rs4521014(A)/2:35539417* intergenic (0.4, -0.017, P = 5.2e-07, N = 7824) (0.36, 0.045, P = 0.37, N = 859)
rs4670465(T)/2:35621644 intergenic (0.55, -0.014, P = 6.4e-08, N = 7824) (0.8, 0.056, P = 0.34, N = 859)
rs2861960(T)/2:80185514 CTNNA2 (0.87, -0.019, P = 8e-06, N = 7824) (0.94, -0.087, P = 0.39, N = 859)
rs7579456(T)/2:84362453* intergenic (0.42, -0.012, P = 1.3e-05, N = 7824) (0.73, -0.027, P = 0.62, N = 859)
rs16991515(A)/20:5915922 TRMT6 (0.95, 0.027, P = 4e-05, N = 7824) (0.97, -0.097, P = 0.45, N = 859)
rs1560921(T)/3:10674308* ATP2B2 (0.61, 0.011, P = 2.4e-05, N = 7824) (0.56, 0.015, P = 0.76, N = 859)
rs9847650(A)/3:137301920 intergenic (0.54, 0.011, P = 3e-05, N = 7824) (0.29, 0.037, P = 0.49, N = 859)
rs4683620(A)/3:141410864* RP11-340E6.1 (0.093, -0.025, P = 3.1e-05, N = 7824) (0.1, 0.075, P = 0.35, N = 859)
rs4680105(A)/3:153553043* RP11-23D24.2 (0.89, 0.019, P = 2.1e-05, N = 7824) (0.98, -0.037, P = 0.82, N = 859)
rs7614971(A)/3:34187468 intergenic (0.94, -0.025, P = 4.3e-05, N = 7824) (0.9, -0.061, P = 0.45, N = 859)
rs11721212(T)/3:53639939* CACNA1D (0.77, 0.014, P = 3.3e-05, N = 7824) (0.89, -0.078, P = 0.32, N = 859)
rs4697735(T)/4:10256289 AC006499.8 (0.017, 0.096, P = 5e-05, N = 7824) (0.31, 0.021, P = 0.68, N = 859)
rs4692861(A)/4:169061427 ANXA10 (0.41, -0.012, P = 1.5e-05, N = 7824) (0.53, 0.05, P = 0.3, N = 859)
rs2130909(A)/4:187588477 FAT1 (0.29, -0.018, P = 6.8e-06, N = 7824) (0.5, 0.046, P = 0.35, N = 859)
rs12503695(C)/4:86925463* ARHGAP24 (0.22, 0.029, P = 2.5e-05, N = 7824) (0.48, 0.031, P = 0.52, N = 859)
rs5745297(A)/5:10680997* DAP (0.08, -0.022, P = 2e-05, N = 7824) (0.013, 0.075, P = 0.72, N = 859)
rs40104(T)/5:115795101* SEMA6A (0.91, 0.029, P = 2.6e-05, N = 7824) (0.75, -0.056, P = 0.32, N = 859)
rs163920(T)/5:141397272* GNPDA1 (0.067, 0.029, P = 1.2e-05, N = 7824) (0.061, 0.16, P = 0.11, N = 859)
rs864969(A)/5:56364907* intergenic (0.8, 0.015, P = 1.4e-05, N = 7824) (0.71, 0.071, P = 0.18, N = 859)
rs287884(A)/6:157124080* ARID1B (0.44, -0.014, P = 2.4e-05, N = 7824) (0.54, 0.035, P = 0.47, N = 859)
rs9347438(T)/6:161083633* LPA (0.44, 0.011, P = 3.9e-05, N = 7824) (0.55, -0.01, P = 0.83, N = 859)
rs9477241(T)/6:16873952* intergenic (0.026, 0.041, P = 4.5e-05, N = 7824) (0.15, 0.00062, P = 0.99, N = 859)
rs6934188(T)/6:19611159* RP1-167F1.2 (0.5, 0.011, P = 3.8e-05, N = 7824) (0.48, -0.031, P = 0.53, N = 859)
rs2067997(T)/6:35471246* TULP1 (0.87, -0.021, P = 9.4e-07, N = 7824) (0.8, 0.076, P = 0.21, N = 859)
rs2073465(A)/6:74229792* EEF1A1 (0.81, 0.014, P = 4.2e-05, N = 7824) (0.91, -0.18, P = 0.04, N = 859)
rs9389466(A)/6:96245744* intergenic (0.028, 0.043, P = 8e-06, N = 7824) (0.057, -0.3, P = 0.0046, N = 859)
rs12542467(A)/8:124624056* CTD-2552K11.2 (0.54, 0.011, P = 4.9e-05, N = 7824) (0.25, -0.092, P = 0.1, N = 859)
rs13282582(T)/8:128577283* intergenic (0.045, 0.059, P = 2.4e-05, N = 7824) (0.046, 0.14, P = 0.23, N = 859)
rs12677068(T)/8:29787927* FAM183CP (0.97, 0.038, P = 3.3e-05, N = 7824) (0.98, 0.14, P = 0.45, N = 859)
rs2719320(A)/8:34187152* RP1-84O15.2 (0.81, -0.015, P = 2.4e-05, N = 7824) (0.52, -2.7e-05, P = 1, N = 859)
rs4376550(T)/9:109178658* RP11-308N19.1 (0.34, -0.014, P = 4.5e-05, N = 7824) (0.48, 0.0021, P = 0.97, N = 859)
rs7867311(A)/9:11790536* intergenic (0.59, 0.014, P = 1.7e-05, N = 7824) (0.69, -0.0011, P = 0.98, N = 859)
rs10975189(T)/9:5590953 RP11-574F11.3 (0.059, 0.026, P = 1.9e-05, N = 7824) (0.072, 0.085, P = 0.37, N = 859)
rs952045(T)/9:73161881* TRPM3 (0.95, -0.029, P = 2e-05, N = 7824) (0.77, -0.046, P = 0.42, N = 859)
rs2224580(A)/9:8142291* intergenic (0.22, 0.016, P = 1.1e-05, N = 7824) (0.34, 0.033, P = 0.5, N = 859)
rs11788042(A)/9:81650381 KRT18P24 (0.24, 0.016, P = 1.9e-06, N = 7824) (0.59, -0.0091, P = 0.86, N = 859)
rs876927(T)/9:88117073* intergenic (0.21, 0.016, P = 5.4e-06, N = 7824) (0.29, -0.1, P = 0.059, N = 859)
rs2841680(A)/9:96161642 intergenic (0.77, 0.015, P = 2e-05, N = 7824) (0.82, 0.068, P = 0.3, N = 859)
Results from Univariable Mendelian Randomization of 2-Hydroxybutyric acid & eGFR - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 81 0.26 (-0.16- 0.69) P=0.23 0.81 0.84 0 (0- 29.5) NA NA -0.022 P=0.032
MR-Egger 81 0.79 (0.14- 1.5) P=0.021 0.81 0.84 0 (0- 29.5) 66 0.85 -0.022 P=0.032
Weighted median 81 0.41 (-0.29- 1.1) P=0.25 0.81 0.84 0 (0- 29.5) NA NA -0.022 P=0.032
Results from Univariable MRPRESSO of 2-Hydroxybutyric acid & eGFR - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0.26 0.22 1.2 0.23
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of 2-Hydroxybutyric acid & eGFR - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 25 0.45 (-0.064- 0.97) P=0.086 1 0.32 0 (0- 37.1) NA NA -0.012 P=0.5
MR-Egger 25 0.67 (-0.22- 1.6) P=0.15 1 0.32 0 (0- 37.1) 16 0.87 -0.012 P=0.5
Weighted median 25 0.31 (-0.58- 1.2) P=0.5 1 0.32 0 (0- 37.1) NA NA -0.012 P=0.5
Results from Univariable MRPRESSO of 2-Hydroxybutyric acid & eGFR - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0.45 0.26 1.72 0.1
beta.exposure Outlier-corrected NA NA NA NA

Beta-Alanine

Instruments Associations with Beta-Alanine & eGFR
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region Beta-Alanine (Shin et al/Long et al) eGFR (CSSCD)
rs4655453(T)/1:213785004* AL592063.1 (0.091, 0.8, P = 3e-06, N = 1950) (0.031, -0.083, P = 0.54, N = 859)
rs34954945(T)/1:34259238 CSMD2 (0.065, 0.17, P = 2.1e-06, N = 1950) (0.16, 0.097, P = 0.15, N = 859)
rs10915665(T)/1:4093717 intergenic (0.13, -0.2, P = 6.9e-06, N = 1950) (0.3, 0.013, P = 0.81, N = 859)
rs7911319(G)/10:133273482 intergenic (0.083, 0.58, P = 3.7e-06, N = 1950) (0.073, -0.088, P = 0.35, N = 859)
rs79254065(A)/10:71415238 intergenic (0.015, -0.26, P = 1.6e-06, N = 1950) (0.097, -0.13, P = 0.11, N = 859)
rs12560861(G)/13:21073518 CRYL1 (0.2, -0.46, P = 4e-06, N = 1950) (0.15, 0.0028, P = 0.97, N = 859)
rs7150563(C)/14:98762345* intergenic (0.4, -0.29, P = 2.8e-06, N = 1950) (0.37, 0.076, P = 0.13, N = 859)
rs4558436(C)/16:7336322 RBFOX1 (0.88, -0.66, P = 5.5e-06, N = 1950) (0.92, -0.27, P = 0.0028, N = 859)
rs62079516(G)/17:80341546 RP13-20L14.1 (0.19, -0.27, P = 8e-06, N = 1950) (0.085, -0.048, P = 0.58, N = 859)
rs62132077(C)/2:17766094* VSNL1 (0.017, 0.17, P = 4.7e-06, N = 1950) (0.028, 0.25, P = 0.08, N = 859)
rs2327549(T)/20:12354153* intergenic (0.98, 0.81, P = 7.5e-06, N = 1950) (0.54, 0.063, P = 0.19, N = 859)
rs5753833(T)/22:32355076 YWHAH (0.17, -0.28, P = 7.5e-06, N = 1950) (0.096, -0.018, P = 0.83, N = 859)
rs6800284(T)/3:30758956* intergenic (0.44, 0.22, P = 1.2e-21, N = 1950) (0.79, 0.0081, P = 0.89, N = 859)
rs10676924(TTG)/3:30798395 GADL1 (0.78, 0.35, P = 1.3e-06, N = 1950) (0.96, 0.31, P = 0.011, N = 859)
rs58714970(TC)/3:30808056* GADL1 (0.43, -0.17, P = 7.4e-07, N = 1950) (0.47, 0.011, P = 0.83, N = 859)
rs9968671(T)/5:39141990* FYB (0.2, -0.17, P = 6.8e-06, N = 1950) (0.37, -0.057, P = 0.28, N = 859)
rs535532587(CA)/5:79976241 MSH3 (0.066, 0.52, P = 7.1e-06, N = 1950) (0.18, 0.017, P = 0.79, N = 859)
rs7037419(T)/9:103103281 TEX10 (0.14, 0.16, P = 4.3e-06, N = 1950) (0.16, 0.015, P = 0.82, N = 859)
rs12341435(G)/9:38575602 ANKRD18A (0.027, -0.65, P = 2.4e-06, N = 1950) (0.068, 0.017, P = 0.86, N = 859)
Results from Univariable Mendelian Randomization of Beta-Alanine & eGFR - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 19 0.07 (-0.02- 0.16) P=0.13 65 60 28.1 (0- 83.2) NA NA 0.013 P=0.72
MR-Egger 19 0.043 (-0.13- 0.22) P=0.64 65 60 28.1 (0- 83.2) 27 0.065 0.013 P=0.72
Weighted median 19 0.064 (-0.048- 0.18) P=0.26 65 60 28.1 (0- 83.2) NA NA 0.013 P=0.72
Results from Univariable MRPRESSO of Beta-Alanine & eGFR - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0.07 0.05 1.53 0.14
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of Beta-Alanine & eGFR - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 12 0.11 (-0.031- 0.25) P=0.13 65 38 37.9 (0- 83.2) NA NA 0.033 P=0.61
MR-Egger 12 0.032 (-0.29- 0.35) P=0.85 65 38 37.9 (0- 83.2) 17 0.069 0.033 P=0.61
Weighted median 12 0.0066 (-0.16- 0.17) P=0.94 65 38 37.9 (0- 83.2) NA NA 0.033 P=0.61
Results from Univariable MRPRESSO of Beta-Alanine & eGFR - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0.11 0.07 1.52 0.16
beta.exposure Outlier-corrected NA NA NA NA

Betaine

Instruments Associations with Betaine & eGFR
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region Betaine (Shin et al/Long et al) eGFR (CSSCD)
rs1538475(A)/1:187534056 FDPSP1 (0.68, 0.01, P = 2.4e-05, N = 7824) (0.77, 0.036, P = 0.53, N = 859)
rs12569219(A)/1:203762990* ZBED6 (0.16, -0.012, P = 5.8e-06, N = 7824) (0.14, -0.064, P = 0.35, N = 859)
rs650264(T)/1:20911830 CDA (0.097, -0.015, P = 2.1e-05, N = 7824) (0.25, 0.065, P = 0.24, N = 859)
rs943523(A)/1:53947922 intergenic (0.89, -0.014, P = 4.7e-05, N = 7824) (0.44, 0.081, P = 0.094, N = 859)
rs232782(A)/1:59128237* MYSM1 (0.17, 0.011, P = 3e-05, N = 7824) (0.41, -0.026, P = 0.57, N = 859)
rs7896866(A)/10:101339828 intergenic (0.3, 0.011, P = 8.3e-06, N = 7824) (0.42, -0.046, P = 0.35, N = 859)
rs1926205(A)/10:20210789 PLXDC2 (0.029, 0.38, P = 4.9e-06, N = 1958) (0.065, 0.075, P = 0.45, N = 859)
rs7126003(T)/11:10888433* ZBED5-AS1 (0.63, 0.018, P = 2.6e-06, N = 7824) (0.79, 0.013, P = 0.82, N = 859)
rs7931762(A)/11:43197753* HNRNPKP3 (0.84, -0.011, P = 3.6e-05, N = 7824) (0.81, -0.01, P = 0.87, N = 859)
rs11111121(A)/12:102397730 DRAM1 (0.99, -0.066, P = 3.8e-05, N = 7824) (0.95, 0.065, P = 0.57, N = 859)
rs2291918(T)/12:280761 IQSEC3 (0.38, 0.011, P = 1.1e-05, N = 7824) (0.4, 0.052, P = 0.3, N = 859)
rs709217(T)/12:92526809 C12orf79 (0.5, -0.0073, P = 3.8e-05, N = 7824) (0.51, 0.085, P = 0.079, N = 859)
rs8002031(A)/13:113285643* intergenic (0.026, 0.16, P = 7.8e-07, N = 1958) (0.19, -0.0084, P = 0.89, N = 859)
rs9600122(C)/13:73968602 intergenic (0.92, -0.017, P = 4.3e-05, N = 7824) (0.84, -0.035, P = 0.58, N = 859)
rs3861122(T)/13:74076150 LINC00393 (0.16, -0.011, P = 3.4e-05, N = 7824) (0.1, -0.16, P = 0.039, N = 859)
rs16944928(A)/13:91572636 LINC00410 (0.98, -0.037, P = 3.8e-05, N = 7824) (0.86, 0.013, P = 0.85, N = 859)
rs12887798(T)/14:87693931 intergenic (0.19, -0.17, P = 1.9e-06, N = 1958) (0.2, 0.023, P = 0.7, N = 859)
rs17223831(A)/14:90601920 KCNK13 (0.11, 0.014, P = 4.9e-05, N = 7824) (0.072, 0.037, P = 0.7, N = 859)
rs1285777(A)/14:91802285* CCDC88C (0.92, -0.016, P = 1.1e-05, N = 7824) (0.9, 0.0015, P = 0.99, N = 859)
rs8021497(A)/14:93567618* ITPK1 (0.21, 0.019, P = 4.7e-05, N = 7824) (0.45, -0.0079, P = 0.87, N = 859)
rs5814078(GTTGT)/15:81935875 CTD-2034I4.1 (0.49, 0.2, P = 8.8e-06, N = 1958) (0.93, -0.023, P = 0.8, N = 859)
rs6602982(A)/15:84257744* SH3GL3 (0.49, -0.0074, P = 3.4e-05, N = 7824) (0.54, 0.0018, P = 0.97, N = 859)
rs12447365(A)/16:14462949* RP11-65J21.1 (0.21, -0.011, P = 2.9e-05, N = 7824) (0.069, 0.061, P = 0.52, N = 859)
rs10153066(T)/16:7257971* RBFOX1 (0.44, 0.0085, P = 2.1e-06, N = 7824) (0.45, -0.088, P = 0.07, N = 859)
rs984327(A)/16:7772217* SNORA40 (0.71, -0.017, P = 4e-05, N = 7824) (0.56, -0.0077, P = 0.87, N = 859)
rs8059060(A)/16:89191264 ACSF3 (0.89, 0.025, P = 3.5e-05, N = 7824) (0.61, -0.049, P = 0.31, N = 859)
rs4646359(T)/17:17470609* PEMT (0.53, -0.0083, P = 3.2e-06, N = 7824) (0.32, -0.016, P = 0.76, N = 859)
rs2345424(A)/17:71233783 C17orf80 (0.99, -0.079, P = 2.3e-05, N = 7824) (0.8, 0.022, P = 0.71, N = 859)
rs2729411(T)/18:28142042 intergenic (0.24, 0.018, P = 4.9e-05, N = 7824) (0.54, -0.0054, P = 0.91, N = 859)
rs8090293(A)/18:4031916 DLGAP1 (0.53, -0.019, P = 2e-05, N = 7824) (0.52, 0.061, P = 0.2, N = 859)
rs7229475(G)/18:6514018* C18orf64 (0.29, -1, P = 3.4e-06, N = 1958) (0.66, 0.025, P = 0.62, N = 859)
rs7246788(T)/19:18575450* ELL (0.2, 0.011, P = 1.4e-05, N = 7824) (0.22, -0.13, P = 0.024, N = 859)
rs9305014(A)/19:24306763 ZNF254 (0.92, 0.017, P = 4.7e-05, N = 7824) (0.65, 0.072, P = 0.16, N = 859)
rs12151827(T)/2:135673387* CCNT2 (0.82, -0.014, P = 6.3e-08, N = 7824) (0.76, 0.044, P = 0.43, N = 859)
rs724394(A)/2:139854856 intergenic (0.82, -0.011, P = 2e-05, N = 7824) (0.93, 0.09, P = 0.33, N = 859)
rs78989095(A)/2:211534417* CPS1 (0.037, 0.12, P = 4.1e-06, N = 1958) (0.066, -0.096, P = 0.32, N = 859)
rs715(T)/2:211543055* CPS1 (0.71, 0.022, P = 2.1e-19, N = 7824) (0.81, -0.061, P = 0.33, N = 859)
rs11887861(A)/2:211548693* CPS1 (0.34, 0.013, P = 1.4e-07, N = 7824) (0.37, -0.11, P = 0.026, N = 859)
rs13021675(T)/2:211661935* intergenic (0.2, -0.012, P = 1.8e-06, N = 7824) (0.16, -0.072, P = 0.28, N = 859)
rs11685209(T)/2:77658045 LRRTM4 (0.37, -0.016, P = 2.9e-05, N = 7824) (0.51, -0.032, P = 0.5, N = 859)
rs6118048(A)/20:8051081 intergenic (0.16, 0.011, P = 4.5e-05, N = 7824) (0.16, -0.017, P = 0.79, N = 859)
rs8131547(T)/21:44320989 NDUFV3 (0.53, 0.01, P = 1.3e-05, N = 7824) (0.71, -0.0069, P = 0.89, N = 859)
rs2851391(T)/21:44487404* CBS (0.46, -0.012, P = 1.1e-11, N = 7824) (0.24, -0.027, P = 0.63, N = 859)
rs134790(T)/22:27653397* intergenic (0.84, -0.011, P = 1.9e-05, N = 7824) (0.91, -0.17, P = 0.049, N = 859)
rs2227089(T)/22:36645089* APOL1 (0.4, -0.2, P = 3.9e-07, N = 1958) (0.28, 0.0031, P = 0.95, N = 859)
rs16835527(C)/3:124205980 KALRN (0.82, -0.011, P = 1.8e-05, N = 7824) (0.95, 0.1, P = 0.35, N = 859)
rs2700868(T)/3:182440135* intergenic (0.15, 0.26, P = 5.9e-06, N = 1958) (0.2, 0.095, P = 0.11, N = 859)
rs11410898(AT)/3:184771382 VPS8 (0.26, -0.17, P = 8.7e-06, N = 1958) (0.15, 0.022, P = 0.75, N = 859)
rs10937433(C)/3:190177112 intergenic (0.5, 0.008, P = 6.6e-06, N = 7824) (0.68, 0.069, P = 0.18, N = 859)
rs1195362(A)/3:190823801 intergenic (0.95, -0.041, P = 3.4e-05, N = 7824) (0.99, 0.062, P = 0.78, N = 859)
rs7668550(T)/4:104384356* intergenic (0.016, -0.037, P = 5.5e-06, N = 7824) (0.24, -0.064, P = 0.25, N = 859)
rs13104073(T)/4:127695984 intergenic (0.01, -0.087, P = 3.5e-05, N = 7824) (0.069, 0.049, P = 0.61, N = 859)
rs10033669(T)/4:177189004 ASB5 (0.089, 0.017, P = 1.5e-05, N = 7824) (0.08, -0.059, P = 0.51, N = 859)
rs17494639(T)/4:80218062 LINC01088 (0.83, -0.011, P = 3.2e-05, N = 7824) (0.97, 0.21, P = 0.1, N = 859)
rs11943623(A)/4:86554948 ARHGAP24 (0.17, -0.011, P = 8.4e-06, N = 7824) (0.17, -0.11, P = 0.081, N = 859)
rs17481649(T)/5:115305573* AQPEP (0.063, -0.019, P = 1.1e-05, N = 7824) (0.078, 0.063, P = 0.48, N = 859)
rs154555(G)/5:115797852 SEMA6A (0.57, -0.46, P = 1.7e-06, N = 1958) (0.26, -0.052, P = 0.34, N = 859)
rs4476723(T)/5:11796865* CTNND2 (0.98, -0.16, P = 5.7e-06, N = 1958) (0.63, -0.081, P = 0.11, N = 859)
rs34199803(CTT)/5:122043333 RP11-166A12.1 (0.014, -0.9, P = 7.9e-07, N = 1958) (0.48, 0.024, P = 0.62, N = 859)
rs164372(T)/5:160621043 intergenic (0.8, 0.012, P = 2.6e-06, N = 7824) (0.63, -0.022, P = 0.66, N = 859)
rs2319470(A)/5:24532664 CDH10 (0.51, -0.0074, P = 3.3e-05, N = 7824) (0.29, -0.046, P = 0.39, N = 859)
rs3797248(A)/5:53509186* ARL15 (0.17, 0.012, P = 4.6e-06, N = 7824) (0.1, -0.086, P = 0.29, N = 859)
rs6862283(T)/5:78319638* DMGDH (0.7, 0.019, P = 7.9e-16, N = 7824) (0.34, 0.043, P = 0.4, N = 859)
rs16876394(T)/5:78346769* DMGDH (0.9, 0.03, P = 1.5e-19, N = 7824) (0.91, -0.064, P = 0.44, N = 859)
rs16876498(T)/5:78402594* DMGDH (0.9, 0.03, P = 2.5e-19, N = 7824) (0.89, 0.00093, P = 0.99, N = 859)
rs1275103(C)/5:78448105* DMGDH (0.61, -0.015, P = 6.8e-11, N = 7824) (0.35, -0.051, P = 0.31, N = 859)
rs17206977(A)/5:85387218 PTP4A1P4 (0.92, -0.017, P = 2.9e-05, N = 7824) (0.97, -0.052, P = 0.69, N = 859)
rs7763624(A)/6:157418960 ARID1B (0.56, -0.2, P = 5e-06, N = 1958) (0.53, 0.013, P = 0.79, N = 859)
rs9457843(T)/6:160560933* SLC22A1 (0.12, 0.015, P = 1.1e-05, N = 7824) (0.14, 0.016, P = 0.82, N = 859)
rs662138(C)/6:160564476* SLC22A1 (0.83, 0.011, P = 1.3e-05, N = 7824) (0.95, 0.099, P = 0.35, N = 859)
rs203887(T)/6:28021269 OR2B8P (0.23, -0.011, P = 2.3e-05, N = 7824) (0.39, -0.016, P = 0.75, N = 859)
rs1535039(T)/6:29411432* OR11A1 (0.91, 0.018, P = 4.5e-07, N = 7824) (0.99, 0.16, P = 0.45, N = 859)
rs7751856(A)/6:32698988* HLA-DQB3 (0.52, 0.0074, P = 3.7e-05, N = 7824) (0.31, 0.051, P = 0.33, N = 859)
rs9462856(T)/6:42926024* GNMT (0.47, -0.0093, P = 2e-07, N = 7824) (0.14, -0.089, P = 0.19, N = 859)
rs4327704(A)/6:57920632 intergenic (0.95, -0.022, P = 9.9e-06, N = 7824) (0.98, -0.15, P = 0.36, N = 859)
rs410300(G)/6:9030949 intergenic (0.25, -0.23, P = 8.3e-06, N = 1958) (0.18, 0.038, P = 0.53, N = 859)
rs9445037(T)/6:93587599* intergenic (0.53, -0.0077, P = 1.7e-05, N = 7824) (0.16, -0.1, P = 0.12, N = 859)
rs2396726(T)/7:114021410 FOXP2 (0.54, -0.018, P = 4.5e-06, N = 7824) (0.21, 0.04, P = 0.5, N = 859)
rs7781104(T)/7:145158487 intergenic (0.27, 0.021, P = 7.8e-06, N = 7824) (0.51, 0.035, P = 0.46, N = 859)
rs2304396(C)/8:131833823* ADCY8 (0.083, 0.26, P = 4e-06, N = 1958) (0.092, -0.012, P = 0.88, N = 859)
rs2705084(A)/8:17386831* SLC7A2 (0.44, 0.0073, P = 4e-05, N = 7824) (0.62, -0.012, P = 0.81, N = 859)
rs7822571(T)/8:40576179* ZMAT4 (0.46, -0.0074, P = 3.1e-05, N = 7824) (0.4, -0.057, P = 0.25, N = 859)
rs9886534(T)/8:40676655* ZMAT4 (0.51, -0.0079, P = 8.7e-06, N = 7824) (0.29, 0.0047, P = 0.93, N = 859)
rs12708158(T)/8:54835697 RGS20 (0.91, 0.026, P = 4.3e-05, N = 7824) (0.97, 0.14, P = 0.37, N = 859)
rs523224(T)/8:93522691* RP11-587H10.1 (0.19, -0.011, P = 2.2e-05, N = 7824) (0.042, -0.14, P = 0.26, N = 859)
rs1545203(T)/9:112119690* intergenic (0.081, -0.017, P = 3.1e-05, N = 7824) (0.022, -0.26, P = 0.12, N = 859)
rs2249768(A)/9:24542184 IZUMO3 (0.3, 0.19, P = 7.7e-06, N = 1958) (0.31, 0.019, P = 0.71, N = 859)
rs13292748(C)/9:8727087 PTPRD (0.14, -0.21, P = 9.9e-06, N = 1958) (0.026, -0.084, P = 0.58, N = 859)
Results from Univariable Mendelian Randomization of Betaine & eGFR - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 88 -0.0034 (-0.064- 0.058) P=0.91 23 71 3.69e-05 (0- 96.4) NA NA 0.0026 P=0.72
MR-Egger 88 -0.0085 (-0.077- 0.06) P=0.81 23 71 3.69e-05 (0- 96.4) 82 0.6 0.0026 P=0.72
Weighted median 88 -0.026 (-0.11- 0.058) P=0.55 23 71 3.69e-05 (0- 96.4) NA NA 0.0026 P=0.72
Results from Univariable MRPRESSO of Betaine & eGFR - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0 0.03 -0.11 0.91
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of Betaine & eGFR - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 45 -0.0076 (-0.088- 0.073) P=0.85 11 24 0.00206 (0- 96.3) NA NA -0.0026 P=0.8
MR-Egger 45 -0.002 (-0.1- 0.096) P=0.97 11 24 0.00206 (0- 96.3) 37 0.74 -0.0026 P=0.8
Weighted median 45 -0.013 (-0.14- 0.12) P=0.85 11 24 0.00206 (0- 96.3) NA NA -0.0026 P=0.8
Results from Univariable MRPRESSO of Betaine & eGFR - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.01 0.04 -0.19 0.85
beta.exposure Outlier-corrected NA NA NA NA

