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Laboratory of Guillaume Lettre

Montreal Heart Institute | Université de Montréal

Université de Montréal Montréal Heart Institute
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Dataset

Blood Cell Consortium (BCX)
Summary association data (see readme_BCX2_meta_analyses.txt), fine-mapping results (see readme_BCX2_CS95_VEP.txt) and g-chromVar enrichment results (see readme_BCX2_gchromVAR_5Sept2019.txt) reported in the following article:

  • Article

MR-MEGA GWAMA
Trans-ethnic Trans-ethnic European East-Asian African Hispanics/Latinos
Red blood cells red blood cell count (RBC count) file file file file file file
hemoglobin concentration (HGB) file file file file file file
hematocrit (HCT) file file file file file file
mean corpuscular hemoglobin (MCH) file file file file file file
mean corpuscular volume (MCV) file file file file file file
mean corpuscular hemoglobin concentration (MCHC) file file file file file file
RBC distribution width (RDW) file file file N.A. file file
White blood cells total white blood cell count (WBC count) file file file file file file
neutrophil count (Neutro) file file file file file file
lymphocyte count (Lympho) file file file file file file
monocyte count (Mono) file file file file file file
basophil count (Baso) file file file file file file
eosinophil count (Eosin) file file file file file file
Platelets platelet count (PLT count) file file file file file file
mean platelet volume (MPV) file file file file file file

Fine-mapping results (95% credible sets) BCX2_CR95_VEP.zip
G-chromVar enrichment results CS.trans_all.PP01.strong_atac_overlap.tsv
CS.trans_subancestry.PP01.strong_atac_overlap.tsv

Blood Cell Consortium (BCX)
Summary ExomeChip association data (for more information, see readme2.txt) reported in the following article:

  • Rare coding variants pinpoint genes that control human hematological traits, PLoS Genet 2017
Red blood cellsred blood cell count (RBC count)meta_rare_rbc.txt.gz (3.3MB)
hemoglobin concentration (HGB)meta_rare_hgb.txt.gz (3.4MB)
hematocrit (HCT)meta_rare_hct.txt.gz (3.4MB)
mean corpuscular hemoglobin (MCH)meta_rare_mch.txt.gz (3.3MB)
mean corpuscular volume (MCV)meta_rare_mcv.txt.gz (3.3MB)
mean corpuscular hemoglobin concentration (MCHC)meta_rare_mchc.txt.gz (3.3MB)
RBC distribution width (RDW)meta_rare_rdw.txt.gz (3.3MB)
White blood cellstotal white blood cell count (WBC count)meta_rare_wbc.txt.gz (3.4MB)
neutrophil count (Neutro)meta_rare_neutro.txt.gz (3.4MB)
lymphocyte count (Lympho)meta_rare_lympho.txt.gz (3.3MB)
monocyte count (Mono)meta_rare_mono.txt.gz (3.3MB)
basophil count (Baso)meta_rare_bas.txt.gz (3.2MB)
eosinophil count (Eosin)meta_rare_eos.txt.gz (3.2MB)
Plateletsplatelet count (PLT count)meta_rare_plt.txt.gz (3.4MB)
mean platelet volume (MPV)meta_rare_mpv.txt.gz (3.2MB)

Blood Cell Consortium (BCX)
Summary ExomeChip association data (for more information, see readme.txt) reported in the following articles:

  • Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits, Am J Hum Genet. 2016 Jun 21
  • Large-Scale Exome-wide Association Analysis Identifies Loci for White Blood Cell Traits and Pleiotropy with Immune-Mediated Diseases, Am J Hum Genet. 2016 Jun 21
  • Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals, Am J Hum Genet. 2016 Jun 21

African ancestryEuropean ancestryAll ancestries
Red blood cellBCX_RBC_AA.tar.gz (56.1MB)BCX_RBC_EA.tar.gz (61.1MB)BCX_RBC_ALL.tar.gz (67.3MB)
White blood cellBCX_WBC_AA.tar.gz (43.4MB)BCX_WBC_EA.tar.gz (48.3MB)BCX_WBC_ALL.tar.gz (56.5MB)
PlateletBCX_PLT_AA.tar.gz (15.8MB)BCX_PLT_EA.tar.gz (17.3MB)BCX_PLT_ALL.tar.gz (19.1MB)

Software

CRISPR Off-Target Tool
This script aims at finding off-targets in CRISPR/Cas9 experiments given a list of single-guide RNAs (sgRNAs).
Version 2.0.5: [Documentation]  [R scripts]
Version 1.02: [Documentation]  [R script]

Supplementary tables for Lessard S, Francioli L, Alfoldi J, Tardif JC, Ellinor PT, MacArthur DG, Lettre G, Orkin SH, and Canver MC. Human genetic variation alters CRISPR/Cas9 on- and off-targeting specificity at therapeutically implicated loci [PNAS 2017]
Supplementary data. List of individual aggregate off-target scores for samples from the 1,000 Genomes Project and their local scores. CFD: cutting frequency determination.
Supplementary data. List of individual aggregate off-target scores for samples from the French Canadian dataset and their local scores. CFD: cutting frequency determination.

KnockoutQT
This script (knockoutQT.rb) aims to find gene knockouts (KOs) and test their association with a given quantitative phenotype.
[Documentation]  [Ruby script]  [R script]


Last Updated on Wednesday, 22 January 2020 10:00