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Laboratory of Guillaume Lettre

Montreal Heart Institute | Université de Montréal

Université de Montréal Montréal Heart Institute
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Dataset

Blood Cell Consortium (BCX)
Summary ExomeChip association data reported in the following article: (for more information, see readme2.txt)

  • Rare coding variants pinpoint genes that control human hematological traits
Red blood cellsred blood cell count (RBC count)meta_rare_rbc.txt.gz (3.3MB)
hemoglobin concentration (HGB)meta_rare_hgb.txt.gz (3.4MB)
hematocrit (HCT)meta_rare_hct.txt.gz (3.4MB)
mean corpuscular hemoglobin (MCH)meta_rare_mch.txt.gz (3.3MB)
mean corpuscular volume (MCV)meta_rare_mcv.txt.gz (3.3MB)
mean corpuscular hemoglobin concentration (MCHC)meta_rare_mchc.txt.gz (3.3MB)
RBC distribution width (RDW)meta_rare_rdw.txt.gz (3.3MB)
White blood cellstotal white blood cell count (WBC count)meta_rare_wbc.txt.gz (3.4MB)
neutrophil count (Neutro)meta_rare_neutro.txt.gz (3.4MB)
lymphocyte count (Lympho)meta_rare_lympho.txt.gz (3.3MB)
monocyte count (Mono)meta_rare_mono.txt.gz (3.3MB)
basophil count (Baso)meta_rare_bas.txt.gz (3.2MB)
eosinophil count (Eosin)meta_rare_eos.txt.gz (3.2MB)
Plateletsplatelet count (PLT count)meta_rare_plt.txt.gz (3.4MB)
mean platelet volume (MPV)meta_rare_mpv.txt.gz (3.2MB)

Blood Cell Consortium (BCX)
Summary ExomeChip association data reported in the following articles: (for more information, see readme.txt)

  • Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits, Am J Hum Genet. 2016 Jun 21
  • Large-Scale Exome-wide Association Analysis Identifies Loci for White Blood Cell Traits and Pleiotropy with Immune-Mediated Diseases, Am J Hum Genet. 2016 Jun 21
  • Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals, Am J Hum Genet. 2016 Jun 21

African ancestryEuropean ancestryAll ancestries
Red blood cellBCX_RBC_AA.tar.gz (56.1MB)BCX_RBC_EA.tar.gz (61.1MB)BCX_RBC_ALL.tar.gz (67.3MB)
White blood cellBCX_WBC_AA.tar.gz (43.4MB)BCX_WBC_EA.tar.gz (48.3MB)BCX_WBC_ALL.tar.gz (56.5MB)
PlateletBCX_PLT_AA.tar.gz (15.8MB)BCX_PLT_EA.tar.gz (17.3MB)BCX_PLT_ALL.tar.gz (19.1MB)

Software

CRISPR Off-Target Tool
This script aims at finding off-targets in CRISPR/Cas9 experiments given a list of single-guide RNAs (sgRNAs).
Version 2.0.5: [Documentation]  [R scripts]
Version 1.02: [Documentation]  [R script]

Supplementary tables for Lessard S, Francioli L, Alfoldi J, Tardif JC, Ellinor PT, MacArthur DG, Lettre G, Orkin SH, and Canver MC. Human genetic variation alters CRISPR/Cas9 on- and off-targeting specificity at therapeutically implicated loci [PNAS 2017]
Supplementary data. List of individual aggregate off-target scores for samples from the 1,000 Genomes Project and their local scores. CFD: cutting frequency determination.
Supplementary data. List of individual aggregate off-target scores for samples from the French Canadian dataset and their local scores. CFD: cutting frequency determination.

KnockoutQT
This script (knockoutQT.rb) aims at finding gene knockouts (KOs) and testing their association with a given quantitative phenotype.
[Documentation]  [Ruby script]  [R script]


Last Updated on Thursday, 14 December 2017 14:29