L-Carnitine

Instruments Associations with L-Carnitine & eGFR
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region L-Carnitine (Shin et al/Long et al) eGFR (CSSCD)
rs12725366(A)/1:105904171 intergenic (0.48, -0.0041, P = 5.5e-06, N = 7824) (0.37, 0.031, P = 0.53, N = 859)
rs3754439(A)/1:110615094 ALX3 (0.4, -0.0066, P = 2.3e-13, N = 7824) (0.26, -0.02, P = 0.72, N = 859)
rs1466788(A)/1:110618730 STRIP1 (0.41, -0.0074, P = 3.1e-16, N = 7824) (0.3, -0.013, P = 0.8, N = 859)
rs17032183(A)/1:114603297 intergenic (0.096, -0.0071, P = 3.9e-05, N = 7824) (0.21, 0.044, P = 0.45, N = 859)
rs61810757(C)/1:115846181 NGF (0.81, -0.24, P = 8.8e-06, N = 1954) (0.91, -0.0089, P = 0.92, N = 859)
rs17370344(A)/1:164263810 intergenic (0.64, -0.0047, P = 1.7e-07, N = 7824) (0.84, 0.12, P = 0.082, N = 859)
rs4534357(A)/1:168167139 TIPRL (0.84, 0.0069, P = 1.8e-05, N = 7824) (0.61, 0.03, P = 0.56, N = 859)
rs17613936(T)/1:193938169 intergenic (0.16, 0.19, P = 8.2e-06, N = 1954) (0.027, 0.064, P = 0.66, N = 859)
rs10920115(T)/1:201071884 CACNA1S (0.55, 0.0044, P = 1.6e-06, N = 7824) (0.34, 0.0011, P = 0.98, N = 859)
rs10800765(T)/1:201216597 intergenic (0.46, -0.0039, P = 1.8e-05, N = 7824) (0.12, -0.074, P = 0.31, N = 859)
rs7551550(A)/1:20437764 PLA2G2D (0.47, -0.004, P = 1.1e-05, N = 7824) (0.66, -0.02, P = 0.69, N = 859)
rs12722987(A)/1:20455220* intergenic (0.13, -0.0071, P = 1.7e-05, N = 7824) (0.18, 0.024, P = 0.71, N = 859)
rs1762470(T)/1:208423850* RP11-2P2.1 (0.55, 0.0037, P = 4.1e-05, N = 7824) (0.81, 0.022, P = 0.72, N = 859)
rs1999890(A)/1:210510894 HHAT (0.5, 0.004, P = 1e-05, N = 7824) (0.21, -0.012, P = 0.85, N = 859)
rs2165993(A)/1:211730036 intergenic (0.47, -0.004, P = 1.5e-05, N = 7824) (0.18, 0.0019, P = 0.98, N = 859)
rs4638188(T)/1:212045896 intergenic (0.47, -0.0037, P = 4.2e-05, N = 7824) (0.16, 0.046, P = 0.48, N = 859)
rs2492788(T)/1:212844187* intergenic (0.55, 0.0049, P = 4.6e-08, N = 7824) (0.75, 0.076, P = 0.17, N = 859)
rs1910488(T)/1:213524165 intergenic (0.6, 0.0037, P = 4.1e-05, N = 7824) (0.34, 0.081, P = 0.12, N = 859)
rs4504898(T)/1:221831403* intergenic (0.39, -0.0041, P = 7e-06, N = 7824) (0.48, 0.03, P = 0.53, N = 859)
rs309517(A)/1:23251592 RP1-74M1.3 (0.62, -1.1, P = 4.8e-06, N = 1954) (0.77, -0.027, P = 0.64, N = 859)
rs6426779(T)/1:23310485 intergenic (0.49, -0.0039, P = 1.3e-05, N = 7824) (0.67, 0.04, P = 0.44, N = 859)
rs10802528(T)/1:236506815 EDARADD (0.45, -0.0047, P = 2e-07, N = 7824) (0.62, -0.046, P = 0.36, N = 859)
rs12128699(C)/1:238258461 intergenic (0.65, -0.24, P = 5.5e-06, N = 1954) (0.37, -0.023, P = 0.64, N = 859)
rs259615(C)/1:238433753 RP11-136B18.1 (0.66, 0.16, P = 2.8e-06, N = 1954) (0.95, 0.23, P = 0.036, N = 859)
rs879067(T)/1:244392816* intergenic (0.44, 0.004, P = 7.5e-06, N = 7824) (0.5, -0.029, P = 0.55, N = 859)
rs1507101(A)/1:25251326* RUNX3 (0.57, 0.004, P = 9.6e-06, N = 7824) (0.28, 0.12, P = 0.031, N = 859)
rs3480(A)/1:33328165 S100PBP (0.6, 0.0037, P = 4.4e-05, N = 7824) (0.49, 0.033, P = 0.49, N = 859)
rs2359233(A)/1:34770104 intergenic (0.37, 0.0038, P = 2.9e-05, N = 7824) (0.7, -0.084, P = 0.12, N = 859)
rs10890169(T)/1:42392584 HIVEP3 (0.53, 0.0038, P = 2.9e-05, N = 7824) (0.61, 0.068, P = 0.17, N = 859)
rs778423(C)/1:56656812 intergenic (0.53, -0.0043, P = 2.3e-06, N = 7824) (0.21, 0.047, P = 0.43, N = 859)
rs844072(T)/1:64755056 intergenic (0.44, -0.85, P = 4.2e-06, N = 1954) (0.68, 0.011, P = 0.82, N = 859)
rs1034251(A)/1:64905833 intergenic (0.34, -0.24, P = 5.2e-06, N = 1954) (0.15, 0.0097, P = 0.88, N = 859)
rs17127807(A)/1:66088370* LEPR (0.99, 0.036, P = 4.8e-05, N = 7824) (0.86, -0.037, P = 0.59, N = 859)
rs12135162(T)/1:91905203 intergenic (0.62, 0.0037, P = 4e-05, N = 7824) (0.52, -0.012, P = 0.8, N = 859)
rs12744011(A)/1:92086966 intergenic (0.48, -0.0039, P = 2.3e-05, N = 7824) (0.74, -0.029, P = 0.6, N = 859)
rs11589858(T)/1:92786742 RPAP2 (0.36, -0.0041, P = 5.3e-06, N = 7824) (0.12, -0.058, P = 0.44, N = 859)
rs10875102(A)/1:98159558 DPYD (0.54, -0.0042, P = 4.6e-06, N = 7824) (0.18, -0.049, P = 0.43, N = 859)
rs10883890(C)/10:105390021 SH3PXD2A (0.45, 0.0046, P = 4.3e-07, N = 7824) (0.43, -0.051, P = 0.31, N = 859)
rs4284335(A)/10:109888793 intergenic (0.41, -0.0046, P = 3.5e-07, N = 7824) (0.75, -0.08, P = 0.15, N = 859)
rs4451642(A)/10:113111516 RP11-381K7.1 (0.11, 0.0071, P = 4e-05, N = 7824) (0.083, -0.022, P = 0.8, N = 859)
rs2254426(A)/10:119683609 intergenic (0.4, 0.0037, P = 3.9e-05, N = 7824) (0.44, -0.011, P = 0.82, N = 859)
rs1929667(T)/10:121966798 intergenic (0.99, -0.2, P = 2.1e-06, N = 1954) (0.71, -0.15, P = 0.0041, N = 859)
rs10749365(C)/10:122005859 intergenic (0.99, 0.42, P = 1e-06, N = 1954) (0.92, -0.17, P = 0.05, N = 859)
rs11257841(T)/10:12550970 CAMK1D (0.56, -0.0039, P = 1.3e-05, N = 7824) (0.67, 0.074, P = 0.15, N = 859)
rs4929820(A)/10:125828819* CHST15 (0.34, -0.0039, P = 1.4e-05, N = 7824) (0.3, -0.021, P = 0.69, N = 859)
rs4531372(A)/10:128257882 C10orf90 (0.43, -0.0045, P = 7.1e-07, N = 7824) (0.13, 0.0096, P = 0.89, N = 859)
rs2225978(A)/10:130286830* intergenic (0.52, -0.004, P = 9.1e-06, N = 7824) (0.75, 0.02, P = 0.72, N = 859)
rs2767290(A)/10:130470565 intergenic (0.35, 0.004, P = 8.3e-06, N = 7824) (0.44, -0.032, P = 0.5, N = 859)
rs6602640(T)/10:13227604 MCM10 (0.88, 0.008, P = 2.5e-06, N = 7824) (0.77, -0.063, P = 0.27, N = 859)
rs12245254(T)/10:132500555* intergenic (0.44, 0.0043, P = 1.9e-06, N = 7824) (0.29, 0.14, P = 0.01, N = 859)
rs3810964(A)/10:135000159 KNDC1 (0.53, -0.0038, P = 2.4e-05, N = 7824) (0.85, -0.007, P = 0.92, N = 859)
rs1218444(T)/10:14368831 FRMD4A (0.86, 0.2, P = 9e-06, N = 1954) (0.82, 0.049, P = 0.42, N = 859)
rs10828408(A)/10:23372303 intergenic (0.6, -0.0037, P = 4.9e-05, N = 7824) (0.63, -0.037, P = 0.47, N = 859)
rs377294850(TA)/10:24441655 KIAA1217 (0.089, -0.55, P = 7.8e-06, N = 1954) (0.85, 0.0016, P = 0.98, N = 859)
rs9419445(T)/10:2529326 intergenic (0.53, 0.0042, P = 3.5e-06, N = 7824) (0.8, 0.063, P = 0.29, N = 859)
rs645838(A)/10:3560515 intergenic (0.13, 0.0067, P = 4.9e-05, N = 7824) (0.16, 0.038, P = 0.57, N = 859)
rs12246131(A)/10:45993782* MARCH8 (0.78, 0.008, P = 2.4e-07, N = 7824) (0.79, 0.11, P = 0.058, N = 859)
rs4319434(A)/10:50345140 FAM170B (0.4, 0.0037, P = 3.7e-05, N = 7824) (0.091, -0.011, P = 0.89, N = 859)
rs6481417(A)/10:60405788 BICC1 (0.97, -0.18, P = 5.4e-06, N = 1954) (0.96, 0.035, P = 0.78, N = 859)
rs1981138(T)/10:61303642 intergenic (0.43, 0.0046, P = 3.3e-07, N = 7824) (0.8, 0.14, P = 0.022, N = 859)
rs12356193(A)/10:61413353* SLC16A9 (0.84, 0.027, P = 3.7e-63, N = 7824) (0.92, 0.016, P = 0.86, N = 859)
rs2242206(T)/10:61414011* SLC16A9 (0.26, 0.012, P = 4.7e-16, N = 7824) (0.09, 0.076, P = 0.36, N = 859)
rs1171610(T)/10:61477697* SLC16A9 (0.62, 0.0081, P = 2.5e-19, N = 7824) (0.54, 0.0046, P = 0.93, N = 859)
rs6479648(A)/10:61510559* LINC00948 (0.42, -0.0087, P = 8.4e-22, N = 7824) (0.57, 0.018, P = 0.72, N = 859)
rs10994097(A)/10:61730651 intergenic (0.48, -0.0038, P = 2.4e-05, N = 7824) (0.28, -0.076, P = 0.15, N = 859)
rs2394298(A)/10:68462751* CTNNA3 (0.59, 0.0047, P = 1.5e-07, N = 7824) (0.65, 0.048, P = 0.34, N = 859)
rs1925611(A)/10:68756918 CTNNA3 (0.47, -0.0048, P = 2e-07, N = 7824) (0.66, -0.016, P = 0.75, N = 859)
rs2762613(T)/10:7225045 SFMBT2 (0.61, -0.0037, P = 4e-05, N = 7824) (0.72, -0.027, P = 0.61, N = 859)
rs9415053(C)/10:73575910 CDH23 (0.47, -0.0042, P = 2.8e-06, N = 7824) (0.28, 0.059, P = 0.27, N = 859)
rs11596100(A)/10:78612153 intergenic (0.4, 0.0039, P = 2.2e-05, N = 7824) (0.21, -0.049, P = 0.39, N = 859)
rs4881523(T)/10:801945 intergenic (0.54, 0.0045, P = 6e-07, N = 7824) (0.82, -0.0069, P = 0.92, N = 859)
rs478982(A)/10:84585708 NRG3 (0.34, 0.004, P = 9.1e-06, N = 7824) (0.52, -0.017, P = 0.73, N = 859)
rs11253451(T)/10:852885 LARP4B (0.42, 0.004, P = 1.3e-05, N = 7824) (0.17, 0.076, P = 0.22, N = 859)
rs1936602(T)/10:92445253 intergenic (0.42, 0.0043, P = 2.5e-06, N = 7824) (0.71, -0.0022, P = 0.97, N = 859)
rs6583992(T)/10:97086735* SORBS1 (0.52, -0.0038, P = 2.5e-05, N = 7824) (0.34, 0.052, P = 0.3, N = 859)
rs11601438(A)/11:101955932 C11orf70 (0.39, -0.0042, P = 2.9e-06, N = 7824) (0.48, -9e-04, P = 0.98, N = 859)
rs470747(A)/11:102661595 MMP1 (0.64, 0.0038, P = 2.8e-05, N = 7824) (0.65, -0.023, P = 0.65, N = 859)
rs4075679(T)/11:11318921 GALNT18 (0.56, -0.0037, P = 3.7e-05, N = 7824) (0.67, -0.042, P = 0.42, N = 859)
rs10789970(T)/11:113773946* HTR3B (0.41, -0.0041, P = 6.6e-06, N = 7824) (0.64, -0.054, P = 0.3, N = 859)
rs2702023(C)/11:125465020 STT3A (0.4, 0.0045, P = 8.6e-07, N = 7824) (0.7, 0.046, P = 0.38, N = 859)
rs4937076(A)/11:125826702* CDON (0.53, 0.0039, P = 1.6e-05, N = 7824) (0.37, 0.023, P = 0.65, N = 859)
rs11022568(A)/11:12966883 TEAD1 (0.36, 0.0039, P = 1.5e-05, N = 7824) (0.5, -0.065, P = 0.19, N = 859)
rs923075(T)/11:130311545 intergenic (0.61, -0.0041, P = 4.8e-06, N = 7824) (0.34, -0.06, P = 0.26, N = 859)
rs11223211(A)/11:132663965* OPCML (0.47, 0.0047, P = 1.7e-07, N = 7824) (0.42, 0.0076, P = 0.87, N = 859)
rs2793471(T)/11:29387798 RP11-460B17.3 (0.57, 0.0041, P = 7.2e-06, N = 7824) (0.82, 0.064, P = 0.31, N = 859)
rs2295756(T)/11:35241229 CD44 (0.65, -0.0038, P = 3.3e-05, N = 7824) (0.76, 0.0011, P = 0.98, N = 859)
rs11033087(T)/11:35374044 SLC1A2 (0.39, 0.0038, P = 3.4e-05, N = 7824) (0.36, -0.031, P = 0.54, N = 859)
rs10501155(A)/11:36445197 PRR5L (0.64, -0.0038, P = 4e-05, N = 7824) (0.57, -0.058, P = 0.25, N = 859)
rs12283045(A)/11:39593279 intergenic (0.023, -0.03, P = 3.6e-05, N = 7824) (0.026, -0.1, P = 0.52, N = 859)
rs4313557(A)/11:39601993 intergenic (0.98, 0.03, P = 3.3e-05, N = 7824) (0.88, -0.072, P = 0.33, N = 859)
rs2595993(A)/11:4964627* MMP26 (0.5, -0.0042, P = 2.9e-06, N = 7824) (0.67, 0.053, P = 0.29, N = 859)
rs7940551(T)/11:60592783 RP11-804A23.1 (0.44, -0.004, P = 8.3e-06, N = 7824) (0.57, 0.055, P = 0.26, N = 859)
rs561895(T)/11:64602757 CDC42BPG (0.66, -0.0042, P = 6.6e-06, N = 7824) (0.39, -0.024, P = 0.63, N = 859)
rs2009453(T)/11:65399528 PCNXL3 (0.56, 0.0038, P = 2.5e-05, N = 7824) (0.4, -0.012, P = 0.81, N = 859)
rs2170082(A)/11:65454795* intergenic (0.52, -0.0047, P = 2.2e-07, N = 7824) (0.39, -0.013, P = 0.79, N = 859)
rs4078258(T)/11:7542298* PPFIBP2 (0.63, -0.0041, P = 6.1e-06, N = 7824) (0.9, 0.076, P = 0.34, N = 859)
rs575929(T)/11:78888265* TENM4 (0.63, 0.0039, P = 1.3e-05, N = 7824) (0.86, 0.014, P = 0.84, N = 859)
rs2508305(T)/11:86410402 CTD-2005H7.1 (0.89, -0.0079, P = 4.1e-06, N = 7824) (0.85, -0.031, P = 0.65, N = 859)
rs12417365(T)/11:93903770 PANX1 (0.52, -0.004, P = 7.8e-06, N = 7824) (0.52, -0.0053, P = 0.91, N = 859)
rs1541301(T)/11:93926656 RP11-680H20.1 (0.41, -0.0037, P = 3.6e-05, N = 7824) (0.51, 0.032, P = 0.51, N = 859)
rs10840262(C)/11:9589840 intergenic (0.52, 0.0041, P = 3.4e-06, N = 7824) (0.74, -0.12, P = 0.035, N = 859)
rs7929841(T)/11:96195715* JRKL-AS1 (0.65, 0.0043, P = 2.1e-06, N = 7824) (0.47, 0.03, P = 0.54, N = 859)
rs996408(T)/12:100051003 ANKS1B (0.52, -0.0046, P = 3.7e-07, N = 7824) (0.75, 0.088, P = 0.12, N = 859)
rs844016(T)/12:101592689* SLC5A8 (0.58, 0.0047, P = 2.2e-07, N = 7824) (0.44, -0.031, P = 0.53, N = 859)
rs7956795(T)/12:107536076 intergenic (0.63, 0.0037, P = 3.2e-05, N = 7824) (0.51, 0.013, P = 0.79, N = 859)
rs11066777(T)/12:109478352 USP30 (0.14, -0.007, P = 1.4e-05, N = 7824) (0.034, -0.052, P = 0.7, N = 859)
rs2062713(T)/12:115176552 RP4-601P9.2 (0.47, -0.0038, P = 2.7e-05, N = 7824) (0.24, 0.0066, P = 0.91, N = 859)
rs1391715(T)/12:115821235 intergenic (0.59, -0.0037, P = 3.7e-05, N = 7824) (0.66, -0.066, P = 0.19, N = 859)
rs514826(A)/12:118809303* TAOK3 (0.34, 0.0038, P = 3.5e-05, N = 7824) (0.27, 0.017, P = 0.75, N = 859)
rs10734956(A)/12:128653360 intergenic (0.034, -0.018, P = 2e-05, N = 7824) (0.11, 0.11, P = 0.14, N = 859)
rs12370755(A)/12:16664330 RP11-424M22.1 (0.49, -0.0039, P = 1.5e-05, N = 7824) (0.8, -0.027, P = 0.65, N = 859)
rs4764292(T)/12:16937829 RP11-239A17.1 (0.58, 0.0044, P = 9.8e-07, N = 7824) (0.48, -0.077, P = 0.11, N = 859)
rs4931109(T)/12:29005992* intergenic (0.097, -0.0072, P = 3.5e-05, N = 7824) (0.16, 0.073, P = 0.28, N = 859)
rs12825454(T)/12:29296989* RP11-946L16.1 (0.95, 0.02, P = 1.2e-05, N = 7824) (0.99, 0.024, P = 0.91, N = 859)
rs11052839(C)/12:33836056 intergenic (0.4, 0.0037, P = 3.9e-05, N = 7824) (0.61, -1e-04, P = 1, N = 859)
rs1449844(C)/12:39521446 intergenic (0.4, -0.0048, P = 9.2e-08, N = 7824) (0.51, -0.03, P = 0.53, N = 859)
rs11183620(A)/12:47212370* SLC38A4 (0.47, 0.005, P = 3e-08, N = 7824) (0.8, -0.00048, P = 0.99, N = 859)
rs3825192(A)/12:54778823 ZNF385A (0.56, -0.0038, P = 2.8e-05, N = 7824) (0.22, 0.0063, P = 0.91, N = 859)
rs1716342(A)/12:54998214 GLYCAM1 (0.34, -0.0092, P = 2.6e-05, N = 7824) (0.42, -0.075, P = 0.12, N = 859)
rs10876579(T)/12:55051647 intergenic (0.51, 0.0037, P = 3.9e-05, N = 7824) (0.32, 0.026, P = 0.62, N = 859)
rs10784558(T)/12:67003883 GRIP1 (0.48, -0.0048, P = 1.1e-07, N = 7824) (0.72, 0.11, P = 0.04, N = 859)
rs6581712(A)/12:67066139 GRIP1 (0.61, 0.0043, P = 2.5e-06, N = 7824) (0.89, -0.13, P = 0.09, N = 859)
rs1144963(T)/12:69335625 CPM (0.56, -0.0046, P = 2.5e-07, N = 7824) (0.86, -0.053, P = 0.44, N = 859)
rs10784751(A)/12:69447462 intergenic (0.51, 0.004, P = 9.3e-06, N = 7824) (0.62, -0.0065, P = 0.9, N = 859)
rs10772367(C)/12:7278538 RBP5 (0.6, -0.004, P = 8.6e-06, N = 7824) (0.68, 0.021, P = 0.68, N = 859)
rs6539588(T)/12:82269057* intergenic (0.39, 0.0043, P = 1.9e-06, N = 7824) (0.23, 0.011, P = 0.85, N = 859)
rs7961308(T)/12:82404500 intergenic (0.65, 0.0039, P = 1.4e-05, N = 7824) (0.73, 0.028, P = 0.6, N = 859)
rs9651972(A)/12:83861845* intergenic (0.54, -0.0037, P = 4e-05, N = 7824) (0.53, 0.047, P = 0.33, N = 859)
rs36110904(G)/13:101621161 NALCN-AS1 (0.12, -0.55, P = 8e-06, N = 1954) (0.075, -0.024, P = 0.8, N = 859)
rs9557806(A)/13:102762742 FGF14 (0.55, -0.0042, P = 2.4e-06, N = 7824) (0.16, 0.018, P = 0.78, N = 859)
rs7981434(T)/13:105494343 intergenic (0.13, -0.0072, P = 1.4e-05, N = 7824) (0.14, -0.07, P = 0.32, N = 859)
rs1771142(T)/13:108581825 intergenic (0.94, 0.01, P = 4.2e-05, N = 7824) (0.83, 0.059, P = 0.36, N = 859)
rs1223979(A)/13:108775403 intergenic (0.34, 0.0039, P = 2.4e-05, N = 7824) (0.26, -0.086, P = 0.11, N = 859)
rs7334548(A)/13:20131135 MRPS31P2 (0.1, -0.007, P = 3.5e-05, N = 7824) (0.18, 0.025, P = 0.68, N = 859)
rs7331418(T)/13:20880993* intergenic (0.49, -0.0037, P = 3.3e-05, N = 7824) (0.24, 0.046, P = 0.42, N = 859)
rs9578362(T)/13:21882381 LINC00422 (0.42, 0.0037, P = 4.2e-05, N = 7824) (0.35, -0.0048, P = 0.92, N = 859)
rs9552478(T)/13:22306355* intergenic (0.41, 0.0037, P = 4.9e-05, N = 7824) (0.38, 0.13, P = 0.011, N = 859)
rs2133813(T)/13:27199422 WASF3 (0.44, 0.0041, P = 9.5e-06, N = 7824) (0.75, -0.056, P = 0.31, N = 859)
rs4769648(T)/13:29518969 intergenic (0.54, -0.0041, P = 2e-05, N = 7824) (0.86, 0.096, P = 0.17, N = 859)
rs9508555(C)/13:30372036 UBL3 (0.6, 0.004, P = 1.2e-05, N = 7824) (0.34, 0.055, P = 0.29, N = 859)
rs7325107(A)/13:31513425 TEX26 (0.65, -0.0037, P = 4.6e-05, N = 7824) (0.55, 0.088, P = 0.071, N = 859)
rs10507402(C)/13:31859378 B3GALTL (0.061, 0.0099, P = 4.3e-05, N = 7824) (0.013, -0.14, P = 0.51, N = 859)
rs1869800(T)/13:32180136 intergenic (0.51, -0.004, P = 1e-05, N = 7824) (0.25, 0.0026, P = 0.96, N = 859)
rs7991989(T)/13:37947132 intergenic (0.61, 0.0041, P = 4.3e-06, N = 7824) (0.58, -0.12, P = 0.018, N = 859)
rs11618539(T)/13:39470388 intergenic (0.34, -0.0038, P = 2.9e-05, N = 7824) (0.21, -0.1, P = 0.095, N = 859)
rs238340(A)/13:42821270 DGKH (0.57, -0.0042, P = 4.8e-06, N = 7824) (0.77, 0.021, P = 0.72, N = 859)
rs2260128(A)/13:51301137 DLEU7 (0.5, 0.0039, P = 2.3e-05, N = 7824) (0.14, 0.061, P = 0.39, N = 859)
rs1326095(T)/13:59921558 intergenic (0.6, -0.0038, P = 2.8e-05, N = 7824) (0.57, -0.0073, P = 0.89, N = 859)
rs3127274(T)/13:61757866 intergenic (0.42, 0.0043, P = 2.1e-06, N = 7824) (0.75, -0.045, P = 0.42, N = 859)
rs3128061(T)/13:62843923 intergenic (0.4, -0.0049, P = 5.7e-08, N = 7824) (0.65, 0.05, P = 0.32, N = 859)
rs1537385(T)/13:73655521 KLF5 (0.96, 0.032, P = 1.2e-06, N = 7824) (0.82, -0.06, P = 0.34, N = 859)
rs9318214(T)/13:74344393 KLF12 (0.6, -0.0039, P = 1.8e-05, N = 7824) (0.57, -0.016, P = 0.73, N = 859)
rs9530362(T)/13:75230797 intergenic (0.57, -0.0044, P = 1.2e-06, N = 7824) (0.49, 0.06, P = 0.22, N = 859)
rs9530483(C)/13:76460888 C13orf45 (0.56, -0.0039, P = 1.5e-05, N = 7824) (0.2, 0.1, P = 0.083, N = 859)
rs12427799(T)/13:76469472 intergenic (0.33, -0.0038, P = 3.4e-05, N = 7824) (0.34, 0.043, P = 0.4, N = 859)
rs17065231(T)/13:76478084 intergenic (0.094, -0.0092, P = 7.2e-08, N = 7824) (0.19, -0.055, P = 0.37, N = 859)
rs2000364(T)/13:83157116 intergenic (0.63, 0.0041, P = 5.7e-06, N = 7824) (0.54, -0.029, P = 0.54, N = 859)
rs2390038(A)/13:98960113 FARP1 (0.52, 0.004, P = 1.9e-05, N = 7824) (0.66, 0.0044, P = 0.93, N = 859)
rs2297732(A)/14:20781361 CCNB1IP1 (0.39, -0.0039, P = 1.9e-05, N = 7824) (0.59, 0.067, P = 0.17, N = 859)
rs1760903(A)/14:20852817* TEP1 (0.44, -0.0045, P = 1e-06, N = 7824) (0.76, 0.078, P = 0.17, N = 859)
rs2204941(T)/14:22364012 TRAV8-4 (0.37, -0.0039, P = 1.6e-05, N = 7824) (0.56, 0.028, P = 0.56, N = 859)
rs979027(A)/14:22488509 intergenic (0.36, -0.0039, P = 1.7e-05, N = 7824) (0.65, 0.059, P = 0.24, N = 859)
rs12891757(C)/14:24758467 DHRS1 (0.5, -0.13, P = 2.1e-06, N = 1954) (0.25, -0.12, P = 0.035, N = 859)
rs11159415(A)/14:26098033 intergenic (0.39, -0.0039, P = 1.9e-05, N = 7824) (0.3, 0.08, P = 0.14, N = 859)
rs10136635(A)/14:26567277* RP11-314P15.2 (0.55, 0.0041, P = 6e-06, N = 7824) (0.57, -0.033, P = 0.51, N = 859)
rs2807822(T)/14:28484921 intergenic (0.45, -0.0039, P = 1.7e-05, N = 7824) (0.27, 0.0084, P = 0.88, N = 859)
rs11844637(T)/14:30023621 intergenic (0.53, -0.0036, P = 5e-05, N = 7824) (0.64, 0.013, P = 0.79, N = 859)
rs4981891(A)/14:32193959 NUBPL (0.37, 0.0037, P = 3.5e-05, N = 7824) (0.68, 0.093, P = 0.07, N = 859)
rs10147032(A)/14:34395888 EGLN3 (0.52, 0.0038, P = 2.1e-05, N = 7824) (0.44, -0.053, P = 0.28, N = 859)
rs17557823(T)/14:38628997 CTD-2058B24.2 (0.64, -0.0037, P = 3.9e-05, N = 7824) (0.89, -0.0056, P = 0.94, N = 859)
rs2022681(A)/14:48147028 MDGA2 (0.52, -0.0039, P = 1.9e-05, N = 7824) (0.45, 0.064, P = 0.19, N = 859)
rs4901008(A)/14:50737669* L2HGDH (0.55, -0.0039, P = 1.6e-05, N = 7824) (0.77, -0.017, P = 0.77, N = 859)
rs10130689(T)/14:51391471 PYGL (0.16, -0.0075, P = 5e-06, N = 7824) (0.064, -0.092, P = 0.34, N = 859)
rs10131515(A)/14:59315152 RP11-112J1.2 (0.86, 0.0072, P = 3.1e-05, N = 7824) (0.82, 0.026, P = 0.68, N = 859)
rs1256061(T)/14:64703593* ESR2 (0.47, -0.0038, P = 3.1e-05, N = 7824) (0.33, 0.062, P = 0.23, N = 859)
rs11620955(A)/14:65491255* FNTB (0.48, -0.0051, P = 1.6e-08, N = 7824) (0.29, -0.016, P = 0.76, N = 859)
rs2526920(A)/14:73101727 DPF3 (0.44, 0.0039, P = 1.7e-05, N = 7824) (0.37, -0.05, P = 0.32, N = 859)
rs740974(A)/14:73188074 DPF3 (0.64, -0.0038, P = 3.3e-05, N = 7824) (0.86, -0.0062, P = 0.93, N = 859)
rs6637(T)/14:77801431 TMED8 (0.62, -0.0038, P = 3.8e-05, N = 7824) (0.86, -0.057, P = 0.42, N = 859)
rs2210185(T)/14:84438761* intergenic (0.53, -0.0039, P = 1.8e-05, N = 7824) (0.54, -0.041, P = 0.39, N = 859)
rs4643242(A)/14:84831048 intergenic (0.47, -0.0038, P = 2.7e-05, N = 7824) (0.61, 0.048, P = 0.3, N = 859)
rs2474028(T)/14:92403660* FBLN5 (0.36, 0.0037, P = 4.5e-05, N = 7824) (0.27, -0.042, P = 0.44, N = 859)
rs11620973(A)/14:96018052 intergenic (0.63, -0.0051, P = 2.3e-08, N = 7824) (0.61, -0.0076, P = 0.88, N = 859)
rs11630130(A)/15:26000551* ATP10A (0.14, 0.0092, P = 5.8e-06, N = 7824) (0.26, 0.043, P = 0.44, N = 859)
rs11070560(A)/15:47256943* intergenic (0.34, -0.0039, P = 1.6e-05, N = 7824) (0.29, -0.032, P = 0.53, N = 859)
rs809760(G)/15:49011421* CEP152 (0.7, 0.12, P = 2.3e-06, N = 1954) (0.69, -0.048, P = 0.34, N = 859)
rs496150(A)/15:53410502 RP11-209E8.1 (0.63, -0.004, P = 9.9e-06, N = 7824) (0.29, 0.039, P = 0.46, N = 859)
rs1189402(A)/15:53728154* intergenic (0.62, 0.0037, P = 4.4e-05, N = 7824) (0.77, 0.03, P = 0.61, N = 859)
rs7162803(A)/15:60160944 RP11-568G20.2 (0.5, 0.0048, P = 8.5e-08, N = 7824) (0.4, 0.062, P = 0.21, N = 859)
rs12595347(T)/15:60284511* intergenic (0.54, -0.0037, P = 3.8e-05, N = 7824) (0.59, -0.092, P = 0.058, N = 859)
rs11635276(C)/15:68757515* intergenic (0.52, -0.0041, P = 5.4e-06, N = 7824) (0.32, -0.088, P = 0.091, N = 859)
rs2114713(T)/15:80528373 RP11-2E17.1 (0.58, -0.005, P = 2.7e-08, N = 7824) (0.43, -0.063, P = 0.21, N = 859)
rs7175825(C)/15:80795419 ARNT2 (0.38, -0.0037, P = 4.2e-05, N = 7824) (0.38, -0.026, P = 0.61, N = 859)
rs11630705(C)/15:84614800 ADAMTSL3 (0.41, 0.0045, P = 5.1e-07, N = 7824) (0.15, -0.0011, P = 0.99, N = 859)
rs12443054(T)/15:89711479 ABHD2 (0.65, 0.0037, P = 4e-05, N = 7824) (0.61, -0.12, P = 0.01, N = 859)
rs7174567(A)/15:94669167* intergenic (0.56, 0.0037, P = 4e-05, N = 7824) (0.58, 0.022, P = 0.65, N = 859)
rs2130882(T)/15:98513845 ARRDC4 (0.49, 0.0044, P = 1.1e-06, N = 7824) (0.89, 0.0049, P = 0.95, N = 859)
rs3743582(A)/16:11650325 LITAF (0.48, -0.0037, P = 3.4e-05, N = 7824) (0.36, 0.016, P = 0.75, N = 859)
rs4633738(A)/16:11742027 intergenic (0.48, 0.0041, P = 5.4e-06, N = 7824) (0.29, -0.047, P = 0.38, N = 859)
rs7500049(A)/16:23006790 intergenic (0.39, 0.004, P = 1e-05, N = 7824) (0.85, 0.079, P = 0.25, N = 859)
rs11863492(A)/16:23044175 intergenic (0.37, 0.0037, P = 4.2e-05, N = 7824) (0.22, -0.04, P = 0.49, N = 859)
rs2014139(T)/16:25433163 CTA-249B10.1 (0.47, -0.0037, P = 3.9e-05, N = 7824) (0.29, -0.049, P = 0.36, N = 859)
rs205120(A)/16:25668663 intergenic (0.44, 0.0039, P = 1.2e-05, N = 7824) (0.28, -0.054, P = 0.31, N = 859)
rs10871453(C)/16:30536918 ZNF768 (0.61, -0.0038, P = 2.8e-05, N = 7824) (0.53, -0.066, P = 0.17, N = 859)
rs2192858(T)/16:51992615* intergenic (0.64, 0.004, P = 1.2e-05, N = 7824) (0.23, -0.061, P = 0.29, N = 859)
rs2432560(T)/16:58533709 NDRG4 (0.63, 0.0042, P = 6.1e-06, N = 7824) (0.64, 0.0099, P = 0.85, N = 859)
rs73549090(T)/16:59454967 intergenic (0.023, -0.83, P = 3.7e-06, N = 1954) (0.13, -0.011, P = 0.87, N = 859)
rs12926141(T)/16:62411321 intergenic (0.37, 0.0039, P = 2e-05, N = 7824) (0.3, -0.056, P = 0.29, N = 859)
rs1544811(A)/16:62656937 intergenic (0.46, 0.004, P = 9e-06, N = 7824) (0.48, -0.0028, P = 0.95, N = 859)
rs2274239(A)/16:68725783 CDH3 (0.61, 0.0039, P = 1.3e-05, N = 7824) (0.67, 0.03, P = 0.56, N = 859)
rs4888504(T)/16:76465969 CNTNAP4 (0.42, 0.0046, P = 2.7e-07, N = 7824) (0.58, -0.11, P = 0.023, N = 859)
rs12934986(A)/16:81553070 CMIP (0.14, -0.0072, P = 1.2e-05, N = 7824) (0.14, 0.065, P = 0.35, N = 859)
rs12931303(C)/16:83613314 CDH13 (0.1, -0.012, P = 1.3e-05, N = 7824) (0.061, -0.19, P = 0.068, N = 859)
rs13330994(C)/16:84414741 ATP2C2 (0.57, 1.2, P = 4.8e-06, N = 1954) (0.57, 0.0012, P = 0.98, N = 859)
rs2132850(A)/16:84975550* RP11-254F19.3 (0.5, 0.0038, P = 2.3e-05, N = 7824) (0.34, 0.029, P = 0.57, N = 859)
rs7203110(A)/16:8523542 intergenic (0.44, -0.0038, P = 2.4e-05, N = 7824) (0.4, 0.034, P = 0.49, N = 859)
rs556436666(CT)/17:1965296 SMG6 (0.08, -1.2, P = 8.8e-06, N = 1954) (0.027, 0.25, P = 0.091, N = 859)
rs2066713(A)/17:28551665 SLC6A4 (0.4, 0.0038, P = 2.4e-05, N = 7824) (0.25, -0.093, P = 0.095, N = 859)
rs4305127(T)/17:31817874 ASIC2 (0.4, -0.005, P = 5.7e-07, N = 7824) (0.86, 0.0037, P = 0.96, N = 859)
rs2158298(T)/17:39072234* intergenic (0.59, 0.0039, P = 1.4e-05, N = 7824) (0.34, 0.0045, P = 0.93, N = 859)
rs3736438(T)/17:45486651 EFCAB13 (0.39, -0.0057, P = 3.2e-10, N = 7824) (0.29, 0.026, P = 0.63, N = 859)
rs12709393(T)/17:55292115 intergenic (0.63, 0.0053, P = 6.4e-09, N = 7824) (0.28, 0.00086, P = 0.99, N = 859)
rs989681(T)/17:67542493 MAP2K6 (0.52, 0.0041, P = 7.4e-06, N = 7824) (0.41, -0.016, P = 0.74, N = 859)
rs4793395(T)/17:68509948 intergenic (0.47, 0.0041, P = 6.6e-06, N = 7824) (0.3, -0.039, P = 0.46, N = 859)
rs12938026(T)/17:68582006 intergenic (0.61, 0.0046, P = 2.8e-07, N = 7824) (0.84, -0.064, P = 0.32, N = 859)
rs8070753(A)/17:9264728* STX8 (0.37, -0.0038, P = 2.8e-05, N = 7824) (0.59, -0.094, P = 0.063, N = 859)
rs12607576(T)/18:13246168 LDLRAD4 (0.54, -0.004, P = 6.7e-06, N = 7824) (0.88, -0.036, P = 0.63, N = 859)
rs9947578(A)/18:14773230 ANKRD30B (0.56, 0.0043, P = 3.9e-06, N = 7824) (0.75, 0.037, P = 0.52, N = 859)
rs175776(C)/18:28624148 DSC3 (0.58, 0.0037, P = 4e-05, N = 7824) (0.68, -0.094, P = 0.071, N = 859)
rs1786077(A)/18:34867844 CELF4 (0.55, 0.0038, P = 2.2e-05, N = 7824) (0.32, 0.0016, P = 0.97, N = 859)
rs1358331(T)/18:41180458 intergenic (0.51, -0.0039, P = 1.7e-05, N = 7824) (0.67, 0.044, P = 0.38, N = 859)
rs2362839(A)/18:42991252* SLC14A2 (0.6, -0.0041, P = 5.1e-06, N = 7824) (0.55, 0.042, P = 0.37, N = 859)
rs9960949(A)/18:46209558 CTIF (0.48, -0.0042, P = 8.8e-06, N = 7824) (0.72, 0.039, P = 0.47, N = 859)
rs515897(A)/18:55209506 intergenic (0.62, -0.0037, P = 4.8e-05, N = 7824) (0.28, -0.0084, P = 0.88, N = 859)
rs4940563(A)/18:60277715 intergenic (0.53, -0.005, P = 5.7e-07, N = 7824) (0.74, -0.037, P = 0.5, N = 859)
rs4436868(T)/18:61958609* RP11-146N18.1 (0.5, 0.0045, P = 4.3e-07, N = 7824) (0.37, -0.0061, P = 0.91, N = 859)
rs618153(A)/18:62753986 intergenic (0.35, 0.0039, P = 2e-05, N = 7824) (0.39, -0.061, P = 0.22, N = 859)
rs536279(A)/18:65497981 RP11-638L3.2 (0.39, -0.004, P = 1.3e-05, N = 7824) (0.16, -0.039, P = 0.55, N = 859)
rs8086262(A)/18:69227590 RP11-510D19.1 (0.66, -0.004, P = 1.5e-05, N = 7824) (0.61, -0.041, P = 0.42, N = 859)
rs492522(T)/18:6986638* LAMA1 (0.55, -0.0037, P = 3.6e-05, N = 7824) (0.46, 0.096, P = 0.041, N = 859)
rs12232577(A)/18:69966132 intergenic (0.91, -0.0074, P = 3.8e-05, N = 7824) (0.92, 0.018, P = 0.83, N = 859)
rs9952198(T)/18:71878838 RP11-669I1.1 (0.53, -0.0039, P = 2e-05, N = 7824) (0.45, -0.048, P = 0.34, N = 859)
rs1866732(A)/18:72933187 TSHZ1 (0.66, 0.0037, P = 4.7e-05, N = 7824) (0.42, 0.0042, P = 0.93, N = 859)
rs6506736(A)/18:76940235 ATP9B (0.52, 0.0042, P = 2.6e-06, N = 7824) (0.2, 0.038, P = 0.52, N = 859)
rs11085752(A)/19:11065409* intergenic (0.58, -0.004, P = 9.5e-06, N = 7824) (0.62, 0.016, P = 0.75, N = 859)
rs11085914(T)/19:14978191* AC005255.6 (0.55, -0.0042, P = 2.9e-06, N = 7824) (0.83, -0.11, P = 0.073, N = 859)
rs8099879(A)/19:17230287 MYO9B (0.38, 0.005, P = 5.7e-07, N = 7824) (0.24, -0.007, P = 0.9, N = 859)
rs287104(A)/19:34290995* KCTD15 (0.65, 0.0038, P = 4.1e-05, N = 7824) (0.79, 0.029, P = 0.61, N = 859)
rs2451996(A)/19:35544963 HPN (0.58, 0.0043, P = 1.7e-06, N = 7824) (0.27, 0.072, P = 0.19, N = 859)
rs1820690(A)/19:48490006 BSPH1 (0.61, -0.15, P = 2.7e-06, N = 1954) (0.77, 0.14, P = 0.013, N = 859)
rs1513628(A)/2:101338644* AC092168.4 (0.37, -0.004, P = 1.3e-05, N = 7824) (0.11, 0.07, P = 0.38, N = 859)
rs6542041(A)/2:112911923 FBLN7 (0.49, -0.0037, P = 4.6e-05, N = 7824) (0.52, 0.059, P = 0.22, N = 859)
rs17355679(T)/2:115964965 DPP10 (0.36, -0.004, P = 1e-05, N = 7824) (0.59, -0.034, P = 0.49, N = 859)
rs2577264(A)/2:11936798* LPIN1 (0.38, 0.0043, P = 2.1e-06, N = 7824) (0.11, 0.02, P = 0.8, N = 859)
rs2043885(T)/2:124856339 CNTNAP5 (0.42, 0.0038, P = 2.9e-05, N = 7824) (0.26, 0.022, P = 0.68, N = 859)
rs11899152(A)/2:125483741 CNTNAP5 (0.54, -0.0037, P = 4.7e-05, N = 7824) (0.45, -0.049, P = 0.3, N = 859)
rs7587616(A)/2:134708496* intergenic (0.47, -0.0037, P = 4.7e-05, N = 7824) (0.37, 0.067, P = 0.17, N = 859)
rs1427617(T)/2:137487339 intergenic (0.37, 0.0038, P = 2.9e-05, N = 7824) (0.39, -0.024, P = 0.64, N = 859)
rs6721330(A)/2:149858906 KIF5C (0.55, -0.0041, P = 4.9e-06, N = 7824) (0.19, 0.018, P = 0.78, N = 859)
rs2881873(T)/2:154524124 intergenic (0.46, -0.0037, P = 4e-05, N = 7824) (0.57, 0.011, P = 0.82, N = 859)
rs1446555(A)/2:158109405 GALNT5 (0.9, 0.008, P = 3.2e-06, N = 7824) (0.79, -0.00072, P = 0.99, N = 859)
rs1424937(A)/2:169566184 CERS6 (0.46, 0.0042, P = 2.3e-06, N = 7824) (0.16, 0.019, P = 0.77, N = 859)
rs2544371(A)/2:170227070 intergenic (0.56, 0.004, P = 8.7e-06, N = 7824) (0.58, -0.02, P = 0.69, N = 859)
rs2969327(T)/2:177422617* intergenic (0.43, -0.0039, P = 1.8e-05, N = 7824) (0.52, -0.033, P = 0.51, N = 859)
rs262273(C)/2:180911563 intergenic (0.39, -0.0042, P = 2.8e-06, N = 7824) (0.53, -0.051, P = 0.29, N = 859)
rs288332(A)/2:183625350* DNAJC10 (0.63, -0.0043, P = 1.8e-06, N = 7824) (0.81, -0.00021, P = 1, N = 859)
rs1981913(T)/2:205169149 DSTNP5 (0.62, 0.0039, P = 2.1e-05, N = 7824) (0.53, 0.035, P = 0.47, N = 859)
rs6435389(T)/2:208696325 PLEKHM3 (0.34, 0.0039, P = 2.1e-05, N = 7824) (0.22, 0.09, P = 0.14, N = 859)
rs7570090(T)/2:210880893* RPE (0.46, -0.0038, P = 3e-05, N = 7824) (0.38, 0.012, P = 0.8, N = 859)
rs12994785(A)/2:212857425* ERBB4 (0.55, 0.0039, P = 1.8e-05, N = 7824) (0.28, -0.044, P = 0.42, N = 859)
rs1250070(A)/2:216557733 LINC00607 (0.39, -0.0042, P = 8.6e-06, N = 7824) (0.28, 0.019, P = 0.72, N = 859)
rs2279014(T)/2:219261176* SLC11A1 (0.37, -0.005, P = 4.9e-08, N = 7824) (0.4, -0.12, P = 0.016, N = 859)
rs526897(A)/2:219433597 RQCD1 (0.61, 0.0038, P = 3.1e-05, N = 7824) (0.75, -0.05, P = 0.36, N = 859)
rs4674438(T)/2:220643119 intergenic (0.36, 0.0046, P = 2.9e-07, N = 7824) (0.6, -0.0078, P = 0.87, N = 859)
rs2710503(C)/2:222374699 EPHA4 (0.44, -0.0044, P = 1.7e-06, N = 7824) (0.13, -0.006, P = 0.94, N = 859)
rs9784110(T)/2:230215502 intergenic (0.61, -0.0042, P = 4e-06, N = 7824) (0.57, -0.11, P = 0.03, N = 859)
rs977041(A)/2:230350848 DNER (0.44, 0.0044, P = 1.3e-06, N = 7824) (0.47, -0.018, P = 0.71, N = 859)
rs2292871(A)/2:238499690 RAB17 (0.58, 0.0045, P = 7.7e-07, N = 7824) (0.22, 0.07, P = 0.23, N = 859)
rs12987376(T)/2:242917306 AC093642.3 (0.45, 0.0037, P = 3.6e-05, N = 7824) (0.2, -0.047, P = 0.43, N = 859)
rs4665406(T)/2:28445438 BRE (0.37, -0.0043, P = 1.9e-06, N = 7824) (0.25, 0.027, P = 0.63, N = 859)
rs7592700(A)/2:3480563* TRAPPC12 (0.47, -0.0037, P = 4.3e-05, N = 7824) (0.86, 0.15, P = 0.026, N = 859)
rs8179836(C)/2:42903239 MTA3 (0.63, 0.0048, P = 1.5e-07, N = 7824) (0.69, 0.014, P = 0.79, N = 859)
rs940052(A)/2:45981142 PRKCE (0.44, -0.0038, P = 2.2e-05, N = 7824) (0.52, -0.011, P = 0.82, N = 859)
rs1374749(A)/2:46596433* EPAS1 (0.44, 0.0037, P = 4.4e-05, N = 7824) (0.5, 0.053, P = 0.27, N = 859)
rs12473182(C)/2:49427446 intergenic (0.4, 0.0038, P = 2.4e-05, N = 7824) (0.45, 0.024, P = 0.61, N = 859)
rs735315(T)/2:51331157 AC007682.1 (0.49, 0.0054, P = 1.9e-09, N = 7824) (0.69, 0.0034, P = 0.95, N = 859)
rs7564248(A)/2:51379098 AC007682.1 (0.6, 0.0045, P = 7.4e-07, N = 7824) (0.56, 0.11, P = 0.024, N = 859)
rs7604464(A)/2:54389318 ACYP2 (0.97, 0.015, P = 5.9e-06, N = 7824) (0.67, 0.0079, P = 0.88, N = 859)
rs4669392(A)/2:5620952* intergenic (0.43, -0.004, P = 9.3e-06, N = 7824) (0.34, 0.011, P = 0.82, N = 859)
rs4672450(T)/2:61944571 intergenic (0.48, 0.0044, P = 1.4e-06, N = 7824) (0.2, 0.0017, P = 0.98, N = 859)
rs549386(T)/2:70667125 intergenic (0.61, -0.0043, P = 1.6e-06, N = 7824) (0.8, 0.019, P = 0.76, N = 859)
rs1345836(T)/2:8200042 LINC00299 (0.45, 0.0038, P = 2.9e-05, N = 7824) (0.64, 0.0087, P = 0.86, N = 859)
rs3097281(A)/2:8508404 LINC00299 (0.58, 0.0038, P = 2.3e-05, N = 7824) (0.56, 0.00028, P = 1, N = 859)
rs6709816(A)/2:85343124* intergenic (0.15, -0.0077, P = 1.9e-06, N = 7824) (0.22, -0.085, P = 0.15, N = 859)
rs7355681(A)/2:85911339 AC012454.4 (0.59, 0.0041, P = 4.9e-06, N = 7824) (0.72, 0.059, P = 0.27, N = 859)
rs6131084(T)/20:1090381 PSMF1 (0.56, 0.0038, P = 2.7e-05, N = 7824) (0.33, 0.041, P = 0.43, N = 859)
rs2327855(A)/20:14477175* MACROD2 (0.58, 0.004, P = 9.6e-06, N = 7824) (0.76, 0.00022, P = 1, N = 859)
rs8120307(T)/20:35803188 RPN2 (0.62, -0.0038, P = 2.5e-05, N = 7824) (0.35, 0.018, P = 0.71, N = 859)
rs6129167(T)/20:37689228 intergenic (0.57, 0.0039, P = 1.1e-05, N = 7824) (0.58, 0.052, P = 0.28, N = 859)
rs6129620(A)/20:39144286* intergenic (0.33, 0.0038, P = 4.6e-05, N = 7824) (0.15, 9.3e-05, P = 1, N = 859)
rs241642(A)/20:3929299 RNF24 (0.44, 0.0038, P = 2.2e-05, N = 7824) (0.71, -0.056, P = 0.28, N = 859)
rs3848713(T)/20:44470676* ACOT8 (0.41, -0.0044, P = 1.1e-06, N = 7824) (0.61, 0.043, P = 0.38, N = 859)
rs4811828(T)/20:55809047 BMP7 (0.88, 0.0077, P = 5.9e-06, N = 7824) (0.78, -0.081, P = 0.17, N = 859)
rs6025935(A)/20:56536168 RP13-379L11.2 (0.38, -0.0038, P = 3.4e-05, N = 7824) (0.24, 0.03, P = 0.59, N = 859)
rs163787(A)/20:57574463* CTSZ (0.18, 0.0065, P = 4.7e-05, N = 7824) (0.14, -0.023, P = 0.75, N = 859)
rs3905228(A)/20:58105747 intergenic (0.47, 0.0041, P = 9e-06, N = 7824) (0.32, 0.0032, P = 0.95, N = 859)
rs4591420(A)/21:16077143* intergenic (0.33, -0.0037, P = 4.6e-05, N = 7824) (0.19, -0.098, P = 0.12, N = 859)
rs1028981(A)/21:21668483 intergenic (0.39, -0.005, P = 5.7e-07, N = 7824) (0.41, -0.0064, P = 0.9, N = 859)
rs1041755(T)/21:33238952* intergenic (0.37, 0.004, P = 1.2e-05, N = 7824) (0.49, 0.074, P = 0.13, N = 859)
rs8134847(T)/21:35020161 ITSN1 (0.4, 0.0041, P = 8.4e-06, N = 7824) (0.34, -0.038, P = 0.45, N = 859)
rs2156411(A)/21:37580807 DOPEY2 (0.64, 0.0038, P = 3.1e-05, N = 7824) (0.85, 0.027, P = 0.69, N = 859)
rs378999(T)/21:40434320 intergenic (0.64, -0.0044, P = 1.2e-06, N = 7824) (0.62, 0.029, P = 0.56, N = 859)
rs8127674(A)/21:42882003 TMPRSS2 (0.59, -0.0041, P = 5.9e-06, N = 7824) (0.67, 0.063, P = 0.22, N = 859)
rs220168(A)/21:43554571* UMODL1 (0.52, -0.004, P = 9.3e-06, N = 7824) (0.52, 0.061, P = 0.2, N = 859)
rs12627165(A)/21:46736694 intergenic (0.35, 0.0044, P = 3.5e-06, N = 7824) (0.64, 0.061, P = 0.2, N = 859)
rs9613019(T)/22:26174397 MYO18B (0.41, -0.0041, P = 7.4e-06, N = 7824) (0.72, -0.019, P = 0.73, N = 859)
rs137181(A)/22:26666246 SEZ6L (0.51, -0.0037, P = 3.5e-05, N = 7824) (0.61, -0.061, P = 0.23, N = 859)
rs5999027(T)/22:33989858* LARGE (0.43, -0.004, P = 9.5e-06, N = 7824) (0.29, -0.0044, P = 0.93, N = 859)
rs132667(A)/22:36565029* Z95114.3 (0.54, 0.0038, P = 2.4e-05, N = 7824) (0.64, -0.026, P = 0.6, N = 859)
rs10854693(A)/22:37252010* CTA-833B7.2 (0.56, -0.0039, P = 3.4e-05, N = 7824) (0.89, -0.059, P = 0.45, N = 859)
rs140572(A)/22:45451727* intergenic (0.51, 0.0047, P = 2.2e-07, N = 7824) (0.15, -0.035, P = 0.61, N = 859)
rs131919(T)/22:47447437* TBC1D22A (0.33, -0.0046, P = 9e-07, N = 7824) (0.41, -0.0032, P = 0.95, N = 859)
rs9838540(A)/3:101986003* ZPLD1 (0.61, 0.0047, P = 1.8e-07, N = 7824) (0.21, 0.064, P = 0.27, N = 859)
rs6437539(T)/3:104513265 intergenic (0.63, -0.0039, P = 2e-05, N = 7824) (0.66, 0.00063, P = 0.99, N = 859)
rs2924149(T)/3:10991346 intergenic (0.38, 0.0038, P = 2.6e-05, N = 7824) (0.1, -0.051, P = 0.52, N = 859)
rs4831113(T)/3:115308015* intergenic (0.39, -0.0038, P = 2.8e-05, N = 7824) (0.87, 0.032, P = 0.65, N = 859)
rs201908613(CT)/3:116189185 LSAMP (0.017, 0.29, P = 2.3e-06, N = 1954) (0.041, 0.044, P = 0.72, N = 859)
rs9873519(T)/3:124921457* SLC12A8 (0.54, 0.0037, P = 3.4e-05, N = 7824) (0.31, 0.075, P = 0.15, N = 859)
rs1225019(A)/3:131669077 CPNE4 (0.58, -0.0043, P = 1.6e-06, N = 7824) (0.32, -0.067, P = 0.19, N = 859)
rs13059536(T)/3:139578650 RP11-166D18.1 (0.11, 0.007, P = 4.1e-05, N = 7824) (0.14, 0.067, P = 0.34, N = 859)
rs6795522(T)/3:143101289* SLC9A9 (0.61, 0.0037, P = 4.9e-05, N = 7824) (0.63, -0.035, P = 0.49, N = 859)
rs9872790(T)/3:143238874 SLC9A9 (0.5, -0.0039, P = 1.9e-05, N = 7824) (0.4, 0.028, P = 0.56, N = 859)
rs355748(T)/3:153964496 ARHGEF26 (0.38, -0.0038, P = 3.3e-05, N = 7824) (0.41, 0.0072, P = 0.88, N = 859)
rs9942113(A)/3:156231801 KCNAB1 (0.38, -0.0049, P = 6e-08, N = 7824) (0.55, 0.0036, P = 0.94, N = 859)
rs11707952(A)/3:158665225 intergenic (0.57, -0.0046, P = 3.9e-07, N = 7824) (0.56, -0.042, P = 0.38, N = 859)
rs4525910(A)/3:159646612 IL12A-AS1 (0.41, -0.0043, P = 2.2e-06, N = 7824) (0.22, -0.071, P = 0.23, N = 859)
rs17236487(T)/3:160171926 TRIM59 (0.78, 0.0062, P = 4.7e-05, N = 7824) (0.83, -0.061, P = 0.34, N = 859)
rs9863328(T)/3:164360829 intergenic (0.43, 0.004, P = 9.1e-06, N = 7824) (0.34, -0.052, P = 0.29, N = 859)
rs1430435(T)/3:169079193 MECOM (0.49, 0.0044, P = 1.3e-06, N = 7824) (0.38, -0.021, P = 0.67, N = 859)
rs6793266(T)/3:175102338* NAALADL2 (0.39, -0.0043, P = 2.9e-06, N = 7824) (0.34, 0.13, P = 0.011, N = 859)
rs9842133(T)/3:179664102 PEX5L (0.66, 0.0064, P = 4.2e-12, N = 7824) (0.47, 0.033, P = 0.5, N = 859)
rs6785807(A)/3:181718601 RP11-416O18.1 (0.12, -0.0068, P = 3.6e-05, N = 7824) (0.054, -0.094, P = 0.38, N = 859)
rs1026527(T)/3:22609529 intergenic (0.58, 0.0038, P = 2e-05, N = 7824) (0.62, -0.07, P = 0.16, N = 859)
rs6550934(A)/3:25052333* AC133680.1 (0.47, 0.0038, P = 2.3e-05, N = 7824) (0.76, -0.036, P = 0.52, N = 859)
rs294280(T)/3:31131692 intergenic (0.39, 0.0042, P = 3.4e-06, N = 7824) (0.52, 0.057, P = 0.25, N = 859)
rs968103(T)/3:34234573 AC018359.1 (0.45, 0.0043, P = 1.5e-06, N = 7824) (0.78, -0.02, P = 0.72, N = 859)
rs1916227(A)/3:34847097 intergenic (0.48, -0.004, P = 1e-05, N = 7824) (0.6, 0.043, P = 0.38, N = 859)
rs7632967(A)/3:34906302 intergenic (0.55, -0.0043, P = 1.7e-06, N = 7824) (0.31, 6.6e-05, P = 1, N = 859)
rs769809(A)/3:3767212 SUMF1 (0.57, 0.0046, P = 3.5e-07, N = 7824) (0.75, -0.0082, P = 0.88, N = 859)
rs533980308(AT)/3:49106976 QRICH1 (0.021, -0.86, P = 9.9e-06, N = 1954) (0.41, 0.061, P = 0.22, N = 859)
rs11915024(T)/3:59492480* RP11-719N22.2 (0.4, -0.0044, P = 9.6e-07, N = 7824) (0.61, -0.013, P = 0.8, N = 859)
rs9874660(A)/3:61931353 PTPRG (0.91, 0.015, P = 2.2e-05, N = 7824) (0.84, 0.064, P = 0.34, N = 859)
rs6797048(A)/3:68904763 FAM19A4 (0.62, -0.0038, P = 3e-05, N = 7824) (0.8, 0.024, P = 0.69, N = 859)
rs6798065(T)/3:75388243 MYLKP1 (0.34, -0.0038, P = 2.6e-05, N = 7824) (0.58, -0.011, P = 0.82, N = 859)
rs9880736(A)/3:79318988 ROBO1 (0.54, -0.0044, P = 1.5e-06, N = 7824) (0.91, -0.054, P = 0.5, N = 859)
rs1431156(G)/3:88082149 intergenic (0.98, -0.35, P = 3.6e-06, N = 1954) (0.72, 0.074, P = 0.18, N = 859)
rs9829940(T)/3:96167649 intergenic (0.56, 0.0038, P = 2e-05, N = 7824) (0.83, -0.00075, P = 0.99, N = 859)
rs9819702(T)/3:97886592 OR5H15 (0.36, -0.0042, P = 5.2e-06, N = 7824) (0.37, -0.058, P = 0.24, N = 859)
rs1114130(T)/4:101363516* EMCN (0.34, -0.0042, P = 4.3e-06, N = 7824) (0.41, -0.088, P = 0.069, N = 859)
rs11722041(T)/4:115411284 intergenic (0.41, 0.0039, P = 1.8e-05, N = 7824) (0.061, 0.061, P = 0.55, N = 859)
rs12510909(T)/4:139206509 RP11-733C7.1 (0.53, -0.0043, P = 1.8e-06, N = 7824) (0.72, -0.027, P = 0.61, N = 859)
rs11930385(T)/4:146845752* ZNF827 (0.4, -0.0043, P = 2.1e-06, N = 7824) (0.69, -0.045, P = 0.4, N = 859)
rs7662505(A)/4:147982321 intergenic (0.4, -0.004, P = 1e-05, N = 7824) (0.39, 0.018, P = 0.72, N = 859)
rs9997562(T)/4:14896179* intergenic (0.52, 0.0043, P = 1.9e-06, N = 7824) (0.27, -0.075, P = 0.18, N = 859)
rs6535870(T)/4:153639925 intergenic (0.65, -0.005, P = 5.5e-08, N = 7824) (0.42, 0.038, P = 0.43, N = 859)
rs2286460(A)/4:15964040* FGFBP2 (0.54, -0.0045, P = 8.4e-07, N = 7824) (0.43, 0.012, P = 0.8, N = 859)
rs195934(A)/4:163582000 intergenic (0.64, 0.0039, P = 2e-05, N = 7824) (0.71, 0.027, P = 0.62, N = 859)
rs4860022(T)/4:167693875 SPOCK3 (0.34, -0.0055, P = 9.6e-10, N = 7824) (0.28, 0.066, P = 0.24, N = 859)
rs12503744(A)/4:172203928* intergenic (0.02, -0.034, P = 4.8e-06, N = 7824) (0.32, -0.014, P = 0.78, N = 859)
rs7686890(T)/4:178411431 RP11-130F10.1 (0.39, 0.004, P = 8e-06, N = 7824) (0.74, -0.057, P = 0.3, N = 859)
rs2309339(C)/4:181350035 intergenic (0.65, 0.0041, P = 7.1e-06, N = 7824) (0.73, 0.0019, P = 0.97, N = 859)
rs1872445(T)/4:186504058* SORBS2 (0.55, -0.0039, P = 1.3e-05, N = 7824) (0.87, 0.068, P = 0.34, N = 859)
rs10489008(A)/4:31718284* intergenic (0.49, 0.0045, P = 4.6e-07, N = 7824) (0.87, -0.047, P = 0.52, N = 859)
rs12500588(A)/4:37111552 RP11-103J17.1 (0.09, -0.0076, P = 1.5e-05, N = 7824) (0.44, -0.095, P = 0.047, N = 859)
rs10517472(T)/4:38287333* RP11-600L4.1 (0.38, 0.0037, P = 4.3e-05, N = 7824) (0.19, -0.001, P = 0.99, N = 859)
rs7665019(T)/4:40600905 RBM47 (0.55, 0.0038, P = 2.2e-05, N = 7824) (0.74, -0.016, P = 0.76, N = 859)
rs4861126(C)/4:41643057 LIMCH1 (0.41, 0.0043, P = 1.6e-06, N = 7824) (0.47, -0.043, P = 0.38, N = 859)
rs7673523(C)/4:4688246 STX18-AS1 (0.53, 0.0037, P = 3.6e-05, N = 7824) (0.61, -0.016, P = 0.75, N = 859)
rs1509657(T)/4:48213011* TEC (0.46, 0.0041, P = 6.3e-06, N = 7824) (0.65, 0.015, P = 0.77, N = 859)
rs6554156(T)/4:55042554 FIP1L1 (0.4, 0.0044, P = 1.1e-06, N = 7824) (0.42, 0.062, P = 0.21, N = 859)
rs2100765(C)/4:60855621 intergenic (0.59, 0.0039, P = 1.5e-05, N = 7824) (0.28, 0.026, P = 0.63, N = 859)
rs6852374(A)/4:61370159 intergenic (0.51, 0.0041, P = 4.4e-06, N = 7824) (0.44, 0.0034, P = 0.94, N = 859)
rs1390746(A)/4:79451461 FRAS1 (0.55, 0.0037, P = 3.3e-05, N = 7824) (0.3, 0.022, P = 0.67, N = 859)
rs7435034(A)/4:88146267 KLHL8 (0.36, -0.0042, P = 3.4e-06, N = 7824) (0.18, 0.0057, P = 0.93, N = 859)
rs13434630(A)/4:88464872* intergenic (0.46, -0.0039, P = 1.2e-05, N = 7824) (0.47, -0.018, P = 0.7, N = 859)
rs2120372(A)/4:90983723* intergenic (0.59, -0.0037, P = 4.2e-05, N = 7824) (0.61, 0.021, P = 0.68, N = 859)
rs7732790(A)/5:103428431* RP11-138J23.1 (0.59, -0.0042, P = 3.7e-06, N = 7824) (0.43, -0.013, P = 0.79, N = 859)
rs2962321(T)/5:10577895 ANKRD33B (0.9, -0.0077, P = 6e-06, N = 7824) (0.85, 0.044, P = 0.52, N = 859)
rs10065061(T)/5:107916909 intergenic (0.52, 0.0037, P = 4.1e-05, N = 7824) (0.3, -0.064, P = 0.22, N = 859)
rs461231(T)/5:110734739 CAMK4 (0.6, -0.0037, P = 4e-05, N = 7824) (0.77, 0.033, P = 0.58, N = 859)
rs1366201(A)/5:115321833 AQPEP (0.6, 0.0037, P = 3.9e-05, N = 7824) (0.84, -0.051, P = 0.45, N = 859)
rs246946(T)/5:126652742 MEGF10 (0.68, 0.0041, P = 9.3e-06, N = 7824) (0.69, 0.026, P = 0.62, N = 859)
rs6866597(T)/5:128877617* ADAMTS19 (0.52, 0.0042, P = 3.6e-06, N = 7824) (0.12, 0.064, P = 0.38, N = 859)
rs10900805(A)/5:131580851* P4HA2 (0.1, -0.007, P = 3.8e-05, N = 7824) (0.11, -0.076, P = 0.33, N = 859)
rs7737937(A)/5:131614981* P4HA2 (0.15, -0.011, P = 4.9e-11, N = 7824) (0.19, 0.066, P = 0.3, N = 859)
rs419291(T)/5:131633355* SLC22A4 (0.37, 0.0079, P = 3.1e-18, N = 7824) (0.22, 0.1, P = 0.086, N = 859)
rs6596361(T)/5:136311770 SPOCK1 (0.59, 0.0044, P = 9.2e-07, N = 7824) (0.58, -0.033, P = 0.5, N = 859)
rs1368388(A)/5:147897161* HTR4 (0.42, -0.0041, P = 4.6e-06, N = 7824) (0.64, -0.035, P = 0.48, N = 859)
rs6862024(A)/5:150428871 TNIP1 (0.37, -0.0055, P = 9e-10, N = 7824) (0.089, 0.0067, P = 0.94, N = 859)
rs6877344(T)/5:150742650* CTB-23I7.1 (0.38, 0.004, P = 1e-05, N = 7824) (0.3, -0.021, P = 0.69, N = 859)
rs1317661(A)/5:151647363 CTB-12O2.1 (0.48, 0.0043, P = 1.9e-06, N = 7824) (0.35, -0.0035, P = 0.94, N = 859)
rs753768(A)/5:152516889 AC091969.1 (0.42, 0.0039, P = 1.4e-05, N = 7824) (0.39, 2e-05, P = 1, N = 859)
rs9313491(C)/5:156621905 ITK (0.64, 0.0047, P = 6.1e-07, N = 7824) (0.7, 0.026, P = 0.62, N = 859)
rs17651643(A)/5:16892438* MYO10 (0.1, -0.011, P = 1.3e-05, N = 7824) (0.23, -0.065, P = 0.25, N = 859)
rs2471005(A)/5:174882207* snoU13 (0.39, 0.004, P = 1e-05, N = 7824) (0.14, 0.091, P = 0.18, N = 859)
rs4866725(T)/5:2164174 intergenic (0.56, -0.0038, P = 2.3e-05, N = 7824) (0.77, -0.02, P = 0.73, N = 859)
rs899584(T)/5:26826799 intergenic (0.36, -0.0047, P = 2.9e-07, N = 7824) (0.58, 0.07, P = 0.15, N = 859)
rs13162168(A)/5:30222534 intergenic (0.38, -0.0041, P = 6.4e-06, N = 7824) (0.24, -0.044, P = 0.45, N = 859)
rs4242263(A)/5:36415364 intergenic (0.36, 0.0038, P = 2.7e-05, N = 7824) (0.55, 0.079, P = 0.11, N = 859)
rs42864(C)/5:39283776 C9 (0.64, -0.0039, P = 2.4e-05, N = 7824) (0.87, -0.0092, P = 0.9, N = 859)
rs1479614(A)/5:50823338 intergenic (0.61, -0.0048, P = 9.9e-08, N = 7824) (0.82, -0.097, P = 0.12, N = 859)
rs2291631(A)/5:75013036 POC5 (0.05, -0.011, P = 1.3e-05, N = 7824) (0.038, -0.13, P = 0.31, N = 859)
rs1392482(T)/5:7555561 ADCY2 (0.4, -0.0039, P = 1.4e-05, N = 7824) (0.25, -0.0029, P = 0.96, N = 859)
rs13182512(A)/5:78573790* JMY (0.38, -0.005, P = 3.4e-08, N = 7824) (0.62, 0.057, P = 0.25, N = 859)
rs11750489(A)/5:80391253 RASGRF2 (0.89, 0.0097, P = 4.9e-05, N = 7824) (0.98, 0.15, P = 0.36, N = 859)
rs1827396(A)/5:81975108 intergenic (0.43, -0.0038, P = 3.2e-05, N = 7824) (0.64, -0.054, P = 0.29, N = 859)
rs699554(T)/5:87022350 CTD-2316B1.2 (0.43, 0.0038, P = 3.2e-05, N = 7824) (0.5, 0.016, P = 0.73, N = 859)
rs11267778(GCCTCTGCCCATGAC)/6:108384189 OSTM1 (0.019, -0.15, P = 4.5e-06, N = 1954) (0.99, 0.013, P = 0.95, N = 859)
rs4713396(A)/6:11312130 NEDD9 (0.45, -0.0044, P = 1.2e-06, N = 7824) (0.6, -0.044, P = 0.39, N = 859)
rs10872303(T)/6:126255034 NCOA7 (0.53, 0.004, P = 1.1e-05, N = 7824) (0.42, -0.037, P = 0.44, N = 859)
rs6917098(A)/6:132925613 TAAR3 (0.61, 0.0038, P = 3.1e-05, N = 7824) (0.57, 0.01, P = 0.83, N = 859)
rs459625(T)/6:134260676 intergenic (0.43, -0.0049, P = 5.2e-08, N = 7824) (0.84, 0.16, P = 0.017, N = 859)
rs6908972(T)/6:134684613* intergenic (0.082, -0.009, P = 8e-07, N = 7824) (0.13, 0.062, P = 0.38, N = 859)
rs4267967(T)/6:135272477 ALDH8A1 (0.56, 0.0037, P = 3.3e-05, N = 7824) (0.52, 0.064, P = 0.18, N = 859)
rs7760148(A)/6:140201675* RP5-899B16.2 (0.36, -0.0042, P = 3.4e-06, N = 7824) (0.52, 0.092, P = 0.055, N = 859)
rs1327674(T)/6:147100481* ADGB (0.43, -0.0037, P = 3.8e-05, N = 7824) (0.24, -0.015, P = 0.79, N = 859)
rs12201109(A)/6:149240393 UST (0.37, -0.0045, P = 1.1e-06, N = 7824) (0.3, -0.044, P = 0.41, N = 859)
rs12197879(T)/6:151895777* CCDC170 (0.6, -0.0044, P = 1.2e-06, N = 7824) (0.16, -0.022, P = 0.73, N = 859)
rs9383693(T)/6:154474871 IPCEF1 (0.55, -0.0042, P = 3.6e-06, N = 7824) (0.53, 0.073, P = 0.14, N = 859)
rs2504927(T)/6:160860430* SLC22A3 (0.44, -0.0041, P = 4.3e-06, N = 7824) (0.47, -0.092, P = 0.058, N = 859)
rs6915537(A)/6:16900872 intergenic (0.41, 0.0038, P = 2.5e-05, N = 7824) (0.31, -0.027, P = 0.6, N = 859)
rs9466453(A)/6:22735375 intergenic (0.52, 0.0038, P = 2.1e-05, N = 7824) (0.46, 0.036, P = 0.46, N = 859)
rs9467703(A)/6:26318903* HIST1H3PS1 (0.37, -0.0045, P = 8.3e-07, N = 7824) (0.098, -0.063, P = 0.44, N = 859)
rs2235232(A)/6:27326863 ZNF204P (0.54, 0.0039, P = 1.3e-05, N = 7824) (0.7, -0.031, P = 0.56, N = 859)
rs1610649(T)/6:29768917* HLA-P (0.61, -0.0049, P = 7.9e-08, N = 7824) (0.52, 0.076, P = 0.12, N = 859)
rs9394368(C)/6:36630525 intergenic (0.35, -0.0037, P = 4.7e-05, N = 7824) (0.56, -0.034, P = 0.49, N = 859)
rs1109773(C)/6:39289164 KCNK16 (0.37, 0.004, P = 9e-06, N = 7824) (0.47, 0.041, P = 0.4, N = 859)
rs2396004(A)/6:43355851* intergenic (0.44, 0.0049, P = 4.3e-08, N = 7824) (0.86, 0.094, P = 0.16, N = 859)
rs6937910(T)/6:51682409 PKHD1 (0.53, -0.0043, P = 1.4e-06, N = 7824) (0.53, 0.013, P = 0.79, N = 859)
rs685893(A)/6:53961784 MLIP (0.64, -0.0037, P = 4.4e-05, N = 7824) (0.53, 0.017, P = 0.73, N = 859)
rs852941(A)/6:72160400 RP1-288M22.2 (0.42, 0.0037, P = 3.7e-05, N = 7824) (0.56, 0.049, P = 0.34, N = 859)
rs1482567(T)/6:72671565 RIMS1 (0.62, 0.004, P = 9.3e-06, N = 7824) (0.62, -0.0029, P = 0.95, N = 859)
rs9351906(A)/6:72987855 RIMS1 (0.4, 0.0037, P = 4.1e-05, N = 7824) (0.27, 0.032, P = 0.56, N = 859)
rs2789599(A)/6:73105163 RIMS1 (0.5, 0.0043, P = 2.2e-06, N = 7824) (0.45, 0.095, P = 0.046, N = 859)
rs2173986(C)/6:8330781* RP11-203H2.1 (0.5, -0.0039, P = 1.5e-05, N = 7824) (0.22, -0.0065, P = 0.91, N = 859)
rs9450000(A)/6:85373267 intergenic (0.89, -0.0072, P = 1.8e-05, N = 7824) (0.77, 0.075, P = 0.19, N = 859)
rs998775(A)/6:93859619 intergenic (0.59, -0.004, P = 1.2e-05, N = 7824) (0.68, 0.0054, P = 0.92, N = 859)
rs2704975(A)/7:106065174 CTB-111H14.1 (0.39, 0.0037, P = 4.3e-05, N = 7824) (0.58, 0.01, P = 0.83, N = 859)
rs2189438(A)/7:10719393 intergenic (0.51, 0.0041, P = 4.5e-06, N = 7824) (0.45, 0.041, P = 0.39, N = 859)
rs10255200(T)/7:123679743 RP5-921G16.1 (0.48, -0.0039, P = 1.1e-05, N = 7824) (0.45, 0.022, P = 0.66, N = 859)
rs983849(T)/7:125248586 intergenic (0.43, 0.0039, P = 1.3e-05, N = 7824) (0.63, 0.011, P = 0.83, N = 859)
rs2106185(T)/7:127184315 intergenic (0.39, 0.009, P = 1.9e-05, N = 7824) (0.04, 0.034, P = 0.79, N = 859)
rs13231650(T)/7:141398942 KIAA1147 (0.43, 0.0041, P = 4.8e-06, N = 7824) (0.19, -0.035, P = 0.58, N = 859)
rs6948399(C)/7:144175166 TPK1 (0.64, 0.54, P = 3.5e-06, N = 1954) (0.31, 0.12, P = 0.022, N = 859)
rs17585288(T)/7:146226654 CNTNAP2 (0.91, -0.0099, P = 1.2e-05, N = 7824) (0.98, 0.065, P = 0.73, N = 859)
rs2961253(T)/7:15175427 intergenic (0.55, -0.005, P = 5.7e-07, N = 7824) (0.67, 0.05, P = 0.32, N = 859)
rs9654697(T)/7:155395948 intergenic (0.6, 0.004, P = 1.2e-05, N = 7824) (0.31, 0.05, P = 0.34, N = 859)
rs115807806(T)/7:157921957 PTPRN2 (0.085, -0.15, P = 4.9e-06, N = 1954) (0.02, 0.24, P = 0.16, N = 859)
rs10231585(T)/7:20182020 MACC1 (0.57, -0.0039, P = 1.8e-05, N = 7824) (0.29, 0.041, P = 0.43, N = 859)
rs13238939(T)/7:21685861* DNAH11 (0.51, 0.004, P = 1e-05, N = 7824) (0.16, 0.01, P = 0.88, N = 859)
rs3757440(A)/7:2272936 MAD1L1 (0.62, 0.0037, P = 4.7e-05, N = 7824) (0.65, -0.044, P = 0.38, N = 859)
rs1544412(T)/7:26498968 AC004540.5 (0.36, -0.0043, P = 2.7e-06, N = 7824) (0.42, -0.06, P = 0.21, N = 859)
rs12484(T)/7:2768626* GNA12 (0.43, -0.005, P = 5.7e-07, N = 7824) (0.6, 0.015, P = 0.76, N = 859)
rs4259315(G)/7:28907437 intergenic (0.49, -0.17, P = 7.9e-06, N = 1954) (0.13, -0.014, P = 0.85, N = 859)
rs4722438(A)/7:3155813* intergenic (0.44, 0.0044, P = 1.2e-06, N = 7824) (0.56, 0.061, P = 0.21, N = 859)
rs10275028(T)/7:34889222 NPSR1 (0.65, 0.0046, P = 4.9e-07, N = 7824) (0.62, 0.0098, P = 0.84, N = 859)
rs4433042(A)/7:43522684 HECW1 (0.56, 0.0037, P = 3.4e-05, N = 7824) (0.82, 0.057, P = 0.38, N = 859)
rs1866570(C)/7:45166118 intergenic (0.58, -0.004, P = 7.8e-06, N = 7824) (0.4, -0.014, P = 0.77, N = 859)
rs3973242(C)/7:75130325 AC018720.10 (0.87, -0.23, P = 8.6e-07, N = 1954) (0.99, -0.13, P = 0.51, N = 859)
rs2714684(C)/7:79291370 intergenic (0.54, -0.004, P = 8.8e-06, N = 7824) (0.56, 0.024, P = 0.61, N = 859)
rs1285441(C)/7:9219283 intergenic (0.061, -0.24, P = 4.6e-07, N = 1954) (0.15, 0.0083, P = 0.9, N = 859)
rs4634560(T)/7:94332392 intergenic (0.91, -0.009, P = 6.8e-06, N = 7824) (0.85, 0.00044, P = 0.99, N = 859)
rs10239136(T)/7:9571623* intergenic (0.6, 0.0044, P = 1.5e-06, N = 7824) (0.45, -0.051, P = 0.29, N = 859)
rs7799978(A)/7:9716062 intergenic (0.82, 0.0072, P = 4.5e-06, N = 7824) (0.63, -0.02, P = 0.7, N = 859)
rs724752(T)/7:98573295 TRRAP (0.37, 0.0043, P = 2.7e-06, N = 7824) (0.19, 0.14, P = 0.02, N = 859)
rs34742539(A)/8:113805521 CSMD3 (0.018, -0.032, P = 3.7e-05, N = 7824) (0.017, 0.12, P = 0.52, N = 859)
rs2068985(C)/8:114053798 CSMD3 (0.35, -0.0041, P = 6.8e-06, N = 7824) (0.72, 0.002, P = 0.97, N = 859)
rs7836397(A)/8:121875083 intergenic (0.43, -0.0038, P = 3.4e-05, N = 7824) (0.069, -0.081, P = 0.39, N = 859)
rs7461025(T)/8:127654091 RP11-89K10.1 (0.59, 0.0043, P = 2.7e-06, N = 7824) (0.2, -0.021, P = 0.73, N = 859)
rs10481187(T)/8:132479119 intergenic (0.37, 0.0045, P = 9.7e-07, N = 7824) (0.36, 0.035, P = 0.49, N = 859)
rs273401(A)/8:132525949 intergenic (0.41, 0.0039, P = 2.1e-05, N = 7824) (0.4, -0.0068, P = 0.89, N = 859)
rs865488(T)/8:133938622 TG (0.68, -0.0041, P = 6.6e-06, N = 7824) (0.6, 0.041, P = 0.41, N = 859)
rs10111368(A)/8:134646398 intergenic (0.55, -0.0041, P = 5e-06, N = 7824) (0.75, 0.044, P = 0.43, N = 859)
rs10505611(T)/8:134662095 intergenic (0.85, 0.0069, P = 2.3e-05, N = 7824) (0.97, -0.12, P = 0.43, N = 859)
rs13275417(A)/8:138365307 intergenic (0.53, 0.0038, P = 2.9e-05, N = 7824) (0.38, -0.031, P = 0.53, N = 859)
rs6988796(T)/8:139312435 FAM135B (0.36, 0.0093, P = 1.5e-05, N = 7824) (0.42, -0.016, P = 0.74, N = 859)
rs7462991(T)/8:17934029* ASAH1 (0.92, 0.0096, P = 4e-05, N = 7824) (0.86, -0.16, P = 0.02, N = 859)
rs6984824(A)/8:1910078 ARHGEF10 (0.1, -0.0075, P = 1.5e-05, N = 7824) (0.14, -0.057, P = 0.41, N = 859)
rs6988339(A)/8:32545916 NRG1 (0.61, -0.0039, P = 2.1e-05, N = 7824) (0.9, -0.17, P = 0.034, N = 859)
rs7817745(T)/8:38550136 intergenic (0.61, -0.0039, P = 1.8e-05, N = 7824) (0.53, 0.032, P = 0.51, N = 859)
rs341815(A)/8:49978424* C8orf22 (0.36, 0.0038, P = 3e-05, N = 7824) (0.25, 0.057, P = 0.3, N = 859)
rs1160269(T)/8:5516034* RP11-281H11.1 (0.44, -0.0039, P = 1.4e-05, N = 7824) (0.17, -0.043, P = 0.48, N = 859)
rs761722563(CAATA)/8:59764368 TOX (0.024, 0.14, P = 1.7e-06, N = 1954) (0.22, 0.03, P = 0.6, N = 859)
rs12541401(A)/8:62805280* RP11-705O24.2 (0.46, -0.0039, P = 1.1e-05, N = 7824) (0.14, 0.026, P = 0.7, N = 859)
rs10095757(C)/8:73043160 intergenic (0.6, 0.0038, P = 2.4e-05, N = 7824) (0.54, 0.021, P = 0.66, N = 859)
rs4568622(T)/8:85779998 RALYL (0.58, -0.0039, P = 1.4e-05, N = 7824) (0.29, -0.023, P = 0.66, N = 859)
rs6468523(T)/8:87900893 CNBD1 (0.48, 0.0039, P = 1.9e-05, N = 7824) (0.29, 0.071, P = 0.18, N = 859)
rs7837480(A)/8:94468378 LINC00535 (0.48, -0.004, P = 9.3e-06, N = 7824) (0.64, -0.037, P = 0.48, N = 859)
rs6471514(T)/8:96100272 RP11-320N21.2 (0.54, -0.0042, P = 2.7e-06, N = 7824) (0.61, 0.05, P = 0.31, N = 859)
rs7815790(A)/8:98902730 MATN2 (0.39, -0.0039, P = 1.8e-05, N = 7824) (0.5, -0.0076, P = 0.87, N = 859)
rs2780956(A)/9:103348634 MURC (0.43, -0.0037, P = 4.5e-05, N = 7824) (0.26, -0.053, P = 0.34, N = 859)
rs10820588(T)/9:106722204 intergenic (0.56, 0.0048, P = 1.6e-07, N = 7824) (0.38, -0.059, P = 0.24, N = 859)
rs1507515(A)/9:106989653* intergenic (0.54, 0.0041, P = 5.2e-06, N = 7824) (0.6, -0.015, P = 0.76, N = 859)
rs2777788(A)/9:107662701* ABCA1 (0.64, -0.005, P = 5.7e-07, N = 7824) (0.27, -0.021, P = 0.7, N = 859)
rs72694252(G)/9:11126335 intergenic (0.18, 0.2, P = 3.4e-06, N = 1954) (0.048, -0.033, P = 0.76, N = 859)
rs1339881(A)/9:111488532 intergenic (0.68, -0.0038, P = 2.7e-05, N = 7824) (0.58, -0.0021, P = 0.97, N = 859)
rs7026148(T)/9:115636588 SNX30 (0.39, -0.0045, P = 4.5e-07, N = 7824) (0.33, -0.014, P = 0.8, N = 859)
rs80794(T)/9:118993074* PAPPA (0.41, 0.004, P = 1.1e-05, N = 7824) (0.51, 0.078, P = 0.098, N = 859)
rs1929425(T)/9:12367988* intergenic (0.39, 0.0043, P = 2.1e-06, N = 7824) (0.71, -0.066, P = 0.21, N = 859)
rs10818924(T)/9:126913862* intergenic (0.63, -0.0045, P = 6.1e-07, N = 7824) (0.57, -0.021, P = 0.65, N = 859)
rs2491102(C)/9:130313343 FAM129B (0.45, 0.0039, P = 2.1e-05, N = 7824) (0.63, -0.011, P = 0.82, N = 859)
rs3003607(A)/9:130968398 DNM1 (0.39, -0.004, P = 1e-05, N = 7824) (0.84, 0.021, P = 0.75, N = 859)
rs482275(T)/9:135351031 C9orf171 (0.57, 0.0041, P = 7.6e-06, N = 7824) (0.84, 0.018, P = 0.78, N = 859)
rs13284789(T)/9:138581671 SOHLH1 (0.14, 0.0079, P = 9.2e-06, N = 7824) (0.022, -0.12, P = 0.45, N = 859)
rs7867510(A)/9:15353410 RN7SL157P (0.16, 0.0068, P = 1.7e-05, N = 7824) (0.11, 0.084, P = 0.28, N = 859)
rs7038757(T)/9:16222474 C9orf92 (0.65, 0.0041, P = 6.1e-06, N = 7824) (0.27, -0.00024, P = 1, N = 859)
rs641522(A)/9:22756895 RP11-399D6.2 (0.54, 0.004, P = 1.1e-05, N = 7824) (0.88, -0.035, P = 0.64, N = 859)
rs3842979(A)/9:28359979* LINGO2 (0.62, -0.0041, P = 1e-05, N = 7824) (0.4, -0.026, P = 0.6, N = 859)
rs2164073(T)/9:28890746 MIR873 (0.1, -0.0073, P = 1.9e-05, N = 7824) (0.2, -0.04, P = 0.5, N = 859)
rs7036584(A)/9:31022187 intergenic (0.4, -0.0038, P = 3.2e-05, N = 7824) (0.4, 0.021, P = 0.66, N = 859)
rs12377990(T)/9:32164142 intergenic (0.54, -0.0038, P = 2.5e-05, N = 7824) (0.55, -0.015, P = 0.75, N = 859)
rs7026407(T)/9:32502525 DDX58 (0.63, -0.0037, P = 4.7e-05, N = 7824) (0.66, 0.099, P = 0.047, N = 859)
rs639102(T)/9:3270045 RFX3 (0.45, 0.0038, P = 2.4e-05, N = 7824) (0.89, -0.055, P = 0.47, N = 859)
rs7850311(T)/9:38060968* SHB (0.42, -0.0039, P = 1.5e-05, N = 7824) (0.5, -0.023, P = 0.64, N = 859)
rs62536941(A)/9:38194965 snoU13 (0.17, -0.55, P = 4.8e-06, N = 1954) (0.1, -0.057, P = 0.49, N = 859)
rs945573(A)/9:71383888 PIP5K1B (0.49, 0.0037, P = 4.1e-05, N = 7824) (0.65, 0.075, P = 0.14, N = 859)
rs10869018(T)/9:74004478 TRPM3 (0.51, -0.0041, P = 5.2e-06, N = 7824) (0.21, -0.00055, P = 0.99, N = 859)
rs1333342(A)/9:77502160 TRPM6 (0.44, 0.0037, P = 4.4e-05, N = 7824) (0.13, -0.092, P = 0.22, N = 859)
rs7863838(T)/9:79425483 PRUNE2 (0.58, -0.0038, P = 2.8e-05, N = 7824) (0.63, -0.0047, P = 0.92, N = 859)
rs273472(A)/9:81876910 intergenic (0.58, -0.0039, P = 1.3e-05, N = 7824) (0.51, -0.027, P = 0.57, N = 859)
rs2164183(T)/9:83127968* intergenic (0.51, -0.004, P = 9.8e-06, N = 7824) (0.21, -0.022, P = 0.71, N = 859)
rs1246267(A)/9:86758069 intergenic (0.59, 0.0045, P = 1.1e-06, N = 7824) (0.62, -0.029, P = 0.57, N = 859)
rs700760(T)/9:88934624* ZCCHC6 (0.55, -0.0042, P = 2.6e-06, N = 7824) (0.81, -0.025, P = 0.69, N = 859)
rs11265783(T)/9:92121724 intergenic (0.36, 0.0037, P = 4.8e-05, N = 7824) (0.21, 0.015, P = 0.8, N = 859)
rs4743148(A)/9:98430574 RP11-180I4.2 (0.62, -0.0038, P = 3.2e-05, N = 7824) (0.65, -0.13, P = 0.0096, N = 859)
Results from Univariable Mendelian Randomization of L-Carnitine & eGFR - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 535 5e-04 (-0.04- 0.041) P=0.98 19 243 0 (0- 31.6) NA NA 0.0019 P=0.44
MR-Egger 535 -0.0028 (-0.045- 0.04) P=0.9 19 243 0 (0- 31.6) 498 0.86 0.0019 P=0.44
Weighted median 535 0.00069 (-0.062- 0.063) P=0.98 19 243 0 (0- 31.6) NA NA 0.0019 P=0.44
Results from Univariable MRPRESSO of L-Carnitine & eGFR - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0 0.02 0.02 0.98
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of L-Carnitine & eGFR - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 399 0.00085 (-0.039- 0.04) P=0.97 25 243 0 (0- 3.58) NA NA 0.00017 P=0.95
MR-Egger 399 0.00058 (-0.042- 0.043) P=0.98 25 243 0 (0- 3.58) 352 0.95 0.00017 P=0.95
Weighted median 399 0.00071 (-0.062- 0.064) P=0.98 25 243 0 (0- 3.58) NA NA 0.00017 P=0.95
Results from Univariable MRPRESSO of L-Carnitine & eGFR - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0 0.02 0.04 0.97
beta.exposure Outlier-corrected NA NA NA NA

Choline

Instruments Associations with Choline & eGFR
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region Choline (Shin et al/Long et al) eGFR (CSSCD)
rs11804649(T)/1:113348570* intergenic (0.18, -0.0065, P = 4.5e-05, N = 7824) (0.081, 0.026, P = 0.76, N = 859)
rs55934782(G)/1:182577385* RGS16 (0.21, -0.19, P = 3e-06, N = 1955) (0.042, 0.026, P = 0.83, N = 859)
rs3737875(A)/1:203140671 MYBPH (0.087, -0.0093, P = 4.9e-05, N = 7824) (0.09, 0.017, P = 0.84, N = 859)
rs12562454(T)/1:26671084* AIM1L (0.2, -0.0067, P = 1.7e-05, N = 7824) (0.14, -0.09, P = 0.21, N = 859)
rs2666482(A)/1:62716806 KANK4 (0.74, -0.0063, P = 4.6e-05, N = 7824) (0.69, -0.058, P = 0.28, N = 859)
rs12039115(T)/1:62995263* DOCK7 (0.13, -0.0088, P = 1.9e-07, N = 7824) (0.11, -0.037, P = 0.62, N = 859)
rs6577322(A)/1:99164434* SNX7 (0.26, 0.0061, P = 2.9e-05, N = 7824) (0.21, 0.012, P = 0.83, N = 859)
rs6584573(C)/10:105570406* SH3PXD2A (0.016, 0.024, P = 1.3e-05, N = 7824) (0.13, -0.11, P = 0.14, N = 859)
rs17642749(T)/10:119647256* intergenic (0.95, -0.017, P = 2.7e-06, N = 7824) (0.96, -0.15, P = 0.23, N = 859)
rs2616664(A)/10:61485660 SLC16A9 (0.94, 0.011, P = 4.6e-05, N = 7824) (0.84, 0.054, P = 0.43, N = 859)
rs11253260(A)/10:625483* DIP2C (0.9, -0.0092, P = 3.6e-05, N = 7824) (0.47, 0.068, P = 0.16, N = 859)
rs9663814(A)/10:77738382* C10orf11 (0.62, 0.0069, P = 1.1e-06, N = 7824) (0.4, -0.014, P = 0.77, N = 859)
rs12253556(A)/10:93285009* intergenic (0.036, 0.51, P = 3.6e-06, N = 1955) (0.27, -0.026, P = 0.63, N = 859)
rs61878861(C)/11:337210 RP11-326C3.15 (0.32, -0.17, P = 4.9e-06, N = 1955) (0.073, 0.0069, P = 0.94, N = 859)
rs116190469(A)/11:88461300 GRM5 (0.059, 0.42, P = 5.5e-06, N = 1955) (0.033, 0.058, P = 0.67, N = 859)
rs10765693(A)/11:94403634* RP11-867G2.8 (0.12, 0.25, P = 8.1e-07, N = 1955) (0.097, -0.044, P = 0.59, N = 859)
rs11066907(A)/12:114486626* intergenic (0.19, -0.0065, P = 3.6e-05, N = 7824) (0.28, -0.02, P = 0.7, N = 859)
rs4765152(T)/12:124985150* NCOR2 (0.15, 0.0083, P = 2.3e-05, N = 7824) (0.21, -0.05, P = 0.4, N = 859)
rs11058334(A)/12:126281125 intergenic (0.023, -0.022, P = 4.3e-06, N = 7824) (0.036, -0.07, P = 0.59, N = 859)
rs7984957(C)/13:60814970* intergenic (0.78, -0.0065, P = 1.9e-05, N = 7824) (0.78, -0.026, P = 0.66, N = 859)
rs3904774(T)/13:74080133 LINC00393 (0.27, -0.0094, P = 5e-05, N = 7824) (0.56, 0.068, P = 0.15, N = 859)
rs1417497(C)/13:88128461 MIR4500HG (0.072, -0.011, P = 5.4e-06, N = 7824) (0.12, -0.026, P = 0.73, N = 859)
rs34569161(C)/13:96140764 CLDN10-AS1 (0.43, 0.13, P = 2.3e-06, N = 1955) (0.72, -0.11, P = 0.046, N = 859)
rs2297615(A)/14:20846521* TEP1 (0.78, 0.007, P = 8.2e-06, N = 7824) (0.67, -0.049, P = 0.32, N = 859)
rs1256105(T)/14:64826806 TEX21P (0.96, 0.014, P = 3e-05, N = 7824) (0.97, -0.14, P = 0.3, N = 859)
rs8003323(C)/14:70826166* COX16 (0.99, 0.031, P = 9.5e-06, N = 7824) (0.96, 0.0094, P = 0.94, N = 859)
rs11631911(A)/15:24915898 NPAP1 (0.85, 0.007, P = 2.4e-05, N = 7824) (0.84, 0.0095, P = 0.88, N = 859)
rs1906159(T)/15:40019682* FSIP1 (0.13, -0.0069, P = 3.5e-05, N = 7824) (0.38, -0.055, P = 0.28, N = 859)
rs8033100(T)/15:71977446* THSD4 (0.86, -0.0083, P = 4.9e-07, N = 7824) (0.66, -0.016, P = 0.75, N = 859)
rs4784175(A)/16:62213038 intergenic (0.86, -0.0091, P = 8.6e-06, N = 7824) (0.98, -0.13, P = 0.44, N = 859)
rs4888896(A)/16:79006490* WWOX (0.5, 0.0084, P = 2.8e-05, N = 7824) (0.34, -0.019, P = 0.71, N = 859)
rs11656215(T)/17:17453067* PEMT (0.5, -0.0079, P = 7.5e-08, N = 7824) (0.32, -0.095, P = 0.076, N = 859)
rs11867208(T)/17:17504609* RP11-524F11.2 (0.39, 0.0062, P = 1.4e-05, N = 7824) (0.4, 0.11, P = 0.025, N = 859)
rs7215931(A)/17:30099125 RP11-805L22.3 (0.2, 0.0079, P = 1.3e-06, N = 7824) (0.15, 0.032, P = 0.64, N = 859)
rs2053158(A)/17:73393459* GRB2 (0.83, 0.0066, P = 4.3e-05, N = 7824) (0.22, -0.019, P = 0.75, N = 859)
rs4789359(T)/17:74820027 intergenic (0.76, 0.0065, P = 2.1e-05, N = 7824) (0.85, 0.046, P = 0.49, N = 859)
rs3786284(A)/18:12010646* IMPA2 (0.15, 0.0077, P = 2e-06, N = 7824) (0.12, 0.1, P = 0.16, N = 859)
rs11663451(T)/18:2636605* intergenic (0.19, 0.25, P = 2.1e-06, N = 1955) (0.47, 0.0016, P = 0.97, N = 859)
rs1600674(A)/18:49450206 intergenic (0.83, 0.18, P = 1.5e-06, N = 1955) (0.59, -0.08, P = 0.11, N = 859)
rs7231686(C)/18:56737737* OACYLP (0.44, -0.2, P = 9.4e-07, N = 1955) (0.42, 0.0099, P = 0.84, N = 859)
rs12964226(T)/18:70957863* intergenic (0.21, -0.18, P = 5.7e-06, N = 1955) (0.24, 0.08, P = 0.16, N = 859)
rs2032334(A)/18:71191392 intergenic (0.79, -0.0068, P = 1.2e-05, N = 7824) (0.71, 0.063, P = 0.24, N = 859)
rs6506578(A)/18:8375039 PTPRM (0.017, -0.039, P = 3.9e-05, N = 7824) (0.064, 0.12, P = 0.22, N = 859)
rs2158004(A)/19:19033089 DDX49 (0.14, -0.0077, P = 1.3e-05, N = 7824) (0.42, 0.079, P = 0.11, N = 859)
rs321941(A)/19:52860348* ZNF610 (0.16, -0.011, P = 4e-05, N = 7824) (0.48, -0.0038, P = 0.94, N = 859)
rs7573335(T)/2:11127705* intergenic (0.89, -0.0088, P = 4.8e-05, N = 7824) (0.76, -0.011, P = 0.85, N = 859)
rs4538138(T)/2:147285915 intergenic (0.19, 0.0071, P = 6.1e-06, N = 7824) (0.45, 0.02, P = 0.69, N = 859)
rs34658429(C)/2:16597553 AC010880.1 (0.68, -0.14, P = 1.6e-06, N = 1955) (0.24, -0.057, P = 0.32, N = 859)
rs715(T)/2:211543055* CPS1 (0.71, 0.008, P = 9.1e-08, N = 7824) (0.81, -0.061, P = 0.33, N = 859)
rs16865057(A)/2:224529849* intergenic (0.97, -0.015, P = 3.8e-05, N = 7824) (0.63, -0.13, P = 0.0065, N = 859)
rs10194073(A)/2:38117987* intergenic (0.79, -0.007, P = 6.3e-06, N = 7824) (0.68, 0.075, P = 0.15, N = 859)
rs12105001(A)/2:44382375* RNU6-566P (0.049, -0.013, P = 7.5e-06, N = 7824) (0.029, -0.22, P = 0.11, N = 859)
rs4293599(C)/2:48944744 LHCGR (0.18, 0.0071, P = 5.9e-06, N = 7824) (0.11, -0.006, P = 0.94, N = 859)
rs7574038(C)/2:5276851 intergenic (0.077, 0.33, P = 5.3e-06, N = 1955) (0.2, 0.13, P = 0.037, N = 859)
rs6716379(C)/2:6896086 LINC00487 (0.15, 0.22, P = 4.7e-06, N = 1955) (0.16, 0.013, P = 0.84, N = 859)
rs6546697(T)/2:71707208 DYSF (0.16, 0.0074, P = 1.3e-05, N = 7824) (0.27, 0.075, P = 0.18, N = 859)
rs3856464(A)/2:9825974 RP11-521D12.2 (0.34, 0.18, P = 8e-06, N = 1955) (0.3, 0.032, P = 0.54, N = 859)
rs6035707(A)/20:20822149* intergenic (0.91, 0.0097, P = 1.1e-05, N = 7824) (0.84, 0.034, P = 0.6, N = 859)
rs2072241(A)/20:52561372 BCAS1 (0.78, 0.0067, P = 1.4e-05, N = 7824) (0.85, -0.0091, P = 0.89, N = 859)
rs2824226(A)/21:18457828 intergenic (0.82, 0.0074, P = 3.2e-06, N = 7824) (0.81, 0.011, P = 0.85, N = 859)
rs2833296(A)/21:32509845 TIAM1 (0.85, -0.0071, P = 1.1e-05, N = 7824) (0.5, -0.023, P = 0.63, N = 859)
rs2268241(A)/21:34781050 IFNGR2 (0.14, -0.007, P = 3.3e-05, N = 7824) (0.35, 0.079, P = 0.11, N = 859)
rs2293370(A)/3:119219934* TIMMDC1 (0.19, 0.0064, P = 4.2e-05, N = 7824) (0.2, 0.014, P = 0.81, N = 859)
rs2049502(A)/3:119254385* CD80 (0.83, -0.0065, P = 4.1e-05, N = 7824) (0.88, -0.016, P = 0.82, N = 859)
rs7645964(A)/3:168709924 intergenic (0.01, -0.79, P = 3.5e-06, N = 1955) (0.12, 0.25, P = 0.00044, N = 859)
rs12485568(G)/3:26669772 LRRC3B (0.54, 0.14, P = 9.1e-06, N = 1955) (0.38, -0.023, P = 0.64, N = 859)
rs555638682(CGGCCG)/3:47517573 SCAP (0.013, -0.64, P = 8.2e-06, N = 1955) (0.019, -0.12, P = 0.5, N = 859)
rs71308083(A)/3:55170650 intergenic (0.053, -0.42, P = 1.2e-06, N = 1955) (0.016, 0.14, P = 0.45, N = 859)
rs1403072(T)/3:70373502* intergenic (0.77, 0.17, P = 8.5e-06, N = 1955) (0.66, -0.023, P = 0.65, N = 859)
rs11930490(A)/4:131803692* RP11-401I19.1 (0.8, -0.0076, P = 1.5e-06, N = 7824) (0.79, -0.062, P = 0.29, N = 859)
rs2867675(A)/4:14214505 RP11-669M16.1 (0.044, -0.39, P = 9.1e-06, N = 1955) (0.012, 0.032, P = 0.88, N = 859)
rs7687295(A)/4:182067936 LINC00290 (0.025, 0.021, P = 4.3e-06, N = 7824) (0.21, -0.082, P = 0.16, N = 859)
rs16885645(A)/4:31678993 intergenic (0.055, 0.011, P = 4.7e-05, N = 7824) (0.14, -0.032, P = 0.64, N = 859)
rs9761879(A)/4:43860178 intergenic (0.77, 0.23, P = 6.3e-06, N = 1955) (0.55, 0.067, P = 0.17, N = 859)
rs12509841(T)/4:46578339 intergenic (0.15, -0.0067, P = 3.1e-05, N = 7824) (0.15, 0.0058, P = 0.93, N = 859)
rs959160(C)/4:47288955* GABRB1 (0.8, -0.0069, P = 1.1e-05, N = 7824) (0.97, 0.026, P = 0.87, N = 859)
rs2136209(A)/5:115384247* ARL14EPL (0.85, -0.0068, P = 2.2e-05, N = 7824) (0.77, -0.04, P = 0.48, N = 859)
rs17140120(A)/5:115892364 SEMA6A (0.16, 0.007, P = 1.1e-05, N = 7824) (0.04, 0.1, P = 0.39, N = 859)
rs3798102(T)/5:132605601 FSTL4 (0.97, -0.025, P = 3.8e-05, N = 7824) (0.38, 0.076, P = 0.12, N = 859)
rs4487482(A)/5:135201771* SLC25A48 (0.8, 0.0081, P = 1.8e-07, N = 7824) (0.9, 0.0042, P = 0.96, N = 859)
rs1573824(A)/5:170269857 intergenic (0.17, -0.0067, P = 2.4e-05, N = 7824) (0.3, 0.025, P = 0.63, N = 859)
rs224947(C)/5:81712715 intergenic (0.28, -0.0059, P = 4.8e-05, N = 7824) (0.25, 0.054, P = 0.34, N = 859)
rs111326958(T)/6:105755606 PREP (0.051, -0.36, P = 5.9e-06, N = 1955) (0.059, 0.033, P = 0.75, N = 859)
rs983669(T)/6:127122998* intergenic (0.55, 0.0063, P = 1.8e-05, N = 7824) (0.64, -0.008, P = 0.87, N = 859)
rs9321388(A)/6:133384863* intergenic (0.18, -0.0072, P = 7.6e-06, N = 7824) (0.74, 0.045, P = 0.4, N = 859)
rs17788268(T)/6:169477819 intergenic (0.2, 0.0066, P = 2.1e-05, N = 7824) (0.042, -0.059, P = 0.63, N = 859)
rs303000(A)/6:25057499 RP3-425P12.1 (0.17, 0.0069, P = 1.3e-05, N = 7824) (0.081, 0.096, P = 0.29, N = 859)
rs7745768(T)/6:29314964* intergenic (0.14, -0.0069, P = 3.3e-05, N = 7824) (0.16, 0.027, P = 0.68, N = 859)
rs2485074(A)/6:75350666 RP11-554D15.1 (0.094, 0.0096, P = 1.3e-05, N = 7824) (0.019, 0.03, P = 0.87, N = 859)
rs2299554(T)/7:126857154* GRM8 (0.96, 0.015, P = 3.6e-05, N = 7824) (0.91, 0.018, P = 0.83, N = 859)
rs2080224(A)/7:19528604* AC007091.1 (0.93, -0.011, P = 2e-06, N = 7824) (0.68, 0.012, P = 0.81, N = 859)
rs156282(G)/7:24200098* intergenic (0.37, 0.2, P = 1.8e-06, N = 1955) (0.67, -0.047, P = 0.36, N = 859)
rs2254363(A)/7:36122030* PP13004 (0.14, 0.0076, P = 1.1e-05, N = 7824) (0.41, 0.032, P = 0.5, N = 859)
rs2371208(T)/7:82337859* intergenic (0.22, -0.0062, P = 3.9e-05, N = 7824) (0.49, -0.001, P = 0.98, N = 859)
rs4262299(A)/8:108342263 ANGPT1 (0.87, 0.0072, P = 1.5e-05, N = 7824) (0.93, -0.04, P = 0.66, N = 859)
rs9694615(T)/8:21219361* intergenic (0.72, 0.0063, P = 3e-05, N = 7824) (0.95, -0.067, P = 0.56, N = 859)
rs4242454(A)/8:50672477* intergenic (0.14, 0.0077, P = 3.2e-06, N = 7824) (0.23, 0.14, P = 0.013, N = 859)
rs11791084(A)/9:138245834 RP11-555H7.2 (0.17, -0.0068, P = 3e-05, N = 7824) (0.15, 0.046, P = 0.49, N = 859)
rs7860932(A)/9:16786898* BNC2 (0.92, -0.0098, P = 1.5e-05, N = 7824) (0.85, -0.00075, P = 0.99, N = 859)
rs10963078(T)/9:17394225 CNTLN (0.3, 0.009, P = 2.7e-05, N = 7824) (0.16, 0.0074, P = 0.91, N = 859)
rs2891282(C)/9:26227745* intergenic (0.85, -0.0067, P = 2.8e-05, N = 7824) (0.74, -0.04, P = 0.46, N = 859)
rs12551252(T)/9:98438329 RP11-180I4.2 (0.075, -0.01, P = 1.5e-05, N = 7824) (0.035, 0.064, P = 0.63, N = 859)
Results from Univariable Mendelian Randomization of Choline & eGFR - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 102 -0.096 (-0.19- -0.0058) P=0.037 6.3 32 8.36 (0- 48.8) NA NA 0.0053 P=0.45
MR-Egger 102 -0.11 (-0.22- -0.011) P=0.032 6.3 32 8.36 (0- 48.8) 98 0.55 0.0053 P=0.45
Weighted median 102 -0.053 (-0.22- 0.12) P=0.54 6.3 32 8.36 (0- 48.8) NA NA 0.0053 P=0.45
Results from Univariable MRPRESSO of Choline & eGFR - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.1 0.05 -2.09 0.04
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of Choline & eGFR - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 50 -0.1 (-0.23- 0.016) P=0.088 7.8 20 17.8 (0- 39.8) NA NA -0.0077 P=0.49
MR-Egger 50 -0.08 (-0.22- 0.059) P=0.26 7.8 20 17.8 (0- 39.8) 50 0.38 -0.0077 P=0.49
Weighted median 50 -0.085 (-0.32- 0.15) P=0.47 7.8 20 17.8 (0- 39.8) NA NA -0.0077 P=0.49
Results from Univariable MRPRESSO of Choline & eGFR - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.1 0.06 -1.71 0.09
beta.exposure Outlier-corrected NA NA NA NA

