Guillaume Lettre, Ph.D.

Guillaume Lettre is a professor of medicine at the Université de Montréal and a principal investigator at the Montreal Heart Institute. He holds the Canada Research Chair in Complex Trait Genetics and is an elected member of the College of the Royal Society of Canada.

In December 2008, he completed 3.5 years of postdoctoral training in the lab of Joel N. Hirschhorn at the Broad Institute and Children’s Hospital Boston working on the genetics of complex human traits using genome-wide association studies. Guillaume obtained his BSc in Biology from the Université de Sherbrooke (2000) and his MSc in Biological Sciences from Cold Spring Harbor Laboratory (2001). In 2005, he completed his PhD in Developmental Genetics at the University of Zurich. Beside genetics, Guillaume likes running, ice hockey and old red Bordeaux.


Ken Sin Lo

Ken Sin Lo joined the group in March 2009 as lead bioinformatician. He oversees computational work in the lab, manages the big data and acts as webmaster.

Melissa Beaudoin, M.Sc.

Melissa Beaudoin joined Dr Lettre and Dr Rioux laboratories in June 2009 as a research assistant. She works on high throughput CRISPR/Cas9 screening and genome editing projects to identify and characterize rare and common genetic variations in genes implicated in cardiovascular diseases, more specifically endothelial dysfunction as well as hematological traits. She is in charge of the wet lab and supervises the students.

Hicham Belhaj, M.Sc.

Hicham Belhaj joined Dr. Guillaume Lettre’s laboratory in November 2021 as a research assistant. He works jointly with members of the laboratory to identify, among thousands of genes, those involved in hypertension and endothelial dysfunction by CRISPR/Cas9 screen. Hicham obtained a bachelor’s and a master’s degree in molecular and cellular biology at the University of Montreal. During his master’s degree, he became interested in the molecular mechanisms of the last step in cell division, cytokinesis. In particular, he was interested in a protein known to be overexpressed in various cancers, anillin.


Yann Ilboudo, M.Sc.

Yann Ilboudo joined the group in Jannuary 2015 as a master’s student in bioinformatics. He is interested in developing tools to predict the severity of sickle cell disease through the identification of metabolic biomarkers involved in the expression of fetal hemoglobin.

Estelle Lecluze, Ph.D.

Estelle Lecluze joined Dr Guillaume Lettre’s lab in September 2020 as a post-doctoral fellow. She is working on the role of endothelial cells in blood pressure regulation. She identifies important genes that may be responsible of endothelial dysfunction by analyzing genomics, epigenomics and transcriptomics data, and participates to functional genomic experiments using CRISPR/Cas9 technology.

Francis Leblanc

Francis Leblanc joined Dr Guillaume Lettre’s lab in May 2018 for a summer internship on endothelial dysfunction. Francis returns to higher education after 10 years in the health and fitness industry. He completed the bachelor in biochemistry with honors at the University of Montreal in April 2019, and is now a PhD student in bioinformatics. His projects will integrate bulk and single nuclei RNAseq and ATACseq to further the molecular understanding of atrial fibrillation and endothelial dysfunction.

Pegah Hejazi, M.Sc.

Pegah Hejazi joined Dr. Lettre’s lab in January 2022 as a PhD student. She is working on single cell methods to study cardiovascular diseases. Precisely, she is interested in transcriptomic and epigenetic of cellular senescence in cardiovascular dysfunction.
Pegah has finished her Masters in Biotechnology. During that time she was involved in cancer research and drug discovery.

Thomas Pincez, M.D., M.Sc.

Thomas Pincez joined the group in January 2020 as a molecular biology PhD’s student. He is interested in red cell genetics and especially sickle cell disease. He will work from genome-wide association data and CRISPR-Cas9 screening.

After medical school and paediatrics residency in Paris, France, Thomas has started a fellowship in haematology-oncology paediatrics at Ste-Justine hospital, Montreal, until the end of 2020. He also has a master degree in immunology.

Nicolas Brosseau, M.Sc.

Nicolas Brosseau joined the group in june 2020 as a PhD student. He is working on the influence of genetique variations on red blood cells traits and the influence these variations have on the severity of sickle cell disease.

Nicolas obtained is BSc and MSc in biomedical sciences at the Université de Montréal. During his master, he studied the resistance mechanisms of cancer cells to chemotherapeutic treatments. More specifically, he was interested by the involvement of membrane transport in the uptake of anthracyclines by targeted cells.



Stronger et al. 2013