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Laboratory of Guillaume Lettre

Montreal Heart Institute | Université de Montréal

Université de Montréal Montréal Heart Institute
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Guillaume LettreGuillaume Lettre, Ph.D.

Dr Guillaume Lettre is an Associate professor of Medicine at the Montreal Heart Institute and the Université de Montréal since January 2009. He holds a Canada Research Chair in Complex Trait Genetics since November 2010. His laboratory is funded by grants from the Canadian Institutes of Health Research (CIHR), the Heart and Stroke Foundation of Canada, the “Fonds de Recherche du Québec – Santé”, and the Montreal Heart Institute Foundation.

In December 2008, he completed 3.5 years of postdoctoral training in the research group of Dr Joel N. Hirschhorn at the Broad Institute of Harvard and MIT and Children’s Hospital Boston. In Boston, his work focused on the identification of common genetic variants associated with complex traits (adult height, fetal hemoglobin levels (a strong modifier of severity in sickle cell disease) and body mass index) and common diseases (type-2 diabetes, hypertension) using genome-wide association studies (GWAS).

Dr Lettre obtained his BSc in Biology from the Université de Sherbrooke, Canada, in 2000, an MSc in Biological Sciences from the Watson School of Biological Sciences at Cold Spring Harbor Laboratory, USA, in 2001, and his PhD in Developmental Genetics from the University of Zurich, Switzerland, in 2005.


Ken Sin LoKen Sin Lo

Ken Sin Lo joined the group in March 2009 as lead bioinformatician. He oversees computational work in the lab and is responsible for developing the next-generation DNA sequencing analysis pipeline. He previously worked at the CHUL Research Center in proteomics, focusing on software for protein identification and quantification by mass spectrometry.

Ken Sin holds a BSc in computer sciences from the Université de Sherbrooke, Canada, and completed a DESS (advanced graduate diploma) degree in bioinformatics at the Université du Québec à Montréal, Canada, in 2005.


Melissa BeaudoinMelissa Beaudoin, M.Sc.

Melissa Beaudoin joined Dr Lettre and Dr Rioux laboratories in June 2009 as a research assistant. She is in charge of the high-throughput next-generation DNA re-sequencing technologies to characterize rare, common, and structural genetic variation in genes previously implicated in cardiovascular diseases (e.g. myocardial infarction, hypertension, dyslipidemia). She previously worked as a research technician in Dr Alan C. Peterson's laboratory at McGill University, Montreal, where she developed an in vivo beta-galactosidase quantification assay driven by myelin promoter. And she was a research assistant in Dr Pascal Chartrand's laboratory at the Université de Montréal, Montréal, where she developed a myotonic dystrophia type 1 cell model to use in a high-throughput screen.

Melissa obtained her BSc in Biology from the Université de Sherbrooke, Canada, in 2000, and her MSc in molecular biology from the Université de Montréal, Clinical research Institute, Canada, in 2003.


Yann IlboudoYann Ilboudo

Yann Ilboudo joined the group in Jannuary 2015 as a master's student in bioinformatics. He is interested in developing tools to predict the severity of sickle cell disease through the identification of metabolic biomarkers involved in the expression of fetal hemoglobin. Yann holds a BSc in Bioengineering with concentration in complex systems and evolution theory from SUNY-Binghamton, US, earned in 2011. There he worked developing intelligent systems and mathematical models. He previously worked as a product manager and a software sales rep in technology companies and start-ups.


Valérie-Anne Codina-FauteuxValérie-Anne Codina-Fauteux

Valérie-Anne Codina-Fauteux joined the team of Dr. Lettre in May 2015 as a trainee for her bachelor's degree in Biochemistry and Molecular Medicine at the Université de Montréal. She is now doing a master in Biochemistry to characterize the isoforms of a gene carrying an intronic SNP associated with myocardial infarction, which has led to a publication in BCM Medical Genetics. She is also working on a project aiming to prioritize causal SNPs associated with cardiovascular diseases in an endothelial dysfunction setting. Amongst others, she will analyze and integrate ATAC-seq, RNA-seq and Hi-C data.