Citric acid

Instruments Associations with Citric acid & eGFR
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region Citric acid (Shin et al/Long et al) eGFR (CSSCD)
rs2392041(A)/1:100056225 intergenic (0.66, -0.0075, P = 3.5e-05, N = 7824) (0.46, -0.013, P = 0.79, N = 859)
rs3125672(T)/1:107822255* NTNG1 (0.3, -0.0076, P = 2.7e-05, N = 7824) (0.1, -0.11, P = 0.15, N = 859)
rs6604130(A)/1:109388656* AKNAD1 (0.19, 0.15, P = 3.9e-06, N = 1958) (0.52, -0.014, P = 0.76, N = 859)
rs17037696(T)/1:12243274 TNFRSF1B (0.26, -0.011, P = 1.2e-05, N = 7824) (0.19, 0.062, P = 0.31, N = 859)
rs12136772(A)/1:19901804 intergenic (0.92, -0.014, P = 4e-05, N = 7824) (0.93, -0.13, P = 0.18, N = 859)
rs6678076(A)/1:199233200* RP11-382E9.1 (0.034, -0.025, P = 1.1e-06, N = 7824) (0.24, -0.0069, P = 0.91, N = 859)
rs6655965(A)/1:203680492* ATP2B4 (0.54, 0.0074, P = 3.6e-05, N = 7824) (0.35, 0.0073, P = 0.88, N = 859)
rs11120725(A)/1:216206768 USH2A (0.46, -0.018, P = 4.6e-06, N = 7824) (0.34, 0.025, P = 0.63, N = 859)
rs265126(A)/1:217620203* GPATCH2 (0.17, 0.011, P = 2.6e-05, N = 7824) (0.35, 0.081, P = 0.11, N = 859)
rs2813960(T)/1:227402299 CDC42BPA (0.67, -0.018, P = 2.5e-05, N = 7824) (0.64, 0.016, P = 0.76, N = 859)
rs11584333(A)/1:230529619* PGBD5 (0.32, -0.15, P = 5e-06, N = 1958) (0.09, 0.081, P = 0.34, N = 859)
rs614612(T)/1:23422692* LUZP1 (0.16, -0.022, P = 1.7e-05, N = 7824) (0.19, 0.12, P = 0.051, N = 859)
rs12748947(T)/1:239463528 intergenic (0.68, -0.0074, P = 4.7e-05, N = 7824) (0.92, 0.068, P = 0.44, N = 859)
rs260969(T)/1:39551621 MACF1 (0.28, -0.0074, P = 4.8e-05, N = 7824) (0.14, 0.068, P = 0.34, N = 859)
rs7512821(A)/1:62774469* KANK4 (0.46, -0.0074, P = 3.2e-05, N = 7824) (0.69, -0.061, P = 0.25, N = 859)
rs11492774(C)/10:109637548 RP11-215N21.1 (0.15, -0.24, P = 6.8e-06, N = 1958) (0.14, 0.025, P = 0.73, N = 859)
rs10787308(A)/10:112908968* intergenic (0.27, -0.009, P = 6e-07, N = 7824) (0.26, 0.016, P = 0.77, N = 859)
rs4880317(A)/10:133880163 intergenic (0.32, -0.0074, P = 4.6e-05, N = 7824) (0.13, -0.015, P = 0.83, N = 859)
rs3750870(T)/10:24548718* KIAA1217 (0.36, 0.0077, P = 1.9e-05, N = 7824) (0.14, 0.1, P = 0.14, N = 859)
rs4589188(A)/10:5567914 CALML3 (0.28, 0.012, P = 3.3e-06, N = 7824) (0.29, 0.0042, P = 0.94, N = 859)
rs7919076(T)/10:68328936 CTNNA3 (0.34, -0.0081, P = 7.8e-06, N = 7824) (0.22, 0.051, P = 0.38, N = 859)
rs2057440(A)/10:77758013 C10orf11 (0.72, 0.0079, P = 1.3e-05, N = 7824) (0.39, -0.053, P = 0.27, N = 859)
rs10824358(T)/10:77827397 C10orf11 (0.55, -0.0072, P = 4.8e-05, N = 7824) (0.75, -0.088, P = 0.11, N = 859)
rs4918082(A)/10:95859929* PLCE1 (0.72, -0.0079, P = 1.3e-05, N = 7824) (0.46, 0.036, P = 0.46, N = 859)
rs3193970(T)/10:97072008* SORBS1 (0.58, 0.0081, P = 6.1e-06, N = 7824) (0.63, 0.051, P = 0.31, N = 859)
rs1998911(T)/10:97266538* SORBS1 (0.29, 0.0075, P = 4.4e-05, N = 7824) (0.58, -0.0063, P = 0.9, N = 859)
rs527936(C)/11:100279586 intergenic (0.88, 0.011, P = 4.5e-05, N = 7824) (0.79, -0.057, P = 0.32, N = 859)
rs7105815(A)/11:12309693 MICALCL (0.3, 0.0091, P = 4.9e-07, N = 7824) (0.38, 0.00062, P = 0.99, N = 859)
rs7950818(T)/11:124385456* OR8B10P (0.12, -0.011, P = 2.1e-05, N = 7824) (0.19, -0.045, P = 0.47, N = 859)
rs2878806(T)/11:17713507* RP11-358H18.3 (0.75, -0.0078, P = 2e-05, N = 7824) (0.17, 0.15, P = 0.02, N = 859)
rs7109624(A)/11:20836004 NELL1 (0.018, -0.031, P = 4.5e-05, N = 7824) (0.036, 0.043, P = 0.74, N = 859)
rs2237897(T)/11:2858546 KCNQ1 (0.058, -0.038, P = 1e-05, N = 7824) (0.086, -0.074, P = 0.39, N = 859)
rs13966(T)/11:61664992* RAB3IL1 (0.47, 0.0082, P = 1e-05, N = 7824) (0.54, 0.079, P = 0.11, N = 859)
rs12797573(T)/11:77255306* CLNS1A (0.69, -0.0076, P = 2.6e-05, N = 7824) (0.87, -0.053, P = 0.45, N = 859)
rs12222578(T)/11:81696265 RP11-179A16.1 (0.29, -0.0073, P = 4.6e-05, N = 7824) (0.11, 0.082, P = 0.29, N = 859)
rs12803308(A)/11:96180609* JRKL-AS1 (0.68, -0.0081, P = 6e-06, N = 7824) (0.82, 0.023, P = 0.71, N = 859)
rs1169072(A)/12:122401501* WDR66 (0.42, 0.0078, P = 1.2e-05, N = 7824) (0.16, 0.011, P = 0.87, N = 859)
rs79424089(G)/12:21485527 SLCO1A2 (0.061, 0.23, P = 2.5e-06, N = 1958) (0.013, -0.11, P = 0.61, N = 859)
rs2080125(T)/12:7727544* intergenic (0.27, 0.0074, P = 4.8e-05, N = 7824) (0.8, 0.079, P = 0.18, N = 859)
rs932829(A)/13:40828542 intergenic (0.47, -0.0078, P = 1.3e-05, N = 7824) (0.41, -0.21, P = 2.9e-05, N = 859)
rs35354791(TG)/13:46419404 SIAH3 (0.45, 0.18, P = 8.7e-06, N = 1958) (0.82, -0.0025, P = 0.97, N = 859)
rs1953192(T)/14:40297539* intergenic (0.42, 0.0077, P = 1.3e-05, N = 7824) (0.1, 0.0087, P = 0.91, N = 859)
rs2236299(A)/14:55255335 SAMD4A (0.31, 0.0087, P = 1.7e-06, N = 7824) (0.14, 0.051, P = 0.46, N = 859)
rs8017368(A)/14:63527183* KCNH5 (0.65, -0.0083, P = 3.9e-06, N = 7824) (0.52, 0.062, P = 0.2, N = 859)
rs10147304(A)/14:79079176 NRXN3 (0.052, 0.018, P = 1.6e-05, N = 7824) (0.2, -0.011, P = 0.85, N = 859)
rs74686496(C)/14:98384933 intergenic (0.12, 0.26, P = 9.5e-06, N = 1958) (0.012, -0.17, P = 0.41, N = 859)
rs8025575(C)/15:26788083* GABRB3 (0.46, -0.0073, P = 4.6e-05, N = 7824) (0.59, -0.03, P = 0.54, N = 859)
rs4779800(A)/15:29411326* APBA2 (0.88, -0.012, P = 6.1e-06, N = 7824) (0.54, -0.021, P = 0.66, N = 859)
rs8025554(C)/15:32418417 CHRNA7 (0.52, -0.008, P = 6.6e-06, N = 7824) (0.34, -0.091, P = 0.076, N = 859)
rs1530219(A)/15:39602380* RP11-462P6.1 (0.48, -0.0078, P = 9.9e-06, N = 7824) (0.16, -0.038, P = 0.56, N = 859)
rs3784283(A)/15:41867782 TYRO3 (0.61, 0.0076, P = 2.1e-05, N = 7824) (0.5, -0.0078, P = 0.87, N = 859)
rs7179219(A)/15:42324479 PLA2G4E (0.15, -0.011, P = 2.3e-05, N = 7824) (0.26, 0.077, P = 0.15, N = 859)
rs2727091(T)/15:66124227* RAB11A (0.12, -0.012, P = 1.4e-05, N = 7824) (0.12, 0.024, P = 0.75, N = 859)
rs11862304(A)/16:17191196 XYLT1 (0.28, 0.0077, P = 2e-05, N = 7824) (0.42, 0.084, P = 0.083, N = 859)
rs2239337(C)/16:22911553 HS3ST2 (0.036, 0.023, P = 7.5e-06, N = 7824) (0.29, 0.02, P = 0.7, N = 859)
rs6502405(A)/17:14834158 intergenic (0.39, -0.0076, P = 2.3e-05, N = 7824) (0.14, -0.045, P = 0.51, N = 859)
rs170149(A)/17:6595930 SLC13A5 (0.074, 0.026, P = 1.4e-13, N = 7824) (0.25, -0.048, P = 0.37, N = 859)
rs218682(T)/17:6614288 SLC13A5 (0.4, 0.0093, P = 3e-07, N = 7824) (0.78, -0.083, P = 0.16, N = 859)
rs4999864(C)/17:66786460 RP11-118B18.2 (0.93, 0.018, P = 4.8e-07, N = 7824) (0.79, 0.026, P = 0.66, N = 859)
rs1509123(T)/17:6683878 FBXO39 (0.048, -0.025, P = 5.2e-09, N = 7824) (0.04, 0.038, P = 0.76, N = 859)
rs12103645(T)/17:6721216* TEKT1 (0.086, -0.018, P = 6.6e-08, N = 7824) (0.18, -0.04, P = 0.51, N = 859)
rs9901983(A)/17:71816764* LINC00469 (0.021, 0.062, P = 4.9e-05, N = 7824) (0.42, 0.0065, P = 0.89, N = 859)
rs6507399(A)/18:38732045 intergenic (0.67, -0.01, P = 1.7e-08, N = 7824) (0.79, -0.025, P = 0.67, N = 859)
rs2552494(A)/18:38751633* intergenic (0.19, 0.011, P = 3.4e-05, N = 7824) (0.41, -0.0041, P = 0.94, N = 859)
rs1792712(A)/18:53834119 CTD-2008L17.2 (0.41, 0.0075, P = 2.7e-05, N = 7824) (0.71, 0.019, P = 0.71, N = 859)
rs17208063(T)/18:67557428 CD226 (0.076, 0.2, P = 9.1e-06, N = 1958) (0.074, 0.044, P = 0.62, N = 859)
rs36013690(CA)/18:74632507 ZNF236 (0.079, -0.23, P = 9.1e-06, N = 1958) (0.8, -0.055, P = 0.36, N = 859)
rs889128(T)/19:10131693 RDH8 (0.67, 0.0082, P = 6.8e-06, N = 7824) (0.39, -0.048, P = 0.33, N = 859)
rs279220(A)/19:11990258 ZNF439 (0.33, 0.18, P = 9.4e-06, N = 1958) (0.44, -0.017, P = 0.72, N = 859)
rs588973(A)/19:50736956* MYH14 (0.65, 0.009, P = 6.8e-06, N = 7824) (0.58, 0.11, P = 0.024, N = 859)
rs2370136(T)/19:57619241* intergenic (0.49, -0.0086, P = 1.2e-06, N = 7824) (0.73, 0.0081, P = 0.88, N = 859)
rs6725836(T)/2:107862691* intergenic (0.7, -0.0077, P = 2e-05, N = 7824) (0.34, -0.00076, P = 0.99, N = 859)
rs11693199(T)/2:119732042 MARCO (0.59, -0.0079, P = 1e-05, N = 7824) (0.92, 0.034, P = 0.7, N = 859)
rs3749114(A)/2:160832996* PLA2R1 (0.46, 0.0078, P = 1.3e-05, N = 7824) (0.9, -0.026, P = 0.74, N = 859)
rs17614686(C)/2:167808253* XIRP2 (0.88, 0.012, P = 1.4e-05, N = 7824) (0.95, 0.12, P = 0.29, N = 859)
rs6747034(A)/2:174238868 intergenic (0.48, -0.0074, P = 3e-05, N = 7824) (0.76, -0.039, P = 0.48, N = 859)
rs4470337(A)/2:228293381 intergenic (0.42, -0.0074, P = 3.6e-05, N = 7824) (0.48, -0.0017, P = 0.97, N = 859)
rs76848421(T)/2:240661614 RP11-315F22.1 (0.017, 0.66, P = 4.3e-06, N = 1958) (0.13, 0.078, P = 0.28, N = 859)
rs4274563(T)/2:30157386 intergenic (0.38, -0.0075, P = 3.3e-05, N = 7824) (0.54, 0.021, P = 0.66, N = 859)
rs7584253(A)/2:48927246* LHCGR (0.7, 0.0083, P = 5e-06, N = 7824) (0.74, 0.062, P = 0.26, N = 859)
rs193031(C)/2:64260458 intergenic (0.18, 0.011, P = 1.2e-05, N = 7824) (0.43, -0.069, P = 0.16, N = 859)
rs939136(C)/2:66677531 MEIS1 (0.67, -0.0076, P = 2.3e-05, N = 7824) (0.48, 0.054, P = 0.26, N = 859)
rs6077792(T)/20:1096116 PSMF1 (0.3, -0.0085, P = 2.8e-06, N = 7824) (0.26, -0.0064, P = 0.91, N = 859)
rs6121327(A)/20:30643515 HCK (0.012, 0.68, P = 4e-06, N = 1958) (0.059, 0.065, P = 0.52, N = 859)
rs1325760(T)/20:46740070 intergenic (0.74, 0.0077, P = 1.8e-05, N = 7824) (0.22, 0.074, P = 0.21, N = 859)
rs12625828(T)/20:48844585 intergenic (0.34, 0.0086, P = 2.1e-06, N = 7824) (0.18, 0.096, P = 0.13, N = 859)
rs11905229(C)/20:55151100 RP5-843L14.1 (0.43, 0.013, P = 5.8e-06, N = 7824) (0.28, 0.032, P = 0.55, N = 859)
rs6133537(A)/20:8039501 intergenic (0.061, 0.018, P = 1.8e-05, N = 7824) (0.093, -0.051, P = 0.55, N = 859)
rs2836710(T)/21:40218782 AP001042.1 (0.63, 0.0077, P = 1.7e-05, N = 7824) (0.75, 0.0025, P = 0.96, N = 859)
rs1125471(A)/22:17656724 CECR1 (0.29, -0.0085, P = 4.5e-06, N = 7824) (0.19, -0.074, P = 0.22, N = 859)
rs807670(A)/22:19154608* AC004463.6 (0.42, 0.011, P = 6.8e-10, N = 7824) (0.44, -0.033, P = 0.49, N = 859)
rs723414(A)/22:19185736* CLTCL1 (0.56, -0.0072, P = 4.6e-05, N = 7824) (0.79, 0.042, P = 0.48, N = 859)
rs361787(T)/22:19263698* CLTCL1 (0.61, -0.0091, P = 3.8e-07, N = 7824) (0.75, 0.0011, P = 0.98, N = 859)
rs738809(A)/22:24405492* CABIN1 (0.72, 0.0077, P = 2.1e-05, N = 7824) (0.7, -0.068, P = 0.21, N = 859)
rs9624921(T)/22:26250248* MYO18B (0.3, 0.0074, P = 4.5e-05, N = 7824) (0.14, 0.037, P = 0.6, N = 859)
rs2413380(T)/22:36519040* intergenic (0.6, -0.0076, P = 2.1e-05, N = 7824) (0.86, -0.035, P = 0.6, N = 859)
rs133064(A)/22:41071731 MCHR1 (0.38, -0.0073, P = 4.6e-05, N = 7824) (0.33, 0.041, P = 0.42, N = 859)
rs11706160(G)/3:1461452 intergenic (0.27, 0.2, P = 6.5e-06, N = 1958) (0.061, -0.0047, P = 0.96, N = 859)
rs11276214(TTTACTACAATTTAC)/3:183088540 MCF2L2 (0.062, -0.24, P = 2.1e-06, N = 1958) (0.55, -0.023, P = 0.62, N = 859)
rs7623540(A)/3:188489540 LPP (0.72, -0.0085, P = 3.4e-06, N = 7824) (0.45, -0.019, P = 0.69, N = 859)
rs10514735(A)/3:85798950* CADM2 (0.98, 0.035, P = 6.5e-06, N = 7824) (0.97, 0.23, P = 0.092, N = 859)
rs17034684(T)/4:105511810 AC004053.1 (0.29, 0.0081, P = 7.9e-06, N = 7824) (0.26, -0.038, P = 0.49, N = 859)
rs697365(A)/4:121377644 intergenic (0.34, -0.0075, P = 3e-05, N = 7824) (0.12, 0.032, P = 0.67, N = 859)
rs12499121(T)/4:12297535* intergenic (0.79, 0.011, P = 1.5e-05, N = 7824) (0.73, -0.049, P = 0.36, N = 859)
rs13151462(A)/4:12670968* intergenic (0.58, 0.0081, P = 5.1e-06, N = 7824) (0.39, -0.0099, P = 0.84, N = 859)
rs1033175(A)/4:128532930* intergenic (0.57, 0.0076, P = 2.1e-05, N = 7824) (0.43, -0.00028, P = 1, N = 859)
rs28446988(T)/4:140140965* intergenic (0.24, 0.12, P = 7.9e-06, N = 1958) (0.5, -0.031, P = 0.51, N = 859)
rs13130021(T)/4:2277763* ZFYVE28 (0.43, -0.0089, P = 1.4e-06, N = 7824) (0.18, 0.1, P = 0.1, N = 859)
rs13128174(C)/4:37739459 intergenic (0.16, -0.21, P = 9.9e-06, N = 1958) (0.065, 0.053, P = 0.59, N = 859)
rs4861079(A)/4:40371287 intergenic (0.86, -0.011, P = 1.7e-05, N = 7824) (0.43, 0.011, P = 0.81, N = 859)
rs1404373(T)/4:58204024 intergenic (0.65, -0.0084, P = 2.9e-06, N = 7824) (0.95, 0.12, P = 0.28, N = 859)
rs6854172(T)/4:6410288* PPP2R2C (0.16, 0.022, P = 2.1e-05, N = 7824) (0.21, 0.027, P = 0.65, N = 859)
rs4235093(A)/4:72346252 SLC4A4 (0.29, -0.0083, P = 5e-06, N = 7824) (0.78, 0.039, P = 0.49, N = 859)
rs13106792(A)/4:80239092 NAA11 (0.63, 0.0078, P = 1.4e-05, N = 7824) (0.68, -0.056, P = 0.28, N = 859)
rs4693453(A)/4:83448507* TMEM150C (0.87, 0.011, P = 2.7e-05, N = 7824) (0.45, 0.012, P = 0.8, N = 859)
rs12509601(A)/4:92222755 CCSER1 (0.71, -0.15, P = 3.7e-06, N = 1958) (0.96, -0.1, P = 0.39, N = 859)
rs1230171(C)/4:99924278* METAP1 (0.68, -0.0076, P = 2.8e-05, N = 7824) (0.85, -0.046, P = 0.5, N = 859)
rs17595102(C)/4:99986316* METAP1 (0.44, -0.0078, P = 1.3e-05, N = 7824) (0.12, 0.032, P = 0.67, N = 859)
rs1549924(A)/5:107216209* FBXL17 (0.079, -0.015, P = 2e-05, N = 7824) (0.17, 0.044, P = 0.48, N = 859)
rs9327706(A)/5:134512608* C5orf66 (0.59, 0.0081, P = 5.6e-06, N = 7824) (0.55, 0.045, P = 0.35, N = 859)
rs111686785(G)/5:14738965 ANKH (0.03, -0.61, P = 1.1e-07, N = 1958) (0.019, 0.077, P = 0.66, N = 859)
rs835154(A)/5:14876569* ANKH (0.58, -0.011, P = 1.1e-10, N = 7824) (0.88, 0.092, P = 0.22, N = 859)
rs1968433(T)/5:155628282 SGCD (0.66, 0.0076, P = 2.2e-05, N = 7824) (0.93, -0.11, P = 0.27, N = 859)
rs10043015(T)/5:168658371 SLIT3 (0.71, 0.0082, P = 5.6e-06, N = 7824) (0.61, -0.13, P = 0.011, N = 859)
rs9313504(A)/5:169830698* CTD-2270F17.1 (0.99, -0.074, P = 3.4e-05, N = 7824) (0.8, 0.072, P = 0.23, N = 859)
rs2731709(T)/5:171788634* SH3PXD2B (0.67, -0.0078, P = 1.6e-05, N = 7824) (0.85, -0.065, P = 0.33, N = 859)
rs12654113(C)/5:20326490 CDH18 (0.47, -0.0077, P = 1.7e-05, N = 7824) (0.83, -0.042, P = 0.51, N = 859)
rs7710027(T)/5:55901945* AC022431.2 (0.29, 0.0081, P = 9.2e-06, N = 7824) (0.65, 0.075, P = 0.13, N = 859)
rs2534835(T)/5:56948443 intergenic (0.24, -0.0083, P = 6.2e-06, N = 7824) (0.081, 0.018, P = 0.83, N = 859)
rs113693608(TAA)/5:7660900 ADCY2 (0.18, 0.23, P = 9.9e-06, N = 1958) (0.2, 0.027, P = 0.66, N = 859)
rs10074809(T)/5:95818902 CTD-2337A12.1 (0.29, 0.0079, P = 1.3e-05, N = 7824) (0.047, 0.06, P = 0.6, N = 859)
rs7734922(T)/5:96745629 RP11-155G15.2 (0.92, 0.029, P = 3.2e-05, N = 7824) (0.79, 0.083, P = 0.16, N = 859)
rs9387010(T)/6:111705944* REV3L (0.065, -0.015, P = 2.9e-05, N = 7824) (0.053, 0.037, P = 0.73, N = 859)
rs9372398(T)/6:114833591 intergenic (0.55, 0.0081, P = 6.7e-06, N = 7824) (0.26, -0.058, P = 0.27, N = 859)
rs768581(T)/6:117277972 intergenic (0.19, -0.011, P = 2.7e-05, N = 7824) (0.26, 0.11, P = 0.046, N = 859)
rs2224382(A)/6:133611341 EYA4 (0.4, -0.01, P = 4.4e-05, N = 7824) (0.43, 0.051, P = 0.3, N = 859)
rs9389071(A)/6:133674634* EYA4 (0.16, -0.012, P = 5.6e-06, N = 7824) (0.23, 0.056, P = 0.32, N = 859)
rs3777804(A)/6:133708746* EYA4 (0.87, 0.011, P = 2.2e-05, N = 7824) (0.71, 0.015, P = 0.78, N = 859)
rs2143327(T)/6:146616239 GRM1 (0.013, 0.039, P = 4.3e-06, N = 7824) (0.28, -0.0049, P = 0.93, N = 859)
rs2294784(T)/6:148852391* SASH1 (0.86, -0.011, P = 4.9e-05, N = 7824) (0.76, 0.01, P = 0.85, N = 859)
rs2880072(A)/6:159825449* intergenic (0.39, 0.0072, P = 5e-05, N = 7824) (0.69, -0.064, P = 0.23, N = 859)
rs9355391(G)/6:162689005 PARK2 (0.18, -0.2, P = 4.2e-06, N = 1958) (0.62, -0.057, P = 0.24, N = 859)
rs12213498(T)/6:169753177 intergenic (0.14, 0.26, P = 8.4e-06, N = 1958) (0.016, 0.24, P = 0.21, N = 859)
rs910616(T)/6:44074976 intergenic (0.5, -0.0093, P = 2e-07, N = 7824) (0.18, -0.025, P = 0.69, N = 859)
rs4236146(T)/6:56960612 ZNF451 (0.19, 0.012, P = 4.7e-05, N = 7824) (0.48, -0.061, P = 0.2, N = 859)
rs11243250(T)/6:8364262* intergenic (0.36, 0.0073, P = 4.6e-05, N = 7824) (0.75, -0.0052, P = 0.93, N = 859)
rs1890954(T)/6:8386802 intergenic (0.3, -0.008, P = 9.8e-06, N = 7824) (0.094, -0.13, P = 0.11, N = 859)
rs422252(A)/6:89893578 GABRR1 (0.48, -0.16, P = 9.5e-06, N = 1958) (0.54, 0.0024, P = 0.96, N = 859)
rs2190406(C)/7:108081246 NRCAM (0.29, 0.0073, P = 4.6e-05, N = 7824) (0.52, 0.067, P = 0.16, N = 859)
rs6467552(T)/7:134390473 intergenic (0.5, 0.0078, P = 1.4e-05, N = 7824) (0.69, -0.13, P = 0.011, N = 859)
rs2299893(A)/7:139618590* TBXAS1 (0.73, -0.0077, P = 3e-05, N = 7824) (0.35, 0.059, P = 0.24, N = 859)
rs940697(A)/7:143183203 EPHA1-AS1 (0.27, 0.0082, P = 5.7e-06, N = 7824) (0.36, -0.076, P = 0.13, N = 859)
rs2717875(T)/7:25222184 C7orf31 (0.93, 0.015, P = 1.5e-05, N = 7824) (0.77, 0.048, P = 0.39, N = 859)
rs17158507(A)/7:83642711 SEMA3A (0.13, -0.011, P = 3.2e-05, N = 7824) (0.077, -0.069, P = 0.45, N = 859)
rs2049649(G)/7:94949329 PON1 (0.31, -0.14, P = 8.7e-06, N = 1958) (0.44, -0.014, P = 0.78, N = 859)
rs6965510(T)/7:95229848* PDK4 (0.059, 0.015, P = 3.4e-05, N = 7824) (0.24, -0.048, P = 0.39, N = 859)
rs3133577(T)/8:101805542* intergenic (0.68, -0.0076, P = 2.3e-05, N = 7824) (0.53, 0.065, P = 0.18, N = 859)
rs7012644(T)/8:118736914* intergenic (0.25, 0.0077, P = 3.1e-05, N = 7824) (0.18, 0.023, P = 0.72, N = 859)
rs7837201(T)/8:133319798 KCNQ3 (0.8, -0.011, P = 2.3e-05, N = 7824) (0.56, 0.066, P = 0.17, N = 859)
rs2623859(T)/8:68677337 intergenic (0.93, 0.29, P = 2.7e-06, N = 1958) (0.87, 0.0081, P = 0.91, N = 859)
rs10093959(A)/8:78050644* intergenic (0.63, -0.0075, P = 2.7e-05, N = 7824) (0.37, -0.04, P = 0.42, N = 859)
rs1380634(A)/8:80237893 intergenic (0.74, -0.0083, P = 5.2e-06, N = 7824) (0.49, 0.023, P = 0.63, N = 859)
rs7465310(T)/8:80266503 intergenic (0.63, -0.008, P = 7.3e-06, N = 7824) (0.24, -0.038, P = 0.51, N = 859)
rs17461032(T)/8:81083077 TPD52 (0.71, -0.0077, P = 2.6e-05, N = 7824) (0.78, 0.017, P = 0.77, N = 859)
rs10818640(A)/9:100997156 TBC1D2 (0.27, 0.008, P = 1.3e-05, N = 7824) (0.17, 0.19, P = 0.0039, N = 859)
rs10978481(C)/9:109195928 RP11-308N19.1 (0.41, 0.0077, P = 1.7e-05, N = 7824) (0.076, 0.00082, P = 0.99, N = 859)
rs2093403(T)/9:117611913 RP11-78H18.2 (0.88, -0.011, P = 2.8e-05, N = 7824) (0.88, 0.0035, P = 0.96, N = 859)
rs2041472(C)/9:125539968* intergenic (0.017, 0.031, P = 1e-05, N = 7824) (0.27, 0.038, P = 0.49, N = 859)
rs11103845(A)/9:138252603* intergenic (0.05, 0.018, P = 2.7e-05, N = 7824) (0.011, 0.059, P = 0.79, N = 859)
rs868395(T)/9:85175793* RP11-15B24.5 (0.67, 0.01, P = 2e-08, N = 7824) (0.92, 0.18, P = 0.047, N = 859)
rs10992722(A)/9:96163761 intergenic (0.016, 0.033, P = 2.4e-06, N = 7824) (0.14, 0.061, P = 0.38, N = 859)
rs6479486(A)/9:96226164 FAM120A (0.98, -0.032, P = 2.7e-06, N = 7824) (0.94, 0.018, P = 0.86, N = 859)
Results from Univariable Mendelian Randomization of Citric acid & eGFR - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 172 0.059 (-0.051- 0.17) P=0.29 3.3 27 1.74e-05 (0- 93) NA NA -0.0018 P=0.72
MR-Egger 172 0.068 (-0.053- 0.19) P=0.27 3.3 27 1.74e-05 (0- 93) 177 0.35 -0.0018 P=0.72
Weighted median 172 0.097 (-0.054- 0.25) P=0.21 3.3 27 1.74e-05 (0- 93) NA NA -0.0018 P=0.72
Results from Univariable MRPRESSO of Citric acid & eGFR - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0.06 0.06 1.05 0.3
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of Citric acid & eGFR - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 101 0.078 (-0.039- 0.2) P=0.19 5.1 25 0.0011 (0- 97.4) NA NA -0.0061 P=0.38
MR-Egger 101 0.1 (-0.027- 0.23) P=0.12 5.1 25 0.0011 (0- 97.4) 109 0.24 -0.0061 P=0.38
Weighted median 101 0.097 (-0.057- 0.25) P=0.22 5.1 25 0.0011 (0- 97.4) NA NA -0.0061 P=0.38
Results from Univariable MRPRESSO of Citric acid & eGFR - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0.08 0.06 1.3 0.2
beta.exposure Outlier-corrected NA NA NA NA

Citrulline

Instruments Associations with Citrulline & eGFR
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region Citrulline (Shin et al/Long et al) eGFR (CSSCD)
rs6678521(T)/1:107387839 intergenic (0.37, -0.007, P = 4.9e-05, N = 7824) (0.32, -0.062, P = 0.24, N = 859)
rs10858075(T)/1:115877522* NGF (0.41, -0.0091, P = 1.1e-07, N = 7824) (0.52, -0.04, P = 0.41, N = 859)
rs2486079(C)/1:116527617 SLC22A15 (0.7, -0.0071, P = 4.1e-05, N = 7824) (0.53, -0.067, P = 0.17, N = 859)
rs310101(A)/1:153040570* SPRR2B (0.96, 0.037, P = 3.9e-06, N = 7824) (0.65, 0.1, P = 0.046, N = 859)
rs72725073(T)/1:182552466 RNASEL (0.2, -0.18, P = 4.2e-06, N = 1955) (0.041, 0.0086, P = 0.94, N = 859)
rs7542381(A)/1:184635055 intergenic (0.01, 0.068, P = 2.6e-05, N = 7824) (0.1, 0.013, P = 0.87, N = 859)
rs1060060(T)/1:200143281* NR5A2 (0.3, -0.0073, P = 2.9e-05, N = 7824) (0.36, 0.073, P = 0.13, N = 859)
rs11119951(T)/1:212665790* intergenic (0.12, 0.012, P = 4.4e-06, N = 7824) (0.02, 0.15, P = 0.39, N = 859)
rs2799085(A)/1:218552455 TGFB2 (0.32, -0.012, P = 2.3e-05, N = 7824) (0.38, 0.049, P = 0.33, N = 859)
rs2247175(T)/1:97001894 intergenic (0.84, 0.24, P = 2.8e-06, N = 1955) (0.96, -0.082, P = 0.51, N = 859)
rs7099144(A)/10:101350970 intergenic (0.61, -0.0075, P = 1.2e-05, N = 7824) (0.59, -0.015, P = 0.76, N = 859)
rs430152(A)/10:119331597* CTA-109P11.1 (0.32, -0.007, P = 4.9e-05, N = 7824) (0.69, -0.0088, P = 0.87, N = 859)
rs7910118(A)/10:129958947 intergenic (0.12, -0.011, P = 1.3e-05, N = 7824) (0.15, -0.05, P = 0.44, N = 859)
rs3814664(C)/10:13740456 FRMD4A (0.69, -0.0071, P = 4.7e-05, N = 7824) (0.51, 0.0095, P = 0.85, N = 859)
rs10906682(T)/10:14500774 FRMD4A (0.87, 0.011, P = 4.1e-05, N = 7824) (0.66, 0.0041, P = 0.94, N = 859)
rs224768(A)/10:34281908 intergenic (0.29, 0.11, P = 4.6e-06, N = 1955) (0.53, -0.055, P = 0.26, N = 859)
rs4881230(G)/10:3939916 intergenic (0.74, -0.19, P = 3.1e-06, N = 1955) (0.53, 0.02, P = 0.69, N = 859)
rs12266210(T)/10:55188322* intergenic (0.3, -0.0074, P = 3.3e-05, N = 7824) (0.33, 0.0024, P = 0.96, N = 859)
rs2704467(A)/10:71530680* intergenic (0.28, -0.0074, P = 4.2e-05, N = 7824) (0.28, -0.022, P = 0.69, N = 859)
rs4244950(T)/10:86020700 RGR (0.64, -0.0072, P = 3.3e-05, N = 7824) (0.27, 0.059, P = 0.3, N = 859)
rs957646(T)/10:92064322 intergenic (0.97, 0.025, P = 3.6e-05, N = 7824) (0.78, -0.12, P = 0.036, N = 859)
rs4075311(T)/10:97574655 ENTPD1 (0.56, -0.0099, P = 5.5e-09, N = 7824) (0.66, -0.034, P = 0.51, N = 859)
rs1935815(A)/10:97631492 ENTPD1 (0.35, 0.011, P = 1.5e-10, N = 7824) (0.14, -0.0081, P = 0.91, N = 859)
rs10509698(A)/10:97792352 CC2D2B (0.076, 0.014, P = 2.4e-05, N = 7824) (0.046, 0.3, P = 0.0091, N = 859)
rs17030423(A)/12:101072465* intergenic (0.34, 0.0076, P = 1.2e-05, N = 7824) (0.41, 0.02, P = 0.67, N = 859)
rs323846(T)/12:125879853* TMEM132B (0.4, 0.007, P = 4.1e-05, N = 7824) (0.2, 0.024, P = 0.69, N = 859)
rs137938435(GA)/12:26377718 SSPN (0.24, 0.18, P = 7e-06, N = 1955) (0.031, 0.042, P = 0.76, N = 859)
rs7953233(A)/12:47223717* SLC38A4 (0.54, -0.007, P = 3.9e-05, N = 7824) (0.32, 0.058, P = 0.29, N = 859)
rs2711706(A)/12:47414993* intergenic (0.29, 0.19, P = 7e-07, N = 1955) (0.59, 0.0033, P = 0.94, N = 859)
rs1466383(T)/12:57231497 RP11-74M13.4 (0.27, 0.0075, P = 2.8e-05, N = 7824) (0.084, -0.083, P = 0.34, N = 859)
rs1546410(A)/12:61582882* intergenic (0.64, -0.0072, P = 3.8e-05, N = 7824) (0.42, -0.038, P = 0.43, N = 859)
rs6581892(A)/12:69817077 RP11-159A18.1 (0.68, 0.0075, P = 1.5e-05, N = 7824) (0.53, -0.014, P = 0.76, N = 859)
rs1868798(A)/12:7284081* CLSTN3 (0.14, -0.011, P = 3.5e-05, N = 7824) (0.2, 0.071, P = 0.24, N = 859)
rs1511589(A)/12:84061431* intergenic (0.46, 0.0077, P = 7.6e-06, N = 7824) (0.27, 0.013, P = 0.81, N = 859)
rs7305379(T)/12:86431706 MGAT4C (0.38, -0.15, P = 7.3e-07, N = 1955) (0.52, 0.079, P = 0.091, N = 859)
rs9514083(A)/13:103680517 intergenic (0.52, -0.0071, P = 3.7e-05, N = 7824) (0.32, 0.013, P = 0.81, N = 859)
rs12874443(T)/13:38304884 TRPC4 (0.43, -0.0075, P = 1.2e-05, N = 7824) (0.084, 0.084, P = 0.34, N = 859)
rs9566810(T)/13:42199332 VWA8 (0.28, 0.0076, P = 1.8e-05, N = 7824) (0.45, -0.013, P = 0.79, N = 859)
rs7331220(T)/13:43294055 intergenic (0.32, -0.0074, P = 2.4e-05, N = 7824) (0.32, 0.089, P = 0.086, N = 859)
rs35543760(C)/14:100221612 EML1 (0.29, 0.18, P = 6.8e-06, N = 1955) (0.12, 0.0014, P = 0.98, N = 859)
rs12147171(C)/14:20529449 OR4L1 (0.12, -0.012, P = 4.8e-06, N = 7824) (0.027, -0.083, P = 0.57, N = 859)
rs11848535(T)/14:20777431* TTC5 (0.44, 0.16, P = 3e-06, N = 1955) (0.26, -0.091, P = 0.1, N = 859)
rs8021336(A)/14:32733465 intergenic (0.31, -0.0086, P = 9.9e-07, N = 7824) (0.31, 0.0079, P = 0.88, N = 859)
rs7157943(A)/14:32754446* intergenic (0.93, 0.015, P = 8.1e-06, N = 7824) (0.81, 0.024, P = 0.7, N = 859)
rs17105196(T)/14:37208917* SLC25A21 (0.28, -0.0074, P = 2.1e-05, N = 7824) (0.16, -0.081, P = 0.22, N = 859)
rs996326(A)/14:40687518* intergenic (0.88, 0.011, P = 1.2e-05, N = 7824) (0.92, -0.098, P = 0.28, N = 859)
rs3916613(T)/14:59552553 intergenic (0.12, 0.011, P = 3.4e-05, N = 7824) (0.1, -0.066, P = 0.4, N = 859)
rs2842322(A)/14:68915416 RAD51B (0.31, -0.0076, P = 1e-05, N = 7824) (0.21, -0.086, P = 0.15, N = 859)
rs11626446(A)/14:78710044 NRXN3 (0.27, -0.0097, P = 2.7e-05, N = 7824) (0.12, -0.1, P = 0.17, N = 859)
rs2057311(C)/14:86086438 FLRT2 (0.58, 0.0074, P = 1.9e-05, N = 7824) (0.58, 0.00029, P = 1, N = 859)
rs2959197(A)/15:101606890 LRRK1 (0.3, -0.0072, P = 4.1e-05, N = 7824) (0.096, 0.21, P = 0.0083, N = 859)
rs892775(A)/15:33824530 RYR3 (0.74, 0.2, P = 2.6e-06, N = 1955) (0.31, -0.053, P = 0.3, N = 859)
rs28631731(C)/15:36829334 intergenic (0.39, 0.16, P = 3.2e-06, N = 1955) (0.45, -0.15, P = 0.0023, N = 859)
rs17718330(T)/15:40123349* GPR176 (0.7, 0.0072, P = 4.2e-05, N = 7824) (0.86, 0.017, P = 0.81, N = 859)
rs10518834(A)/15:56345066* intergenic (0.64, -0.0071, P = 3.9e-05, N = 7824) (0.76, -0.034, P = 0.55, N = 859)
rs8033140(T)/15:68198741* intergenic (0.35, 0.008, P = 4.3e-06, N = 7824) (0.094, -0.086, P = 0.3, N = 859)
rs11634207(A)/15:93526003* CHD2 (0.72, 0.0074, P = 2.8e-05, N = 7824) (0.8, 0.026, P = 0.67, N = 859)
rs1437588(A)/15:96809782 NR2F2-AS1 (0.48, 0.0078, P = 7.7e-06, N = 7824) (0.12, 0.15, P = 0.037, N = 859)
rs3112726(T)/16:2748699* KCTD5 (0.46, 0.0073, P = 3.2e-05, N = 7824) (0.68, -0.035, P = 0.49, N = 859)
rs9806843(A)/16:58704861* SLC38A7 (0.6, -0.0073, P = 2.4e-05, N = 7824) (0.5, -0.059, P = 0.22, N = 859)
rs7194755(T)/16:7064036* RBFOX1 (0.26, -0.0099, P = 1.9e-05, N = 7824) (0.16, -0.061, P = 0.36, N = 859)
rs10781983(A)/16:77441179* ADAMTS18 (0.63, -0.0071, P = 5e-05, N = 7824) (0.35, 0.0079, P = 0.88, N = 859)
rs8054103(A)/16:87420182 FBXO31 (0.55, 0.0071, P = 2.7e-05, N = 7824) (0.11, -0.0028, P = 0.97, N = 859)
rs758186(T)/17:12500658 LINC00670 (0.65, -0.0077, P = 8.7e-06, N = 7824) (0.53, -0.03, P = 0.53, N = 859)
rs733099(A)/17:4658971* intergenic (0.27, 0.0076, P = 1.4e-05, N = 7824) (0.22, -0.023, P = 0.69, N = 859)
rs12600861(C)/17:7355621 CHRNB1 (0.33, -0.14, P = 2.5e-06, N = 1955) (0.37, -0.042, P = 0.39, N = 859)
rs4791811(A)/17:9066853 NTN1 (0.71, 0.0077, P = 1.2e-05, N = 7824) (0.63, -0.029, P = 0.56, N = 859)
rs17681684(A)/17:9792768* GLP2R (0.32, 0.0085, P = 1e-06, N = 7824) (0.054, -0.07, P = 0.5, N = 859)
rs539904(A)/18:22085351 intergenic (0.71, -0.0086, P = 1.5e-06, N = 7824) (0.95, 0.17, P = 0.15, N = 859)
rs544049(A)/18:44204713* LOXHD1 (0.12, -0.011, P = 2.3e-05, N = 7824) (0.23, 0.039, P = 0.49, N = 859)
rs8097717(A)/18:69913058* intergenic (0.44, 0.0069, P = 4.5e-05, N = 7824) (0.43, 0.045, P = 0.36, N = 859)
rs6510448(T)/19:35240154 intergenic (0.67, 0.0077, P = 8.1e-06, N = 7824) (0.59, -0.12, P = 0.017, N = 859)
rs7597477(A)/2:104826331* intergenic (0.93, -0.015, P = 6.8e-06, N = 7824) (0.87, 0.11, P = 0.12, N = 859)
rs2723163(T)/2:113694339 AC079753.5 (0.45, -0.0069, P = 4.5e-05, N = 7824) (0.2, -0.0053, P = 0.93, N = 859)
rs11123366(T)/2:117209104 intergenic (0.86, -0.011, P = 1.6e-05, N = 7824) (0.85, 0.075, P = 0.27, N = 859)
rs7594831(T)/2:204439701 intergenic (0.28, 0.0074, P = 2.2e-05, N = 7824) (0.3, 0.047, P = 0.36, N = 859)
rs1374708(T)/2:205316761 intergenic (0.87, 0.011, P = 2.9e-05, N = 7824) (0.75, 0.031, P = 0.58, N = 859)
rs10190763(T)/2:20573168 intergenic (0.31, 0.0074, P = 1.9e-05, N = 7824) (0.28, -0.059, P = 0.27, N = 859)
rs879126(T)/2:207922006* intergenic (0.33, -0.0086, P = 7.5e-07, N = 7824) (0.37, 0.074, P = 0.12, N = 859)
rs759663(A)/2:208080975* AC007879.1 (0.68, -0.0072, P = 3.8e-05, N = 7824) (0.85, 0.04, P = 0.55, N = 859)
rs2007748(T)/2:211357642 CPS1 (0.53, 0.0095, P = 2.1e-08, N = 7824) (0.2, 0.00063, P = 0.99, N = 859)
rs1509820(A)/2:211386484* CPS1 (0.53, 0.0096, P = 1.7e-08, N = 7824) (0.2, -0.0065, P = 0.91, N = 859)
rs2544307(A)/2:211403117* CPS1 (0.39, -0.0078, P = 5.3e-06, N = 7824) (0.43, -0.056, P = 0.26, N = 859)
rs13010668(T)/2:211470493* CPS1 (0.85, 0.013, P = 3.6e-07, N = 7824) (0.7, -0.016, P = 0.77, N = 859)
rs12470865(A)/2:211557762* intergenic (0.27, 0.009, P = 3.2e-07, N = 7824) (0.3, -0.11, P = 0.041, N = 859)
rs10164524(A)/2:211664333* intergenic (0.68, -0.01, P = 1.1e-08, N = 7824) (0.83, 0.044, P = 0.5, N = 859)
rs895663(C)/2:30874360 intergenic (0.28, -0.2, P = 7e-06, N = 1955) (0.48, -0.029, P = 0.54, N = 859)
rs6740771(T)/2:39789288 AC007246.3 (0.55, -0.14, P = 8.8e-06, N = 1955) (0.24, 0.023, P = 0.69, N = 859)
rs6040877(A)/20:11756767* intergenic (0.27, -0.0081, P = 4e-06, N = 7824) (0.63, 0.039, P = 0.43, N = 859)
rs2809591(A)/20:11763357 intergenic (0.34, -0.0074, P = 1.8e-05, N = 7824) (0.39, -0.015, P = 0.76, N = 859)
rs6136859(T)/20:19833437* intergenic (0.46, 0.0071, P = 3.8e-05, N = 7824) (0.19, 0.067, P = 0.28, N = 859)
rs11086175(T)/20:45137362 ZNF334 (0.51, -0.014, P = 1.9e-05, N = 7824) (0.35, -0.023, P = 0.65, N = 859)
rs163781(A)/20:57563765 NELFCD (0.53, -0.0074, P = 1.6e-05, N = 7824) (0.69, -0.036, P = 0.5, N = 859)
rs229084(A)/21:28251329 intergenic (0.47, -0.0077, P = 6.6e-06, N = 7824) (0.21, -0.12, P = 0.034, N = 859)
rs8140086(A)/22:36610386 intergenic (0.59, -0.0069, P = 4.9e-05, N = 7824) (0.33, -0.0068, P = 0.9, N = 859)
rs1920325(T)/3:103866190* intergenic (0.64, -0.0081, P = 3.7e-06, N = 7824) (0.81, 0.049, P = 0.42, N = 859)
rs11128648(C)/3:13643640 FBLN2 (0.49, -0.007, P = 4.2e-05, N = 7824) (0.4, -0.08, P = 0.11, N = 859)
rs7615965(T)/3:171041464* TNIK (0.71, 0.0086, P = 4.1e-06, N = 7824) (0.61, 0.0089, P = 0.86, N = 859)
rs9824791(A)/3:171061886 TNIK (0.48, 0.0079, P = 6e-06, N = 7824) (0.26, -0.019, P = 0.73, N = 859)
rs11129411(A)/3:30535423 intergenic (0.38, -0.0075, P = 2.3e-05, N = 7824) (0.64, 0.051, P = 0.3, N = 859)
rs73067534(G)/3:32283278* CMTM8 (0.2, -0.21, P = 9.9e-06, N = 1955) (0.038, -0.14, P = 0.29, N = 859)
rs12636544(T)/3:82449136 RP11-260O18.1 (0.2, 0.17, P = 4.2e-06, N = 1955) (0.19, 0.053, P = 0.38, N = 859)
rs1380162(A)/4:119970203* SYNPO2 (0.33, 0.0076, P = 1.4e-05, N = 7824) (0.22, 0.03, P = 0.61, N = 859)
rs12499180(A)/4:130953329 intergenic (0.98, 0.058, P = 2e-05, N = 7824) (0.38, -0.0048, P = 0.92, N = 859)
rs13105113(A)/4:136527846 intergenic (0.88, 0.011, P = 9.2e-06, N = 7824) (0.9, 0.11, P = 0.18, N = 859)
rs706333(T)/4:140517700* SETD7 (0.46, 0.015, P = 1e-05, N = 7824) (0.35, -0.044, P = 0.38, N = 859)
rs1921568(T)/4:185080276* ENPP6 (0.29, 0.0073, P = 3.2e-05, N = 7824) (0.32, -0.12, P = 0.03, N = 859)
rs7696056(C)/4:22549862 intergenic (0.39, -0.014, P = 4.5e-05, N = 7824) (0.21, -0.0053, P = 0.93, N = 859)
rs1089073(G)/4:24788474 SOD3 (0.98, -0.34, P = 1.1e-06, N = 1955) (0.93, 0.036, P = 0.71, N = 859)
rs4692169(A)/4:27124674* intergenic (0.58, -0.0074, P = 1.7e-05, N = 7824) (0.31, 0.041, P = 0.44, N = 859)
rs10489008(A)/4:31718284* intergenic (0.49, -0.0076, P = 7.4e-06, N = 7824) (0.87, -0.047, P = 0.52, N = 859)
rs13122712(A)/4:39801668 intergenic (0.65, -0.14, P = 1e-06, N = 1955) (0.32, 0.011, P = 0.83, N = 859)
rs11721409(T)/4:7753417* AFAP1-AS1 (0.32, 0.0074, P = 1.9e-05, N = 7824) (0.1, 0.021, P = 0.8, N = 859)
rs11940899(T)/4:78352372 RP11-625I7.1 (0.34, -0.0075, P = 1.8e-05, N = 7824) (0.52, 0.089, P = 0.074, N = 859)
rs16841570(T)/4:8016164* ABLIM2 (0.97, 0.025, P = 8.6e-06, N = 7824) (0.96, 0.031, P = 0.8, N = 859)
rs10477454(T)/5:109636551 TMEM232 (0.017, -0.037, P = 4.6e-06, N = 7824) (0.5, 0.023, P = 0.63, N = 859)
rs17142889(T)/5:117041009 intergenic (0.13, 0.011, P = 9.9e-06, N = 7824) (0.68, 0.15, P = 0.003, N = 859)
rs17450677(T)/5:143919043 RN7SKP246 (0.97, 0.021, P = 1.9e-05, N = 7824) (0.98, -0.012, P = 0.95, N = 859)
rs2400156(A)/5:144052940 intergenic (0.84, -0.019, P = 3.1e-05, N = 7824) (0.81, -0.043, P = 0.48, N = 859)
rs6889120(T)/5:158093340 intergenic (0.94, -0.034, P = 7.4e-06, N = 7824) (0.73, -0.064, P = 0.23, N = 859)
rs76001528(C)/5:163839445 CTC-340A15.2 (0.097, -0.2, P = 4.2e-06, N = 1955) (0.16, -0.059, P = 0.37, N = 859)
rs10866666(T)/5:173036786 BOD1 (0.22, -0.21, P = 2.1e-06, N = 1955) (0.028, 0.15, P = 0.3, N = 859)
rs682103(T)/5:53394938* ARL15 (0.71, -0.0097, P = 4.3e-08, N = 7824) (0.93, -0.14, P = 0.15, N = 859)
rs4143655(A)/5:66824167* RP11-434D9.1 (0.14, -0.011, P = 3.6e-05, N = 7824) (0.52, 0.042, P = 0.38, N = 859)
rs224807(A)/5:81686624* ATP6AP1L (0.29, -0.0072, P = 4e-05, N = 7824) (0.28, 0.016, P = 0.77, N = 859)
rs9400834(T)/6:115675458* RP11-126M14.1 (0.7, 0.008, P = 5.6e-06, N = 7824) (0.91, 0.16, P = 0.062, N = 859)
rs9401513(A)/6:122675030 intergenic (0.86, -0.022, P = 3.4e-05, N = 7824) (0.68, -0.093, P = 0.072, N = 859)
rs10456994(T)/6:132515568* intergenic (0.52, -0.007, P = 4.3e-05, N = 7824) (0.79, -0.022, P = 0.71, N = 859)
rs2506864(T)/6:141041299* intergenic (0.41, -0.0076, P = 8.8e-06, N = 7824) (0.37, -0.015, P = 0.77, N = 859)
rs619095(C)/6:169098800* intergenic (0.64, -0.0073, P = 2.7e-05, N = 7824) (0.12, -0.047, P = 0.52, N = 859)
rs7747114(G)/6:29919774* HLA-W (0.53, 0.16, P = 9.9e-06, N = 1955) (0.68, 0.046, P = 0.35, N = 859)
rs112100248(T)/6:30798476* LINC00243 (0.02, 0.51, P = 2.4e-06, N = 1955) (0.035, -0.093, P = 0.46, N = 859)
rs9267536(C)/6:31651194 LY6G5C (0.039, 0.43, P = 3e-06, N = 1955) (0.079, 0.05, P = 0.57, N = 859)
rs239787(A)/6:54798887 FAM83B (0.17, -0.01, P = 4.4e-05, N = 7824) (0.32, -0.13, P = 0.01, N = 859)
rs6899649(T)/6:54892267* intergenic (0.38, 0.0072, P = 2.4e-05, N = 7824) (0.41, 0.059, P = 0.23, N = 859)
rs3846917(T)/6:55257798* GFRAL (0.12, -0.011, P = 4.5e-05, N = 7824) (0.45, -0.022, P = 0.65, N = 859)
rs9354336(T)/6:66609594 intergenic (0.87, 0.011, P = 8.6e-06, N = 7824) (0.87, -0.11, P = 0.11, N = 859)
rs779463(T)/6:69942066 BAI3 (0.3, -0.0077, P = 9.5e-06, N = 7824) (0.048, 0.086, P = 0.46, N = 859)
rs2487410(T)/6:70547652 intergenic (0.47, -0.0081, P = 1.8e-06, N = 7824) (0.54, -0.019, P = 0.69, N = 859)
rs6925293(T)/6:99054479 intergenic (0.58, 0.0073, P = 2.3e-05, N = 7824) (0.12, -0.067, P = 0.35, N = 859)
rs10234187(T)/7:11216782 AC004538.3 (0.32, 0.0085, P = 1.1e-06, N = 7824) (0.31, 0.041, P = 0.42, N = 859)
rs3778842(T)/7:134474096* CALD1 (0.68, 0.0077, P = 1.1e-05, N = 7824) (0.73, 0.058, P = 0.28, N = 859)
rs6952398(T)/7:151396253 PRKAG2 (0.63, -0.0081, P = 1.5e-05, N = 7824) (0.43, 0.0087, P = 0.86, N = 859)
rs12701265(A)/7:32971236* RP9P (0.39, 0.0086, P = 7.4e-07, N = 7824) (0.068, -0.02, P = 0.84, N = 859)
rs17821771(T)/7:33973249 BMPER (0.35, -0.0082, P = 1.9e-06, N = 7824) (0.27, -0.00061, P = 0.99, N = 859)
rs17670957(T)/7:54412203 RP11-436F9.1 (0.39, 0.007, P = 4.4e-05, N = 7824) (0.39, -0.02, P = 0.69, N = 859)
rs28662(T)/7:92775019 SAMD9L (0.18, -0.011, P = 1.3e-05, N = 7824) (0.077, -0.031, P = 0.74, N = 859)
rs17766353(T)/8:10254824 MSRA (0.14, 0.011, P = 4.9e-05, N = 7824) (0.034, 0.061, P = 0.65, N = 859)
rs10955258(T)/8:102593321 GRHL2 (0.23, -0.0097, P = 4.3e-05, N = 7824) (0.25, -0.058, P = 0.3, N = 859)
rs13267180(A)/8:10466482* RP1L1 (0.48, 0.0081, P = 3.8e-06, N = 7824) (0.41, 0.012, P = 0.81, N = 859)
rs7001456(C)/8:10804865 XKR6 (0.61, -0.0078, P = 5.1e-06, N = 7824) (0.64, -0.067, P = 0.17, N = 859)
rs6601541(T)/8:10830743* XKR6 (0.63, -0.0074, P = 2.3e-05, N = 7824) (0.27, -0.062, P = 0.25, N = 859)
rs2350885(A)/8:111233137 intergenic (0.35, -0.0079, P = 8.7e-06, N = 7824) (0.68, 0.019, P = 0.72, N = 859)
rs6994363(A)/8:11125062* LINC00529 (0.87, -0.012, P = 2.5e-06, N = 7824) (0.63, -0.11, P = 0.031, N = 859)
rs73367050(T)/8:134689892 intergenic (0.048, 0.28, P = 6.3e-06, N = 1955) (0.11, 0.05, P = 0.52, N = 859)
rs34161175(T)/8:23631530 RP11-175E9.1 (0.36, 0.19, P = 3.8e-06, N = 1955) (0.065, 0.0084, P = 0.93, N = 859)
rs11993007(A)/8:28307911 FBXO16 (0.32, -0.013, P = 5.2e-06, N = 7824) (0.62, 0.038, P = 0.44, N = 859)
rs6999701(A)/8:74678452 RP11-463D19.2 (0.89, -0.014, P = 1.4e-05, N = 7824) (0.88, -0.021, P = 0.78, N = 859)
rs10504742(A)/8:82788367* intergenic (0.55, -0.0081, P = 2.6e-06, N = 7824) (0.87, 0.003, P = 0.97, N = 859)
rs1610360(A)/9:12385710* intergenic (0.67, 0.008, P = 4.6e-06, N = 7824) (0.76, -0.081, P = 0.14, N = 859)
rs76266684(G)/9:132755555 FNBP1 (0.081, 0.29, P = 1.3e-06, N = 1955) (0.032, 0.073, P = 0.6, N = 859)
rs10901320(A)/9:133290721 HMCN2 (0.43, 0.0087, P = 4.3e-07, N = 7824) (0.27, -0.098, P = 0.073, N = 859)
rs10901047(T)/9:133323675 ASS1 (0.59, -0.009, P = 3e-07, N = 7824) (0.76, 0.024, P = 0.66, N = 859)
rs554710(T)/9:136181848* LCN1P2 (0.71, -0.0084, P = 1.6e-06, N = 7824) (0.46, -0.078, P = 0.11, N = 859)
rs4961685(A)/9:16249141* C9orf92 (0.33, -0.0073, P = 2.4e-05, N = 7824) (0.3, 0.039, P = 0.45, N = 859)
rs12348439(T)/9:89869968 intergenic (0.055, -0.018, P = 1.3e-05, N = 7824) (0.19, 0.1, P = 0.089, N = 859)
Results from Univariable Mendelian Randomization of Citrulline & eGFR - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 166 -0.052 (-0.19- 0.081) P=0.44 3.8 31 1.01 (0- 91.6) NA NA 0.003 P=0.58
MR-Egger 166 -0.072 (-0.22- 0.079) P=0.35 3.8 31 1.01 (0- 91.6) 188 0.096 0.003 P=0.58
Weighted median 166 0.012 (-0.18- 0.2) P=0.9 3.8 31 1.01 (0- 91.6) NA NA 0.003 P=0.58
Results from Univariable MRPRESSO of Citrulline & eGFR - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.05 0.07 -0.77 0.45
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of Citrulline & eGFR - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 96 -0.06 (-0.22- 0.1) P=0.46 5.1 24 2.6 (0- 96.7) NA NA 0.0022 P=0.78
MR-Egger 96 -0.074 (-0.26- 0.11) P=0.44 5.1 24 2.6 (0- 96.7) 121 0.033 0.0022 P=0.78
Weighted median 96 0.031 (-0.17- 0.23) P=0.77 5.1 24 2.6 (0- 96.7) NA NA 0.0022 P=0.78
Results from Univariable MRPRESSO of Citrulline & eGFR - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.06 0.08 -0.73 0.46
beta.exposure Outlier-corrected NA NA NA NA

Creatinine

Instruments Associations with Creatinine & eGFR
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region Creatinine (Shin et al/Long et al) eGFR (CSSCD)
rs6537817(C)/1:114752168* RP4-543J13.1 (0.82, -0.0078, P = 1.2e-05, N = 7824) (0.58, 0.085, P = 0.078, N = 859)
rs4460629(T)/1:155135335 intergenic (0.52, -0.0045, P = 2.2e-06, N = 7824) (0.3, 0.043, P = 0.42, N = 859)
rs6424850(A)/1:182344926 intergenic (0.48, 0.14, P = 8.5e-07, N = 1958) (0.74, 0.045, P = 0.4, N = 859)
rs815759(A)/1:189907398 intergenic (0.048, 0.014, P = 2.8e-05, N = 7824) (0.012, -0.051, P = 0.82, N = 859)
rs10159366(A)/1:204975980 NFASC (0.87, 0.008, P = 2.5e-05, N = 7824) (0.96, 0.023, P = 0.86, N = 859)
rs6663614(A)/1:213097941* intergenic (0.21, -0.01, P = 3.1e-06, N = 7824) (0.23, -0.1, P = 0.073, N = 859)
rs496018(T)/1:238079056* RP11-193H5.1 (0.2, 0.16, P = 1.2e-06, N = 1958) (0.66, 0.11, P = 0.037, N = 859)
rs12142891(C)/1:61652197* NFIA (0.098, 0.23, P = 6.6e-06, N = 1958) (0.015, 0.19, P = 0.33, N = 859)
rs1498350(A)/1:67294143* WDR78 (0.5, 0.0045, P = 1.9e-06, N = 7824) (0.62, 0.047, P = 0.33, N = 859)
rs394282(A)/1:8284657 RP11-431K24.4 (0.11, -0.016, P = 1e-06, N = 7824) (0.22, -0.013, P = 0.83, N = 859)
rs1116866(T)/1:96976835 intergenic (0.1, 0.0094, P = 2.9e-07, N = 7824) (0.027, 0.084, P = 0.58, N = 859)
rs2694773(A)/10:117844652* GFRA1 (0.92, 0.023, P = 2.8e-05, N = 7824) (0.75, 0.0027, P = 0.96, N = 859)
rs11599763(T)/10:11855599* intergenic (0.39, -0.0069, P = 3.2e-05, N = 7824) (0.51, 0.035, P = 0.48, N = 859)
rs10749270(G)/10:120542167* U3 (0.75, 0.21, P = 7.1e-06, N = 1958) (0.69, 0.055, P = 0.3, N = 859)
rs7910801(A)/10:126037889 intergenic (0.96, 0.015, P = 4.5e-05, N = 7824) (0.81, -0.0066, P = 0.92, N = 859)
rs12269670(A)/10:132619537 intergenic (0.97, -0.015, P = 4.3e-05, N = 7824) (0.81, 0.003, P = 0.96, N = 859)
rs703067(T)/10:31909119* intergenic (0.48, 0.18, P = 5.2e-06, N = 1958) (0.25, 0.026, P = 0.65, N = 859)
rs2289804(A)/10:69993032 ATOH7 (0.93, -0.014, P = 1.2e-07, N = 7824) (0.56, -0.017, P = 0.72, N = 859)
rs10823168(T)/10:70019917 KRT19P4 (0.055, 0.013, P = 6.2e-07, N = 7824) (0.16, 0.014, P = 0.82, N = 859)
rs10998157(A)/10:70188523* DNA2 (0.051, 0.011, P = 4.7e-05, N = 7824) (0.16, -0.041, P = 0.54, N = 859)
rs7073038(T)/10:70308535 TMEM14D (0.038, 0.015, P = 1.9e-05, N = 7824) (0.13, -0.053, P = 0.47, N = 859)
rs827334(A)/10:72676412* intergenic (0.12, 0.0076, P = 3.8e-05, N = 7824) (0.025, 0.038, P = 0.8, N = 859)
rs75751082(A)/10:73205549 CDH23 (0.11, -0.19, P = 3.1e-06, N = 1958) (0.077, -0.064, P = 0.48, N = 859)
rs7087345(A)/10:78651808 KCNMA1 (0.95, 0.011, P = 4.9e-05, N = 7824) (0.85, -0.0042, P = 0.95, N = 859)
rs12218515(C)/10:91054291 LIPA (0.86, 0.0075, P = 2.6e-05, N = 7824) (0.88, -0.034, P = 0.64, N = 859)
rs12770938(A)/10:91606212 intergenic (0.11, 0.0077, P = 2.9e-05, N = 7824) (0.33, -0.032, P = 0.54, N = 859)
rs17094111(T)/10:92121337 intergenic (0.92, 0.01, P = 4.8e-05, N = 7824) (0.95, 0.022, P = 0.84, N = 859)
rs482007(T)/11:100228729* CNTN5 (0.89, 0.0077, P = 2.5e-05, N = 7824) (0.8, -0.16, P = 0.0074, N = 859)
rs4937771(A)/11:133307073 snoU13 (0.042, 0.014, P = 2.6e-05, N = 7824) (0.53, 0.019, P = 0.68, N = 859)
rs12801550(T)/11:13993754 SPON1 (0.87, 0.0088, P = 9.6e-07, N = 7824) (0.98, -0.24, P = 0.2, N = 859)
rs11037075(A)/11:42827511* intergenic (0.87, 0.0074, P = 4.8e-05, N = 7824) (0.76, -0.017, P = 0.76, N = 859)
rs11038386(T)/11:45316625* intergenic (0.98, 0.022, P = 2.2e-05, N = 7824) (0.74, -0.029, P = 0.6, N = 859)
rs6578854(A)/11:7385437 SYT9 (0.93, 0.011, P = 3e-05, N = 7824) (0.76, 0.051, P = 0.35, N = 859)
rs11054328(T)/12:11663755 RP11-434C1.3 (0.11, 0.0088, P = 1.5e-06, N = 7824) (0.16, -0.035, P = 0.59, N = 859)
rs2286044(A)/12:120571084 GCN1L1 (0.87, 0.0076, P = 2.3e-05, N = 7824) (0.85, -0.056, P = 0.4, N = 859)
rs10745813(A)/12:98265464 intergenic (0.81, 0.0077, P = 1.4e-05, N = 7824) (0.9, -0.058, P = 0.48, N = 859)
rs9577511(G)/13:113991823 GRTP1 (0.13, 0.21, P = 1e-06, N = 1958) (0.21, 0.1, P = 0.09, N = 859)
rs16943547(A)/13:90552861 intergenic (0.97, 0.018, P = 3.5e-05, N = 7824) (0.98, 0.17, P = 0.31, N = 859)
rs8181962(A)/14:26598213* RP11-314P15.2 (0.14, -0.0077, P = 2.1e-05, N = 7824) (0.2, -0.11, P = 0.081, N = 859)
rs2933188(G)/14:47382492* MDGA2 (0.96, -0.4, P = 6.5e-06, N = 1958) (0.53, -0.023, P = 0.63, N = 859)
rs1044538(A)/14:70833537 SYNJ2BP (0.071, -0.011, P = 1.1e-05, N = 7824) (0.1, -0.073, P = 0.34, N = 859)
rs2332376(T)/14:70889285 RP11-486O13.4 (0.074, -0.011, P = 2e-05, N = 7824) (0.065, -0.017, P = 0.86, N = 859)
rs4904742(T)/14:91510838 RPS6KA5 (0.75, -0.0077, P = 1.2e-05, N = 7824) (0.9, 0.0086, P = 0.92, N = 859)
rs10519445(A)/15:24106808 intergenic (0.53, -0.0045, P = 1.8e-06, N = 7824) (0.18, -0.038, P = 0.53, N = 859)
rs11638382(T)/15:29496888 FAM189A1 (0.19, -0.017, P = 5.1e-06, N = 7824) (0.077, -0.13, P = 0.13, N = 859)
rs12914647(A)/15:56594033 TEX9 (0.46, 0.13, P = 3.6e-06, N = 1958) (0.15, -0.088, P = 0.2, N = 859)
rs12324230(T)/15:75806911 PTPN9 (0.52, 0.0042, P = 8.7e-06, N = 7824) (0.81, 0.018, P = 0.76, N = 859)
rs12916220(T)/15:97091511 CTD-2027G2.1 (0.15, -0.0077, P = 3.5e-05, N = 7824) (0.34, -0.008, P = 0.87, N = 859)
rs11574941(A)/16:30493000 ITGAL (0.13, 0.0078, P = 2.3e-05, N = 7824) (0.028, -0.0073, P = 0.96, N = 859)
rs113479674(C)/16:82193037 MPHOSPH6 (0.11, -0.25, P = 7.1e-07, N = 1958) (0.058, 0.066, P = 0.52, N = 859)
rs146693640(GT)/16:82193730 MPHOSPH6 (0.12, -0.23, P = 5.2e-06, N = 1958) (0.074, 0.041, P = 0.65, N = 859)
rs6502247(A)/17:13203562 AC003664.1 (0.12, -0.009, P = 6.8e-06, N = 7824) (0.58, 0.0089, P = 0.85, N = 859)
rs12103754(T)/17:70912339* SLC39A11 (0.26, -0.21, P = 8.2e-06, N = 1958) (0.19, -0.0023, P = 0.97, N = 859)
rs12961855(A)/18:11670845 RP11-677O4.2 (0.48, 0.0039, P = 4e-05, N = 7824) (0.82, 0.081, P = 0.2, N = 859)
rs10421262(T)/19:14172951 PALM3 (0.69, -0.021, P = 2.7e-05, N = 7824) (0.48, -0.041, P = 0.41, N = 859)
rs4803352(T)/19:41159193* intergenic (0.87, -0.0079, P = 1.4e-05, N = 7824) (0.78, -0.083, P = 0.15, N = 859)
rs10426415(A)/19:41183590* NUMBL (0.88, -0.0086, P = 3.1e-06, N = 7824) (0.8, -0.041, P = 0.49, N = 859)
rs12459641(G)/19:7560784 C19orf45 (0.19, 0.23, P = 9.6e-06, N = 1958) (0.29, 0.052, P = 0.33, N = 859)
rs10202838(C)/2:12749003* AC096559.2 (0.53, 0.014, P = 3.3e-06, N = 7824) (0.12, -0.046, P = 0.52, N = 859)
rs355818(A)/2:165707855 AC019181.2 (0.89, 0.0078, P = 2.2e-05, N = 7824) (0.6, 0.012, P = 0.81, N = 859)
rs1374355(A)/2:200156193 SATB2 (0.11, 0.0083, P = 8.6e-06, N = 7824) (0.46, 0.011, P = 0.82, N = 859)
rs13414802(A)/2:210732686* UNC80 (0.88, 0.0077, P = 2.9e-05, N = 7824) (0.65, -0.021, P = 0.67, N = 859)
rs2048277(A)/2:211151774* MYL1 (0.9, 0.0083, P = 8.8e-06, N = 7824) (0.78, 0.00076, P = 0.99, N = 859)
rs62192370(G)/2:237254757 IQCA1 (0.38, 0.14, P = 6.8e-07, N = 1958) (0.26, 0.0014, P = 0.98, N = 859)
rs35202902(T)/2:240734453 intergenic (0.27, -0.16, P = 3.3e-06, N = 1958) (0.079, -0.13, P = 0.14, N = 859)
rs10175998(C)/2:38559325 ATL2 (0.28, 0.15, P = 1.5e-06, N = 1958) (0.32, -0.02, P = 0.69, N = 859)
rs917969(T)/2:40207338 SLC8A1-AS1 (0.24, 0.0071, P = 4.3e-05, N = 7824) (0.87, -0.02, P = 0.77, N = 859)
rs7596081(A)/2:46464297 intergenic (0.53, -0.14, P = 1.7e-06, N = 1958) (0.46, -0.03, P = 0.53, N = 859)
rs13031396(T)/2:60717399* BCL11A (0.25, -0.0076, P = 9.2e-06, N = 7824) (0.074, -0.19, P = 0.035, N = 859)
rs2219379(A)/2:6711467 intergenic (0.2, 0.0072, P = 4.1e-05, N = 7824) (0.31, -0.12, P = 0.017, N = 859)
rs11694230(T)/2:6839127 intergenic (0.34, -0.0075, P = 9e-06, N = 7824) (0.13, -0.019, P = 0.79, N = 859)
rs4853412(C)/2:79019736 intergenic (0.46, -0.14, P = 8.1e-06, N = 1958) (0.24, -0.014, P = 0.81, N = 859)
rs7263330(A)/20:31534701 intergenic (0.035, -0.015, P = 1.6e-05, N = 7824) (0.13, -0.13, P = 0.06, N = 859)
rs925300(C)/20:5624244 intergenic (0.48, -0.19, P = 1.2e-06, N = 1958) (0.71, 0.07, P = 0.18, N = 859)
rs2833854(A)/21:33869440* EVA1C (0.86, -0.0076, P = 2.1e-05, N = 7824) (0.89, -0.14, P = 0.07, N = 859)
rs3895614(T)/21:43182633* RIPK4 (0.11, -0.0081, P = 1.5e-05, N = 7824) (0.12, -0.016, P = 0.83, N = 859)
rs17002948(T)/22:42688724 TCF20 (0.86, 0.0079, P = 1.9e-05, N = 7824) (0.83, -0.071, P = 0.27, N = 859)
rs1955135(A)/3:105164872* ALCAM (0.87, 0.008, P = 1e-05, N = 7824) (0.83, 0.016, P = 0.8, N = 859)
rs4684042(A)/3:10559202* ATP2B2 (0.98, -0.023, P = 1.2e-05, N = 7824) (0.84, -0.012, P = 0.86, N = 859)
rs2007634(A)/3:139678136* CLSTN2 (0.59, 0.2, P = 5.1e-07, N = 1958) (0.23, -0.018, P = 0.75, N = 859)
rs11715139(A)/3:171732927 intergenic (0.82, 0.0072, P = 4.2e-05, N = 7824) (0.78, 0.12, P = 0.042, N = 859)
rs11925770(T)/3:36339059* intergenic (0.015, -0.76, P = 3.3e-06, N = 1958) (0.17, 0.063, P = 0.33, N = 859)
rs34667937(G)/3:46576351 LRRC2 (0.36, 0.16, P = 7e-06, N = 1958) (0.14, 0.068, P = 0.34, N = 859)
rs35119986(C)/3:74280018 intergenic (0.13, -0.25, P = 9.4e-06, N = 1958) (0.19, -0.004, P = 0.95, N = 859)
rs1447833(C)/3:79039406* ROBO1 (0.091, -0.29, P = 6.6e-07, N = 1958) (0.015, -0.42, P = 0.037, N = 859)
rs17785887(T)/4:179536770 intergenic (0.82, -0.017, P = 2.1e-05, N = 7824) (0.84, -0.028, P = 0.67, N = 859)
rs17533525(T)/5:106779692* EFNA5 (0.15, 0.0082, P = 5e-06, N = 7824) (0.032, -0.18, P = 0.2, N = 859)
rs9312777(T)/5:11556754* CTNND2 (0.48, 0.0043, P = 4.7e-06, N = 7824) (0.64, 0.02, P = 0.67, N = 859)
rs10478509(A)/5:120529790* CTD-2020P22.1 (0.48, -0.0041, P = 1.4e-05, N = 7824) (0.65, -0.0036, P = 0.94, N = 859)
rs2695978(A)/5:165695551 intergenic (0.5, 0.004, P = 2e-05, N = 7824) (0.39, -0.084, P = 0.087, N = 859)
rs28362590(T)/5:176731452* PRELID1 (0.75, -0.18, P = 8.2e-07, N = 1958) (0.86, -0.15, P = 0.04, N = 859)
rs12517218(C)/5:2157589* intergenic (0.067, -0.26, P = 9.1e-06, N = 1958) (0.054, -0.027, P = 0.8, N = 859)
rs1330649(C)/5:26038348 intergenic (0.99, 0.59, P = 3.8e-06, N = 1958) (0.87, 0.053, P = 0.47, N = 859)
rs6452345(T)/5:26568243* intergenic (0.17, -0.0076, P = 1.4e-05, N = 7824) (0.054, 0.14, P = 0.19, N = 859)
rs12517707(A)/5:5131299* CTD-2297D10.2 (0.81, 0.0072, P = 3.7e-05, N = 7824) (0.87, 0.07, P = 0.34, N = 859)
rs2278241(A)/5:76326885* AGGF1 (0.27, -0.19, P = 1.2e-06, N = 1958) (0.078, -0.12, P = 0.2, N = 859)
rs17235037(T)/5:9013608* CTD-2215L10.1 (0.12, 0.0078, P = 1.6e-05, N = 7824) (0.035, 0.22, P = 0.1, N = 859)
rs12175103(A)/6:100706809* intergenic (0.42, 0.0048, P = 4.9e-07, N = 7824) (0.28, 0.045, P = 0.41, N = 859)
rs12660850(C)/6:139903229 intergenic (0.93, -0.011, P = 1.2e-05, N = 7824) (0.93, -0.12, P = 0.19, N = 859)
rs9477021(C)/6:16061453 intergenic (0.018, -0.024, P = 7.7e-06, N = 7824) (0.15, -0.13, P = 0.056, N = 859)
rs9456538(A)/6:160853393* SLC22A3 (0.15, -0.0082, P = 4.2e-06, N = 7824) (0.37, -0.12, P = 0.011, N = 859)
rs4960121(G)/6:5649266* FARS2 (0.75, 0.19, P = 3.6e-06, N = 1958) (0.53, -0.059, P = 0.22, N = 859)
rs6459184(T)/6:57160035 intergenic (0.52, -0.0039, P = 3.9e-05, N = 7824) (0.79, -0.064, P = 0.28, N = 859)
rs849415(A)/7:106552538 PIK3CG (0.9, -0.0078, P = 2.2e-05, N = 7824) (0.81, -0.0093, P = 0.88, N = 859)
rs10216203(T)/7:140168158* MKRN1 (0.88, 0.0078, P = 2e-05, N = 7824) (0.32, 0.035, P = 0.49, N = 859)
rs1990178(T)/7:21300265* intergenic (0.19, -0.016, P = 6.3e-06, N = 7824) (0.069, -0.048, P = 0.61, N = 859)
rs2042499(A)/7:24095366 intergenic (0.48, 0.0052, P = 4.9e-08, N = 7824) (0.2, 0.0026, P = 0.97, N = 859)
rs4720409(A)/7:41884913* intergenic (0.68, 0.0068, P = 4.9e-05, N = 7824) (0.81, 0.08, P = 0.19, N = 859)
rs6955253(T)/7:54619356 VSTM2A (0.84, -0.017, P = 2.8e-05, N = 7824) (0.73, 0.025, P = 0.64, N = 859)
rs13225353(T)/7:68441909 intergenic (0.12, 0.0077, P = 2.1e-05, N = 7824) (0.11, -0.01, P = 0.9, N = 859)
rs2521310(T)/7:89352860 intergenic (0.87, 0.009, P = 6.8e-06, N = 7824) (0.68, -0.026, P = 0.6, N = 859)
rs17198100(T)/8:103928846 KB-1507C5.2 (0.11, 0.02, P = 1.1e-05, N = 7824) (0.024, 0.18, P = 0.26, N = 859)
rs11985537(T)/8:129168086* intergenic (0.13, 0.0076, P = 3.6e-05, N = 7824) (0.086, -0.059, P = 0.48, N = 859)
rs10088988(C)/8:14112859 SGCZ (0.15, 0.0073, P = 4.5e-05, N = 7824) (0.44, -0.02, P = 0.67, N = 859)
rs71217388(AC)/8:18452739 PSD3 (0.13, 0.14, P = 6.6e-06, N = 1958) (0.16, -0.052, P = 0.43, N = 859)
rs17830054(T)/8:1892619* ARHGEF10 (0.12, -0.008, P = 1.5e-05, N = 7824) (0.041, -0.2, P = 0.099, N = 859)
rs4961420(C)/8:20731339* intergenic (0.64, 0.007, P = 3.2e-05, N = 7824) (0.69, -0.05, P = 0.32, N = 859)
rs2979688(T)/8:24814205* NEFL (0.64, 0.24, P = 3.6e-06, N = 1958) (0.3, 0.0069, P = 0.9, N = 859)
rs2543041(A)/8:39817470* IDO2 (0.12, 0.0076, P = 2.7e-05, N = 7824) (0.42, 0.014, P = 0.77, N = 859)
rs17070697(T)/8:4447662 CSMD1 (0.13, -0.0075, P = 2.9e-05, N = 7824) (0.41, 0.038, P = 0.44, N = 859)
rs10968052(T)/9:27678482* intergenic (0.12, 0.0075, P = 3.9e-05, N = 7824) (0.038, 0.065, P = 0.61, N = 859)
rs10970461(A)/9:31632171 intergenic (0.91, 0.01, P = 4.1e-05, N = 7824) (0.99, 0.11, P = 0.61, N = 859)
rs10975539(T)/9:6308729* intergenic (0.23, -0.014, P = 4e-05, N = 7824) (0.034, 0.042, P = 0.75, N = 859)
Results from Univariable Mendelian Randomization of Creatinine & eGFR - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 123 0.056 (-0.031- 0.14) P=0.21 6.3 39 1.53 (0- 80.3) NA NA 0.011 P=0.1
MR-Egger 123 0.015 (-0.084- 0.11) P=0.77 6.3 39 1.53 (0- 80.3) 122 0.47 0.011 P=0.1
Weighted median 123 0.03 (-0.1- 0.16) P=0.66 6.3 39 1.53 (0- 80.3) NA NA 0.011 P=0.1
Results from Univariable MRPRESSO of Creatinine & eGFR - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0.06 0.04 1.27 0.21
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of Creatinine & eGFR - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 71 0.081 (-0.042- 0.2) P=0.2 5.1 18 0 (0- 17.1) NA NA 0.0026 P=0.77
MR-Egger 71 0.068 (-0.095- 0.23) P=0.42 5.1 18 0 (0- 17.1) 54 0.91 0.0026 P=0.77
Weighted median 71 0.086 (-0.14- 0.31) P=0.46 5.1 18 0 (0- 17.1) NA NA 0.0026 P=0.77
Results from Univariable MRPRESSO of Creatinine & eGFR - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0.08 0.06 1.29 0.2
beta.exposure Outlier-corrected NA NA NA NA

