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Laboratory of Guillaume Lettre

Montreal Heart Institute | Université de Montréal

Université de Montréal Montréal Heart Institute




2019-09-10. Dr Guillaume Lettre is elected to the Royal Society of Canada College of New Scholars, Artists and Scientists.

2019-06-11. Dr Guillaume Lettre talks about polygenic risk score relevance, which was applied to predict likelihood of heart disease in French Canadian.

2018-10-11. Dr Guillaume Lettre is the winner of the André-Dupont 2018 Award.

2017-02-02. Dr Guillaume Lettre and Ken Sin Lo's work on a large-scale international study about the genetics of adult height is now published in Nature.

2016-06-29. Publication of three ExomeChip articles in the AJHG by the Blood-Cell Consortium led by Dr Guillaume Lettre. Congratulations to PhD student Nathalie Chami, lead co-author on 2 of the 3 papers.

2015-05-01. Congratulations to Nathalie Chami and Samuel Lessard who were awarded PhD scholarships from FRQS and CIHR! Geneviève Galarneau, former PhD student in the Lettre lab, also received a CIHR postdoctoral fellowship to continue her training at Mount Sinai (New York).

2014-04-28. Dr Guillaume Lettre identifies genetic mutations involved in human blood diseases.

Science cover

2013-10-11. An article with Dr Guillaume Lettre and Samuel Lessard as co-authors made the cover of Science.

2013-10-04. Lip-sync!


2013-07-18. SCD findings highlighted as one of the hottest studies in Blood.

2012-12-12. Dr Guillaume Lettre receives a Doris Duke Innovations in Clinical Research Award.

2012-01-23. Dr Guillaume Lettre talks about height.

2010-11-24. Dr Guillaume Lettre receives a Canada Research Chair.

2010-09-30. Dr Guillaume Lettre's laboratory publishes an important study in Nature on the genetics of adult height.

My group is interested in the genetics of complex traits and common diseases in humans. Based at the Montreal Heart Institute, we aim to identify genetic variation that influences cardiovascular and hematological disease risk using high-throughput DNA genotyping and sequencing technologies, together with state-of-the-art computational and bioinformatics approaches. We are also combining our genetic discoveries with functional characterization largely based on genome editing methods (e.g. CRISPR/Cas9) to gain molecular and mechanistic insights into disease pathophysiology.

The group is part of the Faculty of Medicine at the Université de Montréal. Many of our research projects are wonderful collaborations with colleagues and friends in Montreal and abroad (USA, UK, France, Switzerland, Kenya, etc.).


Opportunities exist for talented and motivated individuals (students, postdocs, fellows, programmers, bioinformaticians, and (bio)statisticians) to join our research activities. Please send email inquiries to Guillaume.Lettre [at] .


Last Updated on Thursday, 12 September 2019 15:59