Abdou MousasAbdou Mousas, M.Sc.

Abdou Mousas started his PhD at the lab of Dr Lettre on January 2016. He holds a B.Sc. in Mathematics (specialization in Algebraic Geometry) from the University of Athens and a M.Sc. in Neuroscience (specialization in Computational Neuroscience) from the University of Crete.

He is interested in understanding how variation at the genetic level influences the expressed phenotypes (Modifier Genetics). More specifically he is interested in blood cell genetics (red/white blood cells and platelets as originating from hematopoietic progenitor cells). He is using standard GWAS analysis techniques as well as novel Machine Learning techniques (joint affiliation with MILA) in order to facilitate:

  • Predictive Medicine - Determine individuals' probability of developing certain diseases (e.g. heart attack, stroke) given their genotype data
  • Precision Medicine - Identify genetic loci that affect disease severity and drug efficacy
  • Scientific Discovery - Uncover novel genetic loci that control complex phenotypic traits and reconstuct the underlying gene regulatory network


Simon LalondeSimon Lalonde, M.Sc.

Simon Lalonde joined the laboratory of Dr Guillaume Lettre in May 2016 as a research assistant to develop genetically engineered cell-based models in vitro using the novel CRISPR-Cas9 technology. He will also help characterize the function of the recently discovered gene PHACTR1 in the vascular system.

Simon has a Master in cellular biology since 2016 and a Bachelor in biochemistry since 2013, both obtained at Université du Québec à Montréal (UQAM), Canada.


Alexandra LangfordAlexandra Langford

Alexandra Langford joined Dr Lettre's team as a trainee in May 2017. In her first internship, she focused on the genetics and epigenomics of neutrophils. As part of a second internship, she works on CARTaGENE data in order to carry out data cleaning, genotype imputation as well as association testing. She is completing her bachelor degree in bioinformatics at the Université de Montréal.


Sébastian Méric de BellefonSébastian Méric de Bellefon, M.Sc.

Sébastian Méric de Bellefon joined the laboratory of Dr Guillaume Lettre in October 2017 as an intern for his bioinformatics Master's program at Université de Montréal. He is interested in blood trait genetics, fine-mapping techniques and tools that promote research reproducibility.

Sébastian has a Master in Informatics from the Institut Supérieur d'Électronique de Paris, after an exchange semester at the ITESM de Monterrey in 2006. He has then worked in companies as informatician and electronics technician.


Francis LeblancFrancis Leblanc

Francis Leblanc joined Dr Guillaume Lettre’s lab in May 2018 for a summer internship. Using RNAseq and ATACseq methods, he is examining endothelial dysfunction by measuring various inflammatory responses in 2 cellular models. Francis returns to studies after 10 years in the field of physical training. He is doing a bachelor degree in biochemistry specialising in genetics at the Université de Montréal and will be done in winter 2019.


Marielle HuotMarielle Huot

Marielle Huot joined the team in autumn 2018 to complete an internship for her biomedical science bachelor at the Université de Montréal. She also studied bioinformatics for a year at the same university. She is interested in endothelial dysfunction leading to cardiovascular diseases and in the development of flow cytometry protocols. She is exploring techniques such as RNAseq and FACS.


Florian WuennemannFlorian Wuennemann, Ph.D.

Florian joined the team in August of 2018 after finishing his Ph.D. in the lab of Dr. Gregor Andelfinger at the CHU Ste-Justine research center. His Ph.D. work has focused on the genetics of congenital heart disease, utilizing exome sequencing in large families with CHD to find causal genetic mutations. Florian has extensive experience with single-cell transcriptomic technologies and will utilize this knowledge in several projects in the lab. His projects in the Lettre lab are focused on better understanding the genetic basis of valvular heart disease and coronary artery disease using high-throughput technologies and quantitative genetics.


Last Updated on Tuesday, 22 January 2019 16:10