L-Cystathionine

Instruments Associations with L-Cystathionine & eGFR
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region L-Cystathionine (Shin et al/Long et al) eGFR (CSSCD)
rs115109644(C)/1:224064269* intergenic (0.015, 0.32, P = 9e-06, N = 1943) (0.49, -0.063, P = 0.21, N = 859)
rs4649409(G)/1:232971657 RNU1-74P (0.89, -0.28, P = 7.6e-07, N = 1943) (0.3, -0.055, P = 0.3, N = 859)
rs72756259(G)/1:232986317 intergenic (0.053, -0.34, P = 3.6e-06, N = 1943) (0.012, 0.00067, P = 1, N = 859)
rs6585049(T)/10:113043378 intergenic (0.89, -0.16, P = 9.6e-06, N = 1943) (0.48, 0.071, P = 0.14, N = 859)
rs7918657(T)/10:14395828 FRMD4A (0.12, 0.24, P = 1.5e-06, N = 1943) (0.091, -0.0053, P = 0.95, N = 859)
rs2660220(T)/10:52736099 intergenic (0.86, 0.18, P = 6.3e-06, N = 1943) (0.96, 0.067, P = 0.59, N = 859)
rs4121607(C)/11:60306301 MS4A13 (0.81, -0.14, P = 7.3e-06, N = 1943) (0.63, -0.025, P = 0.61, N = 859)
rs75745817(C)/12:71938404 LGR5 (0.061, 0.36, P = 4.9e-06, N = 1943) (0.027, -0.018, P = 0.9, N = 859)
rs10048020(T)/15:39651363* RP11-624L4.1 (0.63, -0.17, P = 5.9e-07, N = 1943) (0.72, -0.062, P = 0.25, N = 859)
rs205132(A)/16:25622453 intergenic (0.14, 0.18, P = 4.7e-06, N = 1943) (0.22, -0.048, P = 0.4, N = 859)
rs8051862(C)/16:83386261 CDH13 (0.78, -0.23, P = 9e-06, N = 1943) (0.69, 0.0085, P = 0.87, N = 859)
rs517175(C)/18:11532945 intergenic (0.43, -0.15, P = 6.5e-06, N = 1943) (0.84, -0.016, P = 0.82, N = 859)
rs9964990(A)/18:62249459 intergenic (0.64, 0.18, P = 3.1e-06, N = 1943) (0.91, -0.039, P = 0.63, N = 859)
rs35170371(A)/19:33355081 SLC7A9 (0.2, 0.25, P = 2.2e-07, N = 1943) (0.29, 0.036, P = 0.5, N = 859)
rs13007863(C)/2:1048650 SNTG2 (0.27, 0.19, P = 8.3e-06, N = 1943) (0.35, -0.0045, P = 0.93, N = 859)
rs2365208(T)/2:31355071* GALNT14 (0.78, 0.23, P = 5.9e-06, N = 1943) (0.96, 0.024, P = 0.85, N = 859)
rs9984606(T)/21:47580684 SPATC1L (0.096, 0.25, P = 1e-05, N = 1943) (0.22, -0.042, P = 0.47, N = 859)
rs462790(C)/3:1610784* intergenic (0.98, 0.49, P = 7.3e-06, N = 1943) (0.98, 0.27, P = 0.099, N = 859)
rs9810573(T)/3:5451601* intergenic (0.48, 0.17, P = 3.7e-07, N = 1943) (0.14, -0.012, P = 0.86, N = 859)
rs1166047(T)/3:9898895 TTLL3 (0.74, -0.18, P = 2.7e-06, N = 1943) (0.93, 0.13, P = 0.15, N = 859)
rs16870330(T)/5:2703426 intergenic (0.013, 0.72, P = 6.5e-07, N = 1943) (0.39, -0.0033, P = 0.95, N = 859)
rs16899567(C)/5:2708588 intergenic (0.01, 0.87, P = 4.9e-06, N = 1943) (0.12, 0.057, P = 0.45, N = 859)
rs35492822(A)/6:169020658 SMOC2 (0.22, -0.2, P = 7.5e-07, N = 1943) (0.2, 0.027, P = 0.64, N = 859)
rs9774587(A)/8:107336888 OXR1 (0.23, -0.2, P = 3.1e-06, N = 1943) (0.63, 0.038, P = 0.45, N = 859)
rs7824505(A)/8:97330691* PTDSS1 (0.47, 0.15, P = 7.5e-06, N = 1943) (0.45, 0.067, P = 0.16, N = 859)
rs7026228(G)/9:110191946 RP11-363D24.1 (0.5, 0.16, P = 7.1e-06, N = 1943) (0.21, -0.023, P = 0.7, N = 859)
Results from Univariable Mendelian Randomization of L-Cystathionine & eGFR - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 26 0.0036 (-0.061- 0.068) P=0.91 24 32 0 (0- 31.3) NA NA -0.014 P=0.54
MR-Egger 26 0.041 (-0.1- 0.18) P=0.57 24 32 0 (0- 31.3) 17 0.86 -0.014 P=0.54
Weighted median 26 -0.0038 (-0.13- 0.12) P=0.95 24 32 0 (0- 31.3) NA NA -0.014 P=0.54
Results from Univariable MRPRESSO of L-Cystathionine & eGFR - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0 0.03 0.11 0.91
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of L-Cystathionine & eGFR - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 20 -0.0046 (-0.064- 0.055) P=0.88 25 25 0 (0- 6.84) NA NA -0.029 P=0.24
MR-Egger 20 0.069 (-0.077- 0.22) P=0.37 25 25 0 (0- 6.84) 8 0.98 -0.029 P=0.24
Weighted median 20 -0.0038 (-0.13- 0.12) P=0.95 25 25 0 (0- 6.84) NA NA -0.029 P=0.24
Results from Univariable MRPRESSO of L-Cystathionine & eGFR - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0 0.03 -0.15 0.88
beta.exposure Outlier-corrected NA NA NA NA

Glycine

Instruments Associations with Glycine & eGFR
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region Glycine (Shin et al/Long et al) eGFR (CSSCD)
rs964905(T)/1:101087131 intergenic (0.49, -0.01, P = 2.6e-05, N = 7824) (0.59, -0.0049, P = 0.92, N = 859)
rs8453(T)/1:115259599 CSDE1 (0.16, 0.014, P = 8.1e-06, N = 7824) (0.024, -0.091, P = 0.56, N = 859)
rs12736195(T)/1:173307901 intergenic (0.72, -0.01, P = 4.3e-05, N = 7824) (0.87, 0.085, P = 0.24, N = 859)
rs12089471(A)/1:201162411 IGFN1 (0.35, -0.011, P = 1.1e-05, N = 7824) (0.12, -0.031, P = 0.68, N = 859)
rs782791(A)/1:202998819* TMEM183A (0.7, 0.011, P = 2e-05, N = 7824) (0.64, -0.0051, P = 0.92, N = 859)
rs10754598(A)/1:237463089* RYR2 (0.38, -0.01, P = 2.5e-05, N = 7824) (0.36, 0.031, P = 0.54, N = 859)
rs12035460(T)/1:33198711 intergenic (0.028, -0.2, P = 5.1e-06, N = 1959) (0.039, -0.21, P = 0.097, N = 859)
rs12562983(T)/1:3457311 MEGF6 (0.026, -0.065, P = 2.3e-05, N = 7824) (0.015, 0.091, P = 0.65, N = 859)
rs6683669(A)/1:59041092* TACSTD2 (0.068, -0.02, P = 2.8e-05, N = 7824) (0.3, -0.14, P = 0.0063, N = 859)
rs7079730(A)/10:11392689* intergenic (0.81, -0.014, P = 1.4e-05, N = 7824) (0.96, 0.28, P = 0.019, N = 859)
rs1907218(T)/10:122970216* intergenic (0.31, -0.01, P = 4.9e-05, N = 7824) (0.43, 0.026, P = 0.6, N = 859)
rs2474711(C)/10:33441017* intergenic (0.72, -0.013, P = 9.4e-06, N = 7824) (0.95, -0.044, P = 0.68, N = 859)
rs7908297(A)/10:5251702* AKR1C4 (0.11, 0.016, P = 3.7e-05, N = 7824) (0.033, -0.34, P = 0.013, N = 859)
rs16917276(A)/10:64230835* ZNF365 (0.032, -0.031, P = 9e-06, N = 7824) (0.027, 0.3, P = 0.049, N = 859)
rs619945(A)/11:58468173 GLYAT (0.73, -0.011, P = 4.6e-05, N = 7824) (0.92, 0.081, P = 0.36, N = 859)
rs10898864(T)/11:72405450* ARAP1 (0.26, 0.013, P = 1.7e-05, N = 7824) (0.22, -0.051, P = 0.38, N = 859)
rs491847(A)/12:101349040 ANO4 (0.35, -0.011, P = 5.3e-06, N = 7824) (0.12, 0.014, P = 0.84, N = 859)
rs11111501(T)/12:103614448 intergenic (0.076, -0.021, P = 5.9e-06, N = 7824) (0.03, 0.037, P = 0.79, N = 859)
rs4761007(T)/12:127924890* intergenic (0.74, 0.016, P = 4.1e-07, N = 7824) (0.62, -0.016, P = 0.75, N = 859)
rs7980864(A)/12:133168665 intergenic (0.14, -0.25, P = 7.9e-06, N = 1959) (0.059, 0.087, P = 0.4, N = 859)
rs2189669(A)/12:1586846* ERC1 (0.68, -0.01, P = 4.3e-05, N = 7824) (0.6, -0.089, P = 0.073, N = 859)
rs274987(G)/12:20388368 intergenic (0.43, -0.18, P = 8.7e-06, N = 1959) (0.61, -0.024, P = 0.62, N = 859)
rs739706(C)/12:47482666 PCED1B (0.36, -0.33, P = 9.6e-06, N = 1959) (0.44, -0.12, P = 0.017, N = 859)
rs17120574(T)/12:65988722 RP11-230G5.2 (0.92, 0.019, P = 2.6e-05, N = 7824) (0.61, -0.072, P = 0.13, N = 859)
rs201421(T)/12:99218243* ANKS1B (0.72, 0.011, P = 1.3e-05, N = 7824) (0.63, -0.11, P = 0.029, N = 859)
rs2209634(T)/13:48142372* intergenic (0.012, -0.083, P = 4.4e-05, N = 7824) (0.38, -0.05, P = 0.34, N = 859)
rs1350361(A)/13:60250843* DIAPH3 (0.49, 0.0097, P = 4.7e-05, N = 7824) (0.19, -0.1, P = 0.11, N = 859)
rs9572629(A)/13:71622842* LINC00348 (0.37, -0.01, P = 3.7e-05, N = 7824) (0.28, 0.087, P = 0.11, N = 859)
rs4884012(T)/13:76243575* RP11-29G8.3 (0.64, -0.01, P = 4.1e-05, N = 7824) (0.65, -0.01, P = 0.83, N = 859)
rs10129340(A)/14:100932706 WDR25 (0.6, -0.01, P = 2.4e-05, N = 7824) (0.41, -0.031, P = 0.52, N = 859)
rs268817(A)/14:58029965* SLC35F4 (0.27, 0.013, P = 2.1e-05, N = 7824) (0.047, 0.2, P = 0.078, N = 859)
rs3890482(A)/15:65840645 PTPLAD1 (0.74, 0.59, P = 7.3e-06, N = 1959) (0.31, -0.024, P = 0.65, N = 859)
rs718663(A)/15:67412596 SMAD3 (0.93, -0.022, P = 1.6e-05, N = 7824) (0.91, 0.037, P = 0.67, N = 859)
rs11857350(A)/15:88201409* RP11-648K4.2 (0.81, 0.015, P = 2e-05, N = 7824) (0.96, -0.16, P = 0.16, N = 859)
rs1143115(T)/15:93452297* CHD2 (0.53, -0.017, P = 3.5e-05, N = 7824) (0.59, -0.054, P = 0.25, N = 859)
rs4786584(T)/16:5097593 C16orf89 (0.14, 0.59, P = 1.8e-06, N = 1959) (0.24, -0.0023, P = 0.97, N = 859)
rs804895(T)/16:81099713* C16orf46 (0.078, -0.024, P = 8.4e-07, N = 7824) (0.47, 0.03, P = 0.52, N = 859)
rs8082170(T)/17:62395382 intergenic (0.18, 0.015, P = 1.1e-06, N = 7824) (0.3, 0.0066, P = 0.9, N = 859)
rs17800159(T)/18:28720147 DSC1 (0.13, 0.015, P = 3.6e-05, N = 7824) (0.037, -0.15, P = 0.22, N = 859)
rs9948977(C)/18:38610959* intergenic (0.5, -0.01, P = 2.2e-05, N = 7824) (0.61, -0.051, P = 0.32, N = 859)
rs7243793(G)/18:3862654 DLGAP1 (0.39, 0.32, P = 4.8e-06, N = 1959) (0.78, 0.048, P = 0.41, N = 859)
rs80004741(T)/19:48299916 TPRX1 (0.11, 1.1, P = 6.5e-06, N = 1959) (0.024, -0.076, P = 0.63, N = 859)
rs6738001(A)/2:10660417 intergenic (0.3, 0.011, P = 1.8e-05, N = 7824) (0.39, 0.022, P = 0.66, N = 859)
rs10186202(C)/2:127555929 intergenic (0.56, -0.0099, P = 4.4e-05, N = 7824) (0.43, -0.016, P = 0.75, N = 859)
rs7608258(A)/2:142850098* LRP1B (0.32, -0.011, P = 1e-05, N = 7824) (0.37, 0.0021, P = 0.97, N = 859)
rs7582822(A)/2:172034918 TLK1 (0.39, 0.011, P = 3.8e-06, N = 7824) (0.75, 0.015, P = 0.79, N = 859)
rs6433432(T)/2:174579886 intergenic (0.021, 0.039, P = 1.1e-05, N = 7824) (0.22, 0.017, P = 0.77, N = 859)
rs111251927(TTTTA)/2:211351706 CPS1 (0.22, -0.18, P = 1.5e-06, N = 1959) (0.064, 0.083, P = 0.4, N = 859)
rs2007748(T)/2:211357642 CPS1 (0.53, 0.011, P = 1.9e-06, N = 7824) (0.2, 0.00063, P = 0.99, N = 859)
rs6714124(T)/2:211436065* CPS1 (0.5, -0.017, P = 3.6e-12, N = 7824) (0.57, 0.024, P = 0.61, N = 859)
rs12468557(T)/2:211495587* CPS1 (0.38, -0.02, P = 1.7e-16, N = 7824) (0.19, 0.093, P = 0.13, N = 859)
rs715(T)/2:211543055* CPS1 (0.71, -0.076, P = 1.6e-147, N = 7824) (0.81, -0.061, P = 0.33, N = 859)
rs13386028(A)/2:211547400* CPS1 (0.38, -0.038, P = 3.6e-56, N = 7824) (0.36, -0.12, P = 0.02, N = 859)
rs10164524(A)/2:211664333* intergenic (0.68, 0.03, P = 1.1e-33, N = 7824) (0.83, 0.044, P = 0.5, N = 859)
rs1016403(A)/2:211704356* intergenic (0.86, 0.029, P = 4.2e-14, N = 7824) (0.93, -0.071, P = 0.46, N = 859)
rs13394054(A)/2:211742818* intergenic (0.39, -0.029, P = 1.7e-33, N = 7824) (0.63, -0.064, P = 0.2, N = 859)
rs4310999(A)/2:211750298* intergenic (0.25, 0.035, P = 3e-31, N = 7824) (0.083, 0.077, P = 0.37, N = 859)
rs6720902(T)/2:212094151 intergenic (0.59, -0.0099, P = 4.6e-05, N = 7824) (0.79, -0.012, P = 0.84, N = 859)
rs62141397(G)/2:80246161 CTNNA2 (0.19, 0.18, P = 2.7e-06, N = 1959) (0.054, -0.15, P = 0.16, N = 859)
rs4619658(C)/2:98863523* VWA3B (0.79, 0.23, P = 9.1e-06, N = 1959) (0.87, 0.093, P = 0.2, N = 859)
rs6136611(C)/20:19057513 intergenic (0.036, 0.63, P = 7.4e-06, N = 1959) (0.18, -0.038, P = 0.54, N = 859)
rs4810122(A)/20:56743597 intergenic (0.45, 0.01, P = 3.5e-05, N = 7824) (0.3, -0.013, P = 0.81, N = 859)
rs11578(T)/20:57253275* STX16 (0.29, 0.014, P = 1.9e-07, N = 7824) (0.18, -0.0015, P = 0.98, N = 859)
rs2825016(A)/21:20081605 AL109763.2 (0.32, 0.01, P = 3.1e-05, N = 7824) (0.3, 4.4e-05, P = 1, N = 859)
rs1571724(A)/21:42148836* DSCAM (0.83, 0.014, P = 2.3e-05, N = 7824) (0.85, -0.033, P = 0.63, N = 859)
rs12165565(A)/22:26226630 MYO18B (0.016, 0.21, P = 3.1e-06, N = 1959) (0.047, -0.071, P = 0.54, N = 859)
rs4494904(T)/3:101835064* ZPLD1 (0.4, -0.011, P = 1.5e-05, N = 7824) (0.17, -0.1, P = 0.11, N = 859)
rs1992854(T)/3:125909606* ALDH1L1-AS2 (0.37, -0.011, P = 7e-06, N = 7824) (0.36, -0.073, P = 0.14, N = 859)
rs12496373(A)/3:148497051* intergenic (0.73, -0.011, P = 2.3e-05, N = 7824) (0.54, -0.037, P = 0.45, N = 859)
rs7613813(A)/3:149429485* WWTR1 (0.33, -0.01, P = 2.7e-05, N = 7824) (0.43, 0.0049, P = 0.92, N = 859)
rs9823316(A)/3:7999351 LMCD1-AS1 (0.09, 0.018, P = 1.1e-05, N = 7824) (0.16, 0.06, P = 0.36, N = 859)
rs11942622(T)/4:12360318* intergenic (0.98, 0.071, P = 2.7e-06, N = 7824) (0.78, -0.042, P = 0.47, N = 859)
rs6836137(A)/4:145250822 intergenic (0.014, -0.079, P = 4.8e-06, N = 7824) (0.016, -0.28, P = 0.15, N = 859)
rs4698310(T)/4:15083363 RP11-665G4.1 (0.42, -0.17, P = 2.7e-06, N = 1959) (0.7, 0.058, P = 0.28, N = 859)
rs9998572(T)/4:170687567 intergenic (0.033, -0.049, P = 2.7e-05, N = 7824) (0.16, -0.08, P = 0.23, N = 859)
rs3904756(C)/4:19616531 RP11-608O21.1 (0.17, 0.16, P = 4.3e-06, N = 1959) (0.079, 0.0018, P = 0.98, N = 859)
rs9992408(A)/4:76265330 RP11-542G1.1 (0.077, -0.019, P = 4e-05, N = 7824) (0.066, -0.12, P = 0.23, N = 859)
rs12152753(A)/5:111443094* intergenic (0.32, 0.01, P = 2.9e-05, N = 7824) (0.083, -0.12, P = 0.17, N = 859)
rs2560698(T)/5:115388091 ARL14EPL (0.85, 0.016, P = 1.9e-05, N = 7824) (0.65, -0.04, P = 0.44, N = 859)
rs7709785(T)/5:115406397 intergenic (0.15, -0.018, P = 2e-06, N = 7824) (0.26, -0.016, P = 0.76, N = 859)
rs329319(A)/5:133906609* JADE2 (0.43, 0.013, P = 6.5e-07, N = 7824) (0.52, -0.037, P = 0.44, N = 859)
rs13181561(A)/5:138850905* TMEM173 (0.74, 0.012, P = 4.1e-05, N = 7824) (0.41, -0.12, P = 0.012, N = 859)
rs1423029(A)/5:145930544* intergenic (0.53, -0.01, P = 2.6e-05, N = 7824) (0.5, 0.051, P = 0.3, N = 859)
rs4437350(T)/5:34645265* intergenic (0.16, 0.39, P = 6.4e-06, N = 1959) (0.037, -0.00099, P = 0.99, N = 859)
rs6897751(G)/5:79113505 CTC-431G16.2 (0.057, 0.26, P = 9.3e-06, N = 1959) (0.26, 0.011, P = 0.84, N = 859)
rs268538(T)/5:9458650 SEMA5A (0.021, -0.064, P = 1.5e-05, N = 7824) (0.091, -0.018, P = 0.84, N = 859)
rs160508(A)/5:9588764 intergenic (0.88, 0.017, P = 1.9e-05, N = 7824) (0.96, -0.076, P = 0.55, N = 859)
rs583776(T)/6:10466171* intergenic (0.62, -0.019, P = 8.2e-06, N = 7824) (0.64, 0.036, P = 0.47, N = 859)
rs11152896(C)/6:105997676 intergenic (0.92, 0.022, P = 1.2e-05, N = 7824) (0.73, 0.017, P = 0.75, N = 859)
rs9483617(T)/6:134129708 RP3-323P13.2 (0.032, -0.051, P = 4.6e-05, N = 7824) (0.15, 0.021, P = 0.76, N = 859)
rs229914(A)/6:134323928 SLC2A12 (0.58, -0.011, P = 2.4e-06, N = 7824) (0.49, -0.062, P = 0.2, N = 859)
rs13203202(T)/6:25582771 LRRC16A (0.58, 0.011, P = 9.3e-06, N = 7824) (0.48, -0.0018, P = 0.97, N = 859)
rs9328361(T)/6:6400475* LY86-AS1 (0.14, -0.014, P = 3.5e-05, N = 7824) (0.14, -0.021, P = 0.76, N = 859)
rs1125083(T)/6:73572090* KCNQ5 (0.8, -0.013, P = 3.7e-05, N = 7824) (0.84, 0.049, P = 0.46, N = 859)
rs12532734(A)/7:107472382* intergenic (0.2, -0.013, P = 3.5e-05, N = 7824) (0.12, 0.048, P = 0.53, N = 859)
rs5009270(A)/7:112159178* NPM1P14 (0.31, 0.011, P = 1.7e-05, N = 7824) (0.5, 0.1, P = 0.036, N = 859)
rs7789056(A)/7:112908269 intergenic (0.56, 0.01, P = 3.8e-05, N = 7824) (0.52, -0.0018, P = 0.97, N = 859)
rs12534184(A)/7:123651077* RP4-630C24.3 (0.11, -0.016, P = 4e-05, N = 7824) (0.19, -0.075, P = 0.21, N = 859)
rs9655907(A)/7:137817625* intergenic (0.97, 0.05, P = 3.1e-05, N = 7824) (0.79, -0.0076, P = 0.9, N = 859)
rs17557000(A)/7:151707893 GALNTL5 (0.63, -0.01, P = 3.3e-05, N = 7824) (0.76, -0.092, P = 0.1, N = 859)
rs6464427(T)/7:154147779 DPP6 (0.19, 0.013, P = 4.3e-05, N = 7824) (0.48, -0.1, P = 0.03, N = 859)
rs6951820(A)/7:154381783* DPP6 (0.43, 0.011, P = 4.8e-06, N = 7824) (0.23, 0.076, P = 0.18, N = 859)
rs117039120(T)/7:20607573 intergenic (0.17, 0.15, P = 2.1e-07, N = 1959) (0.038, -0.23, P = 0.056, N = 859)
rs6974377(C)/7:21397405 intergenic (0.32, -0.37, P = 1.7e-06, N = 1959) (0.24, 0.026, P = 0.66, N = 859)
rs10275982(A)/7:27953981 JAZF1 (0.35, -0.01, P = 2.2e-05, N = 7824) (0.17, -0.14, P = 0.038, N = 859)
rs1123227(A)/7:42496495* intergenic (0.76, 0.017, P = 9.8e-06, N = 7824) (0.84, 0.11, P = 0.12, N = 859)
rs983498(C)/7:53113752* intergenic (0.71, -0.02, P = 8e-06, N = 7824) (0.78, -0.018, P = 0.75, N = 859)
rs3211913(G)/7:80294604 CD36 (0.022, -0.36, P = 5.1e-06, N = 1959) (0.33, -0.027, P = 0.61, N = 859)
rs17635249(C)/8:49806968 intergenic (0.36, 0.01, P = 3.9e-05, N = 7824) (0.26, 0.035, P = 0.53, N = 859)
rs182914(T)/8:50060960* intergenic (0.47, -0.0098, P = 4.6e-05, N = 7824) (0.32, -0.079, P = 0.13, N = 859)
rs17370395(A)/9:105976900 RP11-341A22.2 (0.93, 0.047, P = 2e-05, N = 7824) (0.92, 0.018, P = 0.84, N = 859)
rs11573691(T)/9:110081653 RAD23B (0.094, -0.28, P = 5.4e-06, N = 1959) (0.015, -0.088, P = 0.65, N = 859)
rs12349613(T)/9:117607806* RP11-78H18.2 (0.055, 0.034, P = 5.6e-06, N = 7824) (0.18, -0.056, P = 0.36, N = 859)
rs3012739(A)/9:134654306* EIF4A1P3 (0.48, 0.012, P = 2.1e-06, N = 7824) (0.22, -0.0098, P = 0.86, N = 859)
rs4240706(A)/9:137669555 COL5A1 (0.015, -0.1, P = 1.9e-05, N = 7824) (0.25, -0.024, P = 0.67, N = 859)
rs10964319(T)/9:1994871* intergenic (0.097, -0.017, P = 4.7e-05, N = 7824) (0.21, -0.008, P = 0.9, N = 859)
rs10971687(T)/9:33761112* PRSS3 (0.37, -0.01, P = 1.8e-05, N = 7824) (0.13, 0.21, P = 0.0034, N = 859)
rs2297442(T)/9:6540540 GLDC (0.7, 0.011, P = 2.9e-05, N = 7824) (0.83, 0.041, P = 0.53, N = 859)
rs952045(T)/9:73161881 TRPM3 (0.95, 0.025, P = 7.3e-06, N = 7824) (0.77, -0.046, P = 0.42, N = 859)
Results from Univariable Mendelian Randomization of Glycine & eGFR - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 119 0.014 (-0.072- 0.1) P=0.75 15 80 0.00117 (0- 97.3) NA NA 0.0028 P=0.69
MR-Egger 119 0.0051 (-0.091- 0.1) P=0.92 15 80 0.00117 (0- 97.3) 149 0.024 0.0028 P=0.69
Weighted median 119 -0.027 (-0.13- 0.077) P=0.61 15 80 0.00117 (0- 97.3) NA NA 0.0028 P=0.69
Results from Univariable MRPRESSO of Glycine & eGFR - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0.01 0.04 0.32 0.75
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of Glycine & eGFR - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 61 0.003 (-0.068- 0.074) P=0.93 27 73 0 (0- 45) NA NA 0.0054 P=0.57
MR-Egger 61 -0.011 (-0.1- 0.081) P=0.81 27 73 0 (0- 45) 49 0.82 0.0054 P=0.57
Weighted median 61 -0.03 (-0.13- 0.072) P=0.56 27 73 0 (0- 45) NA NA 0.0054 P=0.57
Results from Univariable MRPRESSO of Glycine & eGFR - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0 0.04 0.08 0.93
beta.exposure Outlier-corrected NA NA NA NA

Hippuric acid

Instruments Associations with Hippuric acid & eGFR
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region Hippuric acid (Shin et al/Long et al) eGFR (CSSCD)
rs520229(T)/1:78876209 PTGFR (0.69, -0.15, P = 3.4e-06, N = 1956) (0.58, -0.021, P = 0.67, N = 859)
rs12410147(T)/1:94289120 BCAR3 (0.071, 0.23, P = 8e-06, N = 1956) (0.16, 0.083, P = 0.22, N = 859)
rs10786630(C)/10:103075639 RP11-107I14.2 (0.65, 0.19, P = 7.8e-07, N = 1956) (0.28, 0.12, P = 0.023, N = 859)
rs282692(C)/10:60655066 intergenic (0.78, -0.19, P = 9e-06, N = 1956) (0.4, 0.017, P = 0.73, N = 859)
rs9518260(C)/13:101632306 NALCN-AS1 (0.27, -0.16, P = 9.9e-07, N = 1956) (0.097, -0.019, P = 0.81, N = 859)
rs420176(C)/13:111216902 RAB20 (0.93, 0.34, P = 4.2e-06, N = 1956) (0.75, -0.051, P = 0.37, N = 859)
rs2045930(G)/15:74100160 intergenic (0.46, 0.15, P = 8e-07, N = 1956) (0.098, -0.069, P = 0.39, N = 859)
rs4553581(C)/15:74194348 intergenic (0.56, 0.17, P = 3e-08, N = 1956) (0.33, 0.037, P = 0.45, N = 859)
rs12935540(T)/16:48586557 N4BP1 (0.29, -0.16, P = 3.4e-06, N = 1956) (0.41, -0.013, P = 0.79, N = 859)
rs3095573(G)/16:53377003* intergenic (0.35, 0.15, P = 9.2e-06, N = 1956) (0.11, -0.041, P = 0.59, N = 859)
rs10195231(G)/2:121152012 intergenic (0.48, 0.14, P = 5.2e-06, N = 1956) (0.88, 0.09, P = 0.21, N = 859)
rs6053232(G)/20:5241396 intergenic (0.72, -0.19, P = 3.4e-06, N = 1956) (0.88, 0.14, P = 0.062, N = 859)
rs77077232(A)/3:125463283 OR7E97P (0.039, -0.37, P = 4e-06, N = 1956) (0.38, 0.0089, P = 0.85, N = 859)
rs745168(A)/3:194325010 TMEM44 (0.32, 0.09, P = 8.9e-06, N = 1956) (0.29, 0.0077, P = 0.89, N = 859)
rs1452177(T)/3:83496775* intergenic (0.5, -0.17, P = 1.9e-06, N = 1956) (0.49, 0.074, P = 0.12, N = 859)
rs11730547(G)/4:117903947 intergenic (0.1, -0.32, P = 1.8e-07, N = 1956) (0.16, 0.11, P = 0.097, N = 859)
rs7682799(C)/4:118010613* TRAM1L1 (0.11, -0.34, P = 2.6e-08, N = 1956) (0.18, 0.011, P = 0.87, N = 859)
rs11791193(A)/9:117084020 ORM1 (0.14, 0.26, P = 6.6e-07, N = 1956) (0.024, -0.046, P = 0.77, N = 859)
rs7029058(T)/9:84233764 TLE1 (0.36, -0.13, P = 4.1e-06, N = 1956) (0.61, 0.063, P = 0.21, N = 859)
Results from Univariable Mendelian Randomization of Hippuric acid & eGFR - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 19 -0.05 (-0.18- 0.079) P=0.45 25 24 6.24 (0- 66.7) NA NA 0.019 P=0.64
MR-Egger 19 -0.13 (-0.48- 0.22) P=0.48 25 24 6.24 (0- 66.7) 20 0.25 0.019 P=0.64
Weighted median 19 -0.03 (-0.21- 0.15) P=0.75 25 24 6.24 (0- 66.7) NA NA 0.019 P=0.64
Results from Univariable MRPRESSO of Hippuric acid & eGFR - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.05 0.07 -0.76 0.46
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of Hippuric acid & eGFR - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 16 -0.027 (-0.17- 0.12) P=0.72 23 19 20 (0- 71.8) NA NA 0.037 P=0.41
MR-Egger 16 -0.18 (-0.58- 0.21) P=0.37 23 19 20 (0- 71.8) 18 0.22 0.037 P=0.41
Weighted median 16 -0.046 (-0.25- 0.16) P=0.66 23 19 20 (0- 71.8) NA NA 0.037 P=0.41
Results from Univariable MRPRESSO of Hippuric acid & eGFR - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.03 0.08 -0.36 0.73
beta.exposure Outlier-corrected NA NA NA NA

Indoxyl sulfate

Instruments Associations with Indoxyl sulfate & eGFR
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region Indoxyl sulfate (Shin et al/Long et al) eGFR (CSSCD)
rs6679229(G)/1:15914078* AGMAT (0.3, -0.18, P = 2.1e-06, N = 1954) (0.27, -0.0022, P = 0.97, N = 859)
rs4587548(C)/1:195834979* intergenic (0.62, 0.015, P = 2.5e-05, N = 7339) (0.16, 0.05, P = 0.46, N = 859)
rs4288539(A)/1:25282993* RUNX3 (0.61, -0.015, P = 2.1e-05, N = 7339) (0.89, 0.096, P = 0.23, N = 859)
rs1564485(A)/1:53621628* intergenic (0.48, 0.016, P = 7.8e-06, N = 7339) (0.56, -0.0031, P = 0.95, N = 859)
rs7095620(A)/10:114448218* VTI1A (0.31, -0.016, P = 2.7e-05, N = 7339) (0.68, 0.05, P = 0.35, N = 859)
rs12217409(A)/10:129707769 PTPRE (0.14, -0.27, P = 3e-06, N = 1954) (0.31, 0.085, P = 0.1, N = 859)
rs7100757(C)/10:73325757 CDH23 (0.46, 0.15, P = 4.6e-06, N = 1954) (0.62, -0.027, P = 0.58, N = 859)
rs4937006(C)/11:125252738 PKNOX2 (0.075, 0.036, P = 3.2e-05, N = 7339) (0.17, -0.071, P = 0.27, N = 859)
rs527140(A)/11:57500134* TMX2 (0.75, -0.033, P = 6.8e-06, N = 1758) (0.77, -0.055, P = 0.33, N = 859)
rs1283170(A)/12:52423179 NR4A1 (0.3, -0.03, P = 2.7e-05, N = 1758) (0.32, -0.055, P = 0.3, N = 859)
rs7327909(A)/13:100505367* CLYBL (0.39, 0.016, P = 1.3e-05, N = 7339) (0.27, -0.057, P = 0.31, N = 859)
rs9508849(A)/13:20261939* PSPC1 (0.95, 0.076, P = 3.4e-05, N = 1758) (0.71, 0.031, P = 0.57, N = 859)
rs4363758(T)/13:77386392* intergenic (0.23, 0.018, P = 2.3e-05, N = 7339) (0.2, 0.0031, P = 0.96, N = 859)
rs7161167(A)/14:29740046 RP11-562L8.1 (0.051, -0.036, P = 1.6e-05, N = 7339) (0.2, 0.096, P = 0.12, N = 859)
rs2765904(T)/14:85289193 intergenic (0.51, -0.015, P = 4e-05, N = 7339) (0.19, 0.012, P = 0.84, N = 859)
rs12599018(C)/16:6085186 RBFOX1 (0.19, -0.021, P = 2.6e-05, N = 7339) (0.29, -0.038, P = 0.48, N = 859)
rs12597663(A)/16:66396875* CDH5 (0.63, 0.015, P = 4.4e-05, N = 7339) (0.42, -0.012, P = 0.81, N = 859)
rs3907371(T)/18:69684916 intergenic (0.65, -0.03, P = 1.1e-05, N = 1758) (0.62, -0.038, P = 0.46, N = 859)
rs7937(T)/19:41302706* EGLN2 (0.56, -0.015, P = 1.9e-05, N = 7339) (0.31, -0.028, P = 0.61, N = 859)
rs373996356(G)/19:429599 SHC2 (0.011, -0.56, P = 7.5e-06, N = 1954) (0.061, -0.05, P = 0.63, N = 859)
rs17043547(A)/2:115539056 DPP10 (0.012, -0.079, P = 4.9e-06, N = 7339) (0.036, -0.011, P = 0.93, N = 859)
rs1179644(A)/2:217796770* AC007563.5 (0.93, 0.029, P = 2.6e-05, N = 7339) (0.49, 0.012, P = 0.8, N = 859)
rs7261614(T)/20:17604260* RRBP1 (0.24, 0.034, P = 1.3e-05, N = 1758) (0.65, -0.029, P = 0.57, N = 859)
rs12480161(T)/20:40389664* intergenic (0.75, -0.032, P = 4.1e-05, N = 1758) (0.83, -0.018, P = 0.79, N = 859)
rs7262150(C)/20:62354494 ZGPAT (0.21, 0.24, P = 4.8e-06, N = 1954) (0.078, 0.033, P = 0.72, N = 859)
rs9863394(T)/3:125456532* OR7E53P (0.059, 0.037, P = 2.5e-05, N = 7339) (0.41, -0.0057, P = 0.91, N = 859)
rs7631707(A)/3:20300268* intergenic (0.56, 0.015, P = 2.9e-05, N = 7339) (0.59, -0.089, P = 0.077, N = 859)
rs17024808(T)/4:134386587* intergenic (0.63, 0.015, P = 4.2e-05, N = 7339) (0.4, 0.066, P = 0.18, N = 859)
rs10031835(T)/4:136087584* intergenic (0.7, -0.034, P = 5.8e-06, N = 1758) (0.9, 0.068, P = 0.4, N = 859)
rs295224(T)/4:161227411* intergenic (0.41, -0.017, P = 2.4e-05, N = 7339) (0.26, -0.015, P = 0.79, N = 859)
rs77431462(T)/4:174899979 RP11-161D15.3 (0.74, -0.12, P = 8.6e-06, N = 1954) (0.55, 0.0067, P = 0.89, N = 859)
rs13145712(T)/4:62041029* intergenic (0.73, -0.034, P = 4.1e-05, N = 1758) (0.89, -0.12, P = 0.14, N = 859)
rs2090189(T)/4:64337600* RP11-12K22.1 (0.4, 0.015, P = 1.6e-05, N = 7339) (0.36, 0.093, P = 0.058, N = 859)
rs698172(A)/5:127154927 CTC-228N24.1 (0.42, -0.015, P = 3.4e-05, N = 7339) (0.15, 0.018, P = 0.79, N = 859)
rs1039438(A)/5:156476770* HAVCR1 (0.28, -0.019, P = 1e-05, N = 7339) (0.15, -0.011, P = 0.87, N = 859)
rs13361283(T)/5:169722546 LCP2 (0.92, 0.057, P = 1.8e-05, N = 1758) (0.9, -0.091, P = 0.26, N = 859)
rs2927892(A)/6:120659453 intergenic (0.27, -0.018, P = 3.8e-05, N = 7339) (0.23, 0.012, P = 0.83, N = 859)
rs9489956(T)/6:120781346* intergenic (0.78, 0.04, P = 5.3e-07, N = 1758) (0.75, -0.0097, P = 0.86, N = 859)
rs11758810(T)/6:155418671 TIAM2 (0.38, 0.16, P = 1.9e-06, N = 1954) (0.26, 0.021, P = 0.72, N = 859)
rs9379897(T)/6:26601526* ABT1 (0.87, -0.026, P = 2e-06, N = 7339) (0.86, 0.021, P = 0.77, N = 859)
rs3847067(A)/7:100500615* RN7SL549P (0.29, -0.032, P = 6.7e-06, N = 1758) (0.096, -0.05, P = 0.53, N = 859)
rs2273933(T)/9:14313712* NFIB (0.1, 0.026, P = 3.7e-05, N = 7339) (0.56, 0.0099, P = 0.84, N = 859)
rs7855409(T)/9:24296518 intergenic (0.01, -0.58, P = 8.5e-06, N = 1954) (0.022, -0.23, P = 0.17, N = 859)
rs943628(T)/9:293360* DOCK8 (0.26, 0.018, P = 4.2e-05, N = 7339) (0.34, 0.039, P = 0.45, N = 859)
rs7858948(A)/9:89621759* CDC20P1 (0.011, -0.13, P = 3.5e-05, N = 1758) (0.3, -0.091, P = 0.082, N = 859)
Results from Univariable Mendelian Randomization of Indoxyl sulfate & eGFR - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 45 0.032 (-0.12- 0.19) P=0.68 4.8 10 2.69 (0- 30.2) NA NA 0.0024 P=0.82
MR-Egger 45 0.018 (-0.2- 0.23) P=0.87 4.8 10 2.69 (0- 30.2) 34 0.83 0.0024 P=0.82
Weighted median 45 0.052 (-0.22- 0.33) P=0.71 4.8 10 2.69 (0- 30.2) NA NA 0.0024 P=0.82
Results from Univariable MRPRESSO of Indoxyl sulfate & eGFR - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0.03 0.08 0.41 0.68
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of Indoxyl sulfate & eGFR - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 17 -0.022 (-0.19- 0.15) P=0.81 9.8 8.2 5.28 (0- 69.7) NA NA -0.013 P=0.53
MR-Egger 17 0.034 (-0.22- 0.29) P=0.8 9.8 8.2 5.28 (0- 69.7) 12 0.67 -0.013 P=0.53
Weighted median 17 0.027 (-0.27- 0.32) P=0.86 9.8 8.2 5.28 (0- 69.7) NA NA -0.013 P=0.53
Results from Univariable MRPRESSO of Indoxyl sulfate & eGFR - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.02 0.09 -0.25 0.81
beta.exposure Outlier-corrected NA NA NA NA

Methylmalonylcarnitine

Instruments Associations with Methylmalonyl carnitine & eGFR
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region Methylmalonyl carnitine (Shin et al/Long et al) eGFR (CSSCD)
rs10999344(A)/10:53525932* PRKG1 (0.12, 0.22, P = 9.4e-06, N = 1818) (0.12, 0.012, P = 0.87, N = 859)
rs1842830(T)/11:7863201* RP11-35J10.5 (0.99, -0.6, P = 6.4e-07, N = 1818) (0.88, -0.046, P = 0.52, N = 859)
rs578157537(ATTTTTTT)/12:104366864 TDG (0.039, -0.39, P = 3.4e-06, N = 1818) (0.76, 0.068, P = 0.24, N = 859)
rs880118(C)/13:112023039* intergenic (0.99, -0.47, P = 1.2e-06, N = 1818) (0.7, 0.016, P = 0.77, N = 859)
rs1885076(G)/14:27043304 NOVA1 (0.62, -0.13, P = 1.4e-06, N = 1818) (0.15, -0.17, P = 0.013, N = 859)
rs11890(A)/16:1820992* NME3 (0.77, -0.18, P = 8.3e-07, N = 1818) (0.84, -0.041, P = 0.54, N = 859)
rs2967147(C)/16:57849280* CTD-2600O9.1 (0.079, -0.31, P = 3.6e-06, N = 1818) (0.26, -0.088, P = 0.097, N = 859)
rs56720646(A)/18:49036947 RP11-267C16.1 (0.06, 0.29, P = 2.7e-06, N = 1818) (0.12, -0.01, P = 0.89, N = 859)
rs200472465(C)/2:11956875* LPIN1 (0.014, 0.49, P = 5.8e-06, N = 1818) (0.074, -0.098, P = 0.29, N = 859)
rs140740345(CA)/2:198092325 ANKRD44 (0.22, -0.22, P = 4.9e-06, N = 1818) (0.82, 0.073, P = 0.25, N = 859)
rs112638583(T)/2:23341246 AC016768.1 (0.016, 0.65, P = 7.4e-06, N = 1818) (0.022, 0.0055, P = 0.97, N = 859)
rs1075726(C)/2:23412686* AC016768.1 (0.067, 0.35, P = 4.7e-06, N = 1818) (0.09, 0.12, P = 0.15, N = 859)
rs1569910(G)/20:54377395* intergenic (0.033, -0.37, P = 9.3e-06, N = 1818) (0.063, -0.17, P = 0.083, N = 859)
rs4810141(T)/20:57209899 MGC4294 (0.58, 0.15, P = 6.2e-06, N = 1818) (0.41, 0.021, P = 0.67, N = 859)
rs10077410(A)/5:122450771* PRDM6 (0.14, 0.23, P = 6.7e-06, N = 1818) (0.14, 0.019, P = 0.79, N = 859)
rs3095825(A)/5:31440389* DROSHA (0.82, -0.22, P = 4.4e-06, N = 1818) (0.92, 0.092, P = 0.31, N = 859)
rs59448538(G)/6:150631830 intergenic (0.26, -0.2, P = 2.9e-07, N = 1818) (0.32, -0.072, P = 0.15, N = 859)
rs7810641(C)/7:146979044 CNTNAP2 (0.72, -0.17, P = 6.7e-06, N = 1818) (0.96, -0.14, P = 0.25, N = 859)
rs4743171(T)/9:100908135 CORO2A (0.27, -0.19, P = 6.5e-06, N = 1818) (0.31, 0.018, P = 0.74, N = 859)
rs79410245(C)/9:7666483 intergenic (0.015, 0.59, P = 7.9e-06, N = 1818) (0.069, -0.17, P = 0.075, N = 859)
Results from Univariable Mendelian Randomization of Methylmalonyl carnitine & eGFR - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 20 0.02 (-0.09- 0.13) P=0.72 21 23 21.5 (0- 77.6) NA NA 0.07 P=0.095
MR-Egger 20 -0.18 (-0.42- 0.066) P=0.17 21 23 21.5 (0- 77.6) 23 0.21 0.07 P=0.095
Weighted median 20 -0.01 (-0.15- 0.13) P=0.89 21 23 21.5 (0- 77.6) NA NA 0.07 P=0.095
Results from Univariable MRPRESSO of Methylmalonyl carnitine & eGFR - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0.02 0.06 0.35 0.73
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of Methylmalonyl carnitine & eGFR - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 10 -0.065 (-0.26- 0.13) P=0.51 22 12 24.1 (0- 91.3) NA NA 0.12 P=0.04
MR-Egger 10 -0.45 (-0.8- -0.11) P=0.034 22 12 24.1 (0- 91.3) 8.6 0.38 0.12 P=0.04
Weighted median 10 -0.13 (-0.35- 0.093) P=0.26 22 12 24.1 (0- 91.3) NA NA 0.12 P=0.04
Results from Univariable MRPRESSO of Methylmalonyl carnitine & eGFR - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.07 0.1 -0.66 0.53
beta.exposure Outlier-corrected NA NA NA NA

myo-Inositol

Instruments Associations with myo-Inositol & eGFR
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region myo-Inositol (Shin et al/Long et al) eGFR (CSSCD)
rs10875336(T)/1:101241384 intergenic (0.61, -0.0073, P = 2.4e-05, N = 7824) (0.55, -0.14, P = 0.0037, N = 859)
rs856084(T)/1:158915141* PYHIN1 (0.72, 0.0078, P = 1e-05, N = 7824) (0.92, 0.023, P = 0.8, N = 859)
rs7544659(A)/1:175647041* TNR (0.4, 0.0089, P = 3.1e-07, N = 7824) (0.47, 0.031, P = 0.52, N = 859)
rs7556049(C)/1:200138774 NR5A2 (0.12, 0.22, P = 5.2e-06, N = 1951) (0.39, -0.05, P = 0.3, N = 859)
rs10735491(A)/1:217113278* ESRRG (0.45, 0.0072, P = 3.9e-05, N = 7824) (0.18, 0.037, P = 0.55, N = 859)
rs12744888(A)/1:229336778 intergenic (0.93, -0.02, P = 1.4e-05, N = 7824) (0.99, -0.055, P = 0.8, N = 859)
rs4659612(A)/1:236033290* LYST (0.74, 0.017, P = 5.9e-06, N = 7824) (0.72, 0.11, P = 0.045, N = 859)
rs7541937(T)/1:35341982* DLGAP3 (0.46, 0.0079, P = 2.2e-05, N = 7824) (0.53, -0.05, P = 0.31, N = 859)
rs12146051(C)/1:46742952 RAD54L (0.31, -0.0074, P = 2.8e-05, N = 7824) (0.059, 0.062, P = 0.54, N = 859)
rs12077102(C)/1:60183404 FGGY (0.012, 0.066, P = 1.9e-05, N = 7824) (0.14, -0.015, P = 0.83, N = 859)
rs6584573(C)/10:105570406* SH3PXD2A (0.016, 0.032, P = 2.7e-05, N = 7824) (0.13, -0.11, P = 0.14, N = 859)
rs11192466(A)/10:107278956* intergenic (0.013, 0.069, P = 8.3e-06, N = 7824) (0.12, -0.084, P = 0.25, N = 859)
rs11010733(A)/10:19912562* MALRD1 (0.025, 0.046, P = 4.1e-05, N = 7824) (0.19, -0.02, P = 0.75, N = 859)
rs3004261(A)/10:43491592* MIR5100 (0.42, 0.0082, P = 1.8e-06, N = 7824) (0.33, -0.0069, P = 0.9, N = 859)
rs10996699(A)/10:53063382 PRKG1 (0.77, -0.013, P = 4.4e-05, N = 7824) (0.94, 0.071, P = 0.47, N = 859)
rs7071294(G)/10:53396926 PRKG1 (0.23, -0.25, P = 2.9e-06, N = 1951) (0.19, 0.027, P = 0.66, N = 859)
rs2642588(T)/10:71466578 intergenic (0.31, -0.0079, P = 5.8e-06, N = 7824) (0.52, -0.029, P = 0.55, N = 859)
rs12266321(T)/10:78777947* KCNMA1 (0.99, -0.066, P = 6.1e-06, N = 7824) (0.97, 0.24, P = 0.097, N = 859)
rs265455(A)/10:83075585* intergenic (0.29, 0.0072, P = 4.5e-05, N = 7824) (0.39, -0.042, P = 0.39, N = 859)
rs265487(A)/10:83117262* intergenic (0.49, -0.0077, P = 7.6e-06, N = 7824) (0.26, -0.052, P = 0.33, N = 859)
rs10502069(A)/11:106316611* intergenic (0.73, -0.0078, P = 8.4e-06, N = 7824) (0.77, 0.12, P = 0.03, N = 859)
rs1944518(T)/11:120843742* GRIK4 (0.31, -0.0086, P = 1.3e-06, N = 7824) (0.051, -0.18, P = 0.11, N = 859)
rs2922048(T)/11:41389942 LRRC4C (0.66, 0.0071, P = 4.9e-05, N = 7824) (0.45, -0.0089, P = 0.86, N = 859)
rs2510500(C)/11:79194246 intergenic (0.43, -0.0076, P = 1e-05, N = 7824) (0.48, 0.034, P = 0.48, N = 859)
rs12277739(C)/11:87624457* RP11-665E10.3 (0.97, -0.046, P = 2.2e-05, N = 7824) (0.85, 0.046, P = 0.51, N = 859)
rs7312321(A)/12:120036235* TMEM233 (0.35, -0.0072, P = 3.4e-05, N = 7824) (0.4, -0.067, P = 0.17, N = 859)
rs9651790(T)/12:129389777 GLT1D1 (0.47, -0.0073, P = 2.5e-05, N = 7824) (0.22, 0.056, P = 0.35, N = 859)
rs4759824(T)/12:131486985* GPR133 (0.68, 0.0083, P = 1.9e-06, N = 7824) (0.67, -0.038, P = 0.46, N = 859)
rs10505911(A)/12:24022160* SOX5 (0.23, 0.01, P = 3e-05, N = 7824) (0.33, 0.053, P = 0.31, N = 859)
rs58671007(ATT)/13:37491536 SMAD9 (0.012, 0.44, P = 7.5e-06, N = 1951) (0.16, -0.042, P = 0.52, N = 859)
rs12552(A)/13:53625781* OLFM4 (0.44, 0.0074, P = 1.5e-05, N = 7824) (0.4, 0.13, P = 0.0062, N = 859)
rs9317855(T)/13:70543601* KLHL1 (0.35, -0.008, P = 4.3e-06, N = 7824) (0.42, 0.016, P = 0.74, N = 859)
rs9529872(T)/13:71875477* RABEPKP1 (0.024, 0.048, P = 4.8e-05, N = 7824) (0.16, -0.012, P = 0.86, N = 859)
rs1764963(T)/13:86259295 intergenic (0.65, -0.008, P = 4.4e-06, N = 7824) (0.48, -0.054, P = 0.27, N = 859)
rs1956194(G)/14:59477771* RP11-112J1.2 (0.86, -0.21, P = 5.8e-06, N = 1951) (0.86, 0.059, P = 0.37, N = 859)
rs6573359(T)/14:61582316 intergenic (0.98, 0.048, P = 3.3e-05, N = 7824) (0.64, 0.0012, P = 0.98, N = 859)
rs12589229(T)/14:91820675* CCDC88C (0.33, 0.0083, P = 2.4e-06, N = 7824) (0.22, 0.034, P = 0.56, N = 859)
rs2107582(A)/15:25753469 AC124997.1 (0.32, -0.0075, P = 2.2e-05, N = 7824) (0.42, 7e-05, P = 1, N = 859)
rs11070699(T)/15:49800789* FAM227B (0.65, -0.0075, P = 2e-05, N = 7824) (0.49, 0.031, P = 0.53, N = 859)
rs11631036(T)/15:51298925 AP4E1 (0.11, -0.24, P = 9.4e-06, N = 1951) (0.017, -0.2, P = 0.28, N = 859)
rs72734509(G)/15:76093382 intergenic (0.023, 0.55, P = 9.6e-06, N = 1951) (0.013, -0.092, P = 0.67, N = 859)
rs1896864(A)/15:85382193 ALPK3 (0.65, 0.0075, P = 1.6e-05, N = 7824) (0.69, -0.078, P = 0.14, N = 859)
rs7200640(C)/16:12774993 CPPED1 (0.88, -0.014, P = 1.6e-05, N = 7824) (0.93, 0.16, P = 0.078, N = 859)
rs4788439(T)/16:24931798* ARHGAP17 (0.077, -0.027, P = 6.6e-13, N = 7824) (0.67, -0.1, P = 0.051, N = 859)
rs16974319(A)/16:25054644* RP11-266L9.4 (0.42, -0.0072, P = 3.4e-05, N = 7824) (0.45, -0.0011, P = 0.98, N = 859)
rs6500418(T)/16:48876104 intergenic (0.37, -0.0079, P = 5.9e-06, N = 7824) (0.77, -0.039, P = 0.51, N = 859)
rs17711511(C)/16:80066149 intergenic (0.92, -0.015, P = 1.1e-05, N = 7824) (0.98, 0.083, P = 0.65, N = 859)
rs4243227(T)/16:82028082 SDR42E1 (0.8, 0.011, P = 4e-05, N = 7824) (0.95, 0.02, P = 0.85, N = 859)
rs16957235(T)/16:82424223* intergenic (0.99, -0.071, P = 4.3e-06, N = 7824) (0.88, -4.5e-06, P = 1, N = 859)
rs77193496(T)/17:13106988 intergenic (0.035, 0.45, P = 8.7e-06, N = 1951) (0.097, -0.036, P = 0.66, N = 859)
rs12942795(A)/17:34995473 CTB-75G16.3 (0.64, 0.0099, P = 3.6e-05, N = 7824) (0.92, 0.0081, P = 0.93, N = 859)
rs3760124(T)/17:73597919 MYO15B (0.31, 0.0074, P = 2.6e-05, N = 7824) (0.11, -0.2, P = 0.0085, N = 859)
rs2678795(T)/18:28290604* RP11-675P14.1 (0.64, -0.0071, P = 4e-05, N = 7824) (0.57, 0.0099, P = 0.84, N = 859)
rs4940346(C)/18:45105566 CTD-2130O13.1 (0.13, 0.19, P = 4.7e-06, N = 1951) (0.31, 0.0093, P = 0.86, N = 859)
rs9947181(C)/18:45580229 ZBTB7C (0.03, -0.028, P = 9.2e-07, N = 7824) (0.22, -0.1, P = 0.07, N = 859)
rs411805(T)/18:55298886* RP11-35G9.3 (0.47, -0.0071, P = 3.1e-05, N = 7824) (0.59, -0.11, P = 0.027, N = 859)
rs9959796(C)/18:64647334* intergenic (0.98, 0.029, P = 2.6e-05, N = 7824) (0.98, -0.025, P = 0.9, N = 859)
rs722419(A)/19:13360233 CACNA1A (0.45, 0.008, P = 4e-06, N = 7824) (0.31, -0.098, P = 0.062, N = 859)
rs7251640(T)/19:18614935 ELL (0.84, -0.012, P = 1.5e-06, N = 7824) (0.54, -0.03, P = 0.53, N = 859)
rs4808136(A)/19:18618867* ELL (0.34, 0.013, P = 5.4e-14, N = 7824) (0.75, -0.089, P = 0.11, N = 859)
rs34143665(G)/19:18766030 KLHL26 (0.21, 0.18, P = 7.1e-06, N = 1951) (0.034, 0.039, P = 0.77, N = 859)
rs2160717(T)/19:29822729 CTC-525D6.1 (0.4, -0.0087, P = 4.6e-07, N = 7824) (0.38, 0.028, P = 0.58, N = 859)
rs8113823(A)/19:46959053 intergenic (0.15, -0.028, P = 2.5e-05, N = 7824) (0.042, 0.035, P = 0.76, N = 859)
rs1844852(T)/2:117262186 intergenic (0.88, -0.17, P = 3.8e-06, N = 1951) (0.45, -0.07, P = 0.15, N = 859)
rs1492394(A)/2:141032676 LRP1B (0.037, 0.04, P = 2.6e-05, N = 7824) (0.18, 0.023, P = 0.71, N = 859)
rs1965407(A)/2:1429277 TPO (0.23, -0.017, P = 2.7e-05, N = 7824) (0.28, 0.11, P = 0.031, N = 859)
rs4664918(C)/2:158874088 UPP2 (0.59, 0.0071, P = 4.7e-05, N = 7824) (0.27, -0.05, P = 0.36, N = 859)
rs2060198(A)/2:166245230 SCN2A (0.26, -0.017, P = 2.2e-05, N = 7824) (0.16, 0.095, P = 0.14, N = 859)
rs62188095(A)/2:184130538 LIN28AP1 (0.098, -0.24, P = 4.5e-06, N = 1951) (0.015, -0.16, P = 0.44, N = 859)
rs4399682(A)/2:184891621* intergenic (0.72, 0.018, P = 2.1e-06, N = 7824) (0.87, -0.017, P = 0.81, N = 859)
rs4665191(A)/2:23249712* AC016768.1 (0.3, -0.0076, P = 1.7e-05, N = 7824) (0.75, -0.00067, P = 0.99, N = 859)
rs4811076(A)/20:49109845* intergenic (0.49, -0.0074, P = 1.8e-05, N = 7824) (0.39, -0.0048, P = 0.92, N = 859)
rs16996393(A)/20:9753835 PAK7 (0.69, -0.0083, P = 3.2e-06, N = 7824) (0.48, 0.055, P = 0.27, N = 859)
rs2223728(A)/21:22233992 intergenic (0.34, 0.0073, P = 2.5e-05, N = 7824) (0.26, 0.033, P = 0.54, N = 859)
rs2832576(T)/21:31431705* intergenic (0.86, 0.011, P = 1.5e-05, N = 7824) (0.68, -0.036, P = 0.48, N = 859)
rs2834059(A)/21:34375461 AP000282.2 (0.48, -0.0091, P = 1e-06, N = 7824) (0.25, 0.084, P = 0.13, N = 859)
rs5994710(A)/22:33682273 LARGE (0.077, -0.017, P = 1.2e-06, N = 7824) (0.58, -0.0095, P = 0.85, N = 859)
rs4431081(T)/3:111482048 PLCXD2 (0.45, 0.016, P = 2.2e-06, N = 7824) (0.83, -0.023, P = 0.73, N = 859)
rs12491897(A)/3:116356191 LSAMP (0.18, -0.01, P = 2.8e-05, N = 7824) (0.26, 0.00051, P = 0.99, N = 859)
rs10636873(GGA)/3:158701141 IQCJ (0.64, 0.18, P = 8.3e-06, N = 1951) (0.48, 0.017, P = 0.73, N = 859)
rs6786880(T)/3:165855100 intergenic (0.59, 0.0074, P = 1.9e-05, N = 7824) (0.39, 0.013, P = 0.79, N = 859)
rs13092031(A)/3:1719076 intergenic (0.64, -0.0073, P = 3e-05, N = 7824) (0.33, -0.032, P = 0.53, N = 859)
rs572746052(TAAA)/3:172786606 SPATA16 (0.021, -0.12, P = 4.3e-06, N = 1951) (0.43, -0.019, P = 0.69, N = 859)
rs12635393(T)/3:187091583* RTP4 (0.35, 0.015, P = 3.7e-05, N = 7824) (0.19, 0.087, P = 0.15, N = 859)
rs4687367(T)/3:192631798* MB21D2 (0.46, 0.0073, P = 3.5e-05, N = 7824) (0.62, -0.016, P = 0.75, N = 859)
rs937107(T)/3:22331495* ZNF385D (0.019, 0.051, P = 4e-05, N = 7824) (0.13, 0.12, P = 0.094, N = 859)
rs3872668(C)/3:314429* CHL1 (0.37, -0.018, P = 7.3e-07, N = 7824) (0.4, -0.0091, P = 0.85, N = 859)
rs2887159(A)/3:64128189 PRICKLE2 (0.085, 0.24, P = 8.7e-06, N = 1951) (0.15, 0.15, P = 0.026, N = 859)
rs1899372(A)/3:77385745 ROBO2 (0.083, -0.26, P = 7.3e-06, N = 1951) (0.14, -0.055, P = 0.41, N = 859)
rs11934095(A)/4:11884262 intergenic (0.72, -0.0082, P = 3.1e-06, N = 7824) (0.49, 0.011, P = 0.83, N = 859)
rs7678369(A)/4:124525133 intergenic (0.74, 0.18, P = 2.7e-06, N = 1951) (0.41, -0.00038, P = 0.99, N = 859)
rs200970756(T)/4:19170429 RP11-3J1.1 (0.16, 0.23, P = 2.1e-06, N = 1951) (0.091, 0.082, P = 0.32, N = 859)
rs11942812(A)/4:26273531 RBPJ (0.58, 0.0073, P = 2.9e-05, N = 7824) (0.46, -0.017, P = 0.72, N = 859)
rs16879155(T)/4:27304493* intergenic (0.017, 0.056, P = 1.9e-05, N = 7824) (0.15, -0.11, P = 0.1, N = 859)
rs62294538(T)/4:38989940* TMEM156 (0.59, -0.13, P = 8.3e-06, N = 1951) (0.41, -0.0091, P = 0.86, N = 859)
rs77437403(A)/4:57725538 intergenic (0.035, -0.55, P = 1.2e-06, N = 1951) (0.019, 0.42, P = 0.014, N = 859)
rs4690290(C)/4:689502 intergenic (0.46, 0.034, P = 2.1e-05, N = 7824) (0.59, -0.029, P = 0.55, N = 859)
rs4541491(A)/4:82604912* RP11-689K5.3 (0.62, -0.0078, P = 6.6e-06, N = 7824) (0.63, -0.032, P = 0.53, N = 859)
rs6893586(T)/5:163508338* intergenic (0.43, 0.0072, P = 4e-05, N = 7824) (0.7, 0.023, P = 0.65, N = 859)
rs17063000(T)/5:163645278 CTC-207P7.1 (0.24, -0.01, P = 1.5e-05, N = 7824) (0.081, -0.035, P = 0.68, N = 859)
rs12652381(A)/5:170023542* KCNIP1 (0.61, 0.0091, P = 1.6e-07, N = 7824) (0.91, 0.059, P = 0.47, N = 859)
rs4131290(A)/5:176780682* RGS14 (0.7, -0.013, P = 7.5e-08, N = 7824) (0.91, -0.16, P = 0.055, N = 859)
rs13181802(A)/5:55959493 intergenic (0.68, 0.0077, P = 1.1e-05, N = 7824) (0.61, 0.057, P = 0.28, N = 859)
rs386161(T)/5:57916579* RAB3C (0.58, -0.0075, P = 2.3e-05, N = 7824) (0.82, 0.036, P = 0.56, N = 859)
rs588527(C)/5:9992296 intergenic (0.95, 0.14, P = 7.5e-06, N = 1951) (0.86, -0.14, P = 0.058, N = 859)
rs2400108(T)/6:105810450* PREP (0.85, 0.01, P = 4.6e-05, N = 7824) (0.33, -0.042, P = 0.41, N = 859)
rs12210249(T)/6:110996079 CDK19 (0.032, -0.5, P = 5.9e-06, N = 1951) (0.048, 0.19, P = 0.087, N = 859)
rs17052573(A)/6:125306814* RNF217 (0.63, 0.0072, P = 3.7e-05, N = 7824) (0.93, 0.045, P = 0.64, N = 859)
rs9369768(A)/6:13035947* PHACTR1 (0.55, -0.007, P = 4.9e-05, N = 7824) (0.16, 0.035, P = 0.59, N = 859)
rs2496162(G)/6:13361088 GFOD1 (0.55, 0.14, P = 4.2e-06, N = 1951) (0.62, 0.006, P = 0.91, N = 859)
rs7758383(A)/6:143169723* HIVEP2 (0.51, -0.0074, P = 1.5e-05, N = 7824) (0.69, 0.084, P = 0.11, N = 859)
rs2504067(A)/6:152095987* ESR1 (0.49, 0.0079, P = 8.3e-06, N = 7824) (0.43, -0.11, P = 0.026, N = 859)
rs17083966(T)/6:153698951* intergenic (0.02, 0.056, P = 5e-06, N = 7824) (0.066, 0.12, P = 0.19, N = 859)
rs11751128(T)/6:155561796* TIAM2 (0.29, 0.0072, P = 4e-05, N = 7824) (0.043, -0.027, P = 0.81, N = 859)
rs12191236(C)/6:157304918* ARID1B (0.69, 0.0083, P = 2.3e-06, N = 7824) (0.84, -0.051, P = 0.43, N = 859)
rs7760342(A)/6:45195424 SUPT3H (0.5, 0.016, P = 3.9e-06, N = 7824) (0.22, -0.044, P = 0.45, N = 859)
rs1265213(A)/6:4521298* intergenic (0.8, 0.011, P = 1.1e-05, N = 7824) (0.77, -0.0085, P = 0.88, N = 859)
rs6938321(C)/6:88836054 intergenic (0.11, 0.19, P = 8.3e-06, N = 1951) (0.12, 0.057, P = 0.45, N = 859)
rs57240465(G)/7:125463191 intergenic (0.45, -0.16, P = 9.5e-06, N = 1951) (0.12, 0.03, P = 0.67, N = 859)
rs7805995(A)/7:146516466 CNTNAP2 (0.99, 0.068, P = 2e-05, N = 7824) (0.37, 0.02, P = 0.68, N = 859)
rs10480299(T)/7:151405818* PRKAG2 (0.72, -0.0077, P = 1.3e-05, N = 7824) (0.71, -0.024, P = 0.65, N = 859)
rs12718636(A)/7:52500628* intergenic (0.7, -0.0073, P = 2.8e-05, N = 7824) (0.91, 0.046, P = 0.58, N = 859)
rs41608(T)/7:82651558 PCLO (0.69, 0.0073, P = 2.5e-05, N = 7824) (0.9, -0.014, P = 0.86, N = 859)
rs10086673(T)/8:10305317* intergenic (0.29, 0.0089, P = 5.3e-07, N = 7824) (0.32, -0.025, P = 0.63, N = 859)
rs7837995(T)/8:11485820 intergenic (0.45, 0.0089, P = 4.3e-07, N = 7824) (0.76, 0.0034, P = 0.95, N = 859)
rs10112981(A)/8:114965243* Y_RNA (0.29, -0.008, P = 6.1e-06, N = 7824) (0.48, 0.011, P = 0.82, N = 859)
rs2466216(G)/8:22775716* PEBP4 (0.22, 0.21, P = 2.4e-06, N = 1951) (0.034, -0.094, P = 0.48, N = 859)
rs2726955(T)/8:27797374* SCARA5 (0.65, 0.0071, P = 4.9e-05, N = 7824) (0.59, -0.089, P = 0.071, N = 859)
rs6997739(C)/8:51365291 SNTG1 (0.2, -0.01, P = 1.9e-05, N = 7824) (0.78, 0.052, P = 0.36, N = 859)
rs1483643(A)/8:51459757* SNTG1 (0.13, -0.011, P = 3.6e-05, N = 7824) (0.42, -0.028, P = 0.56, N = 859)
rs6995644(A)/8:63635874 NKAIN3 (0.87, -0.011, P = 4e-05, N = 7824) (0.36, 0.14, P = 0.0071, N = 859)
rs3885979(T)/8:70767051* RP11-159H10.1 (0.093, -0.013, P = 4.9e-05, N = 7824) (0.26, -0.046, P = 0.4, N = 859)
rs3104992(A)/8:96572791 KB-1047C11.2 (0.34, 0.0074, P = 2.2e-05, N = 7824) (0.49, 0.073, P = 0.12, N = 859)
rs2807592(T)/9:126893436 intergenic (0.7, -0.0081, P = 4.5e-06, N = 7824) (0.94, -0.11, P = 0.29, N = 859)
rs16936951(A)/9:18657061 ADAMTSL1 (0.94, -0.015, P = 4.4e-05, N = 7824) (0.95, 0.035, P = 0.76, N = 859)
rs10491883(C)/9:28562256 LINGO2 (0.16, -0.21, P = 8.8e-06, N = 1951) (0.27, -0.0081, P = 0.88, N = 859)
rs744093(A)/9:32700942 intergenic (0.89, -0.024, P = 8.5e-06, N = 7824) (0.99, -0.25, P = 0.21, N = 859)
rs11144033(A)/9:77258265 RORB (0.57, 0.0072, P = 2.8e-05, N = 7824) (0.74, -0.055, P = 0.32, N = 859)
rs10867301(A)/9:81528270 intergenic (0.34, -0.0077, P = 1.2e-05, N = 7824) (0.35, 0.036, P = 0.47, N = 859)
Results from Univariable Mendelian Randomization of myo-Inositol & eGFR - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 139 -0.041 (-0.16- 0.079) P=0.51 4.4 29 0.000591 (0- 92.3) NA NA -0.0032 P=0.62
MR-Egger 139 -0.024 (-0.16- 0.11) P=0.74 4.4 29 0.000591 (0- 92.3) 164 0.06 -0.0032 P=0.62
Weighted median 139 -0.081 (-0.25- 0.09) P=0.35 4.4 29 0.000591 (0- 92.3) NA NA -0.0032 P=0.62
Results from Univariable MRPRESSO of myo-Inositol & eGFR - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.04 0.06 -0.67 0.51
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of myo-Inositol & eGFR - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 76 -0.029 (-0.15- 0.095) P=0.65 6.8 25 2.05 (0- 94.8) NA NA -0.0081 P=0.37
MR-Egger 76 0.0087 (-0.14- 0.16) P=0.91 6.8 25 2.05 (0- 94.8) 88 0.13 -0.0081 P=0.37
Weighted median 76 -0.076 (-0.25- 0.096) P=0.39 6.8 25 2.05 (0- 94.8) NA NA -0.0081 P=0.37
Results from Univariable MRPRESSO of myo-Inositol & eGFR - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.03 0.06 -0.46 0.65
beta.exposure Outlier-corrected NA NA NA NA

Kynurenic acid

Instruments Associations with Kynurenic acid & eGFR
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region Kynurenic acid (Shin et al/Long et al) eGFR (CSSCD)
rs61825638(T)/1:241713402 KMO (0.24, 0.31, P = 2.3e-16, N = 1958) (0.055, 0.021, P = 0.83, N = 859)
rs1499662(C)/1:56057849* RP11-466L17.1 (0.86, -0.22, P = 9e-06, N = 1958) (0.62, 0.017, P = 0.73, N = 859)
rs2114406(G)/10:90033593* RNLS (0.34, -0.19, P = 3.8e-08, N = 1958) (0.17, 0.037, P = 0.56, N = 859)
rs112927155(TAATGGATGTC)/11:58668376 AP001652.1 (0.77, 0.1, P = 9.5e-06, N = 1958) (0.6, -0.046, P = 0.35, N = 859)
rs11531036(A)/12:21241016 SLCO1B7 (0.017, 0.6, P = 5.1e-06, N = 1958) (0.058, -0.21, P = 0.039, N = 859)
rs10784757(A)/12:69508022* AC139931.1 (0.74, 0.19, P = 6.4e-06, N = 1958) (0.6, 0.029, P = 0.55, N = 859)
rs2391396(T)/13:107626059 AL354741.1 (0.51, -0.16, P = 5.9e-07, N = 1958) (0.33, 0.013, P = 0.81, N = 859)
rs1333184(T)/13:107643612 intergenic (0.5, -0.15, P = 7.7e-06, N = 1958) (0.3, 0.057, P = 0.28, N = 859)
rs9597397(C)/13:56963440* intergenic (0.19, 0.19, P = 6.7e-06, N = 1958) (0.068, 0.14, P = 0.16, N = 859)
rs9517419(C)/13:99373101 SLC15A1 (0.11, -0.28, P = 5.5e-06, N = 1958) (0.21, 0.039, P = 0.51, N = 859)
rs8054775(T)/16:58793570* RP11-410D17.2 (0.11, 0.22, P = 4.1e-21, N = 1958) (0.4, -0.11, P = 0.024, N = 859)
rs11864685(T)/16:58805130* RP11-410D17.2 (0.12, 0.42, P = 5.1e-22, N = 1958) (0.39, -0.092, P = 0.055, N = 859)
rs200341493(AT)/17:2808176 RAP1GAP2 (0.071, 0.25, P = 6.2e-06, N = 1958) (0.056, -0.057, P = 0.58, N = 859)
rs57861026(G)/3:76996620 ROBO2 (0.059, 0.41, P = 2e-06, N = 1958) (0.04, 0.081, P = 0.51, N = 859)
rs113677552(G)/4:56843171* CEP135 (0.011, 0.85, P = 6.1e-06, N = 1958) (0.014, 0.12, P = 0.55, N = 859)
rs17208191(G)/5:13846802* DNAH5 (0.15, 0.18, P = 9.7e-06, N = 1958) (0.14, 0.032, P = 0.63, N = 859)
rs546403634(CCCG)/6:151186857 MTHFD1L (0.082, 0.25, P = 2.5e-06, N = 1958) (0.98, 0.31, P = 0.076, N = 859)
rs2342637(T)/6:169020665* SMOC2 (0.69, -0.2, P = 6e-06, N = 1958) (0.54, -0.011, P = 0.81, N = 859)
rs862427(C)/6:38843970 DNAH8 (0.88, 0.22, P = 4e-06, N = 1958) (0.88, -0.071, P = 0.33, N = 859)
rs12533147(G)/7:4200552 SDK1 (0.51, -0.13, P = 4.3e-06, N = 1958) (0.21, 0.075, P = 0.21, N = 859)
rs112860567(C)/8:11273641 C8orf12 (0.13, 0.25, P = 5.8e-06, N = 1958) (0.19, 0.005, P = 0.94, N = 859)
rs7014584(A)/8:59886072 TOX (0.92, -0.3, P = 5.3e-07, N = 1958) (0.98, 0.041, P = 0.83, N = 859)
rs140664372(T)/8:99851438 STK3 (0.016, 0.83, P = 8.6e-07, N = 1958) (0.037, -0.058, P = 0.65, N = 859)
rs12350923(T)/9:8189408 intergenic (0.093, 0.27, P = 7.3e-06, N = 1958) (0.11, 0.15, P = 0.052, N = 859)
Results from Univariable Mendelian Randomization of Kynurenic acid & eGFR - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 24 -0.1 (-0.21- 0.0038) P=0.059 29 35 6.51 (0- 63.7) NA NA -0.0028 P=0.93
MR-Egger 24 -0.093 (-0.33- 0.14) P=0.45 29 35 6.51 (0- 63.7) 25 0.27 -0.0028 P=0.93
Weighted median 24 -0.079 (-0.23- 0.071) P=0.3 29 35 6.51 (0- 63.7) NA NA -0.0028 P=0.93
Results from Univariable MRPRESSO of Kynurenic acid & eGFR - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.1 0.05 -1.89 0.07
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of Kynurenic acid & eGFR - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 15 -0.095 (-0.24- 0.053) P=0.21 28 21 5.73 (0- 74) NA NA -0.02 P=0.63
MR-Egger 15 -0.032 (-0.33- 0.26) P=0.83 28 21 5.73 (0- 74) 15 0.3 -0.02 P=0.63
Weighted median 15 -0.078 (-0.29- 0.13) P=0.47 28 21 5.73 (0- 74) NA NA -0.02 P=0.63
Results from Univariable MRPRESSO of Kynurenic acid & eGFR - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.1 0.08 -1.26 0.23
beta.exposure Outlier-corrected NA NA NA NA

L-Kynurenine

Instruments Associations with L-Kynurenine & eGFR
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region L-Kynurenine (Shin et al/Long et al) eGFR (CSSCD)
rs1530683(G)/1:104990673* intergenic (0.87, -0.2, P = 7.5e-06, N = 1955) (0.78, -0.059, P = 0.32, N = 859)
rs6702848(T)/1:11453577* intergenic (0.6, 0.0077, P = 1.1e-05, N = 7824) (0.5, 0.013, P = 0.79, N = 859)
rs21327(A)/1:146528521* NBPF13P (0.29, 0.0095, P = 1.2e-07, N = 7824) (0.15, -0.0038, P = 0.95, N = 859)
rs7549498(A)/1:182363623* GLUL (0.44, 0.16, P = 3.8e-06, N = 1955) (0.75, 0.022, P = 0.68, N = 859)
rs1687113(T)/1:238082623* RP11-193H5.1 (0.23, 0.19, P = 5.9e-06, N = 1955) (0.66, 0.11, P = 0.037, N = 859)
rs12082398(T)/1:25234781 RUNX3 (0.59, 0.012, P = 9.3e-07, N = 7824) (0.11, 0.058, P = 0.44, N = 859)
rs7548008(A)/1:43202095* CLDN19 (0.5, 0.016, P = 3.6e-06, N = 7824) (0.59, 0.12, P = 0.016, N = 859)
rs9436977(G)/1:56122967 RP11-466L17.1 (0.035, -0.39, P = 6.4e-06, N = 1955) (0.4, -0.03, P = 0.53, N = 859)
rs2375475(T)/1:65211843 RAVER2 (0.32, -0.0084, P = 1.4e-06, N = 7824) (0.78, -0.022, P = 0.71, N = 859)
rs274588(G)/1:74942672 FPGT-TNNI3K (0.58, 0.14, P = 4.5e-06, N = 1955) (0.46, 0.0035, P = 0.94, N = 859)
rs669764(T)/1:78691660* RP11-183M13.1 (0.32, -0.0078, P = 7.7e-06, N = 7824) (0.63, -0.018, P = 0.71, N = 859)
rs11162752(A)/1:80060337* intergenic (0.6, -0.0077, P = 8.1e-06, N = 7824) (0.37, -0.033, P = 0.51, N = 859)
rs2491294(A)/1:88302604* intergenic (0.31, -0.01, P = 5.7e-07, N = 7824) (0.26, 0.02, P = 0.71, N = 859)
rs7906282(T)/10:19083596* intergenic (0.31, 0.0094, P = 8.1e-08, N = 7824) (0.25, 0.00041, P = 0.99, N = 859)
rs16924894(A)/10:24845525* intergenic (0.024, 0.081, P = 2.3e-08, N = 7824) (0.083, -0.14, P = 0.12, N = 859)
rs11593042(A)/10:6933467* RP11-799O21.2 (0.092, 0.015, P = 4.5e-06, N = 7824) (0.016, -0.28, P = 0.16, N = 859)
rs12802337(A)/11:55531892* intergenic (0.078, -0.016, P = 6e-06, N = 7824) (0.16, -0.086, P = 0.17, N = 859)
rs511797(A)/11:95895139 MAML2 (0.13, 0.012, P = 3.8e-06, N = 7824) (0.024, -0.073, P = 0.64, N = 859)
rs3184504(T)/12:111884608* SH2B3 (0.49, 0.015, P = 6e-18, N = 7824) (0.073, -0.03, P = 0.74, N = 859)
rs10744774(A)/12:112090022* BRAP (0.83, 0.012, P = 2.4e-06, N = 7824) (0.98, -0.14, P = 0.37, N = 859)
rs739744(T)/12:113185462 RPH3A (0.55, -0.0082, P = 1.9e-06, N = 7824) (0.46, -0.052, P = 0.3, N = 859)
rs11057695(T)/12:125083336* intergenic (0.057, 0.021, P = 8e-06, N = 7824) (0.016, -0.25, P = 0.19, N = 859)
rs3789978(A)/12:32947193* PKP2 (0.85, 0.012, P = 1.3e-06, N = 7824) (0.67, 0.088, P = 0.083, N = 859)
rs28815546(T)/12:622231 B4GALNT3 (0.026, 0.48, P = 1.2e-06, N = 1955) (0.3, 0.12, P = 0.022, N = 859)
rs3809198(A)/12:96883306* C12orf55 (0.02, 0.055, P = 4.3e-06, N = 7824) (0.078, -0.15, P = 0.082, N = 859)
rs9533582(A)/13:44250866* ENOX1 (0.035, -0.022, P = 1e-05, N = 7824) (0.13, 0.0072, P = 0.92, N = 859)
rs2324935(A)/13:66985241 PCDH9 (0.53, 0.0075, P = 1.5e-05, N = 7824) (0.73, -0.02, P = 0.71, N = 859)
rs1952337(A)/14:67608948 GPHN (0.64, -0.0076, P = 1.2e-05, N = 7824) (0.15, 0.025, P = 0.71, N = 859)
rs434943(A)/14:69314059* RN7SL224P (0.32, -0.0077, P = 1.5e-05, N = 7824) (0.14, -0.086, P = 0.23, N = 859)
rs6575634(T)/14:98248954* RP11-204N11.2 (0.62, -0.016, P = 4.8e-06, N = 7824) (0.38, -0.039, P = 0.42, N = 859)
rs2651516(T)/15:53302309* intergenic (0.66, 0.008, P = 4.3e-06, N = 7824) (0.19, -0.063, P = 0.29, N = 859)
rs11646849(A)/16:82817251* CDH13 (0.5, -0.0086, P = 6.4e-07, N = 7824) (0.29, -0.073, P = 0.16, N = 859)
rs8063871(A)/16:87863500* SLC7A5 (0.71, 0.017, P = 4.7e-12, N = 7824) (0.69, -0.065, P = 0.21, N = 859)
rs8051149(A)/16:87878822* SLC7A5 (0.21, 0.026, P = 9.1e-26, N = 7824) (0.6, 0.045, P = 0.36, N = 859)
rs2434860(T)/16:89696217 DPEP1 (0.41, 0.26, P = 1.1e-07, N = 1955) (0.16, 0.058, P = 0.39, N = 859)
rs164746(A)/16:89709019* DPEP1 (0.41, 0.19, P = 7.8e-08, N = 1955) (0.19, 0.022, P = 0.73, N = 859)
rs12937634(T)/17:47444442* ZNF652 (0.54, -0.0082, P = 2.3e-06, N = 7824) (0.58, -0.0042, P = 0.93, N = 859)
rs180050(T)/17:67977529 AC004562.1 (0.58, 0.008, P = 7.6e-06, N = 7824) (0.097, -0.028, P = 0.74, N = 859)
rs16974854(T)/17:68029032* AC002539.1 (0.038, -0.023, P = 1.2e-06, N = 7824) (0.019, 0.019, P = 0.92, N = 859)
rs7240271(A)/18:56909115* intergenic (0.51, 0.0074, P = 1.4e-05, N = 7824) (0.24, -0.076, P = 0.18, N = 859)
rs4891267(A)/18:73076464* intergenic (0.78, -0.18, P = 2e-06, N = 1955) (0.59, -0.0073, P = 0.88, N = 859)
rs8090890(C)/18:75305345 intergenic (0.64, -0.0075, P = 1.5e-05, N = 7824) (0.57, 0.052, P = 0.3, N = 859)
rs2270623(T)/19:18245512* MAST3 (0.54, -0.0076, P = 1.2e-05, N = 7824) (0.33, 0.012, P = 0.81, N = 859)
rs1496635(A)/19:31692461* CTC-439O9.3 (0.34, -0.0091, P = 2.1e-07, N = 7824) (0.24, 0.014, P = 0.81, N = 859)
rs113916293(GGT)/19:45966650 FOSB (0.28, -0.22, P = 9.4e-06, N = 1955) (0.68, -0.11, P = 0.042, N = 859)
rs260621(T)/2:109628974* intergenic (0.53, 0.026, P = 1.5e-05, N = 7824) (0.91, 0.13, P = 0.11, N = 859)
rs13415349(C)/2:223924792 KCNE4 (0.088, 0.22, P = 4e-06, N = 1955) (0.25, -0.12, P = 0.028, N = 859)
rs2161901(A)/2:36465942 intergenic (0.45, 0.16, P = 8.6e-06, N = 1955) (0.81, 0.027, P = 0.66, N = 859)
rs759507(T)/2:50754813* NRXN1 (0.37, 0.008, P = 5.2e-06, N = 7824) (0.088, -0.055, P = 0.53, N = 859)
rs1239074(T)/2:78842192* intergenic (0.74, 0.011, P = 1.2e-05, N = 7824) (0.58, -0.0094, P = 0.85, N = 859)
rs145129891(A)/20:4798828 RASSF2 (0.058, 0.34, P = 1.8e-06, N = 1955) (0.011, -0.14, P = 0.54, N = 859)
rs756577(T)/21:44118323* PDE9A (0.38, 0.0078, P = 1e-05, N = 7824) (0.06, -0.07, P = 0.48, N = 859)
rs6518219(T)/21:46654717* LINC00334 (0.051, 0.32, P = 1.5e-06, N = 1955) (0.32, 0.091, P = 0.072, N = 859)
rs5756751(C)/22:22423139 IGLVIV-65 (0.36, -0.18, P = 7.9e-06, N = 1955) (0.71, 0.084, P = 0.11, N = 859)
rs3859880(C)/22:26232110* MYO18B (0.34, -0.17, P = 3.5e-06, N = 1955) (0.51, 0.024, P = 0.63, N = 859)
rs4820242(A)/22:36982675* CACNG2 (0.62, -0.0085, P = 9e-07, N = 7824) (0.76, -0.041, P = 0.47, N = 859)
rs3788706(A)/22:46869170* CELSR1 (0.13, -0.012, P = 6.1e-06, N = 7824) (0.16, 0.081, P = 0.21, N = 859)
rs6770323(T)/3:161850410* intergenic (0.43, -0.008, P = 3.3e-06, N = 7824) (0.14, 0.13, P = 0.069, N = 859)
rs7619568(A)/3:191433799* intergenic (0.94, 0.018, P = 9.5e-06, N = 7824) (0.79, 0.021, P = 0.71, N = 859)
rs12490394(T)/3:5496096* intergenic (0.5, 0.0084, P = 8e-06, N = 7824) (0.42, 0.031, P = 0.53, N = 859)
rs9857268(A)/3:83398721* intergenic (0.41, 0.008, P = 3.1e-06, N = 7824) (0.18, -0.045, P = 0.47, N = 859)
rs7619096(A)/3:84199075* intergenic (0.69, 0.008, P = 4.9e-06, N = 7824) (0.59, 0.051, P = 0.29, N = 859)
rs2320536(T)/4:140801676* MAML3 (0.41, 0.0081, P = 3.3e-06, N = 7824) (0.31, 0.024, P = 0.63, N = 859)
rs1426134(C)/4:14179729 RP11-669M16.1 (0.37, -0.0081, P = 3.8e-06, N = 7824) (0.18, -0.058, P = 0.35, N = 859)
rs10857319(T)/4:159729794* FNIP2 (0.35, -0.0086, P = 9.5e-07, N = 7824) (0.061, -0.071, P = 0.49, N = 859)
rs10937762(A)/4:6918679* TBC1D14 (0.57, 0.0078, P = 8.2e-06, N = 7824) (0.68, 0.072, P = 0.16, N = 859)
rs13110221(T)/4:9517737 OR7E83P (0.82, 0.18, P = 8.1e-06, N = 1955) (0.48, -0.0038, P = 0.94, N = 859)
rs6815057(A)/4:97782257 intergenic (0.58, 0.0085, P = 1.1e-06, N = 7824) (0.88, 0.015, P = 0.84, N = 859)
rs10072101(A)/5:105182600 intergenic (0.38, -0.0077, P = 1.4e-05, N = 7824) (0.49, 0.045, P = 0.35, N = 859)
rs3131010(T)/6:31105147 PSORS1C1 (0.15, 0.24, P = 1.5e-06, N = 1955) (0.056, -0.11, P = 0.31, N = 859)
rs112790520(C)/6:33024031 intergenic (0.049, 0.43, P = 3.2e-06, N = 1955) (0.17, 0.093, P = 0.15, N = 859)
rs75219340(C)/7:113576177 PPP1R3A (0.015, -0.74, P = 2.3e-06, N = 1955) (0.16, -0.0023, P = 0.97, N = 859)
rs13224451(T)/7:128155486* intergenic (0.16, -0.18, P = 9.7e-06, N = 1955) (0.22, 0.086, P = 0.14, N = 859)
rs6946693(T)/7:70153068* AUTS2 (0.71, 0.01, P = 9.2e-06, N = 7824) (0.91, -0.14, P = 0.087, N = 859)
rs6978674(T)/7:77859611* MAGI2 (0.59, 0.0076, P = 1.3e-05, N = 7824) (0.88, 0.05, P = 0.49, N = 859)
rs11563854(C)/7:90142005* CTB-13L3.1 (0.067, 0.28, P = 5.1e-06, N = 1955) (0.15, -0.076, P = 0.26, N = 859)
rs10263361(G)/7:93678234 AC003092.1 (0.59, -0.12, P = 9.2e-06, N = 1955) (0.93, -0.17, P = 0.074, N = 859)
rs35534138(A)/8:38894334 ADAM9 (0.29, -0.16, P = 9.3e-07, N = 1955) (0.13, 0.12, P = 0.096, N = 859)
rs10085935(T)/8:39806267* IDO2 (0.38, -0.01, P = 3.3e-09, N = 7824) (0.35, -0.0088, P = 0.86, N = 859)
rs7843776(T)/8:75008787* RP11-6I2.3 (0.4, -0.0084, P = 7.4e-06, N = 7824) (0.31, -0.09, P = 0.084, N = 859)
rs542062(G)/9:134191501 intergenic (0.83, 0.18, P = 5.2e-06, N = 1955) (0.53, 0.016, P = 0.75, N = 859)
rs7851112(T)/9:7029050 KDM4C (0.62, -0.0077, P = 1.2e-05, N = 7824) (0.8, -0.028, P = 0.65, N = 859)
Results from Univariable Mendelian Randomization of L-Kynurenine & eGFR - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 82 0.079 (-0.0076- 0.17) P=0.074 8.1 32 11.1 (0- 82.9) NA NA 0.006 P=0.48
MR-Egger 82 0.059 (-0.046- 0.16) P=0.28 8.1 32 11.1 (0- 82.9) 93 0.16 0.006 P=0.48
Weighted median 82 0.072 (-0.053- 0.2) P=0.26 8.1 32 11.1 (0- 82.9) NA NA 0.006 P=0.48
Results from Univariable MRPRESSO of L-Kynurenine & eGFR - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0.08 0.04 1.79 0.08
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of L-Kynurenine & eGFR - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 28 0.072 (-0.027- 0.17) P=0.16 15 22 21.9 (0- 69.7) NA NA -0.0066 P=0.7
MR-Egger 28 0.091 (-0.047- 0.23) P=0.21 15 22 21.9 (0- 69.7) 31 0.24 -0.0066 P=0.7
Weighted median 28 0.054 (-0.09- 0.2) P=0.46 15 22 21.9 (0- 69.7) NA NA -0.0066 P=0.7
Results from Univariable MRPRESSO of L-Kynurenine & eGFR - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0.07 0.05 1.42 0.17
beta.exposure Outlier-corrected NA NA NA NA

L-Lactic acid

Instruments Associations with L-Lactic acid & eGFR
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region L-Lactic acid (Shin et al/Long et al) eGFR (CSSCD)
rs4631734(T)/1:171220236* RP1-45C12.1 (0.069, 0.017, P = 2.1e-05, N = 7365) (0.12, -0.052, P = 0.47, N = 859)
rs1193345(A)/1:17913714* ARHGEF10L (0.94, -0.022, P = 1.4e-06, N = 7365) (0.79, 0.029, P = 0.62, N = 859)
rs1775466(A)/1:197754967* intergenic (0.2, -0.011, P = 1.8e-05, N = 7365) (0.083, -0.082, P = 0.35, N = 859)
rs2906458(A)/1:44336389* ST3GAL3 (0.75, 0.0096, P = 4.5e-05, N = 7365) (0.2, 0.035, P = 0.56, N = 859)
rs10788232(T)/10:123803584* TACC2 (0.68, -0.011, P = 2.5e-06, N = 7365) (0.31, -0.076, P = 0.15, N = 859)
rs11253881(A)/10:16321532* RP11-461K13.1 (0.067, -0.018, P = 2.1e-05, N = 7365) (0.064, 0.095, P = 0.34, N = 859)
rs16937124(A)/10:36885746* intergenic (0.95, -0.021, P = 5.6e-06, N = 7365) (0.94, -0.014, P = 0.89, N = 859)
rs1930151(A)/10:56331387* PCDH15 (0.025, -0.029, P = 3.3e-05, N = 7365) (0.15, 0.012, P = 0.86, N = 859)
rs5785130(AT)/10:57194371 RP11-168O22.1 (0.4, 0.08, P = 6.9e-06, N = 1957) (0.91, 0.12, P = 0.14, N = 859)
rs7090753(A)/10:67201788* intergenic (0.99, 0.068, P = 3.3e-05, N = 1761) (0.79, -0.2, P = 0.00074, N = 859)
rs10887850(C)/10:90490627* LIPK (0.33, 0.19, P = 3e-06, N = 1957) (0.44, 0.00078, P = 0.99, N = 859)
rs10734178(A)/11:11244511 intergenic (0.82, 0.17, P = 2.9e-06, N = 1957) (0.74, -0.00071, P = 0.99, N = 859)
rs948094(C)/11:121092679 intergenic (0.51, -0.19, P = 8.6e-06, N = 1957) (0.25, -0.17, P = 0.0026, N = 859)
rs939522(C)/11:126691069 KIRREL3 (0.78, 0.21, P = 6.5e-07, N = 1957) (0.95, -0.064, P = 0.57, N = 859)
rs1499511(C)/11:36087853 LDLRAD3 (0.58, 0.18, P = 9.8e-06, N = 1957) (0.86, -0.053, P = 0.44, N = 859)
rs79469454(T)/11:4173635 intergenic (0.24, 0.23, P = 8.7e-06, N = 1957) (0.23, -0.06, P = 0.3, N = 859)
rs72931768(C)/11:69829717 RP11-626H12.1 (0.11, -0.24, P = 4.8e-06, N = 1957) (0.037, 0.11, P = 0.39, N = 859)
rs4763349(G)/12:13623999 intergenic (0.91, 0.3, P = 3.9e-06, N = 1957) (0.86, 0.15, P = 0.027, N = 859)
rs2242578(C)/12:57853153* GLI1 (0.67, -0.011, P = 5.1e-06, N = 7365) (0.49, -0.051, P = 0.29, N = 859)
rs6581752(A)/12:67777751 intergenic (0.22, -0.01, P = 1.9e-05, N = 7365) (0.8, 0.0048, P = 0.94, N = 859)
rs1330523(A)/13:104925616* intergenic (0.23, -0.012, P = 1.6e-06, N = 7365) (0.26, -0.014, P = 0.79, N = 859)
rs278050(A)/13:30436968* TIMM8BP1 (0.8, 0.01, P = 4.2e-05, N = 7365) (0.65, 0.064, P = 0.21, N = 859)
rs1751857(T)/13:40969438* intergenic (0.93, 0.016, P = 2.6e-05, N = 7365) (0.87, 0.083, P = 0.25, N = 859)
rs7995949(T)/13:63339902 intergenic (0.98, 0.031, P = 2.8e-05, N = 7365) (0.89, 0.023, P = 0.77, N = 859)
rs6571843(C)/14:21940701* RAB2B (0.063, 0.018, P = 1.4e-05, N = 7365) (0.016, -0.45, P = 0.019, N = 859)
rs12897027(T)/14:73190091 DPF3 (0.33, -0.14, P = 4.6e-06, N = 1957) (0.15, -0.027, P = 0.68, N = 859)
rs7155689(G)/14:98585327 RP11-61O1.1 (0.39, -0.16, P = 1.1e-06, N = 1957) (0.25, 0.015, P = 0.78, N = 859)
rs17392679(T)/15:49310954* SECISBP2L (0.075, 0.016, P = 4.4e-05, N = 7365) (0.014, 0.19, P = 0.35, N = 859)
rs10851537(C)/15:53555661* intergenic (0.97, 0.49, P = 3.2e-06, N = 1957) (0.96, 0.15, P = 0.25, N = 859)
rs7172532(G)/15:54369796 UNC13C (0.57, 0.17, P = 7.7e-06, N = 1957) (0.22, -0.094, P = 0.12, N = 859)
rs10851750(A)/15:66121590* RAB11A (0.13, -0.013, P = 2.9e-05, N = 7365) (0.3, 0.031, P = 0.58, N = 859)
rs2911125(T)/16:65557406 LINC00922 (0.15, 0.013, P = 3.7e-05, N = 7365) (0.047, -0.16, P = 0.18, N = 859)
rs3096276(T)/16:65577365* LINC00922 (0.16, 0.012, P = 4.5e-05, N = 7365) (0.063, -0.093, P = 0.35, N = 859)
rs17687360(C)/16:7708034* RBFOX1 (0.12, -0.28, P = 6.8e-06, N = 1957) (0.022, -0.005, P = 0.98, N = 859)
rs3785024(A)/16:84136233 MBTPS1 (0.95, -0.022, P = 5.6e-06, N = 7365) (0.98, 0.023, P = 0.88, N = 859)
rs234608(T)/17:15583555 TRIM16 (0.15, -0.021, P = 3.2e-05, N = 1761) (0.28, -0.077, P = 0.15, N = 859)
rs112207538(G)/18:18684507 ROCK1 (0.047, -0.39, P = 4.2e-06, N = 1957) (0.12, -0.09, P = 0.21, N = 859)
rs2000812(T)/18:47093790* LIPG (0.82, 0.011, P = 9.7e-06, N = 7365) (0.96, -0.13, P = 0.31, N = 859)
rs2305996(A)/18:693828 ENOSF1 (0.63, 0.015, P = 3.1e-05, N = 1761) (0.7, -0.047, P = 0.36, N = 859)
rs10424746(A)/19:11839659* ZNF823 (0.98, -0.052, P = 1e-05, N = 1761) (0.75, 0.073, P = 0.18, N = 859)
rs35054599(A)/2:123156656 intergenic (0.47, -0.19, P = 6e-06, N = 1957) (0.39, 0.019, P = 0.69, N = 859)
rs4316948(T)/2:162834595* SLC4A10 (0.8, 0.01, P = 4.3e-05, N = 7365) (0.86, 0.053, P = 0.45, N = 859)
rs780093(T)/2:27742603* GCKR (0.4, 0.012, P = 1.9e-07, N = 7365) (0.14, -0.071, P = 0.3, N = 859)
rs4635489(A)/2:30126856 ALK (0.018, 0.036, P = 5.7e-06, N = 7365) (0.14, -0.15, P = 0.036, N = 859)
rs4425121(C)/2:41341481 intergenic (0.47, -0.13, P = 4.5e-06, N = 1957) (0.28, 0.0067, P = 0.9, N = 859)
rs10202912(G)/2:66786405 MEIS1 (0.54, 0.13, P = 9.5e-06, N = 1957) (0.55, 0.061, P = 0.22, N = 859)
rs13403441(A)/2:83225802* intergenic (0.86, -0.024, P = 1e-06, N = 1761) (0.65, -0.039, P = 0.44, N = 859)
rs6736348(A)/2:85506104* TCF7L1 (0.79, 0.0099, P = 4.2e-05, N = 7365) (0.49, -0.024, P = 0.61, N = 859)
rs6105651(A)/20:16740242 OTOR (0.74, 0.0097, P = 4.8e-05, N = 7365) (0.85, -0.037, P = 0.58, N = 859)
rs13038639(A)/20:24893918* intergenic (0.22, 0.01, P = 1.9e-05, N = 7365) (0.04, 0.054, P = 0.66, N = 859)
rs6139395(A)/20:4309611* intergenic (0.2, -0.011, P = 1.7e-05, N = 7365) (0.069, 0.11, P = 0.23, N = 859)
rs2826779(T)/21:22669952* NCAM2 (0.27, 0.016, P = 4.3e-05, N = 1761) (0.46, -0.093, P = 0.048, N = 859)
rs9607371(T)/22:37083494* CACNG2 (0.79, -0.01, P = 3.9e-05, N = 7365) (0.95, -0.0057, P = 0.96, N = 859)
rs4688540(A)/3:61408148* intergenic (0.041, -0.025, P = 3.1e-05, N = 5604) (0.45, -0.053, P = 0.27, N = 859)
rs3112842(C)/4:112386094 intergenic (0.88, -0.3, P = 9.5e-07, N = 1957) (0.94, 0.021, P = 0.83, N = 859)
rs12648879(T)/4:177900078* intergenic (0.7, -0.0098, P = 3.3e-05, N = 7365) (0.95, 0.036, P = 0.74, N = 859)
rs13101859(T)/4:189247182* intergenic (0.22, -0.01, P = 3.6e-05, N = 7365) (0.35, 0.048, P = 0.35, N = 859)
rs61261762(A)/4:23845240* PPARGC1A (0.014, 0.69, P = 5.8e-06, N = 1957) (0.065, -0.18, P = 0.064, N = 859)
rs7682064(T)/4:25087708* intergenic (0.71, 0.01, P = 2.2e-05, N = 7365) (0.65, 0.033, P = 0.5, N = 859)
rs6820352(C)/4:83644113 SCD5 (0.32, -0.16, P = 4.9e-07, N = 1957) (0.68, 0.0028, P = 0.96, N = 859)
rs327838(T)/5:125159259* intergenic (0.53, 0.0096, P = 3.3e-05, N = 7365) (0.48, 0.019, P = 0.69, N = 859)
rs58808503(A)/5:31913006 PDZD2 (0.14, -0.29, P = 8.7e-08, N = 1957) (0.02, 0.024, P = 0.89, N = 859)
rs10941232(A)/5:35054639* PRLR (0.71, -0.14, P = 9.7e-06, N = 1957) (0.57, 0.0024, P = 0.96, N = 859)
rs10051776(T)/5:39207781* FYB (0.046, -0.39, P = 7.5e-06, N = 1957) (0.088, 0.019, P = 0.83, N = 859)
rs2042342(T)/5:55969146 intergenic (0.97, 0.033, P = 2.3e-05, N = 1761) (0.88, -0.069, P = 0.35, N = 859)
rs10475426(T)/5:8362200* RP11-480D4.1 (0.99, -0.078, P = 2.9e-05, N = 1761) (0.82, -0.02, P = 0.75, N = 859)
rs827867(A)/6:158714489* RP11-732M18.3 (0.9, 0.014, P = 2.5e-05, N = 7365) (0.75, 0.016, P = 0.78, N = 859)
rs4706063(G)/6:79449874 intergenic (0.4, -0.16, P = 3.3e-06, N = 1957) (0.25, -0.041, P = 0.44, N = 859)
rs6976221(T)/7:127833995* intergenic (0.76, 0.01, P = 2.5e-05, N = 7365) (0.69, -0.025, P = 0.64, N = 859)
rs759167(T)/7:55127784 EGFR (0.2, -0.011, P = 1.5e-05, N = 7365) (0.27, 0.012, P = 0.83, N = 859)
rs723526(A)/7:55134819* EGFR (0.2, -0.011, P = 6.6e-06, N = 7365) (0.045, 0.029, P = 0.8, N = 859)
rs4718532(T)/7:66805000 RP11-166O4.5 (0.51, -0.016, P = 6.6e-06, N = 1761) (0.33, 0.065, P = 0.2, N = 859)
rs4841405(A)/8:10506235 RP1L1 (0.28, -0.011, P = 1.3e-05, N = 7365) (0.69, 0.0072, P = 0.89, N = 859)
rs13282889(G)/8:105847029* RP11-127H5.1 (0.34, 0.17, P = 8.6e-06, N = 1957) (0.2, -0.029, P = 0.64, N = 859)
rs1385495(T)/8:120077018* COLEC10 (0.81, 0.0099, P = 4.4e-05, N = 7365) (0.78, 0.028, P = 0.62, N = 859)
rs1551903(A)/8:54462119* intergenic (0.74, 0.01, P = 2.8e-05, N = 7365) (0.94, -0.021, P = 0.84, N = 859)
rs10435634(A)/8:54863001* RGS20 (0.56, -0.0095, P = 4.3e-05, N = 7365) (0.61, -0.073, P = 0.14, N = 859)
rs9298249(A)/8:76037728* intergenic (0.014, 0.04, P = 2.2e-05, N = 7365) (0.046, -0.15, P = 0.19, N = 859)
rs146976936(G)/9:77959488 intergenic (0.011, -0.73, P = 3.4e-06, N = 1957) (0.16, -0.13, P = 0.055, N = 859)
rs1876100(A)/9:81189702 intergenic (0.26, -0.011, P = 9.2e-06, N = 7365) (0.077, 0.019, P = 0.83, N = 859)
Results from Univariable Mendelian Randomization of L-Lactic acid & eGFR - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 80 0.05 (-0.052- 0.15) P=0.34 9.1 36 13 (0- 72) NA NA -0.0085 P=0.37
MR-Egger 80 0.083 (-0.042- 0.21) P=0.2 9.1 36 13 (0- 72) 91 0.15 -0.0085 P=0.37
Weighted median 80 0.0072 (-0.15- 0.16) P=0.93 9.1 36 13 (0- 72) NA NA -0.0085 P=0.37
Results from Univariable MRPRESSO of L-Lactic acid & eGFR - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0.05 0.05 0.96 0.34
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of L-Lactic acid & eGFR - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 33 0.12 (0.00058- 0.24) P=0.049 16 27 17.5 (0- 71.2) NA NA -0.027 P=0.11
MR-Egger 33 0.22 (0.053- 0.38) P=0.014 16 27 17.5 (0- 71.2) 34 0.33 -0.027 P=0.11
Weighted median 33 0.13 (-0.057- 0.31) P=0.18 16 27 17.5 (0- 71.2) NA NA -0.027 P=0.11
Results from Univariable MRPRESSO of L-Lactic acid & eGFR - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0.12 0.06 1.97 0.06
beta.exposure Outlier-corrected NA NA NA NA

Oxalic acid

Instruments Associations with Oxalic acid & eGFR
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region Oxalic acid (Shin et al/Long et al) eGFR (CSSCD)
rs1938451(G)/1:68364218* GNG12-AS1 (0.69, -0.19, P = 1e-06, N = 1957) (0.81, -0.052, P = 0.4, N = 859)
rs12279359(A)/11:130730544 RP11-890B15.2 (0.4, -0.16, P = 2.1e-06, N = 1957) (0.35, -0.063, P = 0.22, N = 859)
rs12419619(T)/11:5952146 TRIM5 (0.46, 0.17, P = 1.3e-06, N = 1957) (0.18, 0.065, P = 0.3, N = 859)
rs113046166(T)/11:62222568* AHNAK (0.14, -0.21, P = 7e-06, N = 1957) (0.07, 0.023, P = 0.81, N = 859)
rs7119319(T)/11:90384749* DISC1FP1 (0.18, 0.22, P = 2.2e-06, N = 1957) (0.49, 0.012, P = 0.8, N = 859)
rs527373600(CAAAAA)/13:111174762 RAB20 (0.024, -0.22, P = 8.8e-06, N = 1957) (0.34, -0.0022, P = 0.97, N = 859)
rs796188220(CT)/13:72333063 DACH1 (0.028, -0.37, P = 2.6e-06, N = 1957) (0.84, -0.083, P = 0.21, N = 859)
rs753041(T)/13:99000485* FARP1 (0.33, -0.17, P = 8.1e-06, N = 1957) (0.11, 0.012, P = 0.87, N = 859)
rs35432338(C)/15:60595448 intergenic (0.4, 0.12, P = 8.3e-06, N = 1957) (0.4, -0.015, P = 0.76, N = 859)
rs72803825(T)/16:77506227 intergenic (0.13, -0.28, P = 4.4e-06, N = 1957) (0.026, 0.032, P = 0.83, N = 859)
rs2289470(A)/2:135214259* TMEM163 (0.16, -0.18, P = 5.8e-06, N = 1957) (0.28, 0.032, P = 0.56, N = 859)
rs4814550(T)/20:16733848 OTOR (0.17, -0.16, P = 3.5e-06, N = 1957) (0.039, 0.026, P = 0.84, N = 859)
rs34230332(G)/3:14725878 C3orf20 (0.076, 0.24, P = 3.7e-06, N = 1957) (0.02, -0.44, P = 0.011, N = 859)
rs6444594(T)/3:191661608 intergenic (0.43, -0.18, P = 4.1e-07, N = 1957) (0.51, -0.016, P = 0.73, N = 859)
rs11132006(C)/4:181512510 intergenic (0.31, -0.18, P = 1.7e-06, N = 1957) (0.28, 0.026, P = 0.64, N = 859)
rs73793418(C)/6:169685826 XXyac-YX65C7_A.3 (0.06, -0.29, P = 1.9e-06, N = 1957) (0.14, 0.052, P = 0.44, N = 859)
rs9477739(T)/6:18422473* RNF144B (0.044, 0.36, P = 7.6e-07, N = 1957) (0.14, 0.082, P = 0.24, N = 859)
rs199549415(A)/6:24291915 DCDC2 (0.1, -0.29, P = 5.2e-06, N = 1957) (0.02, -0.15, P = 0.39, N = 859)
rs116315297(A)/6:24414380 MRS2 (0.011, 0.97, P = 5.4e-07, N = 1957) (0.031, -0.053, P = 0.71, N = 859)
rs77760991(G)/6:72039148 RP3-331H24.5 (0.075, -0.26, P = 1.2e-06, N = 1957) (0.056, 0.0069, P = 0.95, N = 859)
rs58349860(A)/7:143024197* CLCN1 (0.34, -0.18, P = 6.3e-06, N = 1957) (0.45, -0.021, P = 0.67, N = 859)
rs567931256(CT)/8:1177501 CTD-2281E23.2 (0.013, -0.69, P = 8.5e-06, N = 1957) (0.098, 0.078, P = 0.32, N = 859)
rs6992200(C)/8:1835183 ARHGEF10 (0.022, 0.45, P = 9.3e-06, N = 1957) (0.08, 0.084, P = 0.35, N = 859)
Results from Univariable Mendelian Randomization of Oxalic acid & eGFR - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 23 0.023 (-0.067- 0.11) P=0.62 23 27 1.82e-05 (0- 48.6) NA NA 0.019 P=0.51
MR-Egger 23 -0.039 (-0.25- 0.17) P=0.72 23 27 1.82e-05 (0- 48.6) 17 0.74 0.019 P=0.51
Weighted median 23 -0.032 (-0.18- 0.11) P=0.66 23 27 1.82e-05 (0- 48.6) NA NA 0.019 P=0.51
Results from Univariable MRPRESSO of Oxalic acid & eGFR - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0.02 0.05 0.5 0.62
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of Oxalic acid & eGFR - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 16 -2e-04 (-0.11- 0.11) P=1 22 18 0.000204 (0- 80.2) NA NA 0.024 P=0.48
MR-Egger 16 -0.068 (-0.28- 0.15) P=0.55 22 18 0.000204 (0- 80.2) 14 0.46 0.024 P=0.48
Weighted median 16 -0.06 (-0.23- 0.11) P=0.49 22 18 0.000204 (0- 80.2) NA NA 0.024 P=0.48
Results from Univariable MRPRESSO of Oxalic acid & eGFR - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0 0.06 0 1
beta.exposure Outlier-corrected NA NA NA NA

Pantothenic acid

Instruments Associations with Pantothenic acid & eGFR
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region Pantothenic acid (Shin et al/Long et al) eGFR (CSSCD)
rs10919047(A)/1:169033499 LINC00970 (0.14, 0.018, P = 6.8e-07, N = 7160) (0.039, -0.17, P = 0.17, N = 859)
rs3949865(C)/1:183930806* COLGALT2 (0.62, -0.011, P = 9.5e-06, N = 7160) (0.34, 0.019, P = 0.7, N = 859)
rs553719(C)/1:37332937* GRIK3 (0.93, 0.34, P = 2.7e-06, N = 1953) (0.83, 0.017, P = 0.8, N = 859)
rs1998432(A)/10:10743956 intergenic (0.52, -0.011, P = 3.7e-05, N = 7160) (0.35, -0.059, P = 0.24, N = 859)
rs12242254(A)/10:19369100 intergenic (0.69, 0.011, P = 1.6e-05, N = 7160) (0.92, -0.17, P = 0.068, N = 859)
rs2457214(T)/10:50015097 WDFY4 (0.63, -0.011, P = 1.3e-05, N = 7160) (0.35, 0.065, P = 0.19, N = 859)
rs79209616(T)/10:67616849 intergenic (0.059, 0.41, P = 3.1e-06, N = 1953) (0.41, -0.092, P = 0.061, N = 859)
rs4746017(A)/10:71774872* intergenic (0.71, -0.012, P = 5.1e-06, N = 7160) (0.77, -0.056, P = 0.31, N = 859)
rs554027365(CT)/10:86169332 CCSER2 (0.11, 0.28, P = 1.4e-08, N = 1953) (0.16, 0.03, P = 0.64, N = 859)
rs2636805(T)/10:98927016 SLIT1 (0.53, -0.011, P = 3.2e-05, N = 7160) (0.27, -0.081, P = 0.14, N = 859)
rs3781966(A)/11:61956428 SCGB1D1 (0.31, -0.024, P = 2.4e-05, N = 1650) (0.65, -0.036, P = 0.47, N = 859)
rs78668216(T)/11:75873779 intergenic (0.055, -0.39, P = 9.1e-06, N = 1953) (0.019, 0.2, P = 0.25, N = 859)
rs7296705(T)/12:3374675 TSPAN9 (0.83, 0.014, P = 4.2e-05, N = 7160) (0.61, 0.0082, P = 0.87, N = 859)
rs11175024(A)/12:40463950 SLC2A13 (0.59, 0.011, P = 1.9e-05, N = 7160) (0.65, -0.037, P = 0.48, N = 859)
rs9788090(C)/12:67889960* intergenic (0.73, 0.015, P = 1.2e-05, N = 7160) (0.22, 0.075, P = 0.19, N = 859)
rs73133802(A)/12:68038605 DYRK2 (0.054, -0.28, P = 3.6e-06, N = 1953) (0.07, -0.04, P = 0.68, N = 859)
rs1163004(T)/12:81079471 intergenic (0.85, -0.014, P = 3.4e-05, N = 7160) (0.25, 0.0081, P = 0.88, N = 859)
rs199931900(A)/13:107397379 intergenic (0.28, -0.23, P = 2.6e-06, N = 1953) (0.065, -0.0089, P = 0.93, N = 859)
rs9514571(T)/13:107405459 intergenic (0.28, -0.23, P = 6.4e-06, N = 1953) (0.049, -0.051, P = 0.65, N = 859)
rs2183242(C)/13:21271776* IL17D (0.041, 0.029, P = 2.3e-05, N = 7160) (0.11, 0.024, P = 0.76, N = 859)
rs17082600(T)/13:26228314* ATP8A2 (0.019, 0.048, P = 4.1e-07, N = 7160) (0.068, 0.047, P = 0.63, N = 859)
rs9524526(T)/13:95150472 intergenic (0.34, 0.011, P = 2.9e-05, N = 7160) (0.3, 0.0025, P = 0.96, N = 859)
rs7997736(T)/13:98438292 intergenic (0.76, 0.024, P = 3.9e-05, N = 1650) (0.42, -0.049, P = 0.31, N = 859)
rs2346674(A)/14:57795057 intergenic (0.16, 0.015, P = 2.4e-05, N = 7160) (0.027, -0.069, P = 0.65, N = 859)
rs17751805(A)/14:65034363* PPP1R36 (0.96, 0.063, P = 3.4e-06, N = 1650) (0.93, -0.21, P = 0.026, N = 859)
rs2268984(C)/14:69408567 ACTN1 (0.91, 0.02, P = 2.4e-05, N = 7160) (0.94, 0.088, P = 0.39, N = 859)
rs4904868(T)/14:92781001 intergenic (0.44, -0.011, P = 1.4e-05, N = 7160) (0.8, 0.037, P = 0.54, N = 859)
rs7166370(C)/15:60959089* RORA (0.43, 0.012, P = 5.2e-06, N = 7160) (0.25, 0.014, P = 0.8, N = 859)
rs8039191(C)/15:66406574 MEGF11 (0.53, -0.15, P = 3.4e-06, N = 1953) (0.64, 0.0024, P = 0.96, N = 859)
rs1561886(A)/15:71497130* THSD4 (0.067, -0.041, P = 3.1e-05, N = 1650) (0.14, 0.13, P = 0.065, N = 859)
rs8023317(A)/15:86541098 intergenic (0.31, 0.011, P = 3.5e-05, N = 7160) (0.54, 0.006, P = 0.9, N = 859)
rs1975271(T)/16:9497663* RP11-243A14.1 (0.59, 0.012, P = 8.7e-06, N = 7160) (0.89, -0.049, P = 0.51, N = 859)
rs432432(C)/17:15225813* TEKT3 (0.61, -0.011, P = 3.2e-05, N = 7160) (0.8, 0.013, P = 0.82, N = 859)
rs2526477(A)/17:20131193* SPECC1 (0.61, -0.012, P = 3e-06, N = 7160) (0.58, 0.082, P = 0.088, N = 859)
rs2671822(T)/17:33597682 SLFN5 (0.65, -0.011, P = 2.6e-05, N = 7160) (0.86, -0.027, P = 0.69, N = 859)
rs8065435(A)/17:56157617* DYNLL2 (0.33, -0.013, P = 5e-06, N = 7160) (0.066, 0.02, P = 0.84, N = 859)
rs12951496(T)/17:6955671 intergenic (0.87, -0.018, P = 1.7e-05, N = 7160) (0.82, -0.018, P = 0.78, N = 859)
rs4789816(A)/17:80607830 WDR45B (0.33, 0.011, P = 3.5e-05, N = 7160) (0.11, 0.072, P = 0.36, N = 859)
rs74580079(G)/18:6776863 ARHGAP28 (0.048, 0.4, P = 8e-06, N = 1953) (0.016, 0.072, P = 0.71, N = 859)
rs3865404(T)/18:755862 YES1 (0.49, -0.021, P = 3.7e-05, N = 1650) (0.69, -0.015, P = 0.78, N = 859)
rs2967437(A)/19:37086645 AC092295.7 (0.69, -0.013, P = 1.9e-06, N = 7160) (0.79, 0.017, P = 0.77, N = 859)
rs7574257(T)/2:105988447* FHL2 (0.33, 0.012, P = 7.8e-06, N = 7160) (0.2, 0.047, P = 0.45, N = 859)
rs12617095(A)/2:134762590 intergenic (0.039, 0.054, P = 3.2e-05, N = 1650) (0.12, 0.12, P = 0.11, N = 859)
rs1607363(T)/2:156670123* intergenic (0.72, 0.011, P = 3.5e-05, N = 7160) (0.7, -0.052, P = 0.33, N = 859)
rs839524(T)/2:212815801 ERBB4 (0.12, 0.019, P = 8.5e-06, N = 7160) (0.11, 0.13, P = 0.087, N = 859)
rs10185729(T)/2:212842777* ERBB4 (0.86, -0.015, P = 2.1e-05, N = 7160) (0.58, -0.026, P = 0.6, N = 859)
rs1395(A)/2:27424636* SLC5A6 (0.7, 0.017, P = 8.1e-11, N = 7160) (0.23, -0.14, P = 0.019, N = 859)
rs17049936(T)/2:59346812* intergenic (0.89, -0.019, P = 9.6e-06, N = 7160) (0.98, 0.37, P = 0.052, N = 859)
rs12614153(A)/2:99502489 KIAA1211L (0.02, -0.041, P = 1.1e-05, N = 7160) (0.023, 0.092, P = 0.57, N = 859)
rs16996604(C)/20:15792861* MACROD2 (0.97, -0.053, P = 7.2e-06, N = 1650) (0.92, 0.062, P = 0.49, N = 859)
rs6034318(A)/20:15863999* MACROD2 (0.013, 0.11, P = 4.5e-06, N = 1650) (0.11, -0.042, P = 0.58, N = 859)
rs6078500(T)/20:182013* intergenic (0.51, -0.012, P = 4.5e-06, N = 7160) (0.49, 0.12, P = 0.01, N = 859)
rs7280622(A)/21:39417006* DSCR4 (0.7, -0.011, P = 4.3e-05, N = 7160) (0.87, -0.0057, P = 0.94, N = 859)
rs760130(C)/21:41356039 intergenic (0.69, -0.12, P = 4.9e-06, N = 1953) (0.9, -0.14, P = 0.087, N = 859)
rs762407(A)/21:45181446 PDXK (0.3, -0.011, P = 2e-05, N = 7160) (0.38, -0.011, P = 0.83, N = 859)
rs2330959(T)/22:25343430 TMEM211 (0.14, -0.24, P = 7.3e-06, N = 1953) (0.024, 0.12, P = 0.44, N = 859)
rs1350858(A)/3:109874627 intergenic (0.18, 0.015, P = 8.2e-06, N = 7160) (0.36, -0.056, P = 0.26, N = 859)
rs1282954(T)/3:111627743 PHLDB2 (0.98, -0.14, P = 7.1e-07, N = 1650) (0.89, -0.013, P = 0.86, N = 859)
rs2173615(T)/3:191673577* RP11-655G22.2 (0.32, 0.013, P = 1.7e-06, N = 7160) (0.27, -0.048, P = 0.38, N = 859)
rs11719633(A)/3:20402881 intergenic (0.095, -0.021, P = 3e-06, N = 7160) (0.02, -0.22, P = 0.2, N = 859)
rs13091209(A)/3:24958459* AC133680.1 (0.84, 0.014, P = 2.8e-05, N = 7160) (0.93, -0.071, P = 0.46, N = 859)
rs6774965(A)/3:27548813* intergenic (0.86, -0.016, P = 3.2e-06, N = 7160) (0.76, 0.019, P = 0.74, N = 859)
rs11374874(CT)/3:46776965 PRSS50 (0.045, 0.31, P = 6.2e-06, N = 1953) (0.31, 0.032, P = 0.54, N = 859)
rs9813765(T)/3:4896746 AC018816.3 (0.92, 0.02, P = 3.3e-05, N = 7160) (0.76, -0.063, P = 0.27, N = 859)
rs7634314(A)/3:61464280 intergenic (0.31, 0.011, P = 2e-05, N = 7160) (0.21, -0.076, P = 0.21, N = 859)
rs75342462(T)/3:61547164 PTPRG (0.27, 0.17, P = 3.3e-06, N = 1953) (0.13, 0.0054, P = 0.94, N = 859)
rs10510382(T)/3:7997953* LMCD1-AS1 (0.79, -0.015, P = 1.1e-05, N = 7160) (0.89, -0.043, P = 0.57, N = 859)
rs6848070(A)/4:127862814* intergenic (0.35, -0.012, P = 9.9e-06, N = 7160) (0.1, 0.13, P = 0.12, N = 859)
rs795365(A)/4:140485914 SETD7 (0.73, -0.014, P = 2.5e-05, N = 7160) (0.44, 0.047, P = 0.34, N = 859)
rs4692562(T)/4:169990660 intergenic (0.66, -0.027, P = 1.9e-05, N = 1650) (0.62, -0.033, P = 0.5, N = 859)
rs10012798(T)/4:169993004 intergenic (0.67, -0.024, P = 1.4e-05, N = 1650) (0.7, -0.00084, P = 0.99, N = 859)
rs10520541(C)/4:183680605* TENM3 (0.83, 0.014, P = 3.4e-05, N = 7160) (0.9, -0.058, P = 0.48, N = 859)
rs6837566(G)/4:186789501 SORBS2 (0.098, 0.26, P = 6.9e-06, N = 1953) (0.094, 0.06, P = 0.46, N = 859)
rs10024571(C)/4:188772103* intergenic (0.98, -0.082, P = 1.6e-05, N = 1650) (0.97, 0.068, P = 0.61, N = 859)
rs1895918(T)/4:37111619* RP11-103J17.1 (0.56, 0.12, P = 8.4e-06, N = 1953) (0.26, 0.11, P = 0.049, N = 859)
rs2457411(T)/4:48244026* TEC (0.3, 0.011, P = 1.9e-05, N = 7160) (0.052, 0.14, P = 0.18, N = 859)
rs12522179(A)/5:101403134* intergenic (0.82, -0.028, P = 3.8e-05, N = 1650) (0.58, -0.057, P = 0.23, N = 859)
rs4078252(T)/5:112455467* MCC (0.32, -0.011, P = 3.9e-05, N = 7160) (0.13, 0.023, P = 0.75, N = 859)
rs2605200(T)/5:114751410 intergenic (0.22, -0.016, P = 2.1e-05, N = 7160) (0.31, -0.016, P = 0.75, N = 859)
rs248063(A)/5:126500208* intergenic (0.5, -0.024, P = 2.4e-06, N = 1650) (0.68, 0.089, P = 0.082, N = 859)
rs271072(A)/5:144532826 intergenic (0.38, -0.012, P = 5.9e-06, N = 7160) (0.25, 0.0073, P = 0.9, N = 859)
rs726550(T)/5:144668820* intergenic (0.33, 0.011, P = 3.7e-05, N = 7160) (0.58, -0.069, P = 0.15, N = 859)
rs6873171(A)/5:145305766* intergenic (0.065, 0.041, P = 4.5e-05, N = 1650) (0.24, -0.065, P = 0.25, N = 859)
rs1994860(G)/5:152989323 GRIA1 (0.28, 0.19, P = 6.1e-06, N = 1953) (0.1, 0.079, P = 0.31, N = 859)
rs2255493(T)/5:153432970 MFAP3 (0.63, -0.011, P = 3.8e-05, N = 7160) (0.65, 0.04, P = 0.44, N = 859)
rs31705(C)/5:154683887* intergenic (0.33, 0.012, P = 1e-05, N = 7160) (0.39, -0.046, P = 0.36, N = 859)
rs10051445(G)/5:82356099 TMEM167A (0.45, 0.16, P = 5.2e-07, N = 1953) (0.59, 0.0014, P = 0.98, N = 859)
rs1674726(A)/6:153858614* intergenic (0.35, -0.011, P = 4e-05, N = 7160) (0.29, -0.034, P = 0.53, N = 859)
rs6557395(A)/6:155369261 TIAM2 (0.83, -0.015, P = 2.9e-05, N = 7160) (0.88, 0.032, P = 0.67, N = 859)
rs9365106(A)/6:160282834* intergenic (0.68, -0.012, P = 8.1e-06, N = 7160) (0.54, -0.059, P = 0.24, N = 859)
rs960295(T)/6:1726623 GMDS (0.25, -0.025, P = 1.3e-05, N = 1650) (0.084, 0.0017, P = 0.98, N = 859)
rs7774567(A)/6:25425526* LRRC16A (0.083, 0.02, P = 1.8e-05, N = 7160) (0.11, -0.015, P = 0.84, N = 859)
rs13212846(A)/6:50301100 intergenic (0.93, -0.024, P = 2.9e-06, N = 7160) (0.99, 0.21, P = 0.3, N = 859)
rs17141663(T)/6:6063348* intergenic (0.074, -0.021, P = 4.4e-05, N = 7160) (0.072, 0.16, P = 0.091, N = 859)
rs9649040(T)/7:131859395 PLXNA4 (0.12, -0.017, P = 4.3e-05, N = 7160) (0.082, -0.00026, P = 1, N = 859)
rs192735620(T)/7:152543295 ACTR3B (0.012, 0.63, P = 5.8e-06, N = 1953) (0.02, -0.2, P = 0.25, N = 859)
rs754554(T)/7:24758818 DFNA5 (0.15, 0.015, P = 2e-05, N = 7160) (0.21, 0.012, P = 0.84, N = 859)
rs7458704(T)/7:67422093 intergenic (0.98, -0.054, P = 5.6e-07, N = 7160) (0.84, -0.095, P = 0.15, N = 859)
rs17158882(T)/7:83963481* SEMA3A (0.91, -0.024, P = 3.9e-05, N = 7160) (0.92, 0.11, P = 0.25, N = 859)
rs1034495(A)/8:111157151 intergenic (0.7, 0.011, P = 4.2e-05, N = 7160) (0.93, 0.022, P = 0.82, N = 859)
rs283734(G)/8:128270368 intergenic (0.22, -0.15, P = 7.2e-06, N = 1953) (0.5, -0.0055, P = 0.91, N = 859)
rs4269521(A)/8:132358549* intergenic (0.84, 0.017, P = 1e-06, N = 7160) (0.95, 0.18, P = 0.13, N = 859)
rs12544560(A)/8:21368451 intergenic (0.15, 0.016, P = 3.3e-06, N = 7160) (0.065, -0.015, P = 0.88, N = 859)
rs2979166(A)/8:8228245 SGK223 (0.47, 0.011, P = 1.5e-05, N = 7160) (0.74, 0.094, P = 0.092, N = 859)
rs7009776(T)/8:90373191 intergenic (0.33, -0.027, P = 7.1e-06, N = 1650) (0.23, 0.0098, P = 0.87, N = 859)
rs17771752(T)/9:28195226* LINGO2 (0.049, 0.025, P = 2e-05, N = 7160) (0.023, -0.0049, P = 0.98, N = 859)
rs700978(A)/9:98496807* intergenic (0.31, -0.014, P = 1.9e-05, N = 7160) (0.5, 0.069, P = 0.15, N = 859)
Results from Univariable Mendelian Randomization of Pantothenic acid & eGFR - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 107 -0.027 (-0.15- 0.096) P=0.67 4.9 25 1.06 (0- 81.2) NA NA -0.01 P=0.16
MR-Egger 107 0.024 (-0.12- 0.17) P=0.74 4.9 25 1.06 (0- 81.2) 109 0.38 -0.01 P=0.16
Weighted median 107 0.04 (-0.14- 0.22) P=0.67 4.9 25 1.06 (0- 81.2) NA NA -0.01 P=0.16
Results from Univariable MRPRESSO of Pantothenic acid & eGFR - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.03 0.06 -0.43 0.67
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of Pantothenic acid & eGFR - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 62 -0.021 (-0.14- 0.093) P=0.72 7.4 23 2.08 (0- 20.7) NA NA 0.005 P=0.6
MR-Egger 62 -0.044 (-0.2- 0.11) P=0.58 7.4 23 2.08 (0- 20.7) 47 0.88 0.005 P=0.6
Weighted median 62 0.035 (-0.16- 0.23) P=0.72 7.4 23 2.08 (0- 20.7) NA NA 0.005 P=0.6
Results from Univariable MRPRESSO of Pantothenic acid & eGFR - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.02 0.06 -0.36 0.72
beta.exposure Outlier-corrected NA NA NA NA

L-Phenylalanine

Instruments Associations with L-Phenylalanine & eGFR
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region L-Phenylalanine (Shin et al/Long et al) eGFR (CSSCD)
rs10913071(A)/1:175712239 TNR (0.22, -0.0051, P = 2.8e-05, N = 7824) (0.1, 0.2, P = 0.014, N = 859)
rs149766(T)/1:57642394* DAB1 (0.071, -0.0099, P = 2.6e-05, N = 7824) (0.012, -0.33, P = 0.14, N = 859)
rs1865020(A)/10:78688976 KCNMA1 (0.33, 0.0049, P = 3.2e-05, N = 7824) (0.52, -0.037, P = 0.45, N = 859)
rs628223(A)/11:82968164* CCDC90B (0.69, 0.0048, P = 4.3e-05, N = 7824) (0.86, 0.016, P = 0.82, N = 859)
rs1498694(A)/12:103257876* PAH (0.4, 0.0075, P = 7.3e-11, N = 7824) (0.32, 0.08, P = 0.12, N = 859)
rs11066801(T)/12:114319498* RBM19 (0.2, -0.0092, P = 4.8e-05, N = 7824) (0.18, -0.0018, P = 0.98, N = 859)
rs1163900(A)/12:17612617* intergenic (0.26, -0.0054, P = 1e-05, N = 7824) (0.44, -0.018, P = 0.72, N = 859)
rs12370281(C)/12:98249633* intergenic (0.7, -0.0048, P = 4.9e-05, N = 7824) (0.59, -0.088, P = 0.072, N = 859)
rs17300024(A)/13:93913236* GPC6 (0.99, -0.037, P = 2.9e-05, N = 7824) (0.95, -0.069, P = 0.54, N = 859)
rs10145453(T)/14:63735954* RHOJ (0.81, -0.0051, P = 4.7e-05, N = 7824) (0.47, 0.11, P = 0.021, N = 859)
rs16975959(T)/15:96564721* intergenic (0.99, -0.035, P = 2e-05, N = 7824) (0.93, -0.034, P = 0.71, N = 859)
rs12598787(A)/16:77403469* ADAMTS18 (0.88, -0.0089, P = 1.6e-05, N = 7824) (0.98, 0.14, P = 0.39, N = 859)
rs10445272(A)/17:12621782* MYOCD (0.21, 0.0051, P = 3.7e-05, N = 7824) (0.43, -0.0084, P = 0.86, N = 859)
rs2905873(A)/17:29532356* NF1 (0.69, 0.0055, P = 3e-06, N = 7824) (0.94, -0.0093, P = 0.93, N = 859)
rs1468260(A)/17:39052931* intergenic (0.49, -0.0053, P = 3.5e-05, N = 7824) (0.82, -0.012, P = 0.85, N = 859)
rs6736106(C)/2:217328446* SMARCAL1 (0.2, 0.0053, P = 2.1e-05, N = 7824) (0.5, 0.051, P = 0.31, N = 859)
rs10050054(T)/4:178647306* LINC01098 (0.98, -0.033, P = 2.6e-06, N = 7824) (0.67, 0.11, P = 0.029, N = 859)
rs1872445(T)/4:186504058* SORBS2 (0.55, -0.0049, P = 1.9e-05, N = 7824) (0.87, 0.068, P = 0.34, N = 859)
rs4863027(T)/4:190729688* AF146191.4 (0.96, -0.019, P = 4.3e-05, N = 7824) (0.82, 0.086, P = 0.17, N = 859)
rs6831907(T)/4:190761715 AF146191.4 (0.04, 0.021, P = 7.1e-06, N = 7824) (0.04, 0.13, P = 0.27, N = 859)
rs17732494(T)/5:56301267 intergenic (0.46, 0.0076, P = 4.7e-05, N = 7824) (0.63, 0.034, P = 0.51, N = 859)
rs899855(A)/6:130094673* intergenic (0.93, -0.0097, P = 1.4e-05, N = 7824) (0.93, -0.032, P = 0.73, N = 859)
rs7764865(T)/6:42835487 GLTSCR1L (0.059, 0.012, P = 3.9e-05, N = 7824) (0.51, -0.05, P = 0.31, N = 859)
rs2613565(A)/6:95894399 intergenic (0.64, 0.0084, P = 4.5e-05, N = 7824) (0.59, -0.091, P = 0.068, N = 859)
rs2456946(C)/7:113200934* intergenic (0.023, 0.033, P = 4.7e-05, N = 7824) (0.047, -0.077, P = 0.5, N = 859)
rs12706142(A)/7:116775046* ST7 (0.77, -0.0052, P = 2.9e-05, N = 7824) (0.97, 0.029, P = 0.83, N = 859)
rs6965127(A)/7:42866718 AC010132.10 (0.34, -0.005, P = 2.4e-05, N = 7824) (0.051, -0.064, P = 0.54, N = 859)
rs1565225(A)/8:85687107* RALYL (0.24, 0.007, P = 2.3e-06, N = 7824) (0.58, -0.055, P = 0.27, N = 859)
rs12001237(C)/9:115854670 intergenic (0.91, 0.0082, P = 3.5e-05, N = 7824) (0.98, 0.3, P = 0.081, N = 859)
rs944982(T)/9:119847448* ASTN2 (0.11, 0.013, P = 1.1e-05, N = 7824) (0.063, 0.1, P = 0.3, N = 859)
Results from Univariable Mendelian Randomization of L-Phenylalanine & eGFR - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 30 -1.5 (-3.6- 0.62) P=0.16 0.15 0.057 9.11 (0- 77.2) NA NA 0.0016 P=0.94
MR-Egger 30 -1.6 (-4.9- 1.7) P=0.35 0.15 0.057 9.11 (0- 77.2) 40 0.072 0.0016 P=0.94
Weighted median 30 -2.6 (-5.3- 0.16) P=0.065 0.15 0.057 9.11 (0- 77.2) NA NA 0.0016 P=0.94
Results from Univariable MRPRESSO of L-Phenylalanine & eGFR - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -1.5 1.08 -1.39 0.18
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of L-Phenylalanine & eGFR - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 8 -2.4 (-9.7- 4.8) P=0.51 0.15 0.015 41.8 (0- 87.8) NA NA -0.087 P=0.35
MR-Egger 8 6.6 (-12- 26) P=0.52 0.15 0.015 41.8 (0- 87.8) 13 0.044 -0.087 P=0.35
Weighted median 8 -2.3 (-9.5- 4.9) P=0.53 0.15 0.015 41.8 (0- 87.8) NA NA -0.087 P=0.35
Results from Univariable MRPRESSO of L-Phenylalanine & eGFR - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -2.44 3.72 -0.66 0.53
beta.exposure Outlier-corrected NA NA NA NA

L-Proline

Instruments Associations with L-Proline & eGFR
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region L-Proline (Shin et al/Long et al) eGFR (CSSCD)
rs773585(T)/1:113841023* intergenic (0.65, 0.0076, P = 1.9e-05, N = 7824) (0.91, 0.08, P = 0.34, N = 859)
rs11802885(A)/1:113896872 intergenic (0.36, 0.0098, P = 2.3e-08, N = 7824) (0.25, 0.029, P = 0.6, N = 859)
rs17492329(T)/1:202461103 PPP1R12B (0.78, -0.011, P = 2.4e-05, N = 7824) (0.97, 0.27, P = 0.044, N = 859)
rs2993536(A)/1:212154930 INTS7 (0.97, 0.021, P = 3.5e-05, N = 7824) (0.91, -0.12, P = 0.18, N = 859)
rs587043(T)/1:226797522* C1orf95 (0.33, -0.0077, P = 1.3e-05, N = 7824) (0.23, 0.023, P = 0.7, N = 859)
rs10495434(T)/1:239473965* intergenic (0.079, -0.015, P = 3.2e-05, N = 7824) (0.16, -0.0096, P = 0.88, N = 859)
rs1888182(T)/1:54967890 AC099796.1 (0.42, 0.0079, P = 7.9e-06, N = 7824) (0.14, 0.032, P = 0.65, N = 859)
rs852767(G)/1:58287224 DAB1 (0.36, 0.18, P = 9.2e-06, N = 1957) (0.12, 0.045, P = 0.55, N = 859)
rs34821139(T)/1:61645881* NFIA (0.098, 0.23, P = 4.1e-06, N = 1957) (0.02, 0.14, P = 0.43, N = 859)
rs7546702(T)/1:93948403* FNBP1L (0.56, -0.15, P = 4.2e-06, N = 1957) (0.12, -0.096, P = 0.19, N = 859)
rs11192397(G)/10:107070578* intergenic (0.15, -0.27, P = 9.1e-06, N = 1957) (0.026, 0.041, P = 0.79, N = 859)
rs532728(C)/10:129652583* intergenic (0.61, 0.0074, P = 3e-05, N = 7824) (0.71, -0.033, P = 0.54, N = 859)
rs112873694(AT)/10:18655806 CACNB2 (0.056, 0.47, P = 3.6e-06, N = 1957) (0.08, -0.044, P = 0.63, N = 859)
rs12243290(A)/10:66938581* intergenic (0.9, -0.016, P = 4e-06, N = 7824) (0.76, -0.012, P = 0.83, N = 859)
rs10887554(A)/10:87824238 GRID1 (0.53, 0.0072, P = 3.9e-05, N = 7824) (0.25, 0.11, P = 0.042, N = 859)
rs10905627(G)/10:9905850 intergenic (0.74, 0.19, P = 2.8e-06, N = 1957) (0.45, -0.062, P = 0.2, N = 859)
rs4755121(A)/11:105804856 GRIA4 (0.084, 0.015, P = 2.3e-05, N = 7824) (0.025, 0.019, P = 0.9, N = 859)
rs1371674(T)/11:40531941 LRRC4C (0.59, -0.0076, P = 1.9e-05, N = 7824) (0.52, 0.013, P = 0.8, N = 859)
rs10501294(T)/11:43086410 RP11-111A24.2 (0.87, -0.012, P = 3.1e-06, N = 7824) (0.97, -0.13, P = 0.35, N = 859)
rs535633(A)/11:92825738* intergenic (0.58, -0.0086, P = 1e-06, N = 7824) (0.65, 0.023, P = 0.66, N = 859)
rs562808(T)/11:95961049* MAML2 (0.61, -0.0076, P = 1.8e-05, N = 7824) (0.37, 0.0017, P = 0.97, N = 859)
rs7296105(A)/12:117842549 NOS1 (0.88, 0.026, P = 2.3e-06, N = 7824) (0.45, 0.046, P = 0.36, N = 859)
rs11183620(A)/12:47212370* SLC38A4 (0.47, 0.0082, P = 2.3e-06, N = 7824) (0.8, -0.00048, P = 0.99, N = 859)
rs7958568(T)/12:47431496* intergenic (0.47, 0.0078, P = 8.9e-06, N = 7824) (0.62, -0.027, P = 0.59, N = 859)
rs4082475(A)/12:52907240 KRT5 (0.13, 0.011, P = 2e-05, N = 7824) (0.2, -0.032, P = 0.6, N = 859)
rs10783990(A)/12:59976616 RNU4-20P (0.64, 0.0072, P = 4.2e-05, N = 7824) (0.75, 0.0032, P = 0.95, N = 859)
rs10747856(A)/12:60262116 intergenic (0.52, -0.0079, P = 6e-06, N = 7824) (0.44, 0.11, P = 0.022, N = 859)
rs950755(T)/12:61227957* intergenic (0.86, -0.012, P = 8.5e-06, N = 7824) (0.7, 0.036, P = 0.49, N = 859)
rs2278823(A)/12:7288734* CLSTN3 (0.14, -0.011, P = 4.8e-05, N = 7824) (0.2, 0.032, P = 0.59, N = 859)
rs3132360(A)/13:26297093 ATP8A2 (0.21, -0.011, P = 2.1e-05, N = 7824) (0.2, -0.071, P = 0.23, N = 859)
rs17245120(A)/13:31319133 ALOX5AP (0.072, 0.027, P = 4.8e-05, N = 7824) (0.044, 0.029, P = 0.81, N = 859)
rs993158(T)/13:62992697 intergenic (0.86, 0.011, P = 1.5e-05, N = 7824) (0.48, -0.012, P = 0.81, N = 859)
rs2449697(T)/13:64025289 intergenic (0.66, 0.0072, P = 4.9e-05, N = 7824) (0.5, 0.072, P = 0.14, N = 859)
rs9540462(T)/13:66100680 intergenic (0.88, -0.012, P = 4.8e-06, N = 7824) (0.89, -0.0067, P = 0.93, N = 859)
rs9523512(T)/13:92775592* GPC5 (0.47, 0.0077, P = 1.3e-05, N = 7824) (0.8, -0.042, P = 0.49, N = 859)
rs10431644(T)/14:103694331 intergenic (0.028, 0.45, P = 1.9e-06, N = 1957) (0.077, -0.1, P = 0.27, N = 859)
rs62008719(C)/14:103698656 intergenic (0.028, 0.45, P = 1.5e-06, N = 1957) (0.11, -0.16, P = 0.047, N = 859)
rs2101244(A)/14:42848284 CTD-2307P3.1 (0.024, 0.66, P = 4.8e-06, N = 1957) (0.14, 0.045, P = 0.51, N = 859)
rs12889337(T)/14:46784593* LINC00871 (0.36, 0.0077, P = 1.5e-05, N = 7824) (0.82, 0.0092, P = 0.89, N = 859)
rs11848063(A)/14:47235445* intergenic (0.59, 0.0087, P = 7.1e-07, N = 7824) (0.44, -0.028, P = 0.57, N = 859)
rs12901694(A)/15:87326551 AGBL1 (0.4, 0.0076, P = 1.2e-05, N = 7824) (0.84, -0.1, P = 0.12, N = 859)
rs7162266(T)/15:94673885 intergenic (0.6, 0.0072, P = 3.9e-05, N = 7824) (0.69, -0.0069, P = 0.89, N = 859)
rs11638366(T)/15:98810226* CTD-2544M6.1 (0.43, -0.0076, P = 1.6e-05, N = 7824) (0.4, 0.00042, P = 0.99, N = 859)
rs869289(T)/16:12385806* SNX29 (0.38, -0.0077, P = 1.5e-05, N = 7824) (0.27, -0.041, P = 0.45, N = 859)
rs74016008(C)/16:27150916 EEF1A1P38 (0.11, 0.25, P = 2.1e-06, N = 1957) (0.14, 0.027, P = 0.69, N = 859)
rs893175(A)/16:49303818 intergenic (0.59, -0.0086, P = 1.5e-06, N = 7824) (0.33, -0.099, P = 0.05, N = 859)
rs11075967(T)/16:73154049 intergenic (0.67, -0.0087, P = 8.7e-07, N = 7824) (0.3, -0.061, P = 0.22, N = 859)
rs17144033(G)/16:7590752* RBFOX1 (0.089, -0.27, P = 2.7e-06, N = 1957) (0.18, -0.08, P = 0.22, N = 859)
rs1080941(A)/16:77890685 VAT1L (0.63, 0.0078, P = 1.1e-05, N = 7824) (0.41, -0.0023, P = 0.96, N = 859)
rs17750740(T)/16:80651109* CDYL2 (0.83, 0.01, P = 2.2e-05, N = 7824) (0.96, -0.029, P = 0.81, N = 859)
rs7208186(T)/17:10680890* CTC-297N7.5 (0.86, 0.014, P = 6.3e-08, N = 7824) (0.57, 0.038, P = 0.44, N = 859)
rs8077659(A)/17:13042271 intergenic (0.36, 0.0073, P = 3.7e-05, N = 7824) (0.19, 0.035, P = 0.59, N = 859)
rs8080958(A)/17:27508704 MYO18A (0.55, -0.0073, P = 2.7e-05, N = 7824) (0.83, 0.096, P = 0.13, N = 859)
rs1984518(T)/17:41521666 MIR2117 (0.58, -0.0074, P = 2.9e-05, N = 7824) (0.55, 0.023, P = 0.64, N = 859)
rs7209219(A)/17:66300683 ARSG (0.87, -0.013, P = 4.2e-05, N = 7824) (0.88, -0.038, P = 0.61, N = 859)
rs1859930(T)/17:70334561 RP11-1124B17.1 (0.59, 0.0077, P = 1.2e-05, N = 7824) (0.57, -0.077, P = 0.11, N = 859)
rs12955313(T)/18:11952865* intergenic (0.069, -0.29, P = 8.3e-06, N = 1957) (0.061, 0.038, P = 0.71, N = 859)
rs55928301(A)/18:25277047 intergenic (0.055, 0.35, P = 2.1e-06, N = 1957) (0.19, 0.068, P = 0.26, N = 859)
rs2612561(T)/18:42982959* SLC14A2 (0.45, 0.0074, P = 2.7e-05, N = 7824) (0.48, -0.03, P = 0.54, N = 859)
rs34467380(T)/18:6472786 intergenic (0.2, -0.19, P = 4.2e-06, N = 1957) (0.26, 0.13, P = 0.017, N = 859)
rs7241461(T)/18:74778515* MBP (0.47, 0.0074, P = 2.1e-05, N = 7824) (0.42, 0.036, P = 0.48, N = 859)
rs12984032(T)/19:19809147 CTC-412M14.6 (0.76, 0.011, P = 2.5e-05, N = 7824) (0.73, -0.064, P = 0.23, N = 859)
rs4801654(A)/19:56483863 NLRP8 (0.086, 0.014, P = 2.6e-05, N = 7824) (0.18, -0.0035, P = 0.95, N = 859)
rs56375520(T)/19:58434877 ZNF418 (0.24, 0.19, P = 8.6e-06, N = 1957) (0.25, 0.14, P = 0.0081, N = 859)
rs10404819(A)/19:9227673* OR7G1 (0.17, -0.011, P = 1.9e-05, N = 7824) (0.61, 0.036, P = 0.48, N = 859)
rs10183099(A)/2:152245087 intergenic (0.64, -0.0084, P = 2.4e-06, N = 7824) (0.9, 0.0098, P = 0.9, N = 859)
rs2290368(T)/2:152266473 RIF1 (0.57, -0.0075, P = 2.2e-05, N = 7824) (0.62, -0.046, P = 0.36, N = 859)
rs1564080(A)/2:157529960 intergenic (0.32, 0.0079, P = 7.5e-06, N = 7824) (0.45, 0.059, P = 0.23, N = 859)
rs1615586(T)/2:161743385* intergenic (0.77, -0.02, P = 4.2e-06, N = 7824) (0.8, 0.048, P = 0.42, N = 859)
rs11684292(T)/2:172117094 intergenic (0.052, -0.02, P = 1e-05, N = 7824) (0.037, 0.19, P = 0.12, N = 859)
rs17476649(A)/2:17262830* intergenic (0.35, 0.0073, P = 3.5e-05, N = 7824) (0.079, -0.028, P = 0.76, N = 859)
rs1486239(A)/2:180631925 ZNF385B (0.41, -0.0075, P = 2.1e-05, N = 7824) (0.6, -0.043, P = 0.37, N = 859)
rs1534208(C)/2:185009665 intergenic (0.55, -0.16, P = 6.1e-06, N = 1957) (0.15, -0.04, P = 0.55, N = 859)
rs7573642(T)/2:213010332 ERBB4 (0.98, -0.048, P = 4.9e-05, N = 7824) (0.75, -0.0041, P = 0.94, N = 859)
rs7592552(C)/2:214563795 SPAG16 (0.4, 0.16, P = 4.8e-06, N = 1957) (0.6, -0.044, P = 0.38, N = 859)
rs142363454(TCA)/2:215286688* VWC2L (0.12, 0.23, P = 5.2e-06, N = 1957) (0.41, -0.018, P = 0.71, N = 859)
rs7601275(A)/2:239060766 KLHL30 (0.35, 0.15, P = 9e-06, N = 1957) (0.68, 0.01, P = 0.84, N = 859)
rs7560860(A)/2:42497679 EML4 (0.43, 0.0079, P = 6.4e-06, N = 7824) (0.13, -0.04, P = 0.59, N = 859)
rs4564826(A)/2:43058278* AC098824.6 (0.23, -0.19, P = 9.4e-06, N = 1957) (0.22, 0.08, P = 0.17, N = 859)
rs55684321(A)/2:4978939 intergenic (0.38, -0.15, P = 1e-06, N = 1957) (0.17, -0.16, P = 0.015, N = 859)
rs13388859(T)/2:81051251 AC084193.1 (0.011, 0.082, P = 1.3e-05, N = 7824) (0.066, 0.13, P = 0.18, N = 859)
rs408961(C)/20:15045215* MACROD2 (0.64, -0.0073, P = 3.1e-05, N = 7824) (0.29, -0.067, P = 0.21, N = 859)
rs6085052(T)/20:5239399 intergenic (0.98, -0.026, P = 3.3e-05, N = 7824) (0.96, -0.11, P = 0.38, N = 859)
rs6085132(T)/20:5344064 intergenic (0.97, -0.027, P = 4e-06, N = 7824) (0.77, -0.014, P = 0.8, N = 859)
rs6011169(C)/20:62456818 ZBTB46 (0.13, -0.011, P = 2.7e-05, N = 7824) (0.29, -0.048, P = 0.36, N = 859)
rs1009576(T)/21:16542572 intergenic (0.14, -0.28, P = 1.9e-06, N = 1957) (0.75, 0.13, P = 0.016, N = 859)
rs2823289(T)/21:16841195* intergenic (0.58, -0.0073, P = 4.4e-05, N = 7824) (0.49, 0.047, P = 0.33, N = 859)
rs17693038(T)/21:18820372 C21orf37 (0.06, 0.032, P = 1.3e-05, N = 7824) (0.01, 0.12, P = 0.61, N = 859)
rs228029(A)/21:44068362 AP001626.2 (0.38, 0.0072, P = 4.9e-05, N = 7824) (0.24, -0.053, P = 0.34, N = 859)
rs17742907(A)/22:18890615 DGCR6 (0.076, 0.017, P = 9.6e-06, N = 7824) (0.036, 0.098, P = 0.45, N = 859)
rs5747934(T)/22:18915282 PRODH (0.047, 0.071, P = 2e-44, N = 7824) (0.2, -0.025, P = 0.68, N = 859)
rs35059460(C)/22:18964791 DGCR5 (0.66, 0.21, P = 6.4e-09, N = 1957) (0.5, 0.081, P = 0.08, N = 859)
rs2518802(A)/22:18975345* DGCR5 (0.9, -0.053, P = 4.2e-59, N = 7824) (0.86, 0.096, P = 0.18, N = 859)
rs4819778(T)/22:19134083 DGCR14 (0.33, -0.0097, P = 5.5e-08, N = 7824) (0.65, 0.087, P = 0.088, N = 859)
rs9827536(T)/3:191846778 intergenic (0.63, 0.0075, P = 1.9e-05, N = 7824) (0.28, -0.031, P = 0.56, N = 859)
rs1394836(T)/3:192454733* FGF12 (0.6, 0.0083, P = 2.2e-06, N = 7824) (0.84, -0.031, P = 0.64, N = 859)
rs11129161(T)/3:24738868 AC133680.1 (0.59, 0.0078, P = 1.4e-05, N = 7824) (0.73, -0.065, P = 0.23, N = 859)
rs11716669(T)/3:60801815 FHIT (0.4, 0.18, P = 7.8e-06, N = 1957) (0.24, -0.039, P = 0.48, N = 859)
rs6798346(A)/3:73078044* PPP4R2 (0.63, -0.017, P = 8.8e-06, N = 7824) (0.54, 0.0018, P = 0.97, N = 859)
rs6769362(C)/3:99296437* intergenic (0.64, -0.0079, P = 7.8e-06, N = 7824) (0.18, -0.093, P = 0.14, N = 859)
rs10494317(T)/4:130094338* RP11-378N18.1 (0.69, -0.0075, P = 2.5e-05, N = 7824) (0.71, -0.032, P = 0.55, N = 859)
rs17314804(T)/4:140946828* MAML3 (0.35, -0.0074, P = 2.9e-05, N = 7824) (0.082, 0.052, P = 0.54, N = 859)
rs4580644(T)/4:15785201 CD38 (0.49, 0.016, P = 8.2e-06, N = 7824) (0.66, -0.12, P = 0.023, N = 859)
rs2286460(A)/4:15964040* FGFBP2 (0.54, -0.0075, P = 2e-05, N = 7824) (0.43, 0.012, P = 0.8, N = 859)
rs732224(T)/4:162783324 FSTL5 (0.51, 0.0072, P = 3.8e-05, N = 7824) (0.53, 0.042, P = 0.39, N = 859)
rs12503744(A)/4:172203928* intergenic (0.02, -0.055, P = 1.6e-05, N = 7824) (0.32, -0.014, P = 0.78, N = 859)
rs6853509(T)/4:188999227 intergenic (0.44, -0.0076, P = 2.2e-05, N = 7824) (0.82, 0.044, P = 0.48, N = 859)
rs10517422(T)/4:37405256* KIAA1239 (0.2, 0.21, P = 4.8e-06, N = 1957) (0.02, 0.16, P = 0.35, N = 859)
rs4860172(C)/4:60389483* intergenic (0.37, 0.0077, P = 1.5e-05, N = 7824) (0.065, -0.026, P = 0.79, N = 859)
rs6446553(T)/4:6942857 TBC1D14 (0.59, -0.0077, P = 1.8e-05, N = 7824) (0.41, -0.027, P = 0.58, N = 859)
rs10007509(A)/4:71171720 intergenic (0.07, -0.31, P = 1e-05, N = 1957) (0.14, 0.056, P = 0.42, N = 859)
rs10155062(A)/4:7133905* intergenic (0.33, 0.0073, P = 4.3e-05, N = 7824) (0.59, 0.08, P = 0.1, N = 859)
rs1363786(T)/5:102225196 PAM (0.07, 0.016, P = 1.1e-05, N = 7824) (0.24, -0.0028, P = 0.96, N = 859)
rs10073414(C)/5:108436526 FER (0.89, 0.025, P = 3.8e-05, N = 7824) (0.87, -0.013, P = 0.85, N = 859)
rs7702811(G)/5:125923056 ALDH7A1 (0.55, 0.15, P = 2.7e-07, N = 1957) (0.92, 0.0087, P = 0.92, N = 859)
rs4868254(T)/5:172732331 intergenic (0.43, -0.0076, P = 2.7e-05, N = 7824) (0.54, 0.013, P = 0.78, N = 859)
rs147198383(G)/5:17395773 intergenic (0.037, 0.4, P = 9.7e-07, N = 1957) (0.011, 0.26, P = 0.27, N = 859)
rs2935623(A)/5:2767556 intergenic (0.62, -0.0079, P = 8.7e-06, N = 7824) (0.58, -0.043, P = 0.37, N = 859)
rs10512634(A)/5:35987551 UGT3A1 (0.14, 0.012, P = 8.6e-06, N = 7824) (0.023, -0.11, P = 0.49, N = 859)
rs10941406(A)/5:38756294* CTD-2127H9.1 (0.34, 0.0074, P = 3.3e-05, N = 7824) (0.41, -0.081, P = 0.097, N = 859)
rs31242(T)/5:53368869* ARL15 (0.86, 0.011, P = 2.2e-05, N = 7824) (0.92, -0.082, P = 0.35, N = 859)
rs4395600(A)/5:53989831 intergenic (0.083, -0.014, P = 3.7e-05, N = 7824) (0.15, -0.041, P = 0.53, N = 859)
rs16900163(A)/5:71915010 CTC-347C20.2 (0.81, -0.018, P = 4.9e-05, N = 7824) (0.74, -0.077, P = 0.17, N = 859)
rs1650723(T)/5:79922030 DHFR (0.17, 0.011, P = 3e-05, N = 7824) (0.065, 0.086, P = 0.38, N = 859)
rs11963846(A)/6:112489446 LAMA4 (0.45, 0.008, P = 8.6e-06, N = 7824) (0.8, -0.0083, P = 0.89, N = 859)
rs9385646(T)/6:133725127 EYA4 (0.84, -0.23, P = 5.1e-06, N = 1957) (0.42, -0.022, P = 0.66, N = 859)
rs175866(T)/6:151225521* MTHFD1L (0.58, -0.0086, P = 1.1e-06, N = 7824) (0.87, 0.13, P = 0.068, N = 859)
rs4869824(C)/6:154758528* CNKSR3 (0.52, 0.0074, P = 1.8e-05, N = 7824) (0.39, -0.05, P = 0.29, N = 859)
rs7755193(A)/6:158644859* intergenic (0.15, -0.011, P = 2.9e-05, N = 7824) (0.37, -0.026, P = 0.61, N = 859)
rs9396897(A)/6:18668391 intergenic (0.63, 0.0072, P = 3.6e-05, N = 7824) (0.69, -0.015, P = 0.78, N = 859)
rs2185865(A)/6:18828241 intergenic (0.92, 0.018, P = 1.7e-07, N = 7824) (0.85, -0.056, P = 0.4, N = 859)
rs612262(T)/6:35891608* SRPK1 (0.36, -0.0073, P = 3.3e-05, N = 7824) (0.73, -0.0042, P = 0.94, N = 859)
rs12202955(A)/6:53299090 intergenic (0.51, -0.0074, P = 2.5e-05, N = 7824) (0.37, -0.1, P = 0.039, N = 859)
rs2145543(C)/6:66874550 intergenic (0.096, 0.36, P = 3.7e-06, N = 1957) (0.16, 0.014, P = 0.83, N = 859)
rs9360494(T)/6:72485205* intergenic (0.6, -0.0083, P = 2.7e-06, N = 7824) (0.83, -0.0092, P = 0.88, N = 859)
rs60933810(C)/7:120981502 WNT16 (0.1, 0.23, P = 8.3e-06, N = 1957) (0.034, 0.13, P = 0.32, N = 859)
rs10954090(T)/7:125529994 intergenic (0.15, 0.013, P = 4e-07, N = 7824) (0.16, 0.0062, P = 0.92, N = 859)
rs17167391(C)/7:133704633 EXOC4 (0.2, 0.17, P = 3.2e-06, N = 1957) (0.039, -0.075, P = 0.54, N = 859)
rs12540186(T)/7:141728622 MGAM (0.19, -0.011, P = 2.4e-05, N = 7824) (0.18, -0.057, P = 0.38, N = 859)
rs12333473(A)/7:144729497* intergenic (0.66, 0.0072, P = 4.6e-05, N = 7824) (0.7, -0.039, P = 0.45, N = 859)
rs4726811(C)/7:146540777* CNTNAP2 (0.22, 0.19, P = 2.9e-06, N = 1957) (0.16, -0.0031, P = 0.96, N = 859)
rs4509197(A)/7:26594653* AC004947.2 (0.36, -0.0075, P = 2.1e-05, N = 7824) (0.27, -0.0094, P = 0.86, N = 859)
rs1524385(T)/7:54084188 intergenic (0.17, 0.021, P = 3.8e-05, N = 7824) (0.38, 0.097, P = 0.056, N = 859)
rs6465597(C)/7:97180908* intergenic (0.069, 0.2, P = 9.2e-07, N = 1957) (0.21, -0.042, P = 0.47, N = 859)
rs13258818(T)/8:121639595* SNTB1 (0.63, 0.0073, P = 3.5e-05, N = 7824) (0.13, -0.11, P = 0.14, N = 859)
rs7819776(A)/8:135465833* intergenic (0.42, -0.0073, P = 2.9e-05, N = 7824) (0.31, -0.014, P = 0.78, N = 859)
rs11784679(T)/8:22831150* RN7SL303P (0.78, -0.012, P = 3.6e-06, N = 7824) (0.95, 0.075, P = 0.49, N = 859)
rs13258708(C)/8:3938103 CSMD1 (0.1, -0.014, P = 3.1e-05, N = 7824) (0.023, 0.18, P = 0.27, N = 859)
rs2445717(T)/8:95245949 intergenic (0.64, -0.0075, P = 2.1e-05, N = 7824) (0.77, 0.02, P = 0.72, N = 859)
rs2680218(T)/9:109998648* intergenic (0.46, -0.0077, P = 1.1e-05, N = 7824) (0.29, -0.012, P = 0.82, N = 859)
rs4978836(A)/9:112338981* intergenic (0.39, 0.009, P = 6.8e-06, N = 7824) (0.31, 0.059, P = 0.25, N = 859)
rs13285974(A)/9:119579217 ASTN2 (0.42, 0.0076, P = 1.7e-05, N = 7824) (0.64, 0.12, P = 0.022, N = 859)
rs10121207(T)/9:119990164* ASTN2 (0.48, 0.0075, P = 3e-05, N = 7824) (0.56, 0.026, P = 0.59, N = 859)
rs6478330(T)/9:120619093 RP11-281A20.1 (0.9, 0.014, P = 3.4e-05, N = 7824) (0.95, 0.034, P = 0.76, N = 859)
rs1928871(C)/9:12350794* intergenic (0.4, 0.0083, P = 2.8e-06, N = 7824) (0.084, -0.12, P = 0.14, N = 859)
rs1929425(T)/9:12367988* intergenic (0.4, 0.0072, P = 3.9e-05, N = 7824) (0.71, -0.066, P = 0.21, N = 859)
rs7029664(T)/9:132048953* RP11-344B5.2 (0.51, 0.0077, P = 9.7e-06, N = 7824) (0.62, 0.034, P = 0.51, N = 859)
rs776783(A)/9:18653316* ADAMTSL1 (0.97, -0.049, P = 1.7e-05, N = 7824) (0.74, -0.061, P = 0.27, N = 859)
rs12550887(G)/9:32344871 intergenic (0.18, -0.14, P = 2.3e-06, N = 1957) (0.19, 0.013, P = 0.83, N = 859)
rs11143935(T)/9:76966194 intergenic (0.33, 0.18, P = 7e-06, N = 1957) (0.18, 0.014, P = 0.83, N = 859)
rs7858706(T)/9:77966690 intergenic (0.5, -0.0077, P = 9.7e-06, N = 7824) (0.14, 0.011, P = 0.87, N = 859)
Results from Univariable Mendelian Randomization of L-Proline & eGFR - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 161 -0.01 (-0.096- 0.075) P=0.81 6.1 48 9.06 (0- 45.8) NA NA 0.0011 P=0.84
MR-Egger 161 -0.015 (-0.11- 0.082) P=0.76 6.1 48 9.06 (0- 45.8) 165 0.35 0.0011 P=0.84
Weighted median 161 0.051 (-0.087- 0.19) P=0.47 6.1 48 9.06 (0- 45.8) NA NA 0.0011 P=0.84
Results from Univariable MRPRESSO of L-Proline & eGFR - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.01 0.04 -0.24 0.81
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of L-Proline & eGFR - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 97 -0.01 (-0.11- 0.093) P=0.85 7.5 36 16.2 (0- 93.7) NA NA 0.0077 P=0.35
MR-Egger 97 -0.04 (-0.16- 0.08) P=0.51 7.5 36 16.2 (0- 93.7) 121 0.04 0.0077 P=0.35
Weighted median 97 0.068 (-0.084- 0.22) P=0.38 7.5 36 16.2 (0- 93.7) NA NA 0.0077 P=0.35
Results from Univariable MRPRESSO of L-Proline & eGFR - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.01 0.05 -0.19 0.85
beta.exposure Outlier-corrected NA NA NA NA

Pyruvic acid

Instruments Associations with Pyruvic acid & eGFR
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region Pyruvic acid (Shin et al/Long et al) eGFR (CSSCD)
rs12124783(T)/1:176891453* ASTN1 (0.25, 0.018, P = 3.5e-05, N = 7824) (0.3, -0.022, P = 0.68, N = 859)
rs764151(A)/1:20746568* LINC01141 (0.083, 0.029, P = 3.7e-05, N = 7824) (0.17, -0.02, P = 0.76, N = 859)
rs4648464(A)/1:3171929 PRDM16 (0.55, -0.016, P = 9.4e-06, N = 7824) (0.13, -0.024, P = 0.74, N = 859)
rs7085088(A)/10:112799928 intergenic (0.2, -0.018, P = 2.7e-05, N = 7824) (0.29, 0.013, P = 0.8, N = 859)
rs1327690(A)/10:6763749 intergenic (0.095, -0.026, P = 2.8e-05, N = 7824) (0.016, -0.34, P = 0.064, N = 859)
rs2488068(T)/10:94506628* intergenic (0.33, 0.018, P = 3.7e-05, N = 7824) (0.38, -0.15, P = 0.0022, N = 859)
rs11216267(T)/11:116952392* SIK3 (0.64, 0.017, P = 1.6e-06, N = 7824) (0.15, -0.0017, P = 0.98, N = 859)
rs7941871(T)/11:13228006 intergenic (0.84, -0.024, P = 1.6e-06, N = 7824) (0.54, -0.042, P = 0.38, N = 859)
rs922762(A)/11:13228375* intergenic (0.34, 0.017, P = 4e-05, N = 7824) (0.34, -0.072, P = 0.16, N = 859)
rs1983255(T)/11:1836032* intergenic (0.4, -0.015, P = 2e-05, N = 7824) (0.6, -0.093, P = 0.056, N = 859)
rs10835174(T)/11:3853473* RHOG (0.65, -0.015, P = 2.1e-05, N = 7824) (0.77, 0.00046, P = 0.99, N = 859)
rs11038739(A)/11:46017895* PHF21A (0.79, -0.02, P = 3e-06, N = 7824) (0.9, 0.064, P = 0.44, N = 859)
rs505621(A)/11:83277927* DLG2 (0.63, -0.014, P = 4.3e-05, N = 7824) (0.87, -0.0015, P = 0.98, N = 859)
rs16946212(T)/12:116200202 RP11-110L15.1 (0.79, -0.018, P = 1.9e-05, N = 7824) (0.8, 0.016, P = 0.79, N = 859)
rs3925033(T)/12:18456713 PIK3C2G (0.46, -0.016, P = 2.6e-06, N = 7824) (0.58, 0.018, P = 0.73, N = 859)
rs10505896(T)/12:23770330* SOX5 (0.88, 0.025, P = 2.3e-05, N = 7824) (0.91, -0.002, P = 0.98, N = 859)
rs12368229(A)/12:40747462* LRRK2 (0.15, 0.02, P = 4.7e-05, N = 7824) (0.08, 0.068, P = 0.44, N = 859)
rs11063657(A)/12:5517590 RP11-1038A11.1 (0.92, -0.028, P = 4.7e-05, N = 7824) (0.98, -0.15, P = 0.35, N = 859)
rs1305261(A)/12:81141819* intergenic (0.98, 0.16, P = 5.9e-06, N = 7824) (0.82, -0.065, P = 0.29, N = 859)
rs9558110(A)/13:104217164* intergenic (0.73, -0.02, P = 4.2e-05, N = 7824) (0.96, -0.054, P = 0.65, N = 859)
rs924483(A)/13:27061003* intergenic (0.092, -0.029, P = 3.3e-06, N = 7824) (0.19, 0.053, P = 0.39, N = 859)
rs868116(T)/13:70512698* KLHL1 (0.37, -0.015, P = 1.4e-05, N = 7824) (0.51, -0.013, P = 0.78, N = 859)
rs912857(T)/14:33657980* NPAS3 (0.54, 0.014, P = 4.7e-05, N = 7824) (0.58, -0.055, P = 0.27, N = 859)
rs8009583(T)/14:84765763 intergenic (0.77, 0.018, P = 1.5e-05, N = 7824) (0.72, 0.044, P = 0.4, N = 859)
rs1437543(A)/15:61468467* RP11-39M21.1 (0.25, 0.018, P = 2.2e-05, N = 7824) (0.42, 0.035, P = 0.49, N = 859)
rs8028830(A)/15:77508046* PEAK1 (0.85, -0.021, P = 2.9e-05, N = 7824) (0.97, 0.1, P = 0.43, N = 859)
rs11259923(A)/15:84535704 ADAMTSL3 (0.81, 0.042, P = 3.9e-06, N = 7824) (0.72, 0.045, P = 0.4, N = 859)
rs2198307(T)/15:87237609* AGBL1 (0.47, -0.014, P = 4.7e-05, N = 7824) (0.87, -0.019, P = 0.79, N = 859)
rs7206138(T)/16:26504692 intergenic (0.64, -0.017, P = 4.5e-05, N = 7824) (0.77, -0.017, P = 0.76, N = 859)
rs2880608(A)/16:6028451* RP11-420N3.2 (0.5, 0.014, P = 4.3e-05, N = 7824) (0.77, -0.074, P = 0.21, N = 859)
rs6503455(T)/17:44140748* KANSL1 (0.4, -0.014, P = 4.4e-05, N = 7824) (0.25, -0.098, P = 0.074, N = 859)
rs4794245(T)/17:49461290* intergenic (0.26, -0.019, P = 1.1e-05, N = 7824) (0.38, -0.048, P = 0.34, N = 859)
rs4790946(T)/17:63366847* intergenic (0.23, 0.036, P = 3.6e-05, N = 7824) (0.16, 0.068, P = 0.3, N = 859)
rs334384(T)/18:7137068* SLC25A51P2 (0.79, -0.018, P = 3.7e-05, N = 7824) (0.85, 0.09, P = 0.18, N = 859)
rs2115100(C)/19:48522894* ELSPBP1 (0.5, 0.015, P = 3.9e-05, N = 7824) (0.69, -0.0079, P = 0.88, N = 859)
rs2445857(T)/19:58708507* ZNF274 (0.089, -0.028, P = 1.5e-05, N = 7824) (0.28, -0.042, P = 0.43, N = 859)
rs10500204(A)/19:7182963* INSR (0.72, 0.017, P = 4.7e-05, N = 7824) (0.8, -0.079, P = 0.18, N = 859)
rs6743415(A)/2:15826092* AC008271.1 (0.49, 0.015, P = 3.9e-05, N = 7824) (0.68, 0.091, P = 0.081, N = 859)
rs780094(T)/2:27741237* GCKR (0.39, 0.015, P = 1.6e-05, N = 7824) (0.17, -0.11, P = 0.083, N = 859)
rs6432031(A)/2:9831131 RP11-521D12.2 (0.11, 0.029, P = 2.9e-05, N = 7824) (0.19, -0.071, P = 0.25, N = 859)
rs6055991(A)/20:8655834* PLCB1 (0.81, -0.021, P = 3.3e-05, N = 7824) (0.94, 0.014, P = 0.9, N = 859)
rs4816172(T)/20:9742096* PAK7 (0.85, -0.026, P = 2.3e-05, N = 7824) (0.92, 0.025, P = 0.78, N = 859)
rs2833657(A)/21:33478113* LINC00159 (0.83, 0.024, P = 3e-06, N = 7824) (0.72, 0.0038, P = 0.94, N = 859)
rs2252264(A)/22:18640203 USP18 (0.94, 0.07, P = 4.4e-05, N = 7824) (0.76, 0.11, P = 0.056, N = 859)
rs7631540(T)/3:113830519* intergenic (0.48, -0.015, P = 2.5e-05, N = 7824) (0.16, -0.021, P = 0.74, N = 859)
rs1133034(T)/3:182640615* ATP11B (0.076, 0.032, P = 3.9e-06, N = 7824) (0.22, 0.069, P = 0.25, N = 859)
rs2880322(T)/4:108991375* LEF1 (0.088, -0.026, P = 3.6e-05, N = 7824) (0.35, 0.03, P = 0.55, N = 859)
rs11131981(T)/4:181186334* intergenic (0.38, -0.02, P = 3.4e-05, N = 7824) (0.2, -0.027, P = 0.65, N = 859)
rs12515830(T)/5:101178314* intergenic (0.87, 0.024, P = 5.8e-06, N = 7824) (0.98, -0.16, P = 0.33, N = 859)
rs6895278(T)/5:147122020* JAKMIP2 (0.34, 0.017, P = 4.1e-06, N = 7824) (0.21, 0.1, P = 0.083, N = 859)
rs2964063(T)/5:173859251* RP11-267A15.1 (0.99, -0.073, P = 2.2e-06, N = 7824) (0.93, 0.027, P = 0.77, N = 859)
rs2925703(A)/5:6286005* HMGB3P3 (0.81, -0.018, P = 3.6e-05, N = 7824) (0.66, 0.075, P = 0.14, N = 859)
rs7715701(C)/5:92717972 intergenic (0.013, -0.15, P = 1.3e-05, N = 7824) (0.48, 0.031, P = 0.53, N = 859)
rs13195863(A)/6:100393761* MCHR2 (0.2, 0.022, P = 4.1e-07, N = 7824) (0.36, 0.05, P = 0.33, N = 859)
rs11753541(A)/6:154126010 intergenic (0.82, 0.039, P = 2.8e-05, N = 7824) (0.97, -0.029, P = 0.83, N = 859)
rs9505008(T)/6:7033860* intergenic (0.59, 0.014, P = 4.2e-05, N = 7824) (0.25, 0.074, P = 0.18, N = 859)
rs1316976(A)/6:73572196* KCNQ5 (0.49, 0.015, P = 3e-05, N = 7824) (0.67, -0.02, P = 0.69, N = 859)
rs2207444(A)/6:99513061 intergenic (0.7, 0.018, P = 2.4e-05, N = 7824) (0.6, 0.032, P = 0.52, N = 859)
rs848853(A)/7:108993043 intergenic (0.07, -0.03, P = 4.8e-05, N = 7824) (0.34, 0.026, P = 0.62, N = 859)
rs6979475(A)/7:24917974 OSBPL3 (0.25, 0.017, P = 4.7e-05, N = 7824) (0.21, -0.06, P = 0.31, N = 859)
rs10237319(T)/7:4073601* SDK1 (0.15, 0.023, P = 9.8e-06, N = 7824) (0.51, -0.094, P = 0.05, N = 859)
rs13247447(A)/7:5698964 RNF216 (0.44, 0.015, P = 2.3e-05, N = 7824) (0.16, 0.015, P = 0.82, N = 859)
rs7813799(C)/8:135396144* intergenic (0.43, -0.015, P = 2.5e-05, N = 7824) (0.38, -0.047, P = 0.34, N = 859)
rs2748410(A)/8:142503676* MROH5 (0.68, -0.032, P = 3.2e-05, N = 7824) (0.62, 0.094, P = 0.062, N = 859)
rs937970(T)/8:22770139 PEBP4 (0.47, 0.017, P = 3.7e-05, N = 7824) (0.6, -0.011, P = 0.82, N = 859)
rs2350463(A)/8:39640851 ADAM2 (0.82, -0.041, P = 2.9e-05, N = 7824) (0.96, -0.33, P = 0.012, N = 859)
rs13283334(A)/9:117531782* intergenic (0.3, -0.018, P = 2.7e-05, N = 7824) (0.088, 0.062, P = 0.45, N = 859)
rs1948080(T)/9:11852043* intergenic (0.62, -0.015, P = 3.3e-05, N = 7824) (0.87, -0.088, P = 0.21, N = 859)
rs2809428(A)/9:129001029* intergenic (0.67, -0.018, P = 1.5e-05, N = 7824) (0.89, -0.037, P = 0.63, N = 859)
rs9406589(T)/9:16222313 C9orf92 (0.88, -0.024, P = 2.6e-05, N = 7824) (0.75, 0.091, P = 0.1, N = 859)
Results from Univariable Mendelian Randomization of Pyruvic acid & eGFR - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 70 -0.12 (-0.55- 0.3) P=0.56 1.3 1.2 5.87 (0- 64) NA NA 0.0024 P=0.83
MR-Egger 70 -0.17 (-0.77- 0.43) P=0.58 1.3 1.2 5.87 (0- 64) 83 0.11 0.0024 P=0.83
Weighted median 70 -0.3 (-0.87- 0.27) P=0.31 1.3 1.2 5.87 (0- 64) NA NA 0.0024 P=0.83
Results from Univariable MRPRESSO of Pyruvic acid & eGFR - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.12 0.22 -0.58 0.56
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of Pyruvic acid & eGFR - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 21 0.095 (-0.48- 0.67) P=0.75 1.7 0.47 12.7 (0- 78.5) NA NA 0.0054 P=0.79
MR-Egger 21 0.015 (-0.82- 0.85) P=0.97 1.7 0.47 12.7 (0- 78.5) 23 0.24 0.0054 P=0.79
Weighted median 21 -0.03 (-0.73- 0.67) P=0.93 1.7 0.47 12.7 (0- 78.5) NA NA 0.0054 P=0.79
Results from Univariable MRPRESSO of Pyruvic acid & eGFR - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0.09 0.29 0.32 0.75
beta.exposure Outlier-corrected NA NA NA NA

Quinolinic acid

Instruments Associations with Quinolinic acid & eGFR
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region Quinolinic acid (Shin et al/Long et al) eGFR (CSSCD)
rs76358452(G)/1:11052159 CFL1P6 (0.027, 0.6, P = 1.1e-06, N = 1925) (0.46, -0.017, P = 0.73, N = 859)
rs557549(C)/10:115138169* intergenic (0.99, 0.21, P = 1.7e-06, N = 1925) (0.64, -0.062, P = 0.23, N = 859)
rs16921251(T)/10:21201598 NEBL (0.012, -0.78, P = 1.8e-07, N = 1925) (0.1, -0.15, P = 0.063, N = 859)
rs35350651(AC)/12:111907431* ATXN2 (0.5, -0.11, P = 2.6e-06, N = 1925) (0.93, 0.026, P = 0.77, N = 859)
rs76795319(C)/12:24821381* intergenic (0.022, -0.62, P = 4e-06, N = 1925) (0.07, 0.12, P = 0.2, N = 859)
rs373374952(CGT)/12:76934267 OSBPL8 (0.023, -0.57, P = 4.9e-06, N = 1925) (0.46, 0.077, P = 0.11, N = 859)
rs12100998(A)/14:74050925 intergenic (0.018, -0.45, P = 7.3e-06, N = 1925) (0.36, 0.058, P = 0.23, N = 859)
rs576870357(CA)/16:9032196 USP7 (0.032, 0.37, P = 3e-06, N = 1925) (0.13, 0.039, P = 0.58, N = 859)
rs62123404(A)/19:23738581 ZNF675 (0.099, -0.31, P = 5.2e-07, N = 1925) (0.013, 0.34, P = 0.11, N = 859)
rs113615666(CT)/2:29375775* CLIP4 (0.34, 0.19, P = 4.2e-06, N = 1925) (0.2, 0.0023, P = 0.97, N = 859)
rs55849091(G)/2:60600972 AC007381.2 (0.14, 0.3, P = 9.7e-08, N = 1925) (0.16, 0.13, P = 0.053, N = 859)
rs13039318(C)/20:3737232 C20orf27 (0.26, -0.22, P = 7.8e-06, N = 1925) (0.49, 0.067, P = 0.15, N = 859)
rs137076(C)/22:42976456 POLDIP3 (0.11, -0.2, P = 8e-06, N = 1925) (0.31, 0.075, P = 0.16, N = 859)
rs5852001(CT)/3:115957699 LSAMP (0.44, -0.1, P = 3.6e-07, N = 1925) (0.49, -0.016, P = 0.74, N = 859)
rs78044678(G)/3:166732391 intergenic (0.023, -0.46, P = 5.2e-06, N = 1925) (0.042, 0.067, P = 0.58, N = 859)
rs6444180(C)/3:186607448* intergenic (0.96, 0.27, P = 6.6e-06, N = 1925) (0.94, -0.19, P = 0.05, N = 859)
rs529207629(AT)/3:189833176 LEPREL1 (0.098, -0.23, P = 5e-06, N = 1925) (0.11, -0.071, P = 0.35, N = 859)
rs140021783(T)/4:158544831 intergenic (0.032, 0.33, P = 7.3e-06, N = 1925) (0.011, -0.45, P = 0.053, N = 859)
rs143827831(G)/4:69556127 intergenic (0.17, -0.22, P = 3.7e-06, N = 1925) (0.04, 0.085, P = 0.49, N = 859)
rs2306447(G)/4:9499419 UNC93B7 (0.88, 0.25, P = 5e-06, N = 1925) (0.57, -0.0013, P = 0.98, N = 859)
rs35391681(C)/5:117845902 CTD-2281M20.1 (0.091, -0.28, P = 4.7e-06, N = 1925) (0.089, -0.082, P = 0.34, N = 859)
rs60689100(T)/5:159718987 CCNJL (0.097, -0.27, P = 2.5e-06, N = 1925) (0.21, 0.12, P = 0.05, N = 859)
rs10940993(G)/5:32020001* PDZD2 (0.63, 0.17, P = 8.2e-06, N = 1925) (0.2, 0.012, P = 0.85, N = 859)
rs34922076(C)/5:40897141 intergenic (0.24, -0.2, P = 2.5e-06, N = 1925) (0.037, 0.17, P = 0.18, N = 859)
rs62427973(A)/6:121904036 RNU2-8P (0.2, -0.17, P = 1.1e-06, N = 1925) (0.03, -0.047, P = 0.74, N = 859)
rs662138(G)/6:160564476* SLC22A1 (0.17, -0.29, P = 5.9e-08, N = 1925) (0.054, -0.099, P = 0.35, N = 859)
rs7761574(C)/6:33843039* LINC01016 (0.26, 0.19, P = 7.5e-06, N = 1925) (0.45, 0.0096, P = 0.84, N = 859)
rs35559950(G)/7:148162915 intergenic (0.24, 0.17, P = 9.7e-06, N = 1925) (0.095, 0.04, P = 0.63, N = 859)
rs35716920(A)/7:89574638 STEAP2-AS1 (0.07, 0.29, P = 5.6e-06, N = 1925) (0.15, -0.11, P = 0.11, N = 859)
rs4472563(C)/8:1893021 ARHGEF10 (0.034, -0.4, P = 9.1e-06, N = 1925) (0.17, -0.015, P = 0.82, N = 859)
rs149173925(G)/8:55718870 RP11-56A10.1 (0.011, -0.69, P = 8.5e-06, N = 1925) (0.07, 0.17, P = 0.076, N = 859)
rs1121220(G)/8:96592156* KB-1047C11.2 (0.41, -0.19, P = 7.3e-08, N = 1925) (0.28, 0.027, P = 0.61, N = 859)
rs2197049(T)/9:10143304 PTPRD (0.14, -0.21, P = 7.6e-06, N = 1925) (0.11, 0.058, P = 0.45, N = 859)
Results from Univariable Mendelian Randomization of Quinolinic acid & eGFR - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 33 -0.074 (-0.15- -4.6e-05) P=0.05 24 40 19.9 (0- 67.1) NA NA -0.017 P=0.54
MR-Egger 33 -0.03 (-0.19- 0.13) P=0.71 24 40 19.9 (0- 67.1) 40 0.13 -0.017 P=0.54
Weighted median 33 -0.094 (-0.2- 0.0089) P=0.073 24 40 19.9 (0- 67.1) NA NA -0.017 P=0.54
Results from Univariable MRPRESSO of Quinolinic acid & eGFR - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.07 0.04 -1.96 0.06
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of Quinolinic acid & eGFR - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 24 -0.063 (-0.15- 0.022) P=0.15 23 29 28.9 (0- 80.5) NA NA -0.026 P=0.49
MR-Egger 24 -0.002 (-0.19- 0.19) P=0.98 23 29 28.9 (0- 80.5) 33 0.06 -0.026 P=0.49
Weighted median 24 -0.082 (-0.19- 0.027) P=0.14 23 29 28.9 (0- 80.5) NA NA -0.026 P=0.49
Results from Univariable MRPRESSO of Quinolinic acid & eGFR - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.06 0.04 -1.45 0.16
beta.exposure Outlier-corrected NA NA NA NA

Salicyluric acid

Instruments Associations with Salicyluric acid & eGFR
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region Salicyluric acid (Shin et al/Long et al) eGFR (CSSCD)
rs2138800(A)/1:102981095* intergenic (0.98, -0.94, P = 1.5e-05, N = 7824) (0.8, 0.03, P = 0.63, N = 859)
rs10886877(T)/10:85425691 intergenic (0.91, -0.17, P = 1.7e-06, N = 7824) (0.97, -0.32, P = 0.034, N = 859)
rs11824477(T)/11:111103318 intergenic (0.58, 0.095, P = 9.6e-06, N = 7824) (0.65, 0.002, P = 0.97, N = 859)
rs2283208(A)/11:2743859* KCNQ1 (0.49, -0.081, P = 4.2e-05, N = 7824) (0.24, 0.034, P = 0.53, N = 859)
rs2126432(A)/11:38205040* intergenic (0.99, -0.46, P = 3.6e-05, N = 7824) (0.77, -0.05, P = 0.38, N = 859)
rs11105725(T)/12:91045724 intergenic (0.3, -0.11, P = 1.7e-05, N = 7824) (0.041, -0.094, P = 0.44, N = 859)
rs9599763(A)/13:35440514 intergenic (0.036, 0.24, P = 1.7e-05, N = 7824) (0.3, -0.047, P = 0.38, N = 859)
rs9534848(T)/13:48431473 intergenic (0.51, -0.23, P = 1.7e-05, N = 7824) (0.15, 0.039, P = 0.56, N = 859)
rs9599057(A)/13:66611146* intergenic (0.91, -0.14, P = 3.8e-05, N = 7824) (0.99, -0.23, P = 0.33, N = 859)
rs1713440(A)/14:20875269* TEP1 (0.34, -0.089, P = 4e-05, N = 7824) (0.76, 0.077, P = 0.15, N = 859)
rs1951656(T)/14:54530629* intergenic (0.99, -0.42, P = 2.2e-06, N = 7824) (0.68, 0.1, P = 0.052, N = 859)
rs6574873(C)/14:86611700 intergenic (0.02, 1.1, P = 1.1e-05, N = 7824) (0.11, 0.016, P = 0.84, N = 859)
rs17114742(C)/15:25058590* intergenic (0.13, 0.12, P = 3.6e-05, N = 7824) (0.26, 0.024, P = 0.66, N = 859)
rs1484976(T)/15:25839363* intergenic (0.98, -0.34, P = 9.5e-06, N = 7824) (0.98, -0.14, P = 0.39, N = 859)
rs7178993(A)/15:25844529* intergenic (0.98, -0.32, P = 1.2e-05, N = 7824) (0.92, 0.011, P = 0.9, N = 859)
rs3093322(C)/16:27445360 IL21R (0.18, -0.14, P = 2e-05, N = 7824) (0.045, -0.1, P = 0.38, N = 859)
rs37058(A)/16:58563199* CNOT1 (0.069, 0.19, P = 5.3e-06, N = 7824) (0.023, 0.011, P = 0.94, N = 859)
rs10420258(T)/19:33602757 GPATCH1 (0.14, 0.11, P = 4.3e-05, N = 7824) (0.1, 0.019, P = 0.81, N = 859)
rs735507(A)/19:58720360* ZNF274 (0.81, -0.11, P = 4.6e-06, N = 7824) (0.82, -0.054, P = 0.39, N = 859)
rs12461352(A)/19:58869180 ZNF497 (0.47, 0.087, P = 2.6e-05, N = 7824) (0.19, -0.018, P = 0.77, N = 859)
rs12982977(A)/19:9043021* MUC16 (0.95, -0.38, P = 1.5e-05, N = 7824) (0.84, -0.027, P = 0.68, N = 859)
rs2293220(T)/2:152728509* CACNB4 (0.014, 0.41, P = 1.5e-05, N = 7824) (0.17, -0.13, P = 0.04, N = 859)
rs219633(A)/21:27868059 CYYR1 (0.12, 0.15, P = 6e-07, N = 7824) (0.47, -0.033, P = 0.5, N = 859)
rs9977045(T)/21:43363686* C2CD2 (0.6, 0.086, P = 3.4e-05, N = 7824) (0.51, 0.037, P = 0.45, N = 859)
rs4858919(T)/3:162362878 intergenic (0.89, -0.13, P = 2.1e-05, N = 7824) (0.97, -0.099, P = 0.5, N = 859)
rs9848396(A)/3:164977695* RP11-85M11.2 (0.23, 0.095, P = 2.8e-05, N = 7824) (0.13, -0.061, P = 0.39, N = 859)
rs3964616(A)/3:181691234 RP11-416O18.1 (0.7, -0.25, P = 3.6e-05, N = 7824) (0.75, -0.012, P = 0.83, N = 859)
rs7663798(A)/4:141715430* intergenic (0.049, 0.2, P = 7.2e-06, N = 7824) (0.068, 0.057, P = 0.55, N = 859)
rs530424(T)/4:176124914* intergenic (0.97, -0.8, P = 2.6e-05, N = 7824) (0.85, -0.13, P = 0.042, N = 859)
rs919028(A)/4:99208331 RAP1GDS1 (0.95, -0.55, P = 8.7e-06, N = 7824) (0.93, -0.052, P = 0.59, N = 859)
rs6895553(T)/5:114821667 CTB-161J7.1 (0.95, -0.2, P = 1.3e-05, N = 7824) (0.62, -0.021, P = 0.67, N = 859)
rs2961632(A)/5:136640875 SPOCK1 (0.39, -0.081, P = 4.3e-05, N = 7824) (0.43, -0.033, P = 0.5, N = 859)
rs17317833(A)/5:67533624* PIK3R1 (0.14, -0.12, P = 1.4e-05, N = 7824) (0.046, -0.048, P = 0.68, N = 859)
rs3800052(T)/6:1773297* GMDS (0.085, 0.17, P = 5.5e-06, N = 7824) (0.019, -0.096, P = 0.59, N = 859)
rs17537088(T)/7:128027749 IMPDH1 (0.85, -0.12, P = 2.2e-05, N = 7824) (0.96, -0.17, P = 0.18, N = 859)
rs10258070(T)/7:15318473* AGMO (0.72, -0.09, P = 1.7e-05, N = 7824) (0.18, -0.072, P = 0.25, N = 859)
rs2470997(A)/7:47432942 TNS3 (0.72, -0.09, P = 1.8e-05, N = 7824) (0.96, 0.06, P = 0.62, N = 859)
rs6944358(T)/7:5814178* RNF216 (0.47, -0.084, P = 1.1e-05, N = 7824) (0.3, 0.023, P = 0.66, N = 859)
rs1179620(T)/7:75252714* HIP1 (0.55, 0.083, P = 1.2e-05, N = 7824) (0.47, 0.045, P = 0.37, N = 859)
rs17682068(A)/8:119398255* SAMD12 (0.92, -0.18, P = 1.5e-07, N = 7824) (0.99, -0.12, P = 0.56, N = 859)
rs7839700(A)/8:127096690 intergenic (0.96, -0.21, P = 2e-05, N = 7824) (0.93, 0.048, P = 0.62, N = 859)
rs2244320(A)/8:18670908 PSD3 (0.95, -0.22, P = 4.6e-05, N = 7824) (0.95, -0.24, P = 0.026, N = 859)
rs7003385(T)/8:41586750 ANK1 (0.66, -0.086, P = 1.5e-05, N = 7824) (0.89, -0.026, P = 0.74, N = 859)
rs7016707(T)/8:41586822 ANK1 (0.099, 0.14, P = 5.8e-06, N = 7824) (0.36, -0.052, P = 0.3, N = 859)
rs7049159(T)/9:91266181 RP13-60M5.2 (0.17, 0.3, P = 4.3e-05, N = 7824) (0.49, 0.016, P = 0.74, N = 859)
rs10993714(A)/9:93613106* SYK (0.98, -0.29, P = 4.3e-05, N = 7824) (0.88, 0.0054, P = 0.94, N = 859)
Results from Univariable Mendelian Randomization of Salicyluric acid & eGFR - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 46 0.013 (-0.044- 0.071) P=0.65 66 38 7.84 (0- 40.6) NA NA 0.0037 P=0.8
MR-Egger 46 0.005 (-0.084- 0.094) P=0.91 66 38 7.84 (0- 40.6) 41 0.62 0.0037 P=0.8
Weighted median 46 0.0079 (-0.084- 0.1) P=0.87 66 38 7.84 (0- 40.6) NA NA 0.0037 P=0.8
Results from Univariable MRPRESSO of Salicyluric acid & eGFR - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0.01 0.03 0.45 0.65
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of Salicyluric acid & eGFR - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 22 0.027 (-0.063- 0.12) P=0.55 82 22 0 (0- 72.4) NA NA 0.006 P=0.78
MR-Egger 22 0.012 (-0.14- 0.16) P=0.88 82 22 0 (0- 72.4) 17 0.64 0.006 P=0.78
Weighted median 22 0.017 (-0.13- 0.16) P=0.82 82 22 0 (0- 72.4) NA NA 0.006 P=0.78
Results from Univariable MRPRESSO of Salicyluric acid & eGFR - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0.03 0.05 0.59 0.56
beta.exposure Outlier-corrected NA NA NA NA

L-Serine

Instruments Associations with L-Serine & eGFR
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region L-Serine (Shin et al/Long et al) eGFR (CSSCD)
rs1163251(T)/1:120209755* PHGDH (0.6, 0.019, P = 7.1e-27, N = 7824) (0.86, 0.026, P = 0.71, N = 859)
rs3790707(T)/1:120264573* PHGDH (0.027, 0.27, P = 6.1e-09, N = 1957) (0.069, -0.048, P = 0.62, N = 859)
rs12144094(C)/1:120264823 PHGDH (0.85, -0.016, P = 1.8e-07, N = 7824) (0.97, 0.046, P = 0.76, N = 859)
rs921516(A)/1:195854637* intergenic (0.51, 0.0079, P = 8.4e-06, N = 7824) (0.32, -0.027, P = 0.61, N = 859)
rs10863629(A)/1:221682419* RP11-103C3.1 (0.74, 0.01, P = 1.8e-05, N = 7824) (0.92, -0.07, P = 0.43, N = 859)
rs454774(T)/1:30923203* intergenic (0.025, -0.047, P = 2.4e-05, N = 7824) (0.28, -0.046, P = 0.41, N = 859)
rs841845(T)/1:43404713* SLC2A1 (0.78, 0.011, P = 9.2e-06, N = 7824) (0.65, -0.018, P = 0.71, N = 859)
rs6576936(A)/1:84191562 RP11-475O6.1 (0.3, 0.016, P = 1.6e-05, N = 7824) (0.3, 0.0092, P = 0.86, N = 859)
rs12784903(A)/10:124956180* intergenic (0.19, 0.011, P = 1.2e-05, N = 7824) (0.03, -0.22, P = 0.12, N = 859)
rs11248451(T)/10:124973893 AC012391.1 (0.2, 0.0099, P = 4.6e-05, N = 7824) (0.036, -0.14, P = 0.3, N = 859)
rs943097(A)/10:13723773 FRMD4A (0.19, 0.01, P = 4.1e-05, N = 7824) (0.028, -0.011, P = 0.94, N = 859)
rs2277251(T)/10:31996242 RP11-472N13.3 (0.46, 0.0079, P = 9.7e-06, N = 7824) (0.5, 0.035, P = 0.47, N = 859)
rs7908297(A)/10:5251702* AKR1C4 (0.11, 0.016, P = 1.6e-06, N = 7824) (0.033, -0.34, P = 0.013, N = 859)
rs11000319(C)/10:53726843 PRKG1 (0.19, -0.23, P = 4.1e-06, N = 1957) (0.11, 0.1, P = 0.17, N = 859)
rs4747042(A)/10:72263690 PALD1 (0.48, -0.0076, P = 1.3e-05, N = 7824) (0.39, 0.037, P = 0.44, N = 859)
rs580333(A)/10:84643651* NRG3 (0.49, 0.0082, P = 1.8e-06, N = 7824) (0.8, 0.084, P = 0.16, N = 859)
rs2632003(A)/11:11338853* GALNT18 (0.95, -0.02, P = 2.7e-05, N = 7824) (0.8, -0.07, P = 0.24, N = 859)
rs450208(T)/11:2931981 SLC22A18 (0.79, 0.01, P = 2.8e-05, N = 7824) (0.85, 0.0037, P = 0.96, N = 859)
rs1874795(A)/11:80729659 intergenic (0.43, -0.0083, P = 2.3e-06, N = 7824) (0.15, 0.024, P = 0.73, N = 859)
rs7114828(T)/11:95717607 MAML2 (0.041, -0.022, P = 4.2e-05, N = 7824) (0.4, -0.06, P = 0.22, N = 859)
rs12369136(A)/12:20576874 PDE3A (0.99, 0.092, P = 2.1e-05, N = 7824) (0.99, -0.18, P = 0.38, N = 859)
rs1042725(T)/12:66358347* HMGA2 (0.5, -0.0085, P = 8e-07, N = 7824) (0.38, -0.038, P = 0.44, N = 859)
rs7305455(C)/12:73599986* RP11-314D7.2 (0.07, 0.018, P = 1.1e-05, N = 7824) (0.26, 0.02, P = 0.71, N = 859)
rs142170634(TATA)/12:94701019 PLXNC1 (0.19, -0.22, P = 3.2e-06, N = 1957) (0.019, 0.016, P = 0.93, N = 859)
rs10478(T)/13:30777202* KATNAL1 (0.54, -0.0071, P = 3.8e-05, N = 7824) (0.88, -0.037, P = 0.62, N = 859)
rs540497(T)/13:80905334 SPRY2 (0.033, -0.041, P = 1.9e-05, N = 7824) (0.35, 0.013, P = 0.8, N = 859)
rs440371(C)/13:89058784 intergenic (0.99, 0.038, P = 2.5e-05, N = 7824) (0.93, -0.049, P = 0.61, N = 859)
rs4773797(T)/13:95136420* DCT (0.55, 0.0072, P = 3.5e-05, N = 7824) (0.29, 0.013, P = 0.81, N = 859)
rs10483419(T)/14:33168063* AKAP6 (0.44, -0.0074, P = 2.1e-05, N = 7824) (0.23, -0.087, P = 0.14, N = 859)
rs12433855(A)/14:49051094 intergenic (0.51, -0.0073, P = 3.3e-05, N = 7824) (0.54, -0.052, P = 0.29, N = 859)
rs268817(A)/14:58029965* SLC35F4 (0.27, 0.01, P = 2e-05, N = 7824) (0.047, 0.2, P = 0.078, N = 859)
rs59356185(A)/15:30985526 ARHGAP11B (0.17, 0.76, P = 3.6e-06, N = 1957) (0.3, -0.042, P = 0.42, N = 859)
rs1457244(A)/15:37783906* RP11-720L8.1 (0.46, 0.0073, P = 2.9e-05, N = 7824) (0.33, -0.0099, P = 0.84, N = 859)
rs1143115(T)/15:93452297* CHD2 (0.53, -0.014, P = 3.5e-05, N = 7824) (0.59, -0.054, P = 0.25, N = 859)
rs1420235(T)/16:49691859 ZNF423 (0.16, -0.013, P = 2.5e-05, N = 7824) (0.051, -0.11, P = 0.29, N = 859)
rs6564181(A)/16:74905905* WDR59 (0.45, 0.0078, P = 8.2e-06, N = 7824) (0.52, 0.0044, P = 0.93, N = 859)
rs10514413(C)/16:77342569 ADAMTS18 (0.024, -0.27, P = 9.9e-06, N = 1957) (0.029, 0.073, P = 0.62, N = 859)
rs2959520(A)/18:19362376 MIB1 (0.98, -0.054, P = 3.7e-05, N = 7824) (0.81, -0.072, P = 0.24, N = 859)
rs4800190(T)/18:22453101* RP11-449D8.5 (0.85, 0.01, P = 4.4e-05, N = 7824) (0.95, -0.036, P = 0.75, N = 859)
rs11659824(T)/18:36729428 intergenic (0.5, 0.0071, P = 3.4e-05, N = 7824) (0.23, 0.0068, P = 0.9, N = 859)
rs1442089(A)/18:51107079* RP11-202D1.2 (0.91, -0.014, P = 1.9e-05, N = 7824) (0.64, 0.028, P = 0.58, N = 859)
rs34734297(A)/18:67283673 DOK6 (0.6, -0.26, P = 2e-06, N = 1957) (0.55, -0.047, P = 0.33, N = 859)
rs10426856(A)/19:33096406* ANKRD27 (0.9, -0.015, P = 4.2e-06, N = 7824) (0.66, 0.058, P = 0.26, N = 859)
rs12621772(T)/2:114913436 intergenic (0.23, 0.012, P = 1.2e-06, N = 7824) (0.55, 0.044, P = 0.36, N = 859)
rs6740983(T)/2:114913608 intergenic (0.78, -0.012, P = 1.2e-06, N = 7824) (0.45, -0.043, P = 0.37, N = 859)
rs6431176(T)/2:127533079 intergenic (0.36, -0.01, P = 8.3e-06, N = 7824) (0.41, -0.011, P = 0.81, N = 859)
rs7573748(T)/2:160701198* LY75-CD302 (0.83, -0.019, P = 2.4e-05, N = 7824) (0.56, -0.074, P = 0.13, N = 859)
rs12992925(A)/2:179860406 CCDC141 (0.58, 0.0084, P = 1.3e-06, N = 7824) (0.21, 0.11, P = 0.052, N = 859)
rs3900115(A)/2:202050677* CASP10 (0.48, 0.0074, P = 1.8e-05, N = 7824) (0.5, 0.023, P = 0.62, N = 859)
rs7579488(T)/2:207995116* KLF7 (0.9, 0.016, P = 3.7e-05, N = 7824) (0.61, -0.035, P = 0.48, N = 859)
rs715(T)/2:211543055* CPS1 (0.71, -0.022, P = 2.7e-21, N = 7824) (0.81, -0.061, P = 0.33, N = 859)
rs1990797(C)/2:211641068* intergenic (0.17, -0.011, P = 3.7e-05, N = 7824) (0.024, -0.12, P = 0.45, N = 859)
rs986294(A)/2:211671984* intergenic (0.24, 0.015, P = 1.7e-09, N = 7824) (0.12, -0.13, P = 0.079, N = 859)
rs4130275(T)/2:211730557* intergenic (0.83, 0.013, P = 8e-07, N = 7824) (0.73, 0.011, P = 0.84, N = 859)
rs13394054(A)/2:211742818* intergenic (0.39, -0.01, P = 1e-05, N = 7824) (0.63, -0.064, P = 0.2, N = 859)
rs4663379(A)/2:235209795 intergenic (0.89, 0.014, P = 7.8e-06, N = 7824) (0.98, -0.12, P = 0.45, N = 859)
rs1111967(T)/2:45443480 LINC01121 (0.77, 0.011, P = 1.6e-05, N = 7824) (0.93, 0.18, P = 0.057, N = 859)
rs11563112(T)/2:52038675* AC007682.1 (0.39, 0.0094, P = 3.7e-05, N = 7824) (0.66, -0.099, P = 0.051, N = 859)
rs1541543(T)/2:59799996 RP11-444A22.1 (0.62, 0.01, P = 1.9e-05, N = 7824) (0.61, -0.089, P = 0.073, N = 859)
rs13033420(T)/2:98758323 VWA3B (0.44, 0.0082, P = 1.9e-06, N = 7824) (0.46, 0.033, P = 0.5, N = 859)
rs390836(A)/20:15057002* MACROD2 (0.42, -0.0074, P = 2.1e-05, N = 7824) (0.25, -0.03, P = 0.58, N = 859)
rs6069057(C)/20:36806809* intergenic (0.87, 0.013, P = 4.3e-05, N = 7824) (0.91, -0.087, P = 0.31, N = 859)
rs4925188(A)/20:60195570* CDH4 (0.74, -0.0099, P = 2.2e-05, N = 7824) (0.24, 0.033, P = 0.55, N = 859)
rs1001972(C)/21:42147762* DSCAM (0.82, 0.011, P = 8.4e-06, N = 7824) (0.88, -0.017, P = 0.82, N = 859)
rs9981086(T)/21:45446328* TRAPPC10 (0.061, -0.22, P = 6.3e-06, N = 1957) (0.24, 0.17, P = 0.0031, N = 859)
rs17760136(A)/22:22380667* PRAMENP (0.18, -0.022, P = 1.5e-05, N = 7824) (0.022, -0.33, P = 0.048, N = 859)
rs5751770(T)/22:24252842* AP000350.5 (0.37, 0.014, P = 4.9e-05, N = 7824) (0.46, -0.04, P = 0.41, N = 859)
rs131460(A)/22:24931490* GUCD1 (0.17, -0.02, P = 1.8e-05, N = 7824) (0.51, -0.0086, P = 0.86, N = 859)
rs3184121(A)/3:124686733 HEG1 (0.21, -0.01, P = 2e-05, N = 7824) (0.2, -0.068, P = 0.26, N = 859)
rs9874508(A)/3:125902417* ALDH1L1 (0.46, -0.0084, P = 1.4e-06, N = 7824) (0.67, 0.048, P = 0.34, N = 859)
rs67138915(C)/3:13907483 WNT7A (0.17, -0.2, P = 1e-05, N = 1957) (0.24, 0.022, P = 0.7, N = 859)
rs11718229(A)/3:148487600* intergenic (0.15, 0.013, P = 2.1e-05, N = 7824) (0.13, 0.16, P = 0.028, N = 859)
rs701120(C)/3:154102004* GPR149 (0.85, 0.01, P = 4.2e-05, N = 7824) (0.81, -0.086, P = 0.16, N = 859)
rs9882567(T)/3:188988930 TPRG1 (0.05, -0.02, P = 1.1e-05, N = 7824) (0.16, 0.032, P = 0.62, N = 859)
rs941348(T)/3:22113690* ZNF385D (0.2, -0.011, P = 7.1e-06, N = 7824) (0.19, -0.086, P = 0.16, N = 859)
rs12715076(A)/3:26002178* intergenic (0.78, -0.01, P = 1.6e-05, N = 7824) (0.85, 0.029, P = 0.67, N = 859)
rs1388509(C)/3:68354402 FAM19A1 (0.075, -0.24, P = 5.7e-07, N = 1957) (0.024, -0.045, P = 0.78, N = 859)
rs11942744(T)/4:12360579* intergenic (0.98, 0.055, P = 4.5e-05, N = 7824) (0.83, -0.051, P = 0.42, N = 859)
rs2320467(A)/4:18179501 intergenic (0.26, 0.01, P = 1.2e-05, N = 7824) (0.08, -0.0073, P = 0.93, N = 859)
rs4241779(A)/4:184600601* TRAPPC11 (0.58, 0.0082, P = 2.8e-06, N = 7824) (0.37, 0.035, P = 0.49, N = 859)
rs16844542(A)/4:3524909 LRPAP1 (0.97, -0.03, P = 2.4e-05, N = 7824) (0.96, -0.012, P = 0.92, N = 859)
rs4865070(A)/4:57093826 KIAA1211 (0.11, -0.21, P = 8.5e-06, N = 1957) (0.24, -0.053, P = 0.35, N = 859)
rs36790(T)/5:109331459 intergenic (0.74, -0.25, P = 1.5e-06, N = 1957) (0.44, 0.036, P = 0.45, N = 859)
rs197442(A)/5:116861349 LINC00992 (0.6, 0.01, P = 7.6e-06, N = 7824) (0.19, -0.093, P = 0.13, N = 859)
rs403636(A)/5:1438354* SLC6A3 (0.15, -0.012, P = 5.9e-06, N = 7824) (0.28, -0.064, P = 0.23, N = 859)
rs10040689(A)/5:149097211 RN7SL868P (0.53, 0.0082, P = 1.8e-06, N = 7824) (0.65, -0.02, P = 0.69, N = 859)
rs342563(A)/5:16187424 RP11-19O2.2 (0.47, -0.01, P = 7.9e-06, N = 7824) (0.56, -0.0027, P = 0.96, N = 859)
rs17658389(T)/5:172205155* RP11-779O18.3 (0.36, -0.015, P = 3.3e-05, N = 7824) (0.18, -2.8e-05, P = 1, N = 859)
rs11953664(T)/5:23696111 intergenic (0.41, -0.007, P = 4.7e-05, N = 7824) (0.44, -0.0018, P = 0.97, N = 859)
rs710998(T)/5:3591916* IRX1 (0.92, 0.014, P = 5e-05, N = 7824) (0.75, 0.033, P = 0.55, N = 859)
rs1645273(T)/5:53383314 ARL15 (0.78, -0.01, P = 2.1e-05, N = 7824) (0.55, 0.089, P = 0.071, N = 859)
rs35107028(A)/5:93051362 FAM172A (0.1, -0.17, P = 5.4e-07, N = 1957) (0.024, 0.14, P = 0.38, N = 859)
rs9373846(A)/6:106778384 ATG5 (0.81, 0.011, P = 8.9e-06, N = 7824) (0.88, 0.15, P = 0.051, N = 859)
rs6933154(T)/6:129141684 intergenic (0.58, 0.0096, P = 2.4e-05, N = 7824) (0.48, 0.1, P = 0.036, N = 859)
rs12663563(C)/6:25339003 LRRC16A (0.047, -0.021, P = 8.2e-06, N = 7824) (0.099, 0.039, P = 0.63, N = 859)
rs2269713(A)/6:31141127* POU5F1 (0.98, 0.032, P = 1.1e-06, N = 7824) (0.82, -0.013, P = 0.84, N = 859)
rs2762343(A)/6:35066091* intergenic (0.51, 0.0083, P = 1.2e-06, N = 7824) (0.78, -0.039, P = 0.5, N = 859)
rs74394751(A)/6:76964078 intergenic (0.079, -0.97, P = 8.4e-06, N = 1957) (0.015, 0.29, P = 0.15, N = 859)
rs9450325(T)/6:86475814* intergenic (0.56, 0.007, P = 4.8e-05, N = 7824) (0.53, -0.044, P = 0.37, N = 859)
rs17154498(A)/7:107468125 intergenic (0.2, -0.011, P = 6.3e-06, N = 7824) (0.12, 0.1, P = 0.18, N = 859)
rs2189725(A)/7:15041873* intergenic (0.46, 0.0073, P = 4e-05, N = 7824) (0.42, -0.12, P = 0.011, N = 859)
rs4726207(T)/7:152496656 ACTR3B (0.63, 0.01, P = 1.5e-05, N = 7824) (0.34, 0.015, P = 0.77, N = 859)
rs6946890(T)/7:154384796* DPP6 (0.53, -0.0075, P = 1.6e-05, N = 7824) (0.71, -0.057, P = 0.28, N = 859)
rs4338001(A)/7:33701080 intergenic (0.042, 0.023, P = 4.9e-05, N = 7824) (0.051, -0.04, P = 0.72, N = 859)
rs4947534(T)/7:56079094* PSPH (0.25, -0.018, P = 2e-14, N = 7824) (0.37, -0.046, P = 0.35, N = 859)
rs4717437(A)/7:67633440* RP5-945F2.3 (0.31, -0.01, P = 3.8e-05, N = 7824) (0.52, -0.036, P = 0.45, N = 859)
rs7779884(A)/7:76949393* GSAP (0.51, 0.0072, P = 3.5e-05, N = 7824) (0.78, 0.034, P = 0.56, N = 859)
rs38971(A)/7:88956699* ZNF804B (0.83, 0.011, P = 1.9e-05, N = 7824) (0.81, 0.013, P = 0.83, N = 859)
rs11982782(A)/7:94063700* COL1A2 (0.082, -0.017, P = 7.9e-06, N = 7824) (0.5, -0.03, P = 0.53, N = 859)
rs17166293(A)/7:94081432 intergenic (0.081, -0.017, P = 1.3e-05, N = 7824) (0.013, -0.19, P = 0.38, N = 859)
rs12334472(G)/8:55452455 intergenic (0.52, 0.38, P = 5.4e-06, N = 1957) (0.35, -0.019, P = 0.7, N = 859)
rs2979710(A)/8:80652442 intergenic (0.88, -0.013, P = 3.4e-05, N = 7824) (0.8, 0.087, P = 0.13, N = 859)
rs10978424(A)/9:108877072 intergenic (0.047, 0.02, P = 2.9e-05, N = 7824) (0.03, -0.016, P = 0.91, N = 859)
rs315711(A)/9:114548451 C9orf84 (0.54, 0.0073, P = 2.7e-05, N = 7824) (0.49, 0.024, P = 0.61, N = 859)
rs7022371(T)/9:114601074* RNU6-1013P (0.5, 0.0086, P = 6.5e-07, N = 7824) (0.71, -0.0059, P = 0.91, N = 859)
rs28465292(T)/9:115708237 intergenic (0.21, -0.27, P = 9e-06, N = 1957) (0.31, -0.045, P = 0.39, N = 859)
rs10283912(T)/9:12285170 RP11-71E22.1 (0.51, -0.0076, P = 1.3e-05, N = 7824) (0.76, 0.11, P = 0.056, N = 859)
rs10812054(A)/9:24495241* intergenic (0.51, -0.0083, P = 2.6e-06, N = 7824) (0.68, -0.021, P = 0.68, N = 859)
rs10972101(T)/9:34417750* FAM219A (0.11, -0.014, P = 6.9e-06, N = 7824) (0.013, 0.44, P = 0.03, N = 859)
rs572099418(GTT)/9:34608298 RPP25L (0.042, -0.19, P = 3.7e-06, N = 1957) (0.038, -0.14, P = 0.26, N = 859)
rs144362640(A)/9:71839441 TJP2 (0.091, 0.25, P = 8.7e-06, N = 1957) (0.04, 0.22, P = 0.073, N = 859)
Results from Univariable Mendelian Randomization of L-Serine & eGFR - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 121 -0.053 (-0.15- 0.046) P=0.29 10 55 0.00115 (0- 96.1) NA NA 0.0065 P=0.31
MR-Egger 121 -0.074 (-0.18- 0.033) P=0.18 10 55 0.00115 (0- 96.1) 138 0.11 0.0065 P=0.31
Weighted median 121 -0.055 (-0.19- 0.078) P=0.42 10 55 0.00115 (0- 96.1) NA NA 0.0065 P=0.31
Results from Univariable MRPRESSO of L-Serine & eGFR - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.05 0.05 -1.05 0.3
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of L-Serine & eGFR - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 59 -0.03 (-0.13- 0.066) P=0.54 20 54 0 (0- 96.7) NA NA 0.0085 P=0.37
MR-Egger 59 -0.053 (-0.16- 0.056) P=0.34 20 54 0 (0- 96.7) 59 0.4 0.0085 P=0.37
Weighted median 59 -0.054 (-0.18- 0.076) P=0.41 20 54 0 (0- 96.7) NA NA 0.0085 P=0.37
Results from Univariable MRPRESSO of L-Serine & eGFR - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.03 0.05 -0.61 0.54
beta.exposure Outlier-corrected NA NA NA NA

Sorbitol

Instruments Associations with Sorbitol & eGFR
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region Sorbitol (Shin et al/Long et al) eGFR (CSSCD)
rs1343274(T)/1:112875033* RP5-965F6.2 (0.95, 0.088, P = 1.6e-05, N = 7824) (0.79, -0.0031, P = 0.96, N = 859)
rs12720497(T)/1:186830420* PLA2G4A (0.29, -0.056, P = 1.7e-05, N = 7824) (0.11, -0.21, P = 0.0088, N = 859)
rs6687118(A)/1:86551785 COL24A1 (0.96, -0.17, P = 2e-05, N = 7824) (0.68, -0.041, P = 0.42, N = 859)
rs6657899(T)/1:86703902* intergenic (0.032, 0.19, P = 8e-06, N = 7824) (0.038, 0.1, P = 0.41, N = 859)
rs6658767(T)/1:94529895* ABCA4 (0.042, 0.095, P = 2.8e-05, N = 7824) (0.014, 0.14, P = 0.49, N = 859)
rs4917405(T)/10:105638232 OBFC1 (0.044, 0.097, P = 6.3e-06, N = 7824) (0.087, 0.15, P = 0.083, N = 859)
rs12269274(A)/10:2724048* intergenic (0.11, -0.059, P = 4.3e-05, N = 7824) (0.059, 0.062, P = 0.56, N = 859)
rs656587(A)/11:128624028* FLI1 (0.3, -0.078, P = 2.9e-05, N = 7824) (0.094, -0.11, P = 0.2, N = 859)
rs1516988(T)/11:35479735 PAMR1 (0.46, -0.037, P = 4.7e-05, N = 7824) (0.31, 0.041, P = 0.45, N = 859)
rs7303378(A)/12:22258068 ST8SIA1 (0.88, 0.062, P = 1.1e-05, N = 7824) (0.98, -0.17, P = 0.33, N = 859)
rs2900501(T)/12:22387507* ST8SIA1 (0.5, -0.04, P = 1.9e-05, N = 7824) (0.51, 0.049, P = 0.31, N = 859)
rs488225(A)/12:3229827 TSPAN9 (0.39, -0.041, P = 4.9e-06, N = 7824) (0.37, -0.041, P = 0.42, N = 859)
rs1570553(A)/13:76281653* RP11-29G8.3 (0.97, -0.19, P = 2.2e-05, N = 7824) (0.79, 0.076, P = 0.21, N = 859)
rs1998053(A)/14:101320034* MEG3 (0.086, 0.072, P = 5.6e-06, N = 7824) (0.011, -0.04, P = 0.86, N = 859)
rs17488344(T)/14:32909977* AKAP6 (0.9, -0.065, P = 1.8e-05, N = 7824) (0.96, 0.12, P = 0.33, N = 859)
rs7178693(A)/15:51394298 TNFAIP8L3 (0.038, 0.096, P = 3.7e-05, N = 7824) (0.037, -0.1, P = 0.42, N = 859)
rs4489954(T)/15:68072075* MAP2K5 (0.3, -0.041, P = 2.3e-05, N = 7824) (0.35, 0.038, P = 0.46, N = 859)
rs1053730(A)/16:1560886 IFT140 (0.74, -0.073, P = 3.1e-05, N = 7824) (0.42, -0.08, P = 0.1, N = 859)
rs7184992(T)/16:27432010* IL21R (0.3, 0.081, P = 1.3e-06, N = 7824) (0.4, -0.035, P = 0.47, N = 859)
rs1862858(A)/16:55320317 RP11-26L20.3 (0.024, 0.12, P = 4.8e-05, N = 7824) (0.15, 0.041, P = 0.54, N = 859)
rs1020065(T)/16:55369954* RP11-26L20.3 (0.021, 0.14, P = 1.2e-05, N = 7824) (0.11, 0.057, P = 0.45, N = 859)
rs2926133(C)/16:64282835* AC012322.1 (0.41, -0.038, P = 1.5e-05, N = 7824) (0.35, 0.047, P = 0.36, N = 859)
rs16967757(T)/16:64636513* RP11-467L24.1 (0.3, 0.05, P = 1.4e-06, N = 7824) (0.27, 0.025, P = 0.64, N = 859)
rs12934440(A)/16:82458443* intergenic (0.17, -0.059, P = 1.2e-05, N = 7824) (0.29, -0.066, P = 0.23, N = 859)
rs7240261(T)/18:5428938* EPB41L3 (0.56, 0.057, P = 7.5e-06, N = 7824) (0.57, -0.053, P = 0.27, N = 859)
rs317914(T)/19:11476599* DKFZP761J1410 (0.01, 0.35, P = 1.2e-05, N = 7824) (0.11, -0.052, P = 0.5, N = 859)
rs6434811(T)/2:196866420* DNAH7 (0.93, -0.079, P = 3.5e-06, N = 7824) (0.28, 0.067, P = 0.2, N = 859)
rs4831124(T)/3:115945873 LSAMP (0.68, 0.041, P = 4.2e-05, N = 7824) (0.48, 0.018, P = 0.72, N = 859)
rs6786557(A)/3:16766989* intergenic (0.02, 0.14, P = 1.9e-05, N = 7824) (0.2, -0.039, P = 0.5, N = 859)
rs1384953(T)/3:176178846 intergenic (0.63, -0.039, P = 4.1e-05, N = 7824) (0.48, 0.007, P = 0.88, N = 859)
rs10017961(A)/4:141000337 MAML3 (0.27, 0.049, P = 5.6e-06, N = 7824) (0.15, 0.038, P = 0.58, N = 859)
rs2365522(A)/4:72776163 intergenic (0.71, 0.044, P = 6.7e-06, N = 7824) (0.75, 0.056, P = 0.32, N = 859)
rs4859463(T)/4:77760785* intergenic (0.15, -0.053, P = 4.5e-05, N = 7824) (0.19, -0.065, P = 0.28, N = 859)
rs2306337(A)/5:141044472* ARAP3 (0.85, -0.056, P = 1.3e-05, N = 7824) (0.88, 0.0035, P = 0.96, N = 859)
rs4867710(T)/5:172845597* CTB-32H22.1 (0.3, 0.04, P = 4.6e-05, N = 7824) (0.1, -0.034, P = 0.67, N = 859)
rs1532331(T)/5:43116830 ZNF131 (0.7, -0.044, P = 1.9e-05, N = 7824) (0.69, 0.058, P = 0.26, N = 859)
rs1864037(A)/5:65590269 RP11-305P14.1 (0.85, 0.056, P = 1e-05, N = 7824) (0.89, 0.053, P = 0.5, N = 859)
rs9344148(T)/6:82018723* intergenic (0.75, 0.043, P = 4.9e-05, N = 7824) (0.95, -0.0069, P = 0.95, N = 859)
rs11487092(A)/7:107693740* LAMB4 (0.012, 0.25, P = 2.9e-06, N = 7824) (0.58, -0.0046, P = 0.92, N = 859)
rs7809511(A)/7:4240975* SDK1 (0.68, -0.041, P = 2.8e-05, N = 7824) (0.5, 0.014, P = 0.78, N = 859)
rs898931(A)/7:46390643* intergenic (0.15, 0.087, P = 2.1e-05, N = 7824) (0.36, -0.053, P = 0.28, N = 859)
rs1529225(T)/7:9322476* intergenic (0.08, -0.11, P = 4.8e-05, N = 7824) (0.22, -0.053, P = 0.37, N = 859)
rs4404993(T)/9:19367826* DENND4C (0.18, 0.096, P = 3.2e-06, N = 7824) (0.038, 0.01, P = 0.93, N = 859)
rs10811658(A)/9:22128600* intergenic (0.26, -0.061, P = 6.2e-06, N = 7824) (0.45, -0.025, P = 0.6, N = 859)
Results from Univariable Mendelian Randomization of Sorbitol & eGFR - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 44 0.0037 (-0.16- 0.17) P=0.97 9.3 5.2 0 (0- 43.9) NA NA 0.0046 P=0.77
MR-Egger 44 -0.032 (-0.33- 0.27) P=0.83 9.3 5.2 0 (0- 43.9) 38 0.65 0.0046 P=0.77
Weighted median 44 -0.029 (-0.29- 0.23) P=0.83 9.3 5.2 0 (0- 43.9) NA NA 0.0046 P=0.77
Results from Univariable MRPRESSO of Sorbitol & eGFR - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0 0.09 0.04 0.97
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of Sorbitol & eGFR - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 14 0.35 (-2.3e-06- 0.7) P=0.05 7.6 1.4 0 (0- 64.2) NA NA -0.0049 P=0.87
MR-Egger 14 0.4 (-0.36- 1.2) P=0.32 7.6 1.4 0 (0- 64.2) 9.8 0.63 -0.0049 P=0.87
Weighted median 14 0.29 (-0.28- 0.85) P=0.32 7.6 1.4 0 (0- 64.2) NA NA -0.0049 P=0.87
Results from Univariable MRPRESSO of Sorbitol & eGFR - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0.35 0.18 1.96 0.07
beta.exposure Outlier-corrected NA NA NA NA

Sucrose

Instruments Associations with Sucrose & eGFR
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region Sucrose (Shin et al/Long et al) eGFR (CSSCD)
rs72860869(G)/1:9404367* SPSB1 (0.073, 1.4, P = 5.1e-07, N = 1439) (0.31, 0.018, P = 0.73, N = 859)
rs72731803(A)/1:96314983* intergenic (0.15, 1.7, P = 7.5e-06, N = 1439) (0.43, 0.03, P = 0.54, N = 859)
rs845088(C)/10:125208693* RP11-282I1.1 (0.79, 0.6, P = 9e-06, N = 1439) (0.97, 0.34, P = 0.018, N = 859)
rs1893360(C)/11:74399526* RN7SKP297 (0.75, 0.72, P = 7.3e-06, N = 1439) (0.94, -0.08, P = 0.44, N = 859)
rs840225(T)/13:107566858* intergenic (0.41, 0.63, P = 8.6e-06, N = 1439) (0.63, -0.099, P = 0.044, N = 859)
rs2765151(A)/13:24497442* intergenic (0.6, 1.4, P = 6.9e-06, N = 1439) (0.18, -0.12, P = 0.058, N = 859)
rs7151852(A)/14:67945022* TMEM229B (0.026, 1.3, P = 2e-06, N = 1439) (0.036, 0.19, P = 0.14, N = 859)
rs472591(G)/18:40483622* RIT2 (0.76, 1.7, P = 6.4e-06, N = 1439) (0.32, 0.056, P = 0.27, N = 859)
rs60172187(T)/18:9734084* RAB31 (0.05, 1.7, P = 1.9e-06, N = 1439) (0.15, 0.039, P = 0.56, N = 859)
rs34700006(G)/2:175149309* intergenic (0.41, 1.7, P = 5.9e-06, N = 1439) (0.23, 0.1, P = 0.085, N = 859)
rs1413421(A)/20:56580881* intergenic (0.37, 1.7, P = 5.2e-06, N = 1439) (0.36, -0.11, P = 0.04, N = 859)
rs4693441(C)/4:83386179* ENOPH1 (0.45, 0.22, P = 4.3e-06, N = 1439) (0.74, 0.064, P = 0.25, N = 859)
rs17085250(A)/6:149610639* RN7SL234P (0.11, -0.19, P = 7.5e-06, N = 1439) (0.14, 0.025, P = 0.71, N = 859)
rs7767685(A)/6:20276539* RP11-239H6.2 (0.27, 1.7, P = 9.9e-06, N = 1439) (0.12, -0.041, P = 0.58, N = 859)
rs4721056(G)/7:12251262* TMEM106B (0.55, 1.7, P = 6.8e-06, N = 1439) (0.71, -0.049, P = 0.36, N = 859)
rs6945187(C)/7:12509538* AC013470.6 (0.49, 1.7, P = 9.9e-06, N = 1439) (0.6, 0.059, P = 0.23, N = 859)
rs1593306(A)/7:131613963* AC009518.4 (0.92, 0.74, P = 2.8e-06, N = 1439) (0.59, 0.011, P = 0.82, N = 859)
rs6944685(T)/7:85356747* intergenic (0.31, 0.59, P = 3.4e-06, N = 1439) (0.34, -0.028, P = 0.59, N = 859)
rs1457777(T)/8:133272817* KCNQ3 (0.52, 1.7, P = 9.6e-06, N = 1439) (0.17, -0.02, P = 0.76, N = 859)
rs4872085(C)/8:23075488* TNFRSF10A (0.43, 1.5, P = 9.9e-06, N = 1439) (0.15, -0.026, P = 0.7, N = 859)
Results from Univariable Mendelian Randomization of Sucrose & eGFR - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 20 -0.00022 (-0.024- 0.024) P=0.99 -1531 1323 24.2 (0- 89.6) NA NA -0.013 P=0.77
MR-Egger 20 0.0086 (-0.054- 0.071) P=0.79 -1531 1323 24.2 (0- 89.6) 30 0.04 -0.013 P=0.77
Weighted median 20 0.014 (-0.014- 0.042) P=0.32 -1531 1323 24.2 (0- 89.6) NA NA -0.013 P=0.77

Results from Univariable MRPRESSO of Sucrose & eGFR - model1

Results from Univariable Mendelian Randomization of Sucrose & eGFR - model2

Results from Univariable MRPRESSO of Sucrose & eGFR - model2

L-Tryptophan

Instruments Associations with L-Tryptophan & eGFR
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region L-Tryptophan (Shin et al/Long et al) eGFR (CSSCD)
rs2798184(T)/1:109096332 intergenic (0.43, -0.0049, P = 6.4e-08, N = 7824) (0.25, 0.0016, P = 0.98, N = 859)
rs2432(T)/1:114631980 SYT6 (0.47, 0.0046, P = 4.3e-07, N = 7824) (0.19, -0.019, P = 0.75, N = 859)
rs148210(T)/1:114749024 RP4-543J13.1 (0.47, -0.0036, P = 4.9e-05, N = 7824) (0.44, -0.024, P = 0.62, N = 859)
rs12021645(T)/1:146716517 CHD1L (0.064, -0.35, P = 5.7e-06, N = 1959) (0.26, -0.012, P = 0.83, N = 859)
rs6426929(A)/1:154750989 KCNN3 (0.46, 0.0039, P = 1.4e-05, N = 7824) (0.52, -0.021, P = 0.65, N = 859)
rs11582932(T)/1:160369372 VANGL2 (0.64, 0.0039, P = 1.7e-05, N = 7824) (0.68, -0.055, P = 0.3, N = 859)
rs2819322(T)/1:162281028* NOS1AP (0.46, -0.0038, P = 3.3e-05, N = 7824) (0.44, -0.035, P = 0.48, N = 859)
rs2071921(T)/1:167825485 ADCY10 (0.59, 0.0037, P = 4.8e-05, N = 7824) (0.54, 0.011, P = 0.82, N = 859)
rs6685230(T)/1:168368154 RP5-968D22.1 (0.4, -0.0042, P = 7.8e-06, N = 7824) (0.083, 0.0072, P = 0.93, N = 859)
rs2977272(T)/1:17536952* PADI1 (0.34, 0.005, P = 5.7e-07, N = 7824) (0.079, -0.028, P = 0.75, N = 859)
rs12564117(T)/1:179625501 TDRD5 (0.6, 0.004, P = 1.1e-05, N = 7824) (0.66, -0.028, P = 0.57, N = 859)
rs16823952(T)/1:185342562 intergenic (0.91, -0.0083, P = 5.1e-06, N = 7824) (0.91, 0.019, P = 0.82, N = 859)
rs1412972(T)/1:190245977 BRINP3 (0.5, 0.0097, P = 1.6e-06, N = 7824) (0.76, 0.079, P = 0.15, N = 859)
rs17336405(T)/1:204875330 NFASC (0.25, -0.16, P = 5.9e-06, N = 1959) (0.1, -0.06, P = 0.46, N = 859)
rs12754274(T)/1:206670827 IKBKE (0.48, -0.0038, P = 2.9e-05, N = 7824) (0.37, 0.098, P = 0.05, N = 859)
rs6667202(A)/1:206957092 intergenic (0.56, 0.0039, P = 2.3e-05, N = 7824) (0.47, -0.03, P = 0.53, N = 859)
rs7552506(C)/1:209969902 IRF6 (0.35, 0.0037, P = 4.7e-05, N = 7824) (0.25, -0.044, P = 0.43, N = 859)
rs3845524(T)/1:215886709 USH2A (0.39, 0.0038, P = 2.3e-05, N = 7824) (0.42, -0.001, P = 0.98, N = 859)
rs10495209(T)/1:223656537 intergenic (0.49, 0.004, P = 8e-06, N = 7824) (0.38, -0.081, P = 0.11, N = 859)
rs881979(C)/1:231435280 intergenic (0.099, 0.0074, P = 2.5e-05, N = 7824) (0.017, -0.29, P = 0.12, N = 859)
rs10927101(A)/1:244173872 RP11-278H7.1 (0.37, -0.0046, P = 2.7e-07, N = 7824) (0.51, 0.017, P = 0.74, N = 859)
rs1704427(T)/1:245566986 KIF26B (0.43, 0.0037, P = 3.9e-05, N = 7824) (0.42, 0.11, P = 0.022, N = 859)
rs10802308(T)/1:246152478* SMYD3 (0.9, 0.0072, P = 3e-05, N = 7824) (0.63, -0.11, P = 0.034, N = 859)
rs502654(T)/1:31061501 intergenic (0.56, -0.0046, P = 2.6e-07, N = 7824) (0.19, -0.036, P = 0.54, N = 859)
rs4073324(T)/1:3797995 DFFB (0.55, -0.004, P = 1.4e-05, N = 7824) (0.47, 0.018, P = 0.71, N = 859)
rs688627(T)/1:44048283* PTPRF (0.59, 0.0042, P = 3.6e-06, N = 7824) (0.29, -0.089, P = 0.093, N = 859)
rs9793263(A)/1:46722389* RAD54L (0.41, 0.0037, P = 4e-05, N = 7824) (0.64, -0.013, P = 0.8, N = 859)
rs4926571(T)/1:53096614* FAM159A (0.52, -0.0048, P = 9e-08, N = 7824) (0.14, 0.016, P = 0.81, N = 859)
rs699856(T)/1:75089136* C1orf173 (0.37, 0.004, P = 8e-06, N = 7824) (0.17, 0.065, P = 0.31, N = 859)
rs11804149(T)/1:77457748 ST6GALNAC5 (0.47, 0.0041, P = 4.6e-06, N = 7824) (0.21, -0.014, P = 0.82, N = 859)
rs7545284(A)/1:8192898 intergenic (0.43, -0.0038, P = 3.5e-05, N = 7824) (0.19, 0.019, P = 0.76, N = 859)
rs2209695(A)/1:82974427 intergenic (0.53, -0.0038, P = 2.2e-05, N = 7824) (0.69, 0.052, P = 0.32, N = 859)
rs11802417(T)/1:84276046 RP11-475O6.1 (0.58, -0.0041, P = 4.5e-06, N = 7824) (0.71, 0.012, P = 0.82, N = 859)
rs17130048(A)/1:88051115 intergenic (0.99, -0.039, P = 4.3e-05, N = 7824) (0.82, 0.033, P = 0.61, N = 859)
rs2813760(A)/1:90569361* intergenic (0.58, 0.0044, P = 1.2e-06, N = 7824) (0.63, -0.0062, P = 0.9, N = 859)
rs284191(A)/1:92236048 TGFBR3 (0.61, -0.006, P = 2e-09, N = 7824) (0.44, -0.074, P = 0.13, N = 859)
rs7909316(A)/10:108518774 SORCS1 (0.14, 0.007, P = 1.9e-05, N = 7824) (0.3, -0.05, P = 0.34, N = 859)
rs11195297(A)/10:112498838 RBM20 (0.43, 0.0039, P = 1.8e-05, N = 7824) (0.46, 0.044, P = 0.39, N = 859)
rs151598(A)/10:115697178 intergenic (0.42, -0.0039, P = 1.1e-05, N = 7824) (0.28, 0.039, P = 0.47, N = 859)
rs2769419(A)/10:117395006 ATRNL1 (0.48, 0.004, P = 6.2e-06, N = 7824) (0.43, 0.043, P = 0.36, N = 859)
rs4611118(A)/10:122395120 intergenic (0.61, -0.0044, P = 9.4e-07, N = 7824) (0.48, 0.0037, P = 0.94, N = 859)
rs4751282(T)/10:129164681 DOCK1 (0.54, 0.0045, P = 7.4e-07, N = 7824) (0.58, -0.042, P = 0.39, N = 859)
rs4880221(C)/10:134729792 TTC40 (0.29, 0.2, P = 9.1e-06, N = 1959) (0.15, 0.058, P = 0.39, N = 859)
rs1879606(T)/10:14272502 FRMD4A (0.38, 0.004, P = 1.7e-05, N = 7824) (0.24, 0.041, P = 0.48, N = 859)
rs2688858(T)/10:14764993 FAM107B (0.57, 0.0043, P = 2.8e-06, N = 7824) (0.82, -0.011, P = 0.87, N = 859)
rs7072433(T)/10:15231980 intergenic (0.43, 0.0039, P = 3.3e-05, N = 7824) (0.39, -0.1, P = 0.043, N = 859)
rs4880888(A)/10:1661627 ADARB2 (0.48, -0.0046, P = 3.2e-07, N = 7824) (0.58, 0.083, P = 0.09, N = 859)
rs17294277(T)/10:1919532 intergenic (0.95, -0.011, P = 1.8e-05, N = 7824) (0.92, 0.013, P = 0.88, N = 859)
rs1409344(A)/10:20290956 PLXDC2 (0.53, 0.0037, P = 4e-05, N = 7824) (0.34, -0.022, P = 0.66, N = 859)
rs11012548(T)/10:21446033 NEBL (0.12, -0.0071, P = 4.2e-05, N = 7824) (0.081, 0.1, P = 0.25, N = 859)
rs2250411(T)/10:24833137 KIAA1217 (0.4, -0.004, P = 1.2e-05, N = 7824) (0.28, 0.083, P = 0.12, N = 859)
rs2367059(A)/10:24864127 intergenic (0.47, -0.0046, P = 4e-07, N = 7824) (0.45, -0.079, P = 0.11, N = 859)
rs2484178(T)/10:27691799 PTCHD3 (0.61, 0.0043, P = 1.7e-06, N = 7824) (0.56, 0.0022, P = 0.96, N = 859)
rs2388594(A)/10:3137445* PFKP (0.38, -0.0037, P = 3.5e-05, N = 7824) (0.43, 0.042, P = 0.41, N = 859)
rs1332772(A)/10:36891028 intergenic (0.39, 0.0037, P = 4.3e-05, N = 7824) (0.29, -0.028, P = 0.62, N = 859)
rs2505644(T)/10:44175098* ZNF32-AS3 (0.56, 0.005, P = 5.7e-07, N = 7824) (0.58, -0.056, P = 0.25, N = 859)
rs6480970(A)/10:54568664 intergenic (0.62, -0.0049, P = 4.3e-08, N = 7824) (0.45, -0.072, P = 0.14, N = 859)
rs11593406(T)/10:58772842* intergenic (0.55, 0.0037, P = 3.6e-05, N = 7824) (0.14, -0.068, P = 0.31, N = 859)
rs10822056(T)/10:64514111* intergenic (0.51, 0.0042, P = 2.7e-06, N = 7824) (0.6, -0.077, P = 0.11, N = 859)
rs938040(T)/10:65738183 RP11-170M17.1 (0.11, 0.0074, P = 9.1e-06, N = 7824) (0.4, 0.033, P = 0.5, N = 859)
rs10822442(A)/10:66844316 intergenic (0.5, 0.0037, P = 3.5e-05, N = 7824) (0.47, -0.036, P = 0.45, N = 859)
rs11201034(A)/10:81745367 RP11-479O17.7 (0.61, 0.0043, P = 1.9e-06, N = 7824) (0.54, -0.048, P = 0.31, N = 859)
rs2488631(A)/10:86349294 intergenic (0.37, 0.0038, P = 2.6e-05, N = 7824) (0.26, -0.015, P = 0.79, N = 859)
rs11256264(C)/10:9621246 intergenic (0.55, 0.0038, P = 1.9e-05, N = 7824) (0.83, 0.077, P = 0.23, N = 859)
rs1145411(T)/11:100246959 intergenic (0.56, -0.0037, P = 3.3e-05, N = 7824) (0.2, -0.046, P = 0.44, N = 859)
rs7120953(T)/11:101452193 TRPC6 (0.46, 0.0038, P = 2.5e-05, N = 7824) (0.3, 0.033, P = 0.53, N = 859)
rs6591150(A)/11:105941758 KBTBD3 (0.1, -0.0076, P = 1.1e-05, N = 7824) (0.27, -0.053, P = 0.32, N = 859)
rs17393784(T)/11:105982171 RP11-677I18.4 (0.89, 0.0073, P = 1.5e-05, N = 7824) (0.96, -0.15, P = 0.23, N = 859)
rs2510595(A)/11:106863491 GUCY1A2 (0.61, -0.0045, P = 5e-07, N = 7824) (0.79, -0.027, P = 0.66, N = 859)
rs2091289(A)/11:112187392 RP11-356J5.12 (0.59, 0.0043, P = 1.5e-06, N = 7824) (0.91, 0.0029, P = 0.97, N = 859)
rs603446(T)/11:116654435* ZNF259 (0.44, 0.0051, P = 1.4e-08, N = 7824) (0.18, -0.11, P = 0.067, N = 859)
rs7127212(T)/11:118953202* HMBS (0.4, 0.0038, P = 2.9e-05, N = 7824) (0.65, 0.055, P = 0.27, N = 859)
rs1946084(A)/11:126626203* KIRREL3 (0.39, -0.0037, P = 4.3e-05, N = 7824) (0.53, 0.057, P = 0.24, N = 859)
rs2970335(A)/11:14325401* RRAS2 (0.4, 0.0044, P = 1e-06, N = 7824) (0.4, 0.0082, P = 0.86, N = 859)
rs7109477(A)/11:21413780* NELL1 (0.46, -0.0047, P = 1.9e-07, N = 7824) (0.81, 0.013, P = 0.83, N = 859)
rs179785(A)/11:2781519 KCNQ1 (0.47, 0.0038, P = 2e-05, N = 7824) (0.66, 0.074, P = 0.16, N = 859)
rs10836364(T)/11:35306345* SLC1A2 (0.61, 0.005, P = 5.7e-07, N = 7824) (0.88, -0.041, P = 0.59, N = 859)
rs4755291(A)/11:44821921 TSPAN18 (0.46, -0.0041, P = 5.3e-06, N = 7824) (0.58, -0.077, P = 0.11, N = 859)
rs7934096(T)/11:5748396 OR52P1P (0.54, -0.0037, P = 4.1e-05, N = 7824) (0.64, 0.067, P = 0.19, N = 859)
rs2178260(T)/11:62069365 SCGB1D4 (0.43, 0.0042, P = 3.6e-06, N = 7824) (0.17, 0.0093, P = 0.88, N = 859)
rs590336(T)/11:73708521 UCP3 (0.51, -0.004, P = 6.5e-06, N = 7824) (0.68, 0.049, P = 0.34, N = 859)
rs1790398(T)/11:73801265 C2CD3 (0.52, 0.0048, P = 5.8e-08, N = 7824) (0.12, 0.069, P = 0.36, N = 859)
rs575257(A)/11:78869070 TENM4 (0.6, -0.0042, P = 3.5e-06, N = 7824) (0.37, -0.04, P = 0.42, N = 859)
rs7946613(A)/11:83789540 DLG2 (0.89, -0.0072, P = 2.1e-05, N = 7824) (0.9, 0.0014, P = 0.99, N = 859)
rs1871053(A)/11:88476191* GRM5 (0.45, -0.0044, P = 7.7e-07, N = 7824) (0.82, 0.074, P = 0.23, N = 859)
rs1349704(A)/11:96777666* intergenic (0.46, 0.0044, P = 8.3e-07, N = 7824) (0.58, -0.022, P = 0.65, N = 859)
rs12278762(T)/11:98781993 intergenic (0.52, 0.0043, P = 1.6e-06, N = 7824) (0.49, -0.073, P = 0.13, N = 859)
rs10750415(T)/11:99750593* CNTN5 (0.4, 0.0042, P = 2.8e-06, N = 7824) (0.4, 0.0026, P = 0.96, N = 859)
rs1861809(A)/12:110245588 TRPV4 (0.49, -0.0039, P = 1.3e-05, N = 7824) (0.23, 0.024, P = 0.68, N = 859)
rs10845331(C)/12:11474657 intergenic (0.59, -0.0038, P = 2.1e-05, N = 7824) (0.92, 0.051, P = 0.54, N = 859)
rs10846667(T)/12:124884424 NCOR2 (0.49, 0.0045, P = 1.7e-06, N = 7824) (0.11, 0.087, P = 0.25, N = 859)
rs3751181(A)/12:125626535* AACS (0.61, 0.0041, P = 5.2e-06, N = 7824) (0.51, 0.07, P = 0.13, N = 859)
rs871818(A)/12:130700729 RP11-143E21.1 (0.65, -0.0038, P = 3.5e-05, N = 7824) (0.75, 0.031, P = 0.59, N = 859)
rs4418881(A)/12:133058066 intergenic (0.65, 0.004, P = 2.5e-05, N = 7824) (0.43, -0.039, P = 0.44, N = 859)
rs725124(T)/12:23853069* SOX5 (0.64, -0.0038, P = 2.7e-05, N = 7824) (0.44, -0.034, P = 0.48, N = 859)
rs7965657(A)/12:27786415 PPFIBP1 (0.63, 0.0037, P = 4.8e-05, N = 7824) (0.76, -0.038, P = 0.52, N = 859)
rs11062520(T)/12:3241104 TSPAN9 (0.15, -0.0067, P = 3.8e-05, N = 7824) (0.079, 0.016, P = 0.86, N = 859)
rs7137875(A)/12:3697839* PRMT8 (0.62, 0.0038, P = 2.4e-05, N = 7824) (0.62, -0.014, P = 0.78, N = 859)
rs10881004(T)/12:47236571* intergenic (0.48, 0.0041, P = 3.4e-06, N = 7824) (0.89, -0.031, P = 0.69, N = 859)
rs17739600(T)/12:53210145 KRT4 (0.48, 0.0038, P = 2.6e-05, N = 7824) (0.24, -0.065, P = 0.23, N = 859)
rs12818321(T)/12:62120103* FAM19A2 (0.099, -0.0075, P = 1.4e-05, N = 7824) (0.038, -0.2, P = 0.1, N = 859)
rs10784496(A)/12:66160971 RPSAP52 (0.54, 0.0045, P = 5.1e-07, N = 7824) (0.23, -0.028, P = 0.63, N = 859)
rs17114354(A)/12:75291946* intergenic (0.99, 0.025, P = 3.5e-06, N = 7824) (0.88, -0.074, P = 0.31, N = 859)
rs9517869(T)/13:100398242 CLYBL (0.37, -0.0046, P = 3.5e-07, N = 7824) (0.15, 0.078, P = 0.26, N = 859)
rs1015795(A)/13:103225700 intergenic (0.51, 0.0043, P = 2.3e-06, N = 7824) (0.18, 0.11, P = 0.09, N = 859)
rs2391128(T)/13:105219349 intergenic (0.48, -0.0045, P = 4.7e-07, N = 7824) (0.14, -0.021, P = 0.76, N = 859)
rs2181766(A)/13:109057109 intergenic (0.35, 0.0037, P = 4e-05, N = 7824) (0.36, 0.077, P = 0.12, N = 859)
rs9511152(A)/13:19596767 PHF2P2 (0.56, -0.005, P = 3e-08, N = 7824) (0.71, -0.087, P = 0.11, N = 859)
rs8000457(T)/13:22871975* intergenic (0.97, 0.03, P = 4.7e-05, N = 7824) (0.85, -0.023, P = 0.73, N = 859)
rs1330918(A)/13:23373129 RPL7AP73 (0.61, 0.0042, P = 2.2e-06, N = 7824) (0.76, -0.012, P = 0.83, N = 859)
rs736081(T)/13:24659726 SPATA13 (0.45, 0.0039, P = 1.7e-05, N = 7824) (0.66, -0.062, P = 0.23, N = 859)
rs1220605(A)/13:24789809 SPATA13 (0.63, -0.0046, P = 9.3e-07, N = 7824) (0.68, 0.016, P = 0.76, N = 859)
rs9579653(T)/13:31344712 intergenic (0.84, 0.0064, P = 3.9e-05, N = 7824) (0.85, -0.028, P = 0.67, N = 859)
rs9541214(T)/13:35112824* RP11-16D22.2 (0.65, -0.0042, P = 3.8e-06, N = 7824) (0.83, 0.049, P = 0.44, N = 859)
rs9315440(A)/13:37293989 intergenic (0.58, 0.0048, P = 6.7e-08, N = 7824) (0.51, -0.016, P = 0.73, N = 859)
rs7318017(T)/13:52410120 intergenic (0.73, -0.0065, P = 1.3e-05, N = 7824) (0.46, 0.0046, P = 0.92, N = 859)
rs9543391(T)/13:74115140 LINC00393 (0.4, 0.0041, P = 6.4e-06, N = 7824) (0.17, 0.035, P = 0.59, N = 859)
rs1948293(A)/13:82401892 intergenic (0.4, -0.0039, P = 1.2e-05, N = 7824) (0.41, 0.027, P = 0.59, N = 859)
rs982568(T)/13:83438876 intergenic (0.43, 0.0037, P = 3.1e-05, N = 7824) (0.37, 0.0052, P = 0.92, N = 859)
rs9556349(A)/13:87690351 intergenic (0.095, 0.0075, P = 1.3e-05, N = 7824) (0.029, 0.12, P = 0.39, N = 859)
rs1335494(A)/13:89060622* intergenic (0.62, -0.0038, P = 2.9e-05, N = 7824) (0.37, -0.013, P = 0.8, N = 859)
rs9523030(T)/13:91262300 intergenic (0.63, 0.0043, P = 5.6e-06, N = 7824) (0.41, 0.0097, P = 0.84, N = 859)
rs885883(T)/14:107274052 IGHVII-78-1 (0.6, -0.0039, P = 1.3e-05, N = 7824) (0.93, 0.0045, P = 0.96, N = 859)
rs12891553(T)/14:20692188 OR11H6 (0.52, -0.0043, P = 2.4e-06, N = 7824) (0.48, -0.013, P = 0.78, N = 859)
rs718433(A)/14:22235890 TRAV6 (0.61, -0.0039, P = 1.5e-05, N = 7824) (0.66, 0.038, P = 0.45, N = 859)
rs8021242(T)/14:22398968* intergenic (0.59, 0.0049, P = 5.2e-08, N = 7824) (0.79, -0.038, P = 0.51, N = 859)
rs1241503(A)/14:25612502 intergenic (0.43, 0.0039, P = 1.7e-05, N = 7824) (0.62, -0.044, P = 0.35, N = 859)
rs3742929(T)/14:33165182 AKAP6 (0.51, -0.0044, P = 1e-06, N = 7824) (0.8, 0.043, P = 0.47, N = 859)
rs10483460(T)/14:36525290* RP11-116N8.1 (0.96, 0.014, P = 1.5e-05, N = 7824) (0.8, -0.028, P = 0.64, N = 859)
rs428185(T)/14:48321936 intergenic (0.59, -0.0045, P = 6.3e-07, N = 7824) (0.32, -0.0099, P = 0.85, N = 859)
rs4479142(T)/14:51530897 TRIM9 (0.6, -0.0037, P = 4.8e-05, N = 7824) (0.67, -0.053, P = 0.29, N = 859)
rs1254598(A)/14:52781195 PTGER2 (0.8, 0.15, P = 3.8e-06, N = 1959) (0.39, -0.022, P = 0.66, N = 859)
rs1254336(T)/14:60918777 C14orf39 (0.065, -0.29, P = 6.6e-06, N = 1959) (0.28, -0.023, P = 0.66, N = 859)
rs8006663(A)/14:69171003* RAD51B (0.46, -0.0046, P = 3e-07, N = 7824) (0.36, 0.12, P = 0.016, N = 859)
rs4899797(T)/14:82360895* RP11-666E17.1 (0.56, -0.0037, P = 3.1e-05, N = 7824) (0.26, -0.02, P = 0.71, N = 859)
rs12893435(A)/14:83311362* intergenic (0.38, 0.0038, P = 2.7e-05, N = 7824) (0.56, 0.025, P = 0.6, N = 859)
rs10151458(A)/14:89876847 FOXN3 (0.13, 0.007, P = 3.3e-05, N = 7824) (0.45, 0.031, P = 0.53, N = 859)
rs2230532(T)/14:97321689* VRK1 (0.35, 0.005, P = 5.7e-07, N = 7824) (0.18, -0.0087, P = 0.89, N = 859)
rs17744500(T)/15:101599246* LRRK1 (0.46, -0.0041, P = 4.2e-06, N = 7824) (0.52, 0.14, P = 0.0069, N = 859)
rs2444964(A)/15:33433259 FMN1 (0.41, -0.0038, P = 1.9e-05, N = 7824) (0.29, 0.0053, P = 0.92, N = 859)
rs837127(T)/15:37244186 MEIS2 (0.43, -0.0038, P = 2.3e-05, N = 7824) (0.56, 0.1, P = 0.039, N = 859)
rs692155(A)/15:41407061* INO80 (0.51, 0.0038, P = 2.6e-05, N = 7824) (0.21, 0.027, P = 0.65, N = 859)
rs645953(A)/15:42394368 intergenic (0.45, 0.0038, P = 2.6e-05, N = 7824) (0.36, 0.037, P = 0.47, N = 859)
rs682359(T)/15:42426833* intergenic (0.58, 0.0044, P = 6.5e-07, N = 7824) (0.86, 0.066, P = 0.34, N = 859)
rs8043246(C)/15:55330699* intergenic (0.16, -0.0071, P = 1.6e-05, N = 7824) (0.13, 0.16, P = 0.025, N = 859)
rs12595508(T)/15:61870977 RP11-507B12.2 (0.45, 0.0038, P = 1.8e-05, N = 7824) (0.86, 0.029, P = 0.69, N = 859)
rs6494862(A)/15:70671669 intergenic (0.53, 0.0039, P = 1.5e-05, N = 7824) (0.61, 0.048, P = 0.33, N = 859)
rs10519267(A)/15:79924714 intergenic (0.029, 0.014, P = 2.5e-05, N = 7824) (0.021, 0.21, P = 0.21, N = 859)
rs1347648(A)/15:80558947 LINC00927 (0.44, -0.0037, P = 2.9e-05, N = 7824) (0.25, 0.11, P = 0.044, N = 859)
rs4843144(A)/15:83584065 HOMER2 (0.47, -0.0037, P = 4.8e-05, N = 7824) (0.83, 0.058, P = 0.36, N = 859)
rs1455775(T)/15:93015278* C15orf32 (0.44, -0.0039, P = 1.2e-05, N = 7824) (0.37, 0.0075, P = 0.88, N = 859)
rs830727(A)/16:12309785* SNX29 (0.43, -0.0038, P = 2.6e-05, N = 7824) (0.84, -0.076, P = 0.25, N = 859)
rs928963(A)/16:13616231 U91319.1 (0.4, 0.0042, P = 3.6e-06, N = 7824) (0.38, 0.15, P = 0.0027, N = 859)
rs7206838(A)/16:17356812* XYLT1 (0.57, 0.0037, P = 4e-05, N = 7824) (0.93, -0.1, P = 0.29, N = 859)
rs7189972(A)/16:19490008 TMC5 (0.043, -0.011, P = 3e-05, N = 7824) (0.18, -0.098, P = 0.12, N = 859)
rs2520117(A)/16:26576299* intergenic (0.45, 0.0045, P = 5.1e-07, N = 7824) (0.55, 0.016, P = 0.74, N = 859)
rs10521275(T)/16:52907039 intergenic (0.47, -0.0042, P = 3.6e-06, N = 7824) (0.49, 0.041, P = 0.39, N = 859)
rs8056052(C)/16:52912738 intergenic (0.6, 0.0042, P = 3.3e-06, N = 7824) (0.57, -0.04, P = 0.42, N = 859)
rs2111118(T)/16:54049153 FTO (0.62, 0.0051, P = 1.2e-08, N = 7824) (0.19, 0.064, P = 0.29, N = 859)
rs8046426(A)/16:7232302 RBFOX1 (0.37, 0.004, P = 8.1e-06, N = 7824) (0.32, -0.018, P = 0.72, N = 859)
rs12919838(C)/16:7533330 RBFOX1 (0.51, 0.0039, P = 1.5e-05, N = 7824) (0.89, -0.095, P = 0.23, N = 859)
rs62059845(G)/16:75430713 CFDP1 (0.34, 0.08, P = 9.4e-06, N = 1959) (0.35, -0.013, P = 0.79, N = 859)
rs6500981(T)/16:7593575* RBFOX1 (0.9, -0.25, P = 3.5e-06, N = 1959) (0.81, 0.032, P = 0.61, N = 859)
rs881562(T)/16:7760884 RBFOX1 (0.5, 0.0044, P = 1.5e-06, N = 7824) (0.74, 0.039, P = 0.5, N = 859)
rs2966079(T)/16:81511806 CMIP (0.54, -0.0042, P = 2.5e-06, N = 7824) (0.67, -0.042, P = 0.41, N = 859)
rs4783276(T)/16:82826944* CDH13 (0.51, 0.0037, P = 4.6e-05, N = 7824) (0.29, 0.019, P = 0.73, N = 859)
rs4783024(T)/16:84624525 COTL1 (0.49, -0.004, P = 2.8e-05, N = 7824) (0.59, -0.026, P = 0.6, N = 859)
rs7198470(T)/16:87061782 intergenic (0.61, 0.004, P = 9e-06, N = 7824) (0.68, 0.046, P = 0.37, N = 859)
rs17698249(A)/16:87319938 RP11-178L8.5 (0.57, -0.0041, P = 5.5e-06, N = 7824) (0.91, -0.071, P = 0.38, N = 859)
rs205021(T)/17:11320392 SHISA6 (0.89, 0.0074, P = 1.5e-05, N = 7824) (0.73, -0.047, P = 0.39, N = 859)
rs11078180(A)/17:13622654* intergenic (0.52, -0.0037, P = 4.7e-05, N = 7824) (0.4, 0.0079, P = 0.87, N = 859)
rs2078340(T)/17:13807276 COX10-AS1 (0.53, 0.0039, P = 2.7e-05, N = 7824) (0.5, -0.029, P = 0.56, N = 859)
rs7217154(T)/17:14168109* intergenic (0.44, -0.0037, P = 4.1e-05, N = 7824) (0.67, 0.033, P = 0.52, N = 859)
rs2386434(G)/17:20470679 COTL1P2 (0.43, 0.18, P = 4.4e-06, N = 1959) (0.52, 0.11, P = 0.026, N = 859)
rs9635769(T)/17:33288363 CCT6B (0.57, 0.0037, P = 4.9e-05, N = 7824) (0.28, 0.081, P = 0.13, N = 859)
rs4790581(T)/17:4066657 ANKFY1 (0.4, -0.0037, P = 3.2e-05, N = 7824) (0.69, 0.0013, P = 0.98, N = 859)
rs17842784(C)/17:41440236 intergenic (0.95, 0.011, P = 1.7e-05, N = 7824) (0.56, 0.012, P = 0.81, N = 859)
rs1825734(T)/17:50332557 intergenic (0.85, 0.0069, P = 4.2e-05, N = 7824) (0.76, -0.037, P = 0.52, N = 859)
rs11654913(A)/17:52369879 intergenic (0.56, -0.004, P = 6.9e-06, N = 7824) (0.5, 0.039, P = 0.43, N = 859)
rs8073123(A)/17:5773900* WSCD1 (0.49, 0.0038, P = 3e-05, N = 7824) (0.37, -0.11, P = 0.023, N = 859)
rs9947364(A)/18:25425442 intergenic (0.64, -0.004, P = 1.2e-05, N = 7824) (0.49, 0.0031, P = 0.95, N = 859)
rs11564346(T)/18:25826962 intergenic (0.51, 0.0037, P = 2.9e-05, N = 7824) (0.5, -0.083, P = 0.092, N = 859)
rs17801274(A)/18:28858921 intergenic (0.044, 0.011, P = 1.5e-05, N = 7824) (0.13, -0.069, P = 0.33, N = 859)
rs1037419(T)/18:31557113 NOL4 (0.58, -0.0039, P = 1.9e-05, N = 7824) (0.73, -0.013, P = 0.81, N = 859)
rs9948912(A)/18:34853641* CELF4 (0.36, 0.004, P = 9.6e-06, N = 7824) (0.29, 0.15, P = 0.0035, N = 859)
rs7230740(A)/18:3636288* DLGAP1 (0.67, 0.0044, P = 1.6e-06, N = 7824) (0.72, 0.12, P = 0.028, N = 859)
rs540343(A)/18:41007699 intergenic (0.62, -0.0037, P = 4.8e-05, N = 7824) (0.83, -0.037, P = 0.56, N = 859)
rs9989564(A)/18:41305359 intergenic (0.51, -0.0042, P = 3.1e-06, N = 7824) (0.34, 0.019, P = 0.7, N = 859)
rs4890592(A)/18:43370963 RP11-618K16.4 (0.63, -0.0038, P = 3.2e-05, N = 7824) (0.77, -0.057, P = 0.32, N = 859)
rs1623892(A)/18:47456441* MYO5B (0.44, 0.0038, P = 2.1e-05, N = 7824) (0.58, -0.017, P = 0.73, N = 859)
rs993927(T)/18:50101294 DCC (0.38, 0.0042, P = 2.6e-06, N = 7824) (0.13, 0.027, P = 0.71, N = 859)
rs9959836(A)/18:50225499* DCC (0.098, -0.0069, P = 4.3e-05, N = 7824) (0.26, 0.043, P = 0.44, N = 859)
rs9950125(A)/18:50548544 DCC (0.45, -0.004, P = 7.7e-06, N = 7824) (0.43, -0.06, P = 0.23, N = 859)
rs2658761(T)/18:54059039* intergenic (0.43, -0.0048, P = 6.7e-08, N = 7824) (0.44, 0.028, P = 0.57, N = 859)
rs8088963(A)/18:59047314* CDH20 (0.64, 0.0044, P = 8.3e-07, N = 7824) (0.63, 0.0095, P = 0.85, N = 859)
rs11152350(A)/18:60240352 ZCCHC2 (0.47, -0.0038, P = 1.9e-05, N = 7824) (0.47, 0.029, P = 0.54, N = 859)
rs860916(A)/18:60665539 intergenic (0.42, -0.0047, P = 1.5e-07, N = 7824) (0.9, 0.1, P = 0.2, N = 859)
rs7505177(T)/18:75220892 RP11-176N18.2 (0.41, -0.0043, P = 5.9e-06, N = 7824) (0.75, -0.00022, P = 1, N = 859)
rs1249489(A)/18:8711942 RP11-674N23.1 (0.37, 0.0042, P = 3.7e-06, N = 7824) (0.68, -0.024, P = 0.65, N = 859)
rs8110890(T)/19:19848485* ZNF14 (0.47, 0.0045, P = 7.5e-07, N = 7824) (0.64, -0.091, P = 0.06, N = 859)
rs7246393(A)/19:23388805 RP11-15H20.2 (0.52, 0.0043, P = 1.6e-06, N = 7824) (0.81, -0.035, P = 0.56, N = 859)
rs1834970(A)/19:28615716 CTD-2043I16.1 (0.43, 0.0037, P = 4e-05, N = 7824) (0.27, 0.055, P = 0.31, N = 859)
rs7251154(A)/19:42305941 CEACAM3 (0.37, -0.0037, P = 4.5e-05, N = 7824) (0.63, 0.051, P = 0.31, N = 859)
rs6509523(T)/19:51767205 SIGLECL1 (0.5, 0.0043, P = 2.5e-06, N = 7824) (0.79, -0.022, P = 0.71, N = 859)
rs875283(A)/19:51767485 SIGLECL1 (0.49, -0.0043, P = 2.3e-06, N = 7824) (0.2, 0.0046, P = 0.94, N = 859)
rs10406056(T)/19:9536418* ZNF266 (0.58, 0.0039, P = 1.6e-05, N = 7824) (0.66, 0.048, P = 0.35, N = 859)
rs13001325(T)/2:102939036 IL1RL1 (0.38, -0.004, P = 7.4e-06, N = 7824) (0.15, 0.033, P = 0.64, N = 859)
rs6729061(A)/2:106182953* intergenic (0.37, 0.004, P = 1.1e-05, N = 7824) (0.6, 0.061, P = 0.22, N = 859)
rs4849291(C)/2:114594099* AC104653.1 (0.61, 0.0041, P = 5.9e-06, N = 7824) (0.12, -0.041, P = 0.58, N = 859)
rs7584842(T)/2:11756260* GREB1 (0.54, -0.005, P = 4.2e-08, N = 7824) (0.43, 0.0034, P = 0.94, N = 859)
rs2580344(T)/2:122047352* TFCP2L1 (0.62, 0.0044, P = 8e-07, N = 7824) (0.53, -0.042, P = 0.38, N = 859)
rs4063769(T)/2:132731387* AJ239322.1 (0.53, -0.0043, P = 1.3e-06, N = 7824) (0.83, 0.02, P = 0.76, N = 859)
rs1316293(A)/2:156659919* intergenic (0.6, -0.0039, P = 1.7e-05, N = 7824) (0.62, 0.036, P = 0.47, N = 859)
rs1534259(T)/2:156911378* intergenic (0.5, 0.0038, P = 2.8e-05, N = 7824) (0.64, 0.033, P = 0.51, N = 859)
rs16843561(T)/2:159875840 TANC1 (0.1, -0.0073, P = 1.7e-05, N = 7824) (0.084, 0.21, P = 0.019, N = 859)
rs4972588(A)/2:174444590 AC013410.1 (0.51, -0.0046, P = 3.7e-07, N = 7824) (0.27, 0.016, P = 0.78, N = 859)
rs577687(A)/2:174451691* intergenic (0.61, -0.0043, P = 2.3e-06, N = 7824) (0.66, -0.013, P = 0.8, N = 859)
rs7570357(A)/2:181079460 intergenic (0.45, -0.0037, P = 4.5e-05, N = 7824) (0.25, 0.033, P = 0.55, N = 859)
rs288354(A)/2:183679421* intergenic (0.59, -0.004, P = 1.1e-05, N = 7824) (0.74, -0.056, P = 0.32, N = 859)
rs10931041(T)/2:183685562 intergenic (0.58, -0.0042, P = 3.4e-06, N = 7824) (0.47, 0.009, P = 0.85, N = 859)
rs7421372(A)/2:1855717* MYT1L (0.48, 0.0037, P = 3.9e-05, N = 7824) (0.7, -0.07, P = 0.19, N = 859)
rs7597815(A)/2:188436536* intergenic (0.58, -0.0038, P = 2.7e-05, N = 7824) (0.8, -0.088, P = 0.13, N = 859)
rs992005(C)/2:199504765 AC019330.1 (0.58, -0.0039, P = 1.5e-05, N = 7824) (0.81, -0.0098, P = 0.87, N = 859)
rs295142(A)/2:201211716 SPATS2L (0.59, -0.0048, P = 1.5e-07, N = 7824) (0.37, -0.03, P = 0.55, N = 859)
rs2349729(A)/2:202521624 MPP4 (0.51, -0.0041, P = 6.4e-06, N = 7824) (0.71, -0.03, P = 0.58, N = 859)
rs6730726(A)/2:205154353 intergenic (0.53, -0.004, P = 7.2e-06, N = 7824) (0.23, 0.034, P = 0.55, N = 859)
rs1453165(A)/2:207813972 CPO (0.46, 0.0038, P = 2.6e-05, N = 7824) (0.63, 0.072, P = 0.16, N = 859)
rs2854717(A)/2:208996761 CRYGC (0.65, -0.0037, P = 4.9e-05, N = 7824) (0.74, 0.064, P = 0.24, N = 859)
rs2286963(T)/2:211060050* ACADL (0.65, 0.0039, P = 1.1e-05, N = 7824) (0.87, 0.0011, P = 0.99, N = 859)
rs6435723(T)/2:213580723* AC079610.1 (0.9, -0.008, P = 6.9e-06, N = 7824) (0.91, 0.067, P = 0.42, N = 859)
rs207938(A)/2:217041881 XRCC5 (0.4, -0.0043, P = 1.3e-06, N = 7824) (0.2, -0.094, P = 0.12, N = 859)
rs1835335(T)/2:218636444 intergenic (0.48, -0.0038, P = 1.8e-05, N = 7824) (0.59, 0.046, P = 0.34, N = 859)
rs6735596(A)/2:228093883* COL4A3 (0.63, -0.0038, P = 3.4e-05, N = 7824) (0.7, -0.001, P = 0.98, N = 859)
rs12468084(T)/2:230596352* intergenic (0.54, -0.0044, P = 1.2e-06, N = 7824) (0.25, -0.034, P = 0.53, N = 859)
rs11678851(T)/2:233825947 NGEF (0.41, 0.0041, P = 5.9e-06, N = 7824) (0.27, -0.022, P = 0.69, N = 859)
rs4663553(A)/2:236100852 intergenic (0.89, 0.0073, P = 1.5e-05, N = 7824) (0.39, 0.012, P = 0.8, N = 859)
rs6736036(T)/2:239834334 intergenic (0.1, -0.22, P = 2.6e-06, N = 1959) (0.26, -0.02, P = 0.71, N = 859)
rs719564(A)/2:242101368 PPP1R7 (0.61, 0.0044, P = 1.3e-06, N = 7824) (0.88, 0.077, P = 0.29, N = 859)
rs6746911(A)/2:2587538* intergenic (0.57, -0.0037, P = 3.7e-05, N = 7824) (0.48, -0.0048, P = 0.92, N = 859)
rs2304681(A)/2:27315252* KHK (0.37, -0.0037, P = 3.7e-05, N = 7824) (0.31, 0.042, P = 0.43, N = 859)
rs1260326(T)/2:27730940* GCKR (0.4, 0.0042, P = 2.7e-06, N = 7824) (0.14, -0.019, P = 0.79, N = 859)
rs829590(T)/2:30623062 intergenic (0.46, -0.0038, P = 1.8e-05, N = 7824) (0.31, -0.021, P = 0.69, N = 859)
rs7594598(A)/2:31026603 CAPN13 (0.43, 0.004, P = 9.5e-06, N = 7824) (0.21, -0.025, P = 0.67, N = 859)
rs7582140(T)/2:3326203 TSSC1 (0.64, 0.0038, P = 3e-05, N = 7824) (0.39, -0.11, P = 0.022, N = 859)
rs1448561(A)/2:33854344 intergenic (0.52, 0.0037, P = 4.1e-05, N = 7824) (0.64, -0.0088, P = 0.87, N = 859)
rs6747650(A)/2:3451507 TRAPPC12 (0.58, -0.0041, P = 4.4e-06, N = 7824) (0.78, 0.045, P = 0.43, N = 859)
rs6708411(T)/2:37718181* intergenic (0.52, -0.0038, P = 1.6e-05, N = 7824) (0.54, 0.023, P = 0.64, N = 859)
rs1371404(A)/2:43040577 intergenic (0.44, 0.0038, P = 2.5e-05, N = 7824) (0.61, 0.062, P = 0.21, N = 859)
rs3936042(T)/2:43107039* intergenic (0.39, 0.0038, P = 2.5e-05, N = 7824) (0.18, 0.045, P = 0.46, N = 859)
rs1530625(T)/2:46658067 TMEM247 (0.46, 0.0038, P = 2.3e-05, N = 7824) (0.42, -0.031, P = 0.53, N = 859)
rs17038105(A)/2:49266747 FSHR (0.98, -0.016, P = 2.2e-05, N = 7824) (0.7, 0.087, P = 0.096, N = 859)
rs4971590(A)/2:52528277* AC007682.1 (0.4, 0.0039, P = 1.6e-05, N = 7824) (0.62, 0.00046, P = 0.99, N = 859)
rs12329050(A)/2:55894428 PNPT1 (0.4, -0.0037, P = 4.6e-05, N = 7824) (0.62, 0.0072, P = 0.88, N = 859)
rs13008096(A)/2:62792689 RSL24D1P2 (0.4, -0.0042, P = 3.3e-06, N = 7824) (0.81, 0.0011, P = 0.99, N = 859)
rs6759991(T)/2:75696816 AC007099.2 (0.86, 0.0076, P = 2.5e-06, N = 7824) (0.59, -0.017, P = 0.72, N = 859)
rs11126537(T)/2:76744940* intergenic (0.55, 0.0036, P = 4.7e-05, N = 7824) (0.33, 0.012, P = 0.82, N = 859)
rs2861078(A)/2:77697995* LRRTM4 (0.54, 0.0038, P = 2.7e-05, N = 7824) (0.63, 0.038, P = 0.45, N = 859)
rs10171387(A)/2:80261406 CTNNA2 (0.91, 0.008, P = 5.1e-06, N = 7824) (0.98, 0.25, P = 0.16, N = 859)
rs3927971(T)/2:8776102 intergenic (0.52, 0.0042, P = 9e-06, N = 7824) (0.42, -0.018, P = 0.71, N = 859)
rs11691641(A)/2:98360443 ZAP70 (0.48, -0.0037, P = 4.1e-05, N = 7824) (0.39, -0.041, P = 0.41, N = 859)
rs6079133(A)/20:1419294 NSFL1C (0.43, 0.0038, P = 2.4e-05, N = 7824) (0.28, -0.044, P = 0.42, N = 859)
rs6074798(A)/20:14761710 MACROD2 (0.5, -0.0037, P = 3.3e-05, N = 7824) (0.22, 0.02, P = 0.73, N = 859)
rs6110544(T)/20:15166775 MACROD2 (0.44, 0.004, P = 7e-06, N = 7824) (0.2, 0.047, P = 0.43, N = 859)
rs2208167(A)/20:20239744 C20orf26 (0.53, 0.0037, P = 3.1e-05, N = 7824) (0.57, 0.0029, P = 0.95, N = 859)
rs6036180(A)/20:22679977 intergenic (0.58, -0.0037, P = 5e-05, N = 7824) (0.89, -0.1, P = 0.2, N = 859)
rs6075944(A)/20:22725941 intergenic (0.21, -0.0062, P = 4.3e-05, N = 7824) (0.22, -0.0025, P = 0.97, N = 859)
rs6130271(T)/20:41612425* PTPRT (0.54, -0.004, P = 7.4e-06, N = 7824) (0.51, -0.038, P = 0.43, N = 859)
rs7262469(A)/20:4184858 intergenic (0.53, 0.0039, P = 2.2e-05, N = 7824) (0.091, 0.048, P = 0.57, N = 859)
rs112259693(A)/20:42794090 JPH2 (0.072, 0.24, P = 5.4e-06, N = 1959) (0.016, -0.17, P = 0.37, N = 859)
rs2425672(A)/20:43526137 YWHAB (0.43, -0.0038, P = 2.6e-05, N = 7824) (0.3, 0.024, P = 0.65, N = 859)
rs459011(A)/20:44364020* intergenic (0.63, 0.0038, P = 3.7e-05, N = 7824) (0.34, 0.019, P = 0.72, N = 859)
rs6104350(A)/20:44423843* DNTTIP1 (0.65, 0.0037, P = 4.6e-05, N = 7824) (0.36, 0.035, P = 0.47, N = 859)
rs8183309(A)/20:49076893 intergenic (0.59, 0.0038, P = 2.7e-05, N = 7824) (0.75, -0.055, P = 0.32, N = 859)
rs4811174(T)/20:50048133 NFATC2 (0.47, -0.0037, P = 4.6e-05, N = 7824) (0.77, -0.045, P = 0.43, N = 859)
rs1276434(T)/20:55479307* intergenic (0.55, 0.0038, P = 2.3e-05, N = 7824) (0.63, -0.016, P = 0.75, N = 859)
rs1418942(A)/20:58164306* PHACTR3 (0.58, -0.004, P = 7.1e-06, N = 7824) (0.85, 0.02, P = 0.76, N = 859)
rs6101058(T)/20:59336158 intergenic (0.063, -0.0096, P = 3.4e-05, N = 7824) (0.14, -0.024, P = 0.72, N = 859)
rs1884639(T)/20:719854* intergenic (0.39, 0.0039, P = 1.7e-05, N = 7824) (0.5, -0.097, P = 0.047, N = 859)
rs6077611(T)/20:9893691 intergenic (0.48, -0.0041, P = 5.3e-06, N = 7824) (0.25, 0.024, P = 0.67, N = 859)
rs1663501(A)/21:28219307* ADAMTS1 (0.46, -0.0047, P = 2.4e-07, N = 7824) (0.57, 0.08, P = 0.098, N = 859)
rs1155158(C)/21:29039413 intergenic (0.5, 0.0037, P = 4.4e-05, N = 7824) (0.35, 0.047, P = 0.35, N = 859)
rs2834164(A)/21:34621948* IFNAR2 (0.5, -0.0045, P = 4.8e-07, N = 7824) (0.55, 0.068, P = 0.16, N = 859)
rs6517254(T)/21:36080290* CLIC6 (0.4, -0.0042, P = 3.1e-06, N = 7824) (0.63, 0.037, P = 0.46, N = 859)
rs460574(T)/21:39986245 ERG (0.43, 0.0038, P = 2.4e-05, N = 7824) (0.29, 0.12, P = 0.033, N = 859)
rs2836842(T)/21:40392537* intergenic (0.57, -0.0038, P = 2.2e-05, N = 7824) (0.44, 0.02, P = 0.68, N = 859)
rs1015993(T)/21:42005288* DSCAM (0.47, 0.0041, P = 7.3e-06, N = 7824) (0.59, 0.034, P = 0.49, N = 859)
rs6586235(A)/21:43174436 RIPK4 (0.46, 0.0043, P = 1.6e-06, N = 7824) (0.42, 0.12, P = 0.012, N = 859)
rs150795(A)/21:43462379* intergenic (0.56, 0.0039, P = 1.5e-05, N = 7824) (0.65, 0.0054, P = 0.91, N = 859)
rs234705(T)/21:44483772* CBS (0.35, 0.004, P = 1.2e-05, N = 7824) (0.24, 0.013, P = 0.81, N = 859)
rs9941787(A)/21:45116042* RRP1B (0.39, -0.0039, P = 2.6e-05, N = 7824) (0.23, 0.014, P = 0.81, N = 859)
rs2838569(C)/21:45898223* MTND5P1 (0.5, -0.0038, P = 2.6e-05, N = 7824) (0.79, -0.021, P = 0.73, N = 859)
rs4819811(A)/22:19609256 intergenic (0.37, 0.0038, P = 3e-05, N = 7824) (0.23, 0.06, P = 0.3, N = 859)
rs6001129(T)/22:22506340* LL22NC03-30E12.10 (0.13, -0.009, P = 6.8e-06, N = 7824) (0.41, -0.047, P = 0.34, N = 859)
rs5997110(T)/22:27036505 ISCA2P1 (0.52, -0.005, P = 5.7e-07, N = 7824) (0.42, -0.021, P = 0.66, N = 859)
rs1884134(A)/22:27831650 intergenic (0.63, 0.0039, P = 1.9e-05, N = 7824) (0.66, -0.093, P = 0.064, N = 859)
rs9613768(T)/22:29402832 ZNRF3 (0.41, 0.0038, P = 1.9e-05, N = 7824) (0.076, -0.15, P = 0.11, N = 859)
rs13056963(T)/22:33622667* LARGE (0.44, 0.0043, P = 5.6e-06, N = 7824) (0.27, -0.12, P = 0.02, N = 859)
rs9610322(A)/22:35980173 intergenic (0.52, -0.0043, P = 1.1e-06, N = 7824) (0.41, 0.064, P = 0.19, N = 859)
rs2144411(A)/22:47478839 TBC1D22A (0.38, -0.0037, P = 3.6e-05, N = 7824) (0.46, 0.08, P = 0.099, N = 859)
rs4824056(A)/22:49928073 C22orf34 (0.82, 0.011, P = 1.8e-05, N = 7824) (0.33, -0.02, P = 0.71, N = 859)
rs7621216(A)/3:112463310 RP11-572C15.5 (0.47, 0.0036, P = 4.8e-05, N = 7824) (0.74, -0.19, P = 3e-04, N = 859)
rs3772343(A)/3:1273716 CNTN6 (0.99, 0.028, P = 3.1e-06, N = 7824) (0.99, -0.25, P = 0.24, N = 859)
rs62284469(T)/3:151185595 intergenic (0.28, 0.13, P = 3.1e-06, N = 1959) (0.15, -0.056, P = 0.4, N = 859)
rs11719675(A)/3:168353685 EGFEM1P (0.4, -0.0041, P = 5.1e-06, N = 7824) (0.5, 0.074, P = 0.12, N = 859)
rs1798231(A)/3:169921441 intergenic (0.42, -0.0038, P = 3.2e-05, N = 7824) (0.35, -0.049, P = 0.32, N = 859)
rs16848052(A)/3:172247863* intergenic (0.016, -0.033, P = 2e-05, N = 7824) (0.11, 0.00058, P = 0.99, N = 859)
rs4129414(T)/3:178385917 KCNMB2 (0.6, -0.0039, P = 1.2e-05, N = 7824) (0.82, -0.016, P = 0.8, N = 859)
rs11720862(T)/3:1838974* intergenic (0.6, -0.0046, P = 3.6e-07, N = 7824) (0.53, -0.015, P = 0.75, N = 859)
rs12497219(T)/3:1861001 intergenic (0.55, -0.0045, P = 5.3e-07, N = 7824) (0.72, -0.00026, P = 1, N = 859)
rs4686980(T)/3:188302851 LPP (0.36, 0.005, P = 5.7e-07, N = 7824) (0.41, 0.016, P = 0.74, N = 859)
rs1013667(A)/3:191089680 CCDC50 (0.61, -0.0041, P = 5.7e-06, N = 7824) (0.31, -0.025, P = 0.63, N = 859)
rs972459(T)/3:191855497 FGF12 (0.58, 0.005, P = 2e-08, N = 7824) (0.91, 0.022, P = 0.79, N = 859)
rs9877345(A)/3:197808975 ANKRD18DP (0.56, -0.0039, P = 1.5e-05, N = 7824) (0.59, 0.0041, P = 0.93, N = 859)
rs1356792(A)/3:20378153* intergenic (0.58, 0.0037, P = 3.8e-05, N = 7824) (0.76, 0.017, P = 0.77, N = 859)
rs4306882(T)/3:21062584* intergenic (0.62, -0.0057, P = 2.5e-10, N = 7824) (0.65, -0.025, P = 0.62, N = 859)
rs116683205(A)/3:22515451 intergenic (0.2, 0.23, P = 6.7e-06, N = 1959) (0.31, -0.033, P = 0.52, N = 859)
rs4356783(C)/3:25004834 AC133680.1 (0.59, -0.0041, P = 6.7e-06, N = 7824) (0.54, -0.034, P = 0.49, N = 859)
rs9842801(C)/3:25047228* AC133680.1 (0.51, 0.0044, P = 7.9e-07, N = 7824) (0.29, 0.017, P = 0.74, N = 859)
rs6786397(A)/3:31721774 OSBPL10 (0.58, -0.0038, P = 2.5e-05, N = 7824) (0.18, 0.011, P = 0.86, N = 859)
rs430727(T)/3:41128564 intergenic (0.46, 0.0041, P = 5.1e-06, N = 7824) (0.36, 0.055, P = 0.29, N = 859)
rs4973952(C)/3:41525357* ULK4 (0.41, -0.0041, P = 6.5e-06, N = 7824) (0.48, 0.019, P = 0.69, N = 859)
rs6807794(T)/3:446221 CHL1 (0.033, 0.39, P = 5.5e-06, N = 1959) (0.32, 0.031, P = 0.55, N = 859)
rs7638383(A)/3:4994341 BHLHE40-AS1 (0.4, 0.0047, P = 1.6e-07, N = 7824) (0.36, -0.083, P = 0.1, N = 859)
rs341973(T)/3:5268162 intergenic (0.49, 0.005, P = 5.7e-07, N = 7824) (0.66, 0.0074, P = 0.88, N = 859)
rs3773729(T)/3:53204845* PRKCD (0.63, 0.004, P = 8.6e-06, N = 7824) (0.3, 0.025, P = 0.64, N = 859)
rs6793158(A)/3:55235233* intergenic (0.47, -0.0039, P = 1.1e-05, N = 7824) (0.27, -0.021, P = 0.68, N = 859)
rs1403699(T)/3:63415109 SYNPR (0.47, -0.0038, P = 1.7e-05, N = 7824) (0.76, 0.073, P = 0.19, N = 859)
rs11706832(A)/3:66502981 LRIG1 (0.52, -0.0038, P = 2e-05, N = 7824) (0.86, 0.021, P = 0.76, N = 859)
rs3864070(T)/3:7691250* GRM7 (0.61, -0.0037, P = 4.1e-05, N = 7824) (0.57, 0.043, P = 0.38, N = 859)
rs4684599(T)/3:8626572 AC034187.2 (0.63, -0.0042, P = 2.9e-06, N = 7824) (0.73, 0.03, P = 0.57, N = 859)
rs7675057(T)/4:104007996 BDH2 (0.81, -0.0064, P = 4.8e-05, N = 7824) (0.68, 0.027, P = 0.6, N = 859)
rs958962(A)/4:109974200 COL25A1 (0.64, 0.0038, P = 2.6e-05, N = 7824) (0.3, 0.049, P = 0.35, N = 859)
rs4989308(A)/4:115289204 intergenic (0.37, -0.0045, P = 8.4e-07, N = 7824) (0.55, 0.039, P = 0.41, N = 859)
rs11729831(T)/4:11735115 RP11-281P23.2 (0.61, 0.004, P = 8.6e-06, N = 7824) (0.39, 0.032, P = 0.51, N = 859)
rs7663985(T)/4:12105392 intergenic (0.38, 0.0038, P = 3e-05, N = 7824) (0.41, 0.032, P = 0.51, N = 859)
rs6858525(A)/4:127425634 intergenic (0.15, 0.014, P = 1.4e-05, N = 7824) (0.13, -0.0025, P = 0.97, N = 859)
rs6534667(C)/4:129066488 LARP1B (0.42, -0.0043, P = 1.5e-06, N = 7824) (0.16, 0.13, P = 0.046, N = 859)
rs4975249(A)/4:129676063 snoU13 (0.62, 0.0039, P = 1.6e-05, N = 7824) (0.32, 0.028, P = 0.6, N = 859)
rs17034862(C)/4:135178352 RP11-400D2.2 (0.52, -0.004, P = 6.9e-06, N = 7824) (0.45, 0.097, P = 0.052, N = 859)
rs6537156(T)/4:139067202* SLC7A11-AS1 (0.45, 0.004, P = 8.1e-06, N = 7824) (0.36, 0.09, P = 0.082, N = 859)
rs1995960(A)/4:142916958 intergenic (0.59, -0.0047, P = 1.6e-07, N = 7824) (0.14, 0.022, P = 0.75, N = 859)
rs1878284(A)/4:153919578 intergenic (0.39, 0.0037, P = 4e-05, N = 7824) (0.69, -0.00083, P = 0.99, N = 859)
rs4691944(T)/4:156753174* ASIC5 (0.9, 0.011, P = 2e-10, N = 7824) (0.97, -0.0081, P = 0.96, N = 859)
rs67803018(T)/4:156769319 ASIC5 (0.072, -0.33, P = 1.3e-06, N = 1959) (0.024, 0.2, P = 0.21, N = 859)
rs13122250(T)/4:156808288* TDO2 (0.55, 0.0062, P = 8.9e-12, N = 7824) (0.2, 0.024, P = 0.69, N = 859)
rs6826247(T)/4:161635568 intergenic (0.51, 0.0048, P = 8.8e-08, N = 7824) (0.36, -0.11, P = 0.025, N = 859)
rs34686132(A)/4:169547663 PALLD (0.54, 0.19, P = 2e-06, N = 1959) (0.25, -0.023, P = 0.68, N = 859)
rs1508513(C)/4:172003439 intergenic (0.64, 0.0042, P = 2.4e-06, N = 7824) (0.36, 0.049, P = 0.34, N = 859)
rs9884164(A)/4:182662819 intergenic (0.098, 0.0077, P = 1.1e-05, N = 7824) (0.13, -0.066, P = 0.36, N = 859)
rs7687160(A)/4:183170004 TENM3 (0.44, 0.0039, P = 2.2e-05, N = 7824) (0.65, 0.025, P = 0.62, N = 859)
rs6841061(A)/4:185999543* RP11-386B13.3 (0.64, 0.0038, P = 2.3e-05, N = 7824) (0.68, 0.073, P = 0.16, N = 859)
rs1519309(T)/4:187015089* intergenic (0.65, -0.0044, P = 1.2e-06, N = 7824) (0.4, -0.00082, P = 0.99, N = 859)
rs12650762(A)/4:188071662 intergenic (0.5, 0.0038, P = 2.1e-05, N = 7824) (0.81, -0.056, P = 0.37, N = 859)
rs937382(T)/4:189971532 intergenic (0.45, -0.0046, P = 2.3e-07, N = 7824) (0.54, 0.053, P = 0.28, N = 859)
rs6819555(A)/4:27342170 intergenic (0.59, -0.0043, P = 3.7e-06, N = 7824) (0.92, -0.054, P = 0.53, N = 859)
rs4355437(A)/4:32728207 intergenic (0.61, 0.0036, P = 4.6e-05, N = 7824) (0.61, -0.047, P = 0.33, N = 859)
rs16990420(T)/4:34855432 intergenic (0.63, 0.0039, P = 1.5e-05, N = 7824) (0.21, -0.054, P = 0.38, N = 859)
rs10517336(T)/4:34920784* intergenic (0.36, 0.0039, P = 1.5e-05, N = 7824) (0.41, -0.054, P = 0.28, N = 859)
rs4695289(A)/4:43965710 intergenic (0.35, -0.0045, P = 7.9e-07, N = 7824) (0.42, 0.082, P = 0.1, N = 859)
rs10007704(T)/4:44276751* KCTD8 (0.64, -0.0044, P = 1.2e-06, N = 7824) (0.59, 0.033, P = 0.5, N = 859)
rs4695138(A)/4:45956180 intergenic (0.54, 0.0052, P = 8e-09, N = 7824) (0.75, 0.003, P = 0.96, N = 859)
rs1512142(A)/4:47004305 GABRB1 (0.44, -0.0038, P = 2.6e-05, N = 7824) (0.45, 0.024, P = 0.62, N = 859)
rs16836288(A)/4:4807203 intergenic (0.044, 0.013, P = 5.6e-06, N = 7824) (0.34, 0.04, P = 0.42, N = 859)
rs6554068(A)/4:54032319 SCFD2 (0.62, 0.0038, P = 2.2e-05, N = 7824) (0.68, 0.052, P = 0.31, N = 859)
rs11729908(T)/4:55221410* RP11-231C18.1 (0.5, 0.0039, P = 1.6e-05, N = 7824) (0.71, -0.044, P = 0.41, N = 859)
rs6824858(A)/4:57439695 THEGL (0.95, -0.013, P = 1e-05, N = 7824) (0.85, -0.0045, P = 0.95, N = 859)
rs12649436(A)/4:59015876 intergenic (0.51, 0.0038, P = 2.7e-05, N = 7824) (0.75, 0.027, P = 0.63, N = 859)
rs13112589(A)/4:8525162 intergenic (0.42, -0.0038, P = 2.7e-05, N = 7824) (0.16, 0.027, P = 0.68, N = 859)
rs12109383(T)/5:105956344 intergenic (0.64, -0.0039, P = 2.1e-05, N = 7824) (0.75, 0.024, P = 0.66, N = 859)
rs1697901(A)/5:11019405* CTNND2 (0.35, 0.0049, P = 6.3e-08, N = 7824) (0.18, -0.026, P = 0.67, N = 859)
rs10900784(A)/5:125514918 RP11-114J13.1 (0.42, -0.0044, P = 9.7e-07, N = 7824) (0.74, 0.017, P = 0.76, N = 859)
rs968355(A)/5:126140350* LMNB1 (0.59, 0.0037, P = 4.1e-05, N = 7824) (0.62, 0.067, P = 0.17, N = 859)
rs10071669(T)/5:126271596* MARCH3 (0.47, -0.004, P = 1e-05, N = 7824) (0.39, -0.04, P = 0.42, N = 859)
rs813165(A)/5:127144681 CTC-228N24.1 (0.61, -0.0039, P = 4e-05, N = 7824) (0.82, -0.095, P = 0.13, N = 859)
rs1422444(C)/5:128114022 SLC27A6 (0.37, 0.0039, P = 1.3e-05, N = 7824) (0.25, 0.022, P = 0.7, N = 859)
rs1434630(T)/5:136557055 SPOCK1 (0.15, 0.0071, P = 1.3e-05, N = 7824) (0.33, 0.016, P = 0.75, N = 859)
rs16903000(T)/5:13995236 intergenic (0.71, -0.0067, P = 7.9e-06, N = 7824) (0.76, 0.011, P = 0.85, N = 859)
rs2569188(A)/5:140008419 CD14 (0.51, 0.0037, P = 3.3e-05, N = 7824) (0.55, 0.016, P = 0.74, N = 859)
rs33980(C)/5:141941993 RPS12P10 (0.91, -0.0077, P = 9.1e-06, N = 7824) (0.68, 0.0051, P = 0.92, N = 859)
rs258763(A)/5:142652361 intergenic (0.56, -0.0042, P = 2.3e-06, N = 7824) (0.34, 0.059, P = 0.24, N = 859)
rs1016522(A)/5:143193326 HMHB1 (0.58, 0.0058, P = 1.6e-10, N = 7824) (0.86, -0.11, P = 0.12, N = 859)
rs161551(T)/5:143270815 intergenic (0.4, 0.0042, P = 2.7e-06, N = 7824) (0.3, 0.0049, P = 0.93, N = 859)
rs1042713(A)/5:148206440 ADRB2 (0.36, 0.0039, P = 1.5e-05, N = 7824) (0.49, 0.044, P = 0.36, N = 859)
rs4958379(A)/5:154010041* intergenic (0.43, -0.005, P = 2.2e-08, N = 7824) (0.32, -0.0063, P = 0.9, N = 859)
rs6873777(T)/5:156488903 HAVCR1 (0.38, -0.0039, P = 1.9e-05, N = 7824) (0.38, 0.027, P = 0.6, N = 859)
rs154246(T)/5:16602451 FAM134B (0.61, -0.0049, P = 6.7e-08, N = 7824) (0.47, -0.0016, P = 0.97, N = 859)
rs1501803(T)/5:166430508 intergenic (0.42, 0.0042, P = 4.6e-06, N = 7824) (0.23, 0.043, P = 0.45, N = 859)
rs1875977(T)/5:168250429* SLIT3 (0.57, 0.0038, P = 2.4e-05, N = 7824) (0.74, 0.092, P = 0.092, N = 859)
rs875184(T)/5:170124362 KCNIP1 (0.4, -0.0041, P = 5.7e-06, N = 7824) (0.18, -0.037, P = 0.54, N = 859)
rs4867633(A)/5:170258093 intergenic (0.41, -0.0036, P = 4.9e-05, N = 7824) (0.59, 0.046, P = 0.35, N = 859)
rs1559063(C)/5:172348594* ERGIC1 (0.62, 0.0052, P = 7.8e-09, N = 7824) (0.78, 0.087, P = 0.14, N = 859)
rs1549225(T)/5:174611949 intergenic (0.61, 0.0045, P = 6.1e-07, N = 7824) (0.36, 0.045, P = 0.38, N = 859)
rs5025649(A)/5:20358539 CDH18 (0.45, 0.0037, P = 4.2e-05, N = 7824) (0.83, -0.054, P = 0.4, N = 859)
rs10942222(T)/5:26970581 CDH9 (0.57, -0.0039, P = 1.5e-05, N = 7824) (0.9, 0.11, P = 0.16, N = 859)
rs2261659(C)/5:413594 AHRR (0.44, -0.0043, P = 1.6e-06, N = 7824) (0.53, 0.026, P = 0.6, N = 859)
rs7706787(T)/5:56336189 intergenic (0.12, 0.017, P = 4.1e-05, N = 7824) (0.34, -0.0039, P = 0.94, N = 859)
rs10805503(T)/5:57390158 intergenic (0.63, 0.0043, P = 2e-06, N = 7824) (0.4, 0.013, P = 0.78, N = 859)
rs347661(T)/5:62549141* intergenic (0.44, -0.0042, P = 6.8e-06, N = 7824) (0.31, 0.019, P = 0.72, N = 859)
rs4615256(A)/5:62700867 intergenic (0.53, 0.0049, P = 5e-08, N = 7824) (0.74, -0.045, P = 0.42, N = 859)
rs7730404(T)/5:72242733* intergenic (0.86, -0.012, P = 3.7e-05, N = 7824) (0.93, -0.2, P = 0.037, N = 859)
rs6862529(T)/5:75551209* SV2C (0.46, 0.0037, P = 4.4e-05, N = 7824) (0.41, 0.051, P = 0.29, N = 859)
rs3797435(A)/5:75953678 IQGAP2 (0.47, 0.0037, P = 4.1e-05, N = 7824) (0.58, -0.046, P = 0.35, N = 859)
rs353957(T)/5:77113027 TBCA (0.44, -0.0036, P = 4.6e-05, N = 7824) (0.39, 0.027, P = 0.59, N = 859)
rs1373962(T)/5:83527862 EDIL3 (0.6, 0.005, P = 2.7e-08, N = 7824) (0.72, 0.041, P = 0.45, N = 859)
rs3822782(T)/5:9245629 SEMA5A (0.43, 0.0039, P = 1.4e-05, N = 7824) (0.24, 0.0031, P = 0.96, N = 859)
rs2662269(A)/5:98076517 intergenic (0.42, 0.0045, P = 7.1e-07, N = 7824) (0.38, 0.039, P = 0.44, N = 859)
rs970079(A)/5:98119864 RGMB (0.49, -0.0041, P = 4.8e-06, N = 7824) (0.14, 0.069, P = 0.32, N = 859)
rs1876564(T)/6:106292430 intergenic (0.57, 0.0037, P = 4.6e-05, N = 7824) (0.31, 0.053, P = 0.31, N = 859)
rs2126498(T)/6:110336225 intergenic (0.62, -0.0042, P = 2.8e-06, N = 7824) (0.48, 0.0085, P = 0.86, N = 859)
rs6901004(C)/6:111554822* RP11-428F8.2 (0.57, -0.0061, P = 1.1e-11, N = 7824) (0.44, -0.042, P = 0.38, N = 859)
rs12203093(T)/6:111585382* KIAA1919 (0.86, -0.0075, P = 3.9e-06, N = 7824) (0.98, 0.094, P = 0.56, N = 859)
rs1535353(T)/6:123925257* TRDN (0.85, 0.007, P = 1.4e-05, N = 7824) (0.68, -0.086, P = 0.1, N = 859)
rs6935961(A)/6:125636350* intergenic (0.56, -0.0056, P = 3.8e-10, N = 7824) (0.23, -0.031, P = 0.59, N = 859)
rs4374833(T)/6:129169353 intergenic (0.45, 0.0037, P = 3.7e-05, N = 7824) (0.62, -0.066, P = 0.2, N = 859)
rs9482945(A)/6:129170987 intergenic (0.55, -0.0037, P = 3.7e-05, N = 7824) (0.31, 0.02, P = 0.71, N = 859)
rs11154507(A)/6:130144867* RP11-174C7.3 (0.51, 0.0039, P = 4e-05, N = 7824) (0.79, 0.046, P = 0.43, N = 859)
rs9483215(G)/6:131415664 intergenic (0.54, 0.11, P = 1.9e-06, N = 1959) (0.78, 0.031, P = 0.59, N = 859)
rs9476538(A)/6:14349707 intergenic (0.47, 0.0039, P = 2.8e-05, N = 7824) (0.49, -0.012, P = 0.81, N = 859)
rs2473156(A)/6:144660881 UTRN (0.6, -0.004, P = 1.1e-05, N = 7824) (0.92, 0.1, P = 0.25, N = 859)
rs4870304(A)/6:154991843 intergenic (0.58, 0.0041, P = 8.3e-06, N = 7824) (0.39, 0.014, P = 0.77, N = 859)
rs13197644(A)/6:159122879 SYTL3 (0.47, -0.0037, P = 5e-05, N = 7824) (0.54, 0.029, P = 0.56, N = 859)
rs17620480(T)/6:16035382 intergenic (0.46, -0.0037, P = 3.9e-05, N = 7824) (0.57, 0.042, P = 0.38, N = 859)
rs623897(A)/6:16769798 RP1-151F17.2 (0.36, -0.004, P = 1.5e-05, N = 7824) (0.2, 0.02, P = 0.73, N = 859)
rs806971(G)/6:26144791* intergenic (0.013, -0.93, P = 1.8e-06, N = 1959) (0.33, 0.011, P = 0.84, N = 859)
rs10807322(A)/6:45542617* RP1-166H4.2 (0.59, 0.0043, P = 2e-06, N = 7824) (0.39, 0.026, P = 0.61, N = 859)
rs9464137(A)/6:54669826 intergenic (0.56, 0.0041, P = 4.4e-06, N = 7824) (0.5, -0.0016, P = 0.97, N = 859)
rs508920(A)/6:69574261 BAI3 (0.52, -0.0038, P = 2e-05, N = 7824) (0.23, 0.053, P = 0.34, N = 859)
rs9346328(T)/6:70382139* LMBRD1 (0.41, -0.0038, P = 2.8e-05, N = 7824) (0.23, 0.0093, P = 0.87, N = 859)
rs2063601(A)/6:78578306* MEI4 (0.25, -0.011, P = 5.2e-06, N = 7824) (0.063, -0.31, P = 0.0023, N = 859)
rs6454864(T)/6:92234894* MIR4643 (0.37, 0.004, P = 8.9e-06, N = 7824) (0.29, 0.086, P = 0.1, N = 859)
rs201262(T)/6:9987615* OFCC1 (0.56, 0.0047, P = 1.4e-07, N = 7824) (0.59, 0.085, P = 0.085, N = 859)
rs42162(T)/7:106475927 intergenic (0.55, 0.004, P = 8.2e-06, N = 7824) (0.76, 0.042, P = 0.46, N = 859)
rs40903(A)/7:108173891 PNPLA8 (0.62, -0.0039, P = 1.8e-05, N = 7824) (0.79, 0.034, P = 0.56, N = 859)
rs13228748(T)/7:109785262 intergenic (0.35, 0.004, P = 1.3e-05, N = 7824) (0.098, -0.053, P = 0.52, N = 859)
rs2709480(T)/7:114694662* intergenic (0.63, 0.0037, P = 3.8e-05, N = 7824) (0.46, -0.096, P = 0.046, N = 859)
rs10261671(T)/7:120783551* CPED1 (0.38, -0.0037, P = 3.8e-05, N = 7824) (0.35, 0.027, P = 0.59, N = 859)
rs10225863(T)/7:131910303* PLXNA4 (0.39, -0.004, P = 9.8e-06, N = 7824) (0.57, 0.043, P = 0.37, N = 859)
rs6946136(A)/7:135423424 FAM180A (0.61, 0.0037, P = 4e-05, N = 7824) (0.89, -0.032, P = 0.69, N = 859)
rs38271(A)/7:14307031 DGKB (0.59, -0.0051, P = 1.2e-08, N = 7824) (0.18, -0.013, P = 0.84, N = 859)
rs4725832(T)/7:149543751 ZNF862 (0.59, 0.0038, P = 3.1e-05, N = 7824) (0.29, 0.087, P = 0.11, N = 859)
rs11760861(G)/7:155938607 intergenic (0.19, 0.23, P = 6.4e-06, N = 1959) (0.37, 0.032, P = 0.52, N = 859)
rs1000137(T)/7:157644152* PTPRN2 (0.47, -0.005, P = 5.7e-07, N = 7824) (0.59, 0.025, P = 0.61, N = 859)
rs12533939(A)/7:158450965 NCAPG2 (0.39, 0.0045, P = 6.5e-07, N = 7824) (0.58, 0.033, P = 0.49, N = 859)
rs12531256(T)/7:17281820 intergenic (0.5, 0.0037, P = 3.6e-05, N = 7824) (0.26, -0.039, P = 0.48, N = 859)
rs3800908(T)/7:2159437 MAD1L1 (0.42, -0.0081, P = 4.2e-05, N = 7824) (0.57, 0.033, P = 0.48, N = 859)
rs2722380(A)/7:24376142 intergenic (0.59, 0.0042, P = 3.9e-06, N = 7824) (0.45, -0.031, P = 0.53, N = 859)
rs4720151(A)/7:34160523* BMPER (0.6, 0.0039, P = 1.7e-05, N = 7824) (0.75, -0.085, P = 0.12, N = 859)
rs2109365(C)/7:38303120 TRGC1 (0.33, 0.16, P = 6.4e-06, N = 1959) (0.57, 9.9e-05, P = 1, N = 859)
rs11535192(C)/7:39324349* POU6F2 (0.39, -0.0039, P = 1.4e-05, N = 7824) (0.36, 0.048, P = 0.35, N = 859)
rs12702179(T)/7:45913913 intergenic (0.5, 0.0038, P = 2.1e-05, N = 7824) (0.41, 0.044, P = 0.39, N = 859)
rs1997238(A)/7:48538770 ABCA13 (0.51, 0.0045, P = 6.1e-07, N = 7824) (0.91, 0.097, P = 0.23, N = 859)
rs10239854(A)/7:55714282* TUBBP6 (0.46, -0.0039, P = 1.4e-05, N = 7824) (0.3, -0.11, P = 0.033, N = 859)
rs6947698(C)/7:55954993* MRPS17 (0.46, -0.004, P = 8.3e-06, N = 7824) (0.4, 0.1, P = 0.037, N = 859)
rs3843530(T)/7:64732388 AC092685.1 (0.06, -0.0099, P = 5e-05, N = 7824) (0.1, 0.076, P = 0.35, N = 859)
rs10256726(T)/7:70547132 intergenic (0.5, -0.0039, P = 1.8e-05, N = 7824) (0.48, -0.016, P = 0.74, N = 859)
rs2158735(C)/7:70601065 WBSCR17 (0.51, 0.0038, P = 2.8e-05, N = 7824) (0.41, 0.038, P = 0.43, N = 859)
rs1179636(A)/7:75230392 HIP1 (0.54, -0.0045, P = 1.8e-06, N = 7824) (0.89, 0.045, P = 0.55, N = 859)
rs10247586(T)/7:7980650 RPA3-AS1 (0.41, 0.0039, P = 1.5e-05, N = 7824) (0.5, -0.039, P = 0.42, N = 859)
rs7810390(A)/7:82662097 PCLO (0.59, -0.0045, P = 5.6e-07, N = 7824) (0.45, 0.079, P = 0.11, N = 859)
rs1208853(A)/7:88904674 ZNF804B (0.61, 0.0039, P = 1.8e-05, N = 7824) (0.53, 0.011, P = 0.83, N = 859)
rs2051957(T)/7:89709883* STEAP2-AS1 (0.75, 0.0066, P = 1.7e-05, N = 7824) (0.33, 0.042, P = 0.41, N = 859)
rs651430(A)/7:99429843* CYP3A43 (0.53, 0.004, P = 1.4e-05, N = 7824) (0.16, -0.043, P = 0.49, N = 859)
rs1013482(A)/8:110505710 PKHD1L1 (0.38, 0.0047, P = 1.7e-07, N = 7824) (0.54, -0.0066, P = 0.89, N = 859)
rs7463805(T)/8:110753672 intergenic (0.52, -0.0053, P = 4.6e-09, N = 7824) (0.36, 0.0033, P = 0.95, N = 859)
rs4076446(T)/8:130706301 intergenic (0.47, -0.0038, P = 3.9e-05, N = 7824) (0.48, -0.039, P = 0.42, N = 859)
rs4144737(A)/8:130761182* GSDMC (0.58, 0.004, P = 9.9e-06, N = 7824) (0.24, 0.067, P = 0.24, N = 859)
rs9649963(T)/8:131697816* intergenic (0.63, 0.0041, P = 5.8e-06, N = 7824) (0.81, -0.069, P = 0.26, N = 859)
rs7006068(T)/8:142656636* intergenic (0.63, 0.0045, P = 4.8e-07, N = 7824) (0.36, 0.093, P = 0.068, N = 859)
rs2717586(A)/8:143897882 RP11-706C16.8 (0.4, 0.0043, P = 2.3e-06, N = 7824) (0.27, -0.046, P = 0.38, N = 859)
rs1366671(T)/8:15488238* TUSC3 (0.44, -0.0041, P = 4.9e-06, N = 7824) (0.5, 0.013, P = 0.8, N = 859)
rs2604365(T)/8:15614315 TUSC3 (0.64, 0.0044, P = 1.5e-06, N = 7824) (0.87, 0.06, P = 0.4, N = 859)
rs2055092(A)/8:16838292* intergenic (0.38, -0.004, P = 1.3e-05, N = 7824) (0.41, -0.017, P = 0.72, N = 859)
rs10087419(T)/8:236656* intergenic (0.6, -0.0039, P = 1.9e-05, N = 7824) (0.3, 0.014, P = 0.78, N = 859)
rs7012981(T)/8:29383034 RP11-486M23.1 (0.52, 0.17, P = 7.4e-06, N = 1959) (0.1, -0.11, P = 0.15, N = 859)
rs4355794(A)/8:3154167 CSMD1 (0.35, -0.0038, P = 1.9e-05, N = 7824) (0.56, 0.039, P = 0.42, N = 859)
rs2554639(T)/8:3939181 CSMD1 (0.54, 0.0039, P = 3.1e-05, N = 7824) (0.23, -0.077, P = 0.19, N = 859)
rs4736967(A)/8:41182841 intergenic (0.6, 0.0037, P = 4.9e-05, N = 7824) (0.84, -0.019, P = 0.78, N = 859)
rs13281365(T)/8:55477437 RP11-53M11.3 (0.39, 0.0038, P = 3.4e-05, N = 7824) (0.1, 0.014, P = 0.87, N = 859)
rs1849395(T)/8:5657312 intergenic (0.5, -0.0039, P = 1.3e-05, N = 7824) (0.57, -0.039, P = 0.43, N = 859)
rs6471830(A)/8:60713371 intergenic (0.54, 0.0038, P = 2.2e-05, N = 7824) (0.76, -0.029, P = 0.61, N = 859)
rs7009696(T)/8:72731717* U8 (0.62, 0.0041, P = 6.2e-06, N = 7824) (0.49, -0.057, P = 0.23, N = 859)
rs4588900(A)/8:73890425 intergenic (0.52, 0.0038, P = 2.6e-05, N = 7824) (0.32, -0.043, P = 0.4, N = 859)
rs10808793(T)/8:74060655 intergenic (0.49, -0.0038, P = 1.9e-05, N = 7824) (0.73, 0.024, P = 0.67, N = 859)
rs75534375(T)/8:76013726 intergenic (0.07, -0.33, P = 1.7e-06, N = 1959) (0.014, 0.21, P = 0.31, N = 859)
rs2941461(T)/8:76447309 HNF4G (0.24, 0.2, P = 5.7e-06, N = 1959) (0.37, -0.036, P = 0.47, N = 859)
rs7843149(T)/8:91474961 AF070718.1 (0.39, -0.0041, P = 6.6e-06, N = 7824) (0.79, -0.011, P = 0.85, N = 859)
rs7027650(A)/9:101741969 COL15A1 (0.63, 0.0037, P = 4.6e-05, N = 7824) (0.34, 0.031, P = 0.54, N = 859)
rs1929487(A)/9:104272503* TMEM246 (0.42, -0.0041, P = 4.9e-06, N = 7824) (0.23, 0.0096, P = 0.87, N = 859)
rs833413(T)/9:10555561 PTPRD (0.48, 0.0037, P = 4.6e-05, N = 7824) (0.6, -0.02, P = 0.68, N = 859)
rs893922(A)/9:112060144 EPB41L4B (0.37, 0.0042, P = 3.9e-06, N = 7824) (0.15, -0.033, P = 0.64, N = 859)
rs915281(T)/9:119967963* ASTN2 (0.51, -0.0041, P = 4.4e-06, N = 7824) (0.25, -0.072, P = 0.19, N = 859)
rs9299251(A)/9:120184143 intergenic (0.37, -0.0037, P = 3.6e-05, N = 7824) (0.18, 0.038, P = 0.54, N = 859)
rs10819114(T)/9:128846829 RP11-343J18.2 (0.26, 0.21, P = 1.7e-06, N = 1959) (0.29, 0.022, P = 0.68, N = 859)
rs7028558(T)/9:128918482* RP11-343J18.2 (0.48, 0.0039, P = 1.2e-05, N = 7824) (0.25, -0.013, P = 0.81, N = 859)
rs625958(G)/9:136842109 VAV2 (0.6, -0.15, P = 2.4e-06, N = 1959) (0.65, -0.075, P = 0.13, N = 859)
rs2224447(C)/9:17624700* SH3GL2 (0.53, 0.0037, P = 3.5e-05, N = 7824) (0.78, -0.062, P = 0.29, N = 859)
rs2383131(T)/9:19902822 intergenic (0.44, -0.0043, P = 3.1e-06, N = 7824) (0.69, 0.031, P = 0.54, N = 859)
rs12350168(T)/9:31257450 SLC25A6P2 (0.46, 0.0037, P = 4.1e-05, N = 7824) (0.19, 0.012, P = 0.84, N = 859)
rs3780494(T)/9:33126224 B4GALT1 (0.99, -0.023, P = 7e-06, N = 7824) (0.98, 0.071, P = 0.71, N = 859)
rs776008(C)/9:37921959* SHB (0.47, 0.004, P = 1e-05, N = 7824) (0.4, 0.026, P = 0.59, N = 859)
rs458552(T)/9:4833437 RCL1 (0.59, -0.0037, P = 4.2e-05, N = 7824) (0.18, 0.026, P = 0.68, N = 859)
rs1009282(A)/9:77752967 OSTF1 (0.43, 0.0037, P = 4.4e-05, N = 7824) (0.75, 0.15, P = 0.0053, N = 859)
rs1502682(C)/9:85617668* RASEF (0.49, -0.0037, P = 3.4e-05, N = 7824) (0.47, 0.044, P = 0.35, N = 859)
rs9330454(A)/9:92515514 RP5-1050E16.2 (0.4, -0.0066, P = 6e-06, N = 7824) (0.54, 0.012, P = 0.8, N = 859)
rs6478302(T)/9:98392340 intergenic (0.38, 0.004, P = 1.1e-05, N = 7824) (0.34, 0.037, P = 0.47, N = 859)
Results from Univariable Mendelian Randomization of L-Tryptophan & eGFR - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 505 0.0054 (-0.071- 0.082) P=0.89 1.2 30 0 (0- 89.1) NA NA -0.0052 P=0.038
MR-Egger 505 0.026 (-0.054- 0.11) P=0.53 1.2 30 0 (0- 89.1) 488 0.67 -0.0052 P=0.038
Weighted median 505 -0.0063 (-0.12- 0.11) P=0.91 1.2 30 0 (0- 89.1) NA NA -0.0052 P=0.038
Results from Univariable MRPRESSO of L-Tryptophan & eGFR - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0.01 0.04 0.14 0.89
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of L-Tryptophan & eGFR - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 348 0.033 (-0.072- 0.14) P=0.54 1.6 27 0 (0- 27.3) NA NA -0.0061 P=0.049
MR-Egger 348 0.069 (-0.047- 0.18) P=0.25 1.6 27 0 (0- 27.3) 308 0.93 -0.0061 P=0.049
Weighted median 348 0.076 (-0.083- 0.23) P=0.35 1.6 27 0 (0- 27.3) NA NA -0.0061 P=0.049
Results from Univariable MRPRESSO of L-Tryptophan & eGFR - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0.03 0.05 0.61 0.54
beta.exposure Outlier-corrected NA NA NA NA

Uric acid

Instruments Associations with Uric acid & eGFR
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region Uric acid (Shin et al/Long et al) eGFR (CSSCD)
rs9725388(A)/1:104894190 intergenic (0.19, 0.0072, P = 2.8e-05, N = 7824) (0.25, -0.097, P = 0.077, N = 859)
rs2143295(C)/1:11669919 RP1-69M21.2 (0.058, -0.31, P = 9.2e-06, N = 1958) (0.081, 0.019, P = 0.83, N = 859)
rs6427351(T)/1:157066950* ETV3L (0.94, 0.016, P = 2.7e-05, N = 7824) (0.84, 0.063, P = 0.33, N = 859)
rs1316637(T)/1:18024794 ARHGEF10L (0.58, 0.007, P = 4.3e-05, N = 7824) (0.81, -0.022, P = 0.72, N = 859)
rs17352664(A)/1:20559927* intergenic (0.11, -0.0095, P = 4.6e-05, N = 7824) (0.1, -0.012, P = 0.88, N = 859)
rs510032(T)/1:226724202 intergenic (0.17, 0.009, P = 6.8e-06, N = 7824) (0.062, 0.074, P = 0.46, N = 859)
rs12137216(A)/1:30632171 intergenic (0.89, 0.01, P = 3.7e-05, N = 7824) (0.95, -0.078, P = 0.49, N = 859)
rs13375139(T)/1:30691713* intergenic (0.17, -0.0075, P = 1.5e-05, N = 7824) (0.42, 0.024, P = 0.63, N = 859)
rs1323821(T)/1:58225872* AL137855.1 (0.43, 0.0067, P = 3.3e-05, N = 7824) (0.66, 0.0075, P = 0.88, N = 859)
rs12027847(A)/1:81766037* intergenic (0.11, 0.01, P = 3.3e-05, N = 7824) (0.028, -0.15, P = 0.3, N = 859)
rs12138486(T)/1:93865391* intergenic (0.79, 0.0074, P = 1.5e-05, N = 7824) (0.25, -0.15, P = 0.011, N = 859)
rs7906282(T)/10:19083596* intergenic (0.31, 0.008, P = 1.1e-06, N = 7824) (0.25, 0.00041, P = 0.99, N = 859)
rs35345503(AC)/10:28955618 RNU6-1067P (0.17, -0.28, P = 1.6e-07, N = 1958) (0.37, -0.013, P = 0.79, N = 859)
rs2659999(C)/10:68293030 CTNNA3 (0.81, -0.0073, P = 2.7e-05, N = 7824) (0.43, -0.02, P = 0.7, N = 859)
rs10490946(A)/10:9143876* intergenic (0.033, 0.017, P = 2.7e-05, N = 7824) (0.097, -0.071, P = 0.39, N = 859)
rs16924665(T)/11:11780607* RP11-756D7.1 (0.84, -0.0071, P = 4.2e-05, N = 7824) (0.91, -0.043, P = 0.6, N = 859)
rs353632(T)/11:35187348 CD44 (0.23, 0.013, P = 4.1e-05, N = 7824) (0.3, 0.0015, P = 0.98, N = 859)
rs4378353(T)/11:98429388 intergenic (0.49, 0.007, P = 1.3e-05, N = 7824) (0.29, 0.061, P = 0.25, N = 859)
rs12817597(T)/12:114132363 RP11-438N16.1 (0.021, 0.023, P = 2.5e-05, N = 7824) (0.013, 0.3, P = 0.17, N = 859)
rs12579148(T)/12:26803493 ITPR2 (0.19, -0.0077, P = 5.9e-06, N = 7824) (0.031, 0.067, P = 0.63, N = 859)
rs10844317(T)/12:32874640 DNM1L (0.16, -0.0086, P = 1.1e-06, N = 7824) (0.22, -0.057, P = 0.32, N = 859)
rs17782050(T)/12:4340106* intergenic (0.31, -0.0068, P = 3.3e-05, N = 7824) (0.12, -0.069, P = 0.36, N = 859)
rs7487146(A)/12:73794865 intergenic (0.88, -0.017, P = 2.5e-05, N = 7824) (0.95, 0.014, P = 0.9, N = 859)
rs35800043(C)/12:9029812 A2ML1 (0.26, -0.13, P = 9.3e-06, N = 1958) (0.13, -0.085, P = 0.24, N = 859)
rs1901044(C)/12:98218675 intergenic (0.17, 0.0071, P = 3.6e-05, N = 7824) (0.47, 0.05, P = 0.29, N = 859)
rs9557545(A)/13:101578114 NALCN-AS1 (0.032, 0.018, P = 7.8e-06, N = 7824) (0.029, -0.067, P = 0.64, N = 859)
rs4550321(A)/13:23823888* SGCG (0.36, 0.0065, P = 4.5e-05, N = 7824) (0.23, 0.064, P = 0.26, N = 859)
rs9510740(C)/13:24017110 intergenic (0.23, 0.0073, P = 1.4e-05, N = 7824) (0.18, 0.04, P = 0.53, N = 859)
rs9549021(T)/13:40543493* intergenic (0.61, -0.013, P = 2.9e-06, N = 7824) (0.59, 0.0068, P = 0.89, N = 859)
rs7327319(A)/13:40928617* RP11-172E9.2 (0.19, -0.01, P = 1.7e-05, N = 7824) (0.15, -0.009, P = 0.89, N = 859)
rs7329766(T)/13:54732465* intergenic (0.87, -0.017, P = 2e-05, N = 7824) (0.8, -0.048, P = 0.42, N = 859)
rs1540639(T)/13:82344020* intergenic (0.15, 0.0072, P = 4.5e-05, N = 7824) (0.22, 0.026, P = 0.65, N = 859)
rs10145908(C)/14:63753329* RHOJ (0.073, 0.28, P = 9.1e-06, N = 1958) (0.73, -0.057, P = 0.29, N = 859)
rs2535896(T)/14:73434531 ZFYVE1 (0.25, 0.013, P = 4.3e-05, N = 7824) (0.51, 0.012, P = 0.8, N = 859)
rs8011758(A)/14:89626459* FOXN3 (0.34, -0.0067, P = 4.8e-05, N = 7824) (0.39, 0.009, P = 0.86, N = 859)
rs1286087(T)/14:91437370 RPS6KA5 (0.84, 0.0077, P = 8.1e-06, N = 7824) (0.84, -0.029, P = 0.66, N = 859)
rs4594244(A)/15:101340649* RP11-66B24.5 (0.067, 0.014, P = 3e-05, N = 7824) (0.17, -0.06, P = 0.34, N = 859)
rs35907301(G)/15:29139319 APBA2 (0.32, -0.13, P = 6.6e-06, N = 1958) (0.77, 0.075, P = 0.19, N = 859)
rs1471226(T)/15:29888567 intergenic (0.26, -0.0067, P = 4.9e-05, N = 7824) (0.3, -0.0049, P = 0.93, N = 859)
rs12396(C)/15:52413316 GNB5 (0.54, 0.013, P = 4.5e-05, N = 7824) (0.15, -0.073, P = 0.29, N = 859)
rs17184999(T)/15:63818369* USP3 (0.85, -0.0076, P = 1.5e-05, N = 7824) (0.98, 0.043, P = 0.81, N = 859)
rs374181299(GTCTA)/16:23622399 PALB2 (0.14, 0.2, P = 8e-06, N = 1958) (0.19, 0.077, P = 0.19, N = 859)
rs12919486(A)/16:53093720* CHD9 (0.25, 0.0072, P = 2.4e-05, N = 7824) (0.17, -0.028, P = 0.66, N = 859)
rs16953268(A)/16:54286557 RP11-324D17.1 (0.069, -0.011, P = 7.7e-06, N = 7824) (0.14, 0.14, P = 0.038, N = 859)
rs62065022(C)/16:59029432 RP11-410D17.2 (0.29, 0.2, P = 1.2e-06, N = 1958) (0.082, 0.11, P = 0.21, N = 859)
rs7203578(A)/16:70758855* VAC14 (0.83, 0.0072, P = 3.1e-05, N = 7824) (0.64, 0.083, P = 0.11, N = 859)
rs17762472(A)/16:74860912* intergenic (0.71, -0.0067, P = 3.8e-05, N = 7824) (0.91, 0.061, P = 0.48, N = 859)
rs9923451(A)/16:78952439* WWOX (0.011, 0.056, P = 4e-05, N = 7824) (0.23, -0.062, P = 0.27, N = 859)
rs8080896(A)/17:14890929* intergenic (0.16, 0.0075, P = 1.7e-05, N = 7824) (0.24, 0.0013, P = 0.98, N = 859)
rs4793781(A)/17:52962115 intergenic (0.2, 0.0072, P = 2e-05, N = 7824) (0.084, 0.064, P = 0.45, N = 859)
rs35401841(G)/17:66378322 ARSG (0.086, 0.23, P = 5e-06, N = 1958) (0.064, 0.074, P = 0.46, N = 859)
rs112095783(C)/2:111785895 ACOXL (0.09, -0.29, P = 5.5e-07, N = 1958) (0.016, 0.076, P = 0.7, N = 859)
rs35613251(A)/2:130166917 intergenic (0.68, -0.13, P = 5.4e-06, N = 1958) (0.12, 0.032, P = 0.66, N = 859)
rs10490734(A)/2:138012183* THSD7B (0.83, 0.0077, P = 7.9e-06, N = 7824) (0.75, 0.063, P = 0.25, N = 859)
rs17642263(T)/2:138637196 AC020601.1 (0.47, -0.13, P = 5e-06, N = 1958) (0.34, 0.037, P = 0.46, N = 859)
rs16853726(A)/2:168396030* AC074363.1 (0.98, 0.047, P = 1.2e-05, N = 7824) (0.87, 0.19, P = 0.0077, N = 859)
rs6731691(A)/2:173331754* ITGA6 (0.17, -0.008, P = 5.3e-06, N = 7824) (0.1, -0.035, P = 0.65, N = 859)
rs10165148(C)/2:208707326 PLEKHM3 (0.34, 0.17, P = 4.2e-06, N = 1958) (0.32, -0.0011, P = 0.98, N = 859)
rs17010477(A)/2:31145844 GALNT14 (0.21, 0.0071, P = 4.7e-05, N = 7824) (0.13, 0.0076, P = 0.92, N = 859)
rs3770872(T)/2:36685242 CRIM1 (0.02, -0.63, P = 5.3e-07, N = 1958) (0.047, -0.0052, P = 0.96, N = 859)
rs7596989(G)/2:5421053* intergenic (0.61, -0.17, P = 1.4e-06, N = 1958) (0.67, -0.043, P = 0.42, N = 859)
rs2422441(G)/2:65370766 intergenic (0.72, -0.17, P = 7.4e-06, N = 1958) (0.44, 0.038, P = 0.42, N = 859)
rs2223710(C)/20:11968878 intergenic (0.17, 0.0072, P = 3e-05, N = 7824) (0.45, -0.06, P = 0.21, N = 859)
rs1569683(A)/20:12068758* intergenic (0.16, 0.0073, P = 3.4e-05, N = 7824) (0.25, 0.074, P = 0.19, N = 859)
rs742840(G)/20:2545527 TMC2 (0.11, -0.29, P = 7.6e-06, N = 1958) (0.21, 0.013, P = 0.83, N = 859)
rs6051416(C)/20:2798425 C20orf141 (0.023, 0.45, P = 6.5e-06, N = 1958) (0.28, -0.036, P = 0.49, N = 859)
rs16993414(T)/20:7308538* intergenic (0.98, 0.024, P = 4.6e-05, N = 7824) (0.96, -0.067, P = 0.59, N = 859)
rs2838690(A)/21:46222486* UBE2G2 (0.15, 0.0073, P = 3.1e-05, N = 7824) (0.16, 0.097, P = 0.15, N = 859)
rs235320(A)/21:46277214* PTTG1IP (0.82, -0.0079, P = 3.7e-06, N = 7824) (0.76, 0.05, P = 0.37, N = 859)
rs11913285(A)/22:19844492* C22orf29 (0.81, -0.0072, P = 2.9e-05, N = 7824) (0.95, 0.11, P = 0.31, N = 859)
rs2073079(A)/22:44385594 SAMM50 (0.82, 0.0072, P = 3.7e-05, N = 7824) (0.79, -0.053, P = 0.37, N = 859)
rs13318012(T)/3:106674944 LINC00882 (0.84, -0.0078, P = 8.4e-06, N = 7824) (0.86, -0.0023, P = 0.97, N = 859)
rs145484282(A)/3:159102816 IQCJ-SCHIP1 (0.062, 0.31, P = 2.7e-06, N = 1958) (0.015, -0.38, P = 0.049, N = 859)
rs10936697(A)/3:171391416 PLD1 (0.21, -0.0075, P = 1e-05, N = 7824) (0.23, 0.092, P = 0.098, N = 859)
rs73197782(G)/3:190853411 intergenic (0.21, 0.19, P = 9.2e-06, N = 1958) (0.1, -0.12, P = 0.13, N = 859)
rs1523125(A)/3:43115161 intergenic (0.17, 0.007, P = 5e-05, N = 7824) (0.041, -0.32, P = 0.0094, N = 859)
rs11130013(T)/3:43833177* intergenic (0.15, -0.0081, P = 5.1e-06, N = 7824) (0.14, 0.026, P = 0.71, N = 859)
rs872114(A)/3:68603563* intergenic (0.97, -0.021, P = 2.3e-06, N = 7824) (0.85, -0.078, P = 0.24, N = 859)
rs2133450(A)/3:7336452* GRM7 (0.55, -0.007, P = 1.2e-05, N = 7824) (0.75, 0.032, P = 0.56, N = 859)
rs6849273(T)/4:10021595 SLC2A9 (0.57, 0.017, P = 1.7e-26, N = 7824) (0.37, 0.099, P = 0.049, N = 859)
rs9926(A)/4:10076860* WDR1 (0.22, 0.015, P = 1.3e-19, N = 7824) (0.076, -0.043, P = 0.62, N = 859)
rs1978274(T)/4:10245087* intergenic (0.79, 0.029, P = 1e-66, N = 7824) (0.78, 0.071, P = 0.21, N = 859)
rs1558488(A)/4:10327414 intergenic (0.29, 0.0069, P = 2.8e-05, N = 7824) (0.49, 0.0072, P = 0.88, N = 859)
rs2868941(T)/4:10509699 CLNK (0.28, -0.01, P = 1.2e-09, N = 7824) (0.15, 0.049, P = 0.45, N = 859)
rs6835088(T)/4:114357856* intergenic (0.74, -0.0069, P = 3.5e-05, N = 7824) (0.91, 0.094, P = 0.28, N = 859)
rs706344(A)/4:140549479* intergenic (0.77, -0.0074, P = 3.7e-05, N = 7824) (0.79, -0.042, P = 0.47, N = 859)
rs62333080(G)/4:161389764 intergenic (0.26, 0.22, P = 4.3e-06, N = 1958) (0.11, -0.095, P = 0.22, N = 859)
rs17055114(A)/4:170658731* C4orf27 (0.8, -0.0073, P = 3.4e-05, N = 7824) (0.69, -0.023, P = 0.67, N = 859)
rs10866262(A)/4:184383036 intergenic (0.65, -0.11, P = 3.9e-06, N = 1958) (0.73, 0.041, P = 0.44, N = 859)
rs10517140(A)/4:28341254* intergenic (0.14, -0.0073, P = 3e-05, N = 7824) (0.03, 0.0057, P = 0.97, N = 859)
rs10024206(A)/4:33782293 RNU7-131P (0.94, 0.024, P = 1.8e-05, N = 7824) (0.73, 0.051, P = 0.35, N = 859)
rs1158742(C)/4:58139506* intergenic (0.75, 0.0072, P = 1.4e-05, N = 7824) (0.73, 0.014, P = 0.8, N = 859)
rs13110980(T)/4:63337758 intergenic (0.29, -0.21, P = 6.3e-06, N = 1958) (0.079, -0.19, P = 0.028, N = 859)
rs6857147(A)/4:71250769 SMR3B (0.96, 0.014, P = 3.9e-05, N = 7824) (0.92, 0.18, P = 0.035, N = 859)
rs2231142(T)/4:89052323* ABCG2 (0.11, 0.012, P = 8.4e-07, N = 7824) (0.027, -0.18, P = 0.23, N = 859)
rs1825043(A)/4:9573740* intergenic (0.96, 0.019, P = 5.3e-07, N = 7824) (0.69, -0.046, P = 0.38, N = 859)
rs7678732(T)/4:9693253* FAM86MP (0.037, -0.019, P = 2.1e-06, N = 7824) (0.042, -0.022, P = 0.85, N = 859)
rs938554(C)/4:9925692* SLC2A9 (0.23, -0.035, P = 5.8e-93, N = 7824) (0.46, -0.014, P = 0.77, N = 859)
rs233340(A)/5:13592425 intergenic (0.071, -0.013, P = 2.5e-06, N = 7824) (0.11, 0.18, P = 0.024, N = 859)
rs13159834(C)/5:141045281* ARAP3 (0.84, -0.0072, P = 4.4e-05, N = 7824) (0.88, 0.0085, P = 0.91, N = 859)
rs11749230(T)/5:149146535* PPARGC1B (0.054, -0.024, P = 3.4e-05, N = 7824) (0.25, 0.033, P = 0.56, N = 859)
rs9313506(T)/5:169948896* KCNIP1 (0.67, -0.0069, P = 2e-05, N = 7824) (0.78, -0.011, P = 0.86, N = 859)
rs11741189(T)/5:179543546* RASGEF1C (0.18, -0.0087, P = 3.8e-07, N = 7824) (0.14, 0.00046, P = 0.99, N = 859)
rs11750694(A)/5:29023304* intergenic (0.16, 0.0074, P = 2.7e-05, N = 7824) (0.048, -0.014, P = 0.9, N = 859)
rs2956574(A)/5:36498183* intergenic (0.73, 0.0068, P = 4.7e-05, N = 7824) (0.5, -0.0049, P = 0.92, N = 859)
rs10058947(T)/5:74227503 CTD-2503O16.1 (0.79, 0.22, P = 5.2e-07, N = 1958) (0.41, -0.018, P = 0.71, N = 859)
rs6927639(A)/6:108009018 intergenic (0.85, -0.0078, P = 9.3e-06, N = 7824) (0.88, -0.15, P = 0.04, N = 859)
rs4712645(T)/6:21970303 CASC15 (0.97, -0.47, P = 9.9e-06, N = 1958) (0.62, -0.054, P = 0.28, N = 859)
rs12614(T)/6:31914179* CFB (0.083, -0.26, P = 3.8e-06, N = 1958) (0.33, 0.08, P = 0.12, N = 859)
rs1338715(C)/6:87243828 intergenic (0.69, -0.14, P = 5e-06, N = 1958) (0.37, -0.017, P = 0.74, N = 859)
rs6941452(T)/6:90678323 BACH2 (0.28, -0.0071, P = 4.5e-05, N = 7824) (0.46, -0.0089, P = 0.85, N = 859)
rs10229191(T)/7:143796891* OR2A12 (0.88, -0.022, P = 1.2e-05, N = 7824) (0.64, 0.0064, P = 0.89, N = 859)
rs4724354(T)/7:45104623* CCM2 (0.78, -0.0075, P = 1.3e-05, N = 7824) (0.74, 0.0045, P = 0.94, N = 859)
rs9785033(T)/7:92537054 AC002454.1 (0.17, 0.0076, P = 1.6e-05, N = 7824) (0.5, -0.016, P = 0.73, N = 859)
rs11786665(A)/8:144550160* ZC3H3 (0.068, -0.011, P = 4.4e-05, N = 7824) (0.019, -0.041, P = 0.81, N = 859)
rs6982652(T)/8:4977252* intergenic (0.73, 0.0071, P = 1.8e-05, N = 7824) (0.38, -0.077, P = 0.12, N = 859)
rs10957085(T)/8:60217240 intergenic (0.15, 0.17, P = 6.1e-06, N = 1958) (0.52, -0.033, P = 0.49, N = 859)
rs6980733(T)/8:84738607 intergenic (0.5, -0.007, P = 1.5e-05, N = 7824) (0.86, -0.031, P = 0.66, N = 859)
rs11791985(A)/9:102507514 RP11-554F20.1 (0.15, -0.0075, P = 2.2e-05, N = 7824) (0.034, -0.065, P = 0.61, N = 859)
rs10981877(C)/9:116431022 RP11-18B16.2 (0.68, 0.007, P = 2.4e-05, N = 7824) (0.44, 0.05, P = 0.3, N = 859)
rs10982829(T)/9:118347052* intergenic (0.035, -0.64, P = 2.4e-08, N = 1958) (0.11, 0.019, P = 0.81, N = 859)
rs10513281(C)/9:119812714 ASTN2 (0.83, -0.0075, P = 1.6e-05, N = 7824) (0.83, -0.12, P = 0.067, N = 859)
rs13288611(C)/9:28501477* LINGO2 (0.3, -0.0072, P = 1.4e-05, N = 7824) (0.34, 0.028, P = 0.6, N = 859)
rs10973300(A)/9:37331037 ZCCHC7 (0.16, 0.0079, P = 3.9e-05, N = 7824) (0.076, 0.16, P = 0.083, N = 859)
Results from Univariable Mendelian Randomization of Uric acid & eGFR - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 124 -0.026 (-0.11- 0.06) P=0.55 5.8 35 0 (0- 87.5) NA NA 0.0023 P=0.73
MR-Egger 124 -0.035 (-0.14- 0.065) P=0.49 5.8 35 0 (0- 87.5) 128 0.34 0.0023 P=0.73
Weighted median 124 -0.034 (-0.16- 0.094) P=0.61 5.8 35 0 (0- 87.5) NA NA 0.0023 P=0.73
Results from Univariable MRPRESSO of Uric acid & eGFR - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.03 0.04 -0.59 0.55
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of Uric acid & eGFR - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 64 -0.0055 (-0.12- 0.11) P=0.92 9 29 0.000742 (0- 98.9) NA NA 0.0025 P=0.82
MR-Egger 64 -0.015 (-0.15- 0.12) P=0.83 9 29 0.000742 (0- 98.9) 80 0.063 0.0025 P=0.82
Weighted median 64 -0.012 (-0.15- 0.13) P=0.87 9 29 0.000742 (0- 98.9) NA NA 0.0025 P=0.82
Results from Univariable MRPRESSO of Uric acid & eGFR - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.01 0.06 -0.1 0.92
beta.exposure Outlier-corrected NA NA NA NA

Cholecystectomy

Deoxycholic acid glycine conjugate

Instruments Associations with Deoxycholic acid glycine conjugate & Cholecystectomy
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region Deoxycholic acid glycine conjugate (Shin et al/Long et al) Cholecystectomy (CSSCD)
rs1776220(T)/1:10874522* intergenic (0.55, -0.066, P = 1e-05, N = 1457) (0.28, -0.23, P = 0.13, N = 1084)
rs6585252(C)/10:115723678* intergenic (0.96, -0.15, P = 8.5e-07, N = 1457) (0.76, -0.23, P = 0.14, N = 1084)
rs10741178(T)/10:130903004* intergenic (0.21, 0.092, P = 3.6e-05, N = 868) (0.72, 0.13, P = 0.4, N = 1084)
rs2647530(A)/11:9105636* SCUBE2 (0.88, -0.084, P = 3.9e-05, N = 1457) (0.84, -0.16, P = 0.38, N = 1084)
rs963167(A)/11:9111558* SCUBE2 (0.12, 0.093, P = 1.6e-05, N = 1457) (0.16, 0.0033, P = 0.99, N = 1084)
rs833718(A)/12:103071086* intergenic (0.47, -0.056, P = 2.6e-05, N = 1457) (0.37, -0.065, P = 0.63, N = 1084)
rs9669375(T)/12:15188765* intergenic (0.34, -0.089, P = 2.3e-05, N = 868) (0.31, 0.24, P = 0.11, N = 1084)
rs806784(T)/12:32438189* BICD1 (0.72, -0.095, P = 1.5e-06, N = 868) (0.45, -0.055, P = 0.7, N = 1084)
rs10506675(T)/12:75481828* KCNC2 (0.096, 0.088, P = 4e-05, N = 1457) (0.12, -0.23, P = 0.27, N = 1084)
rs9301881(T)/13:94105286* GPC6 (0.57, 0.059, P = 5.8e-06, N = 1457) (0.74, 0.055, P = 0.71, N = 1084)
rs8016700(A)/14:100695157* RP11-638I2.4 (0.045, 0.14, P = 4.7e-05, N = 1457) (0.1, -0.026, P = 0.91, N = 1084)
rs17124276(T)/14:88685076* KCNK10 (0.22, 0.07, P = 1.9e-05, N = 1457) (0.14, 0.26, P = 0.19, N = 1084)
rs3825678(T)/14:88693676* KCNK10 (0.26, 0.061, P = 4.9e-05, N = 1457) (0.37, 0.22, P = 0.1, N = 1084)
rs11642055(A)/16:56644265* MT2A (0.15, -0.093, P = 1.9e-05, N = 1457) (0.026, -0.58, P = 0.18, N = 1084)
rs16966727(A)/16:63943790* intergenic (0.033, 0.22, P = 1.8e-05, N = 868) (0.081, 0.0045, P = 0.99, N = 1084)
rs7190849(A)/16:79472854* intergenic (0.92, -0.1, P = 4e-05, N = 1457) (0.84, 0.15, P = 0.42, N = 1084)
rs4432315(T)/18:31293792* ASXL3 (0.5, -0.054, P = 3.1e-05, N = 1457) (0.58, -0.067, P = 0.63, N = 1084)
rs11660001(A)/18:55220229* FECH (0.21, 0.077, P = 2.8e-05, N = 1457) (0.12, 0.085, P = 0.69, N = 1084)
rs4808544(T)/19:17083711* CPAMD8 (0.22, 0.069, P = 2.2e-05, N = 1457) (0.38, -0.036, P = 0.8, N = 1084)
rs7257166(T)/19:17788804* UNC13A (0.83, -0.075, P = 2.2e-05, N = 1457) (0.44, 0.27, P = 0.048, N = 1084)
rs737094(A)/2:100089078* REV1 (0.28, -0.062, P = 1.7e-05, N = 1457) (0.095, -0.06, P = 0.8, N = 1084)
rs7561272(T)/2:121856858* intergenic (0.98, -0.27, P = 3.1e-05, N = 868) (0.78, -0.095, P = 0.54, N = 1084)
rs10490230(A)/2:50538327* NRXN1 (0.13, 0.084, P = 3.3e-05, N = 1457) (0.29, -0.07, P = 0.64, N = 1084)
rs12477733(T)/2:72347041* intergenic (0.052, 0.13, P = 8.2e-06, N = 1457) (0.21, 0.017, P = 0.91, N = 1084)
rs2420201(A)/2:72356370* CYP26B1 (0.049, 0.15, P = 1.9e-06, N = 1457) (0.14, -0.25, P = 0.18, N = 1084)
rs6081530(A)/20:19179535* intergenic (0.27, 0.086, P = 2.3e-05, N = 868) (0.028, -0.62, P = 0.11, N = 1084)
rs1741315(A)/20:4155948* SMOX (0.42, -0.059, P = 2e-05, N = 1457) (0.15, 0.14, P = 0.45, N = 1084)
rs133588(A)/22:48666450* MIR3201 (0.84, -0.077, P = 2e-05, N = 1457) (0.51, -0.17, P = 0.2, N = 1084)
rs2360865(A)/3:143407129* SLC9A9 (0.35, -0.061, P = 1.1e-05, N = 1457) (0.12, -0.3, P = 0.13, N = 1084)
rs6797793(T)/3:147087164* RP11-649A16.1 (0.83, -0.1, P = 2.1e-05, N = 868) (0.5, 0.038, P = 0.78, N = 1084)
rs7609993(A)/3:5858488* intergenic (0.83, 0.076, P = 1.8e-05, N = 1457) (0.83, 0.033, P = 0.86, N = 1084)
rs6445500(T)/3:65712905* MAGI1 (0.3, 0.059, P = 3.9e-05, N = 1457) (0.5, 0.12, P = 0.38, N = 1084)
rs329044(A)/3:7748565* GRM7 (0.97, -0.18, P = 4.5e-05, N = 1457) (0.87, -0.23, P = 0.24, N = 1084)
rs230526(A)/4:103458825* NFKB1 (0.4, 0.057, P = 2.3e-05, N = 1457) (0.42, -0.044, P = 0.74, N = 1084)
rs13124866(A)/4:137834834* RP11-138I17.1 (0.41, -0.066, P = 1.3e-05, N = 1457) (0.3, 0.14, P = 0.34, N = 1084)
rs9312547(T)/4:174620399* intergenic (0.55, -0.06, P = 2.5e-05, N = 1457) (0.71, 0.35, P = 0.022, N = 1084)
rs17746543(A)/4:55227440* intergenic (0.51, -0.088, P = 3.7e-06, N = 868) (0.095, 0.25, P = 0.3, N = 1084)
rs420460(T)/5:150548930* intergenic (0.37, -0.061, P = 2.3e-05, N = 1457) (0.44, 0.076, P = 0.58, N = 1084)
rs2591578(A)/5:165407709* intergenic (0.3, 0.06, P = 2.5e-05, N = 1457) (0.18, -0.17, P = 0.34, N = 1084)
rs6881524(T)/5:174168668* intergenic (0.29, -0.12, P = 4.8e-05, N = 868) (0.47, 0.2, P = 0.13, N = 1084)
rs11949031(A)/5:2370336* intergenic (0.16, 0.075, P = 3.5e-05, N = 1457) (0.21, -0.0025, P = 0.99, N = 1084)
rs2524222(T)/6:30511170* GNL1 (0.23, -0.07, P = 2.1e-05, N = 1457) (0.058, 0.078, P = 0.79, N = 1084)
rs7746971(T)/6:52742295* RP11-392A23.5 (0.96, -0.18, P = 4e-05, N = 868) (0.74, 0.26, P = 0.093, N = 1084)
rs4338010(T)/7:152624870* intergenic (0.079, -0.11, P = 5.7e-06, N = 1457) (0.32, 0.0034, P = 0.98, N = 1084)
rs3905501(T)/7:76542080* UPK3B (0.83, 0.11, P = 1.3e-05, N = 868) (0.89, -0.42, P = 0.066, N = 1084)
rs10253564(T)/7:85262972* AC092013.1 (0.27, -0.095, P = 2.6e-05, N = 868) (0.83, 0.46, P = 0.013, N = 1084)
rs818555(A)/8:49999211* intergenic (0.5, -0.056, P = 3.3e-05, N = 1457) (0.32, 0.019, P = 0.9, N = 1084)
rs4734519(T)/8:92358729* SLC26A7 (0.67, 0.061, P = 1.6e-05, N = 1457) (0.52, -0.02, P = 0.89, N = 1084)
rs12349595(T)/9:121310484* intergenic (0.86, 0.081, P = 3.1e-05, N = 1457) (0.8, -0.097, P = 0.57, N = 1084)
rs7856830(T)/9:136457146* intergenic (0.15, -0.089, P = 2.3e-06, N = 1457) (0.5, 0.16, P = 0.25, N = 1084)
Results from Univariable Mendelian Randomization of Deoxycholic acid glycine conjugate & Cholecystectomy - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 50 0.76 (0.47- 1.2) P=0.28 2.6 11 11.1 (0- 52.3) NA NA -0.018 P=0.77
MR-Egger 50 0.89 (0.28- 2.9) P=0.85 2.6 11 11.1 (0- 52.3) 57 0.18 -0.018 P=0.77
Weighted median 50 1 (0.48- 2.2) P=0.95 2.6 11 11.1 (0- 52.3) NA NA -0.018 P=0.77
Results from Univariable MRPRESSO of Deoxycholic acid glycine conjugate & Cholecystectomy - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.27 0.25 -1.08 0.29
beta.exposure Outlier-corrected NA NA NA NA

Results from Univariable Mendelian Randomization of Deoxycholic acid glycine conjugate & Cholecystectomy - model2

Results from Univariable MRPRESSO of Deoxycholic acid glycine conjugate & Cholecystectomy - model2

Taurodeoxycholic acid

Instruments Associations with Taurodeoxycholic acid & Cholecystectomy
Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19) Gene Region Taurodeoxycholic acid (Shin et al/Long et al) Cholecystectomy (CSSCD)
rs1942235(C)/1:116083074* intergenic (0.9, 0.32, P = 3.7e-06, N = 1943) (0.55, -0.034, P = 0.8, N = 1084)
rs1737349(T)/1:15124318 KAZN (0.56, 0.054, P = 4.6e-05, N = 963) (0.59, 0.34, P = 0.013, N = 1084)
rs2805468(G)/1:237721111* RYR2 (0.7, -0.13, P = 7.7e-06, N = 1943) (0.43, -0.16, P = 0.25, N = 1084)
rs4294448(T)/1:248847828* OR14I1 (0.88, 0.081, P = 4.2e-05, N = 963) (0.68, -0.093, P = 0.52, N = 1084)
rs16829526(T)/1:42907711 ZMYND12 (0.14, -0.062, P = 2.6e-05, N = 1543) (0.045, -0.25, P = 0.44, N = 1084)
rs691135(A)/1:87266383* intergenic (0.037, -0.11, P = 1.9e-05, N = 1543) (0.089, -0.16, P = 0.48, N = 1084)
rs1220398(A)/1:9994339* LZIC (0.13, -0.062, P = 4.2e-05, N = 1543) (0.51, 0.11, P = 0.4, N = 1084)
rs10741178(T)/10:130903004* intergenic (0.21, 0.065, P = 4.3e-05, N = 963) (0.72, 0.13, P = 0.4, N = 1084)
rs12781751(T)/10:31872826* intergenic (0.54, 0.13, P = 5.7e-06, N = 1943) (0.48, 0.099, P = 0.46, N = 1084)
rs3004260(A)/10:43487986* intergenic (0.4, -0.046, P = 1.4e-05, N = 1543) (0.32, 0.23, P = 0.12, N = 1084)
rs7067796(A)/10:86843226 intergenic (0.78, 0.05, P = 2.7e-05, N = 1543) (0.52, -0.095, P = 0.48, N = 1084)
rs17403795(A)/11:10581217* LYVE1 (0.12, 0.073, P = 5.6e-06, N = 1543) (0.022, -0.43, P = 0.37, N = 1084)
rs508479(A)/11:119775811* intergenic (0.19, 0.055, P = 2.1e-05, N = 1543) (0.46, 0.13, P = 0.37, N = 1084)
rs11234448(A)/11:85568363 CCDC83 (0.046, -0.51, P = 3e-07, N = 1943) (0.058, -0.31, P = 0.28, N = 1084)
rs10898422(T)/11:85582459 CCDC83 (0.047, -0.49, P = 4.9e-07, N = 1943) (0.11, 0.36, P = 0.1, N = 1084)
rs11234461(T)/11:85596772 CCDC83 (0.047, -0.5, P = 1.3e-07, N = 1943) (0.087, -0.2, P = 0.42, N = 1084)
rs2647873(A)/12:103081192* intergenic (0.49, 0.043, P = 2.6e-05, N = 1543) (0.16, 0.23, P = 0.22, N = 1084)
rs7961079(A)/12:109123064* CORO1C (0.62, 0.053, P = 1.5e-06, N = 1543) (0.92, 0.22, P = 0.38, N = 1084)
rs11170624(T)/12:54030238 RP11-972K6.1 (0.16, 0.057, P = 4.4e-05, N = 1543) (0.51, -0.42, P = 0.0011, N = 1084)
rs7299605(G)/12:77285134 intergenic (0.15, -0.27, P = 3.2e-06, N = 1943) (0.15, 0.31, P = 0.11, N = 1084)
rs17022499(A)/12:94901589* intergenic (0.23, 0.054, P = 9.7e-06, N = 1543) (0.082, 0.043, P = 0.86, N = 1084)
rs12428322(T)/13:83109538* intergenic (0.14, 0.063, P = 3.8e-05, N = 1543) (0.13, -0.012, P = 0.95, N = 1084)
rs7984555(A)/13:90887749* KRT18P27 (0.16, -0.061, P = 2e-05, N = 1543) (0.089, -0.23, P = 0.32, N = 1084)
rs10146068(A)/14:51820214 RP11-255G12.2 (0.18, -0.23, P = 2.8e-06, N = 1943) (0.32, -0.2, P = 0.17, N = 1084)
rs7140891(T)/14:97171176 intergenic (0.98, -0.19, P = 2.2e-05, N = 963) (0.88, -0.031, P = 0.88, N = 1084)
rs3803481(A)/15:61278958* RORA (0.81, -0.068, P = 3.4e-05, N = 963) (0.71, -0.073, P = 0.62, N = 1084)
rs1532761(G)/15:97323639 SPATA8 (0.45, -0.15, P = 3.7e-06, N = 1943) (0.51, 0.15, P = 0.25, N = 1084)
rs1362633(A)/16:50062572* CNEP1R1 (0.73, -0.046, P = 3.3e-05, N = 1543) (0.42, 0.043, P = 0.76, N = 1084)
rs7184864(A)/16:50188783 PAPD5 (0.8, -0.058, P = 9.1e-06, N = 1543) (0.62, -0.03, P = 0.82, N = 1084)
rs732329(A)/16:83392422* CDH13 (0.12, 0.066, P = 1.9e-05, N = 1543) (0.25, 0.027, P = 0.86, N = 1084)
rs12452524(T)/17:36581020 ARHGAP23 (0.81, 0.068, P = 3.8e-05, N = 1543) (0.56, -0.14, P = 0.3, N = 1084)
rs75587136(A)/18:65460203 RP11-638L3.1 (0.11, -0.23, P = 3.8e-06, N = 1943) (0.03, -0.93, P = 0.018, N = 1084)
rs12968034(T)/18:7023548 LAMA1 (0.031, -0.13, P = 4.4e-05, N = 1543) (0.049, -0.15, P = 0.63, N = 1084)
rs5022665(A)/19:15783162 CYP4F12 (0.89, 0.074, P = 3.3e-05, N = 1543) (0.89, 0.034, P = 0.87, N = 1084)
rs7251585(T)/19:17800702 UNC13A (0.058, 0.092, P = 3.3e-05, N = 1543) (0.041, -0.41, P = 0.25, N = 1084)
rs10490431(T)/2:17108634* intergenic (0.052, -0.093, P = 3e-05, N = 1543) (0.031, -0.49, P = 0.21, N = 1084)
rs1153699(T)/2:175922786* intergenic (0.24, 0.06, P = 3.9e-06, N = 1543) (0.4, -0.088, P = 0.53, N = 1084)
rs371887376(TA)/2:183851142 NCKAP1 (0.02, -0.64, P = 6e-06, N = 1943) (0.13, -0.13, P = 0.51, N = 1084)
rs1898906(A)/2:188892386* LINC01090 (0.03, 0.14, P = 4.1e-06, N = 1543) (0.1, -0.15, P = 0.5, N = 1084)
rs1377635(T)/2:5261555* intergenic (0.61, 0.14, P = 9.7e-06, N = 1943) (0.52, 0.021, P = 0.87, N = 1084)
rs17588324(T)/2:68310748 C1D (0.87, -0.063, P = 4.8e-05, N = 1543) (0.95, 0.32, P = 0.33, N = 1084)
rs11906184(C)/20:58785070* RP5-1043L13.1 (0.022, -0.55, P = 3.5e-06, N = 1943) (0.081, -0.27, P = 0.29, N = 1084)
rs1297246(T)/21:16726906* intergenic (0.43, -0.045, P = 2.7e-05, N = 1543) (0.14, 0.15, P = 0.45, N = 1084)
rs2032297(C)/21:22455320* NCAM2 (0.79, 0.057, P = 3.9e-06, N = 1543) (0.57, -0.019, P = 0.89, N = 1084)
rs2776341(A)/21:42490274* intergenic (0.48, -0.045, P = 2.2e-05, N = 1543) (0.6, -0.1, P = 0.46, N = 1084)
rs8137495(A)/22:23972409 C22orf43 (0.74, 0.06, P = 7.8e-06, N = 1543) (0.74, 0.0029, P = 0.98, N = 1084)
rs28453905(C)/3:135665019 intergenic (0.31, 0.19, P = 8.7e-06, N = 1943) (0.49, 0.094, P = 0.49, N = 1084)
rs1799598(A)/3:172409798 NCEH1 (0.79, 0.068, P = 1.3e-05, N = 963) (0.75, 0.022, P = 0.89, N = 1084)
rs112391358(CA)/3:184673755 VPS8 (0.1, -0.3, P = 4.6e-07, N = 1943) (0.94, 0.2, P = 0.48, N = 1084)
rs11131020(A)/3:65411716* MAGI1 (0.53, 0.048, P = 4.6e-05, N = 1543) (0.92, 0.055, P = 0.84, N = 1084)
rs11712688(A)/3:71379546* FOXP1 (0.47, 0.043, P = 1.4e-05, N = 1543) (0.13, -0.081, P = 0.69, N = 1084)
rs1445516(A)/4:137797233 RP11-138I17.1 (0.29, 0.047, P = 3.3e-05, N = 1543) (0.15, -0.1, P = 0.57, N = 1084)
rs4076797(T)/4:159225610 intergenic (0.051, 0.098, P = 2e-05, N = 1543) (0.31, 0.17, P = 0.23, N = 1084)
rs4632709(T)/4:159246141 RXFP1 (0.95, -0.15, P = 4e-07, N = 963) (0.68, -0.19, P = 0.17, N = 1084)
rs4692552(C)/4:169764631* PALLD (0.28, 0.2, P = 6.6e-06, N = 1943) (0.096, -0.089, P = 0.7, N = 1084)
rs929617(A)/4:18240774* intergenic (0.17, 0.062, P = 1.6e-05, N = 1543) (0.02, 0.42, P = 0.41, N = 1084)
rs11728685(A)/4:18465884* intergenic (0.35, -0.056, P = 3e-05, N = 963) (0.21, 0.032, P = 0.85, N = 1084)
rs6553268(T)/4:189956524* intergenic (0.074, 0.098, P = 4.8e-05, N = 963) (0.25, -0.17, P = 0.27, N = 1084)
rs2291530(A)/4:20756007 KCNIP4 (0.02, 0.16, P = 2.7e-05, N = 1543) (0.042, 0.4, P = 0.22, N = 1084)
rs10464005(C)/5:103769981 RP11-6N13.1 (0.3, -0.23, P = 2e-06, N = 1943) (0.23, 0.23, P = 0.16, N = 1084)
rs1820806(A)/5:108720463 PJA2 (0.94, 0.087, P = 4.4e-05, N = 1543) (0.61, 0.015, P = 0.92, N = 1084)
rs289027(A)/5:114109101* intergenic (0.34, 0.045, P = 3.7e-05, N = 1543) (0.14, -0.07, P = 0.73, N = 1084)
rs11241933(A)/5:126944341 intergenic (0.27, -0.061, P = 1.1e-06, N = 1543) (0.14, -0.054, P = 0.78, N = 1084)
rs3733672(A)/5:149439494* CSF1R (0.11, 0.068, P = 2.6e-05, N = 1543) (0.1, -0.39, P = 0.092, N = 1084)
rs905177(T)/5:18833784 intergenic (0.6, -0.068, P = 4.8e-05, N = 963) (0.79, 0.17, P = 0.29, N = 1084)
rs11949031(A)/5:2370336* intergenic (0.16, 0.066, P = 1.5e-06, N = 1543) (0.21, -0.0025, P = 0.99, N = 1084)
rs12654530(T)/5:77490596* AP3B1 (0.052, 0.075, P = 4e-05, N = 1543) (0.038, -0.16, P = 0.64, N = 1084)
rs7718530(A)/5:92485295 intergenic (0.32, -0.14, P = 8e-06, N = 1943) (0.53, 0.2, P = 0.15, N = 1084)
rs4896370(A)/6:138818837 NHSL1 (0.35, 0.056, P = 4.2e-06, N = 1543) (0.39, -0.014, P = 0.92, N = 1084)
rs7763112(A)/6:159699814 intergenic (0.82, 0.056, P = 2.6e-05, N = 1543) (0.53, -0.15, P = 0.25, N = 1084)
rs9347691(A)/6:163249645* PACRG (0.95, 0.094, P = 2.3e-05, N = 1543) (0.94, 0.016, P = 0.96, N = 1084)
rs10246722(A)/7:18965590 HDAC9 (0.77, 0.049, P = 3.1e-05, N = 1543) (0.89, -0.28, P = 0.18, N = 1084)
rs17150615(T)/7:29219062 CPVL (0.084, -0.079, P = 1.5e-05, N = 1543) (0.015, 0.24, P = 0.68, N = 1084)
rs4719970(C)/7:29423773* CHN2 (0.45, -0.18, P = 5.9e-06, N = 1943) (0.5, -0.033, P = 0.81, N = 1084)
rs17374391(T)/7:3507092* SDK1 (0.9, -0.067, P = 4.7e-05, N = 1543) (0.78, -0.051, P = 0.76, N = 1084)
rs6959191(A)/7:52165673* intergenic (0.016, 0.23, P = 1.9e-05, N = 963) (0.1, -0.25, P = 0.23, N = 1084)
rs2374374(A)/7:90579226 CDK14 (0.8, 0.16, P = 4e-07, N = 1943) (0.88, 0.083, P = 0.69, N = 1084)
rs1207732(T)/7:96649668 DLX5 (0.76, 0.05, P = 3.5e-05, N = 1543) (0.82, -0.069, P = 0.7, N = 1084)
rs7845099(T)/8:39316048 ADAM3A (0.89, 0.086, P = 3.2e-05, N = 1543) (0.67, 0.044, P = 0.77, N = 1084)
rs75543373(T)/8:70043220 GS1-44D20.1 (0.086, -0.28, P = 6.2e-06, N = 1943) (0.027, 0.67, P = 0.13, N = 1084)
rs10820542(A)/9:106517270 intergenic (0.15, -0.15, P = 4.2e-06, N = 1943) (0.18, 0.077, P = 0.66, N = 1084)
rs925837(T)/9:108868577 intergenic (0.59, -0.044, P = 2.9e-05, N = 1543) (0.18, -0.03, P = 0.87, N = 1084)
rs1780158(C)/9:15133616* RP11-54D18.3 (0.089, -0.073, P = 3.9e-05, N = 1543) (0.31, -0.044, P = 0.76, N = 1084)
rs144820845(CGT)/9:16855132 BNC2 (0.047, -0.42, P = 5.9e-06, N = 1943) (0.023, -0.42, P = 0.33, N = 1084)
rs3847229(A)/9:1801822 intergenic (0.74, -0.052, P = 2e-05, N = 1543) (0.25, 0.028, P = 0.86, N = 1084)
rs993233(G)/9:25890226 intergenic (0.64, -0.1, P = 9e-06, N = 1943) (0.39, 0.28, P = 0.039, N = 1084)
rs10975331(T)/9:5877594* KIAA2026 (0.036, 0.12, P = 9.6e-06, N = 1543) (0.12, 0.44, P = 0.029, N = 1084)
Results from Univariable Mendelian Randomization of Taurodeoxycholic acid & Cholecystectomy - model1
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
IVW(re) 87 1 (0.79- 1.3) P=0.95 8.8 41 4.13 (0- 43.2) NA NA -0.033 P=0.26
MR-Egger 87 1.2 (0.82- 1.7) P=0.38 8.8 41 4.13 (0- 43.2) 88 0.39 -0.033 P=0.26
Weighted median 87 1.2 (0.82- 1.8) P=0.33 8.8 41 4.13 (0- 43.2) NA NA -0.033 P=0.26
Results from Univariable MRPRESSO of Taurodeoxycholic acid & Cholecystectomy - model1
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw 0.01 0.13 0.06 0.95
beta.exposure Outlier-corrected NA NA NA NA
Results from Univariable Mendelian Randomization of Taurodeoxycholic acid & Cholecystectomy - model2
Heterogeneity Statistics
Method nSNP Beta (95% CI) Pval F Var_ex I2 Q Q_pval Egger intercept (Beta Pval)
taurodeoxycholate cholecystectomy IVW(re) 0.95 (0.67- 1.3) P=0.77 20.1 (0- 73.6) 45 12 28 NA
taurodeoxycholate cholecystectomy MR-Egger 1.2 (0.75- 2.1) P=0.4 20.1 (0- 73.6) 45 12 28 58
taurodeoxycholate cholecystectomy Weighted median 1.2 (0.76- 2) P=0.39 20.1 (0- 73.6) 45 12 28 NA
Results from Univariable MRPRESSO of Taurodeoxycholic acid & Cholecystectomy - model2
Exposure MR.Analysis Causal.Estimate Sd T.stat P.value
beta.exposure Raw -0.05 0.18 -0.30 0.77
beta.exposure Outlier-corrected -0.02 0.16 -0.12 